Development and Characterization of Emulsomes for Macrophage Targeted Multidrug Therapy against Tuberculosis

Swati Gupta1,2, Yashwant Pathak2

1Nanomedicine Research Center, Department of Pharmaceutics, I.S.F. College of Pharmacy, Moga 142 001 (PB), INDIA; 2Department of Pharmaceutical Sciences, College of Pharmacy, USF Health, Tampa, FL, 33612, USA

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Summary
Glyceryl tridecanoate (tricaprin) based nanosize lipid particles (emulsomes) stabilized by soya phosphatidylcholine (PC) were prepared as a new drug delivery system for alveolar macrophage targeting for the treatment of tuberculosis. Multidrugs (rifampicin, isoniazid, pyrazinamide) encapsulated emulsomes dry powder inhaler (DPI) resulted in high concentration of drugs in the lungs.

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