Mechanisms of PAMAM Dendrimer Transepithelial Transport and Tight Junction Modulation

D. Goldberg1,2*, P.W. Swaan1-3 and H. Ghandehari1,4

1Department of Bioengineering, University of Maryland, College Park, MD 20742, USA 2Center for Nanomedicine & Cellular Delivery & 3Department of Pharmaceutical Sciences, University of Maryland, Baltimore, MD 21201, USA 4Departments of Pharmaceutics and Pharmaceutical Chemistry & Bioengineering, Center for Nanomedicine, Nano Institute of Utah, University of Utah, Salt Lake City, UT 84108, USA


PAMAM dendrimers have shown potential as oral drug delivery carriers due to their ability to translocate across epithelial cell monolayers and open tight junctions. In this work, we demonstrate that dendrimer uptake and transcytosis is governed by dynamin-dependent vesicular mechanisms including clathrin- and caveolin-mediated endocytosis and that cellular internalization is a requisite step for dendrimer modulation of tight junction integrity.

© Copyright Controlled Release Society  | Contact Us - Report a Bad Link |
Admin Access