Polyspermine imidazole-4, 5-imine, a Chemically Dynamic and Biologically Responsive Carrier System for Intracellular Delivery of siRNA

Shiyue Duan, Weien Yuan, Fei Wu, and Tuo Jin

School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China


We report a structurally simple yet highly functional cationic polymer, polyspermine imidazole-4,5-imine, which accomplishes four of the total five essential tasks to achieve therapeutically feasible delivery of siRNA.

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