Polymeric styrene maleic acid-miceller anticancer drugs: Enhanced antitumor activity-based on EPR-effect in solid tumors.


Khaled Greish and Hiroshi Maeda. Department of Microbiology, Jumamoto University. Department of Pharmaceutics, Sojo University, Japan.


This presentation describes the use of permeability and retention effect to target anti-cancer drugs selectively and how styrene maleic acid-miceller drugs enhance the effect. The AUC of this micelle is more than 40% higher than free THP and 13 times better in tumor concentration.


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