Hyaluronic Acid – Gold Nanoparticle / Interferon α Complex for Targeted Treatment of Hepatitis C Virus Infection

Sei Kwang Hahn1,2,*, Min-Young Lee1, and Jeong-A Yang1
1Department of Materials Science & Engineering, 2School of Interdisciplinary Bioscience and Bioengineering,
Pohang University of Science and Technology (POSTECH), Pohang, Kyungbuk 790-784, Korea

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Summary
In vivo real-time confocal microscopy of hyaluronic acid (HA) - quantum dot (QD) conjugates successfully visualized the target specific delivery and accumulation of HA-QD conjugates from the fluorescently-labeled blood vessels to the liver tissues. On the basis of the results, target-specific long-acting delivery system of interferon α (IFNα) was successfully developed using hybrid materials of HA and gold nanoparticles (AuNPs) for the treatment of hepatitis C virus (HCV) infection. The HA–AuNP/ IFNα complex was target-specifically delivered and accumulated in the murine liver tissue. Accordingly, the HA–AuNP/IFNα complex significantly enhanced the expression of OAS1 for innate immune responses to viral infection in the liver tissues.

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