Development of oral nanoparticulate coenzyme Q10 formulations: Nanostructured lipid carriers (NLC) and drug nanocrystals

J. Pardeike1, A. Hommoss2, A. Zimmer1

1Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology, Karl-Franzens Universität Graz, Universitätsplatz 1, 8010 Graz, Austria; 2Arab International University, Faculty of Pharmacy, Ghabaghib, Daraa, Syria Arab Republic 


Coenzyme Q10-loaded NLC, Coenzyme Q10 nanocrystals and Coenzyme Q10 suspension for oral application with an active content of 4.8% were developed  and compared with regards to  in vitro drug release, mucoadhesion and permeation through porcine intestine. The two nanoparticlulate formulations showed a faster drug release, a higher mucoadhesion and a higher permeability through porcine intestine compared to the microparticulate suspension making them promising systems for oral application of Coenzyme Q10.

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