Influence of the vehicle type on the in-vitro skin permeation of acetyl hexapeptide-8

M. Hoppel1, D. Mahrhauser2, G. Reznicek3, C. Valenta1,2

1Research Platform ‘Characterisation of Drug Delivery Systems on Skin and Investigations of Involved Mechanisms’, University of Vienna, 1090 Vienna, Austria
2Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, 1090 Vienna, Austria
3Department of Pharmacognosy, University of Vienna, 1090 Vienna, Austria

VIEW PRESENTATION

Summary
The in-vitro skin permeation of acetyl hexapeptide-8 (AH8) from three different vehicles, namely from a multiple water-in-oil-in-water (W/O/W), a water-in-oil (W/O) and an oil-in-water (O/W) emulsion, was investigated by Franz-type diffusion cell experiments. Moreover, the suitability of LC-MS/MS as a sensitive analytical method for assessing skin permeation of AH8 was confirmed in this study. Additional ATR-FTIR measurements combined with tape stripping were conducted to gain better insight into the skin penetration of the different vehicles.

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