Real time Raman imaging to understand dissolution performance of amorphous solid dispersions

Francesco Tres1, Stephen A. C. Wren2, Jonathan W. Aylott1, and Jonathan C. Burley1

1School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, United Kingdom; 2Pharmaceutical Development, AstraZeneca, Macclesfield, SK10 2NA, United Kingdom


We have employed Raman spectroscopic imaging to investigate in real time and in-situ the dissolution mechanisms that underpin amorphous solid dispersions of poorly water soluble felodipine in a polymeric matrix of Kollidon VA64. It was found that the increase of the drug loading in the formulation leads to re-crystallisation of the active ingredient, negatively impacting the dissolution performance.

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