Comparison of Recombinant Silk-Elastinlike Hydrogels for Viral Gene Delivery with Poloxamers

R. Price1,2*, K. Greish1,2, J. Frandsen2,3, J. Gustafson2,3, and H. Ghandehari1-3

1Department of Pharmaceutics and Pharmaceutical Chemistry, 2Center for Nanomedicine, Nano Institute of Utah, 3Department of Bioengineering, University of Utah, Salt Lake City, UT, 84108, USA


The in vivo transfection efficiency of matrix-mediated viral gene delivery by two distinct classes of polymers, namely silk-elastinlike recombinant protein polymers (SELPs) and polyoxypropylene-polyoxyethylene copolymers (poloxamers), was compared in a head and neck squamous cell carcinoma model. Viruses entrapped in SELPs showed higher expression levels in the tumors through day 11, and had statistically significant higher expression levels at day 21. The poloxamer group no longer showed any expression from day 21, while select animals in the SELP group showed expression until day 35.

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