Photocrosslinked poly(ester anhydride)s in drug delivery: modification of in vivo peptide release by oligomer chemistry and visualization of surface erosion controlled release

J. Mönkäre1, R.A. Hakala2, M. Kovalainen1, J. Pajander3, K.H. Herzig4,5, H. Korhonen2, J.V. Seppälä2, K. Järvinen1

1 School of Pharmacy, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland; 2Laboratory of Polymer Technology, School of Science and Technology, Aalto University, P.O. Box 16100, FI-00076 Aalto, Finland; 3 Department of Pharmaceutics and Analytical Chemistry, University of Copenhagen, 2100 Copenhagen, Denmark; 4 Institute of Biomedicine and Biocenter of Oulu, University of Oulu, P.O. Box 5000, FI-90014 Oulu, Finland; 5 Department Psychiatry, Kuopio University Hospital, Box 1627, FI-70211 Kuopio, Finland juha.monkare@uef.fi

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Summary
Peptide YY3-36 (PYY3-36), a promising drug candidate for treatment of obesity, was administered subcutaneously in rats via tunable photocrosslinked poly(ester anhydride)s (PEAHs) which sustained PYY3-36 release and increased its subcutaneous bioavailability. By tuning hydrophobicity of the PEAH oligomers, in vivo release rate of PYY3-36 could be tailored as the release was controlled by the surface erosion of PEAHs. Micro-computed tomography (micro-CT) was used for visual and quantitative analysis of the surface erosion mechanisms of PEAHs. In conclusion, the present and earlier study indicate that photocrosslinked PEAHs enable tailored, surface erosion controlled drug delivery.

 

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