Randy Mrsny, Department of Pharmacy and Pharmacology, University of Bath. Unity Pharmaceuticals.
This presentation describes challenges to and strategies for oral delivery of macromolecules. Focusing on the small intestine because of its large surface area is one such strategy. There are two major routes of distribution following uptake in the small intestine – lymphatic and hepatic portal systems. Circumnavigating the GI tracts’ normal function of digesting and distributing macromolecules is essential to the potential delivery of drug macromolecules. This presentation discusses the challenges of approaching either of the two basic pathways for macromolecule delivery within the small intestine --paracellular vs. transcellular. The advantages of successful oral delivery of macromolecules is that the delivery mechanism is similar to natural release of hormones from the pancreas and intestine.