Targeted Nano-NRTI Formulations for Suppression of HIV-1 Infection in the Brain

Serguei V. Vinogradov, Santhi Gorantla, Thulani Senanayake, Edward Makarov, Yaman Lu
University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha NE 68198-6025

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Summary
A brain-targeted antiviral nanoformulations of triphosphorylated nucleoside reverse transcriptase inhibitors (nano-NRTI) were developed and evaluated using several in vitro and in vivo models. These drug formulations demonstrated the ability to penetrate the blood-brain barrier (BBB), accumulate in infected macrophages, and inhibit the HIV-1 activity in humanized mouse model of HIV-1 infection in the brain.

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