2015 CRS Annual Meeting Abstracts

Abstracts available to current members and 2015 annual meeting attendees.
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collapse College of Fellows Panel

How Can We Make Nanomedicine Work?
Presenter: Susan Cady.
Merial Ltd.
collapse Cost-Effective Encapsulation for Industrial Applications: Limitations and Solutions

53 Improved Formulation for Cellular Uptake of Peptides in the Skin
Presenter: Franz Suter Authors: F Suter, D Schmid, F Zuelli.
Mibelle Biochemistry, Switzerland

54 Cost effective encapsulation of flavors
Presenter: Jenny Weissbrodt Authors: J Weissbrodt, I Reiss.
Symrise AG, Germany

55 Cost effective encapsulation of active ingredients in the agricultural chemical and microbial control industries
Presenter: Ian Tomlinson Authors: I A Tomlinson, L Liu, M Zhao, R E Boucher, F Zeng, T Ghosh.
Dow Advanced Materials, U.S.A.
collapse Delivery of Peptides and Proteins

34 Cell-Penetrating Peptides for Oral Delivery of Peptide and Protein Drugs
Presenter: Noriyasu Kamei Authors: N Kamei, M Takeda-Morishita.
Kobe Gakuin University, Japan

35 Advances in Oral GLP-1 Delivery
Presenter: Ulrik Rahbek Authors: U L Rahbek.
Novo Nordisk A/S, Denmark

61 A New Structural Design of a Closed-Loop Insulin Delivery Implant Extends the Duration of Insulin Efficacy in a Type 1 Diabetic Rat Model by Impeding Immune Cell Infiltration
Presenter: Jason Li Authors: J Li, M K Chu, C R Gordijo, A Giacca, M Lohn, O Plettenburg, X Wu.
Leslie L. Dan Faculty of Pharmacy, University of Toronto, Canada

81 Creation of human TNFR1-selective antagonistic TNF mutants using phage display to develop novel anti-inflammatory biodrugs
Presenter: Daisuke Ando Authors: D Ando, H Kamada, M Inoue, K Nagano, Y Mukai, Y Tsutsumi, S Tsunoda.
National Institute of Biomedical Innovation, Japan

131 Parkinsonian monkeys showed brain structural and functional recovery following local delivery of microencapsulated GDNF
Presenter: Elisa Garbayo Authors: E Garbayo, H Lana, G D´Addario, M Carmona, I Marcilla, J Lanciego, M Luquin, M Blanco-Prieto.
Pharmacy and Pharmaceutical Technology Department, University of Navarra, Spain

144 Pseudomonas Exotoxin A as a drug carrier for oral protein delivery
Presenter: Floriane Laurent Authors: F Laurent, J Mackay, R Mrsny.
Univ of Bath, United Kingdom

160 The Use of Inkjet Printing for Dosing Biomacromolecular Actives in Drug Delivery Systems
Presenter: MIGUEL MONTENEGRO-NICOLINI Authors: M MONTENEGRO-NICOLINI, V MIRANDA, E TORO, J O MORALES.
UNIVERSITY OF CHILE, Chile
collapse Delivery of Proteins, Peptides, and Vaccines

57 A liquid-in-liquid multi-compartmental system for the oral delivery of subunit vaccines to treat colorectal cancer
Presenter: Jin Jau Liau Authors: J Liau, K Kaneko, S Bobbala, B Gibson, A Highton, S Hook, C A Prestidge, T J Barnes.
University of South Australia, Australia

59 A microscopic-enabled microfluidic device for transport of nanoparticles in intestinal mucus
Presenter: Sourav Bhattacharjee Authors: S Bhattacharjee, D Hristov, E Mahon, K A Dawson, D J Brayden.
University College Dublin, Ireland

60 A Multisystem to Orally Co-deliver Glucagon-like Peptide-1 and Dipeptidyl Peptidase 4 Inhibitor for Type 2 Diabetes Mellitus Therapy
Presenter: Francisca Araújo Authors: F Araújo, N Shrestha, M Shahbazi, D Liu, B Herranz-Blanco, E M Mäkilä, J J Salonen, J T Hirvonen, P L Granja, B Sarmento, H A Santos.
INEB - Instituto Engenharia Biomédica, University of Porto, Portugal

64 A Supramolecular Carrier for Regulating Oral Absorption Profile of Insulin
Presenter: Kohsaku Kawakami Authors: K Kawakami, Y Daimon, N Kamei, Y Haraya-Takechi, H Izawa, M Takeda-Morishita, H Saito, H Sakai, M Abe, K Ariga.
National Institute for Materials Science, Japan

67 Active transport and lysosome-evading dual functional nanocomplexes for oral insulin delivery
Presenter: Weiwei Fan Authors: W Fan, D Xia, C Zhu, L Hovgaard, M Yang, Y Gan.
Shanghai Institute of Materia Medica, China

68 Alteration of carbon nanotube’s length and surface charge affects antigen uptake and immune response induced by dendritic cell in vitro
Presenter: Hatem Hassan Authors: H F Hassan.
Faculty of Life Sciences and Medicine, King's College London, United Kingdom

69 Aqueous Remote Loading of Cationic Peptides in PLGA microspheres
Presenter: Morgan Giles Authors: M B Giles, A C Doty, S P Schwendeman.
University of Michigan, U.S.A.

70 BBB-shuttle peptides for CNS drug delivery
Presenter: Meritxell Teixido Authors: M Teixido, B Oller-Salvia, R Prades, P Arranz-Gibert, E Giralt.
Institute for Research in Biomedicine, Spain

72 Bioactivity of Liposomal Antimicrobial Peptides in Herpes Virus In Vitro Models
Presenter: Gershon Golomb Authors: S Ron Doitch, M M Nordling David, O Feldman, B Sawodny, A Samanta, J Phopase, O Almalek, M Griffith, S Rupp, G Golomb.
Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Israel

74 Brain Delivery of Peptide Drugs via Intranasal Administration for Alzheimer's Disease Treatment
Presenter: Noriyasu Kamei Authors: N Kamei, H Choi, M Tanaka, R Itokazu, T Shingaki, Y Kanayama, Y Watanabe, M Takeda-Morishita.
Kobe Gakuin University, Japan

75 Comparative in vitro and in vivo analysis of nanovaccine - immune cell interactions
Presenter: Noemi Csaba Authors: E Presas, M Peleteiro, J Gonzalez Aramundiz, A Gonzalez, M Alonso, N Csaba.
CIMUS - USC, Spain

77 Comparison the Pharmacokinetic Profiles between Monomeric and Oligomeric Transferrin
Presenter: Hsuan-Yao Wang Authors: H Wang, J L Zaro, W Shen.
Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, U.S.A.

78 Controlled Release of biologicals from Microspheres Using Layer-by-Layer (LbL) Technology
Presenter: Omar Sakr Authors: O Sakr, O Jordan, G Borchard.
University of Geneva, Switzerland

79 Controlled Release of Biologics from Core-Sheath Electrospun Fibers with High Loading
Presenter: Quynh Pham Authors: Q Pham.
Arsenal Medical, U.S.A.

82 Dendritic cell subsets interact with pathogen mimicking particles in a size dependent manner
Presenter: Krishnendu Roy Authors: J Leleux, P Pradhan, K Roy.
Georgia Institute of Technology, U.S.A.

83 Developing recombinant single-chain Fc dimer fusion proteins for protein drug delivery
Presenter: Li Zhou Authors: L Zhou, C T Okamoto, W Shen, J L Zaro.
University of Southern California, U.S.A.

86 Development and characterization of aqueous core nanocapsules designed for protein oral delivery
Presenter: Hélène Malhaire Authors: H Malhaire, V Lavastre, G Pénarier, F Benetti, J Benoît, F Lagarce.
INSERM U1066 – Micro et Nanomédecines Biomimétiques; LUNAM – Université d’Angers, France

87 Development and evaluation of a monoclonal antibody against Eph receptor A10 for novel molecularly targeted therapy of breast cancer
Presenter: Kazuya Nagano Authors: K Nagano, Y Maeda, T Yamashita, M Inoue, Y Mukai, H Kamada, K Higashisaka, Y Yoshioka, Y Tsutsumi, S Tsunoda.
National Institute of Biomedical Innovation, Japan

88 Development of a novel enzymatic nano-reactor for the application of biodetoxification
Presenter: Hengmin Tang Authors: H Tang, T Mori, S Tanaka, Y Katayama, A Kishimura.
Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Japan

89 Development of a personalized treatment vaccination for melanoma
Presenter: Bernadette DSouza Authors: B DSouza, A Patel, T Vo, G W Bumgarner.
Samford University, U.S.A.

90 Development of Alendronate and Heparin Incorporated Atelocollagen Matrices for Controlling BMP-2 Release and Osteogenic Differentiation
Presenter: Si-Nae Park Authors: H Jeong, J Ko, D Oh, S Park, S Park.
Dalim Tissen Co., Ltd., Korea

91 Development of Novel Immunoliposome for the Enhancement of Antibody-Based Therapy
Presenter: Takako Niwa Authors: T Niwa, K Morita, H Yoshida, A Hashimoto, T Ohnishi, K Fujiwara, K Ichikawa, Y Kasuya.
Daiichi Sankyo Co., LTD, Japan

93 Dual functional Collagen Nerve Conduits, Endowed with Collagen Binding Neurotrophic Factor and Guidance Fibers, Trigger Axonal Outgrowth
Presenter: Bruno Gander Authors: B Gander, S Madduri.
Institute of Pharmaceutical Sciences, Switzerland

94 Electrosprayed pp65489-503 peptide-loaded PLGA-nanoparticles enhance proliferation of antigen-specific cytotoxic T cells as compared to non-encapsulated peptide
Presenter: Britta Kandil Authors: B Kandil, A Gomez, B Kaiser-Heemskerk.
Miltenyi Biotec GmbH, Germany

97 Enhanced Paracellular Transport of Insulin Can Be Achieved Via Transient Induction of Myosin Light Chain Phosphorylation
Presenter: Alistair Taverner Authors: A Taverner, R Mrsny.
Univ of Bath, United Kingdom

98 Enhanced uptake and transports of bovine lactoferrin in human intestinal Caco-2 cells by pectin and chitosan modified solid lipid particles
Presenter: Jingyuan Wen Authors: J Wen.
University of Auckland, New Zealand

100 Enzymatic Bio-surgery: replacing surgical blades with tissue-cleaving enzymes
Presenter: Assaf Zinger Authors: a zinger, C Tzror, M Alper, O Adir, A Herman, A Schroeder.
Technion – Israel Institute of Technology, Israel

101 Fabrication of Double-wall Microparticles with Protein Loaded in the Hydrophilic Gel Core Using Coaxial Electrohydrodynamic Atomization
Presenter: Chi-Hwa Wang Authors: F Feng, K Noeh, P Davoodi, C Wang.
National University of Singapore, Singapore

102 Formulation and Characterization of Microemulsion System for Oral Peptidal Delivery
Presenter: SUMIT SHARMA Authors: S SHARMA, V R SINHA.
UIPS, PANJAB UNIVERSITY, CHANDIGARH, India

103 HER2-Targeted Hepatitis B Virus Core Particle as Nanocarriers to Treat Cancer
Presenter: Khuloud Al-Jamal Authors: I Bin Mohamed Suffian, M Garcia-Maya, P Brown, Y Nishimura, R Klippstein, C Ogino, K T Al-Jamal.
King's College London, United Kingdom

104 Highly Efficient Delivery of Functional Cargoes by the Synergistic Effect of GAG Binding Motifs and Cell-Penetrating Peptides
Presenter: James Dixon Authors: J E Dixon, G Osman, G E Morris, H Markides, M J Rotherham, Z Bayoussef, A El-Haj, C Denning, K M Shakesheff.
University of Nottingham, United Kingdom

106 Identification of Potential Binding Partners for the N-Terminal Domain of Occludin
Presenter: Theresa Ikem Authors: T Ikem, M Lloyd, R Mrsny.
Univ of Bath, United Kingdom

107 Immobilized transglutaminase for enzymatic protein PEGylation.
Presenter: Antonella Grigoletto Authors: A Grigoletto, G Pasut, A Mero, K Maso.
University of Padua, Italy

108 Impact of Freeze-drying and Cryoprotectant Loading on the Stability of Insulin Loaded into PLGA Nanoparticles
Presenter: Pedro Fonte Authors: P Fonte, S Soares, F Sousa, A Costa, V Seabra, S Reis, B Sarmento.
REQUIMTE, Department of Chemical Sciences - Applied Chemistry Lab, Faculty of Pharmacy, University of Porto, Portugal

110 In vivo evidence of nasal vaccination with novel poly (β-amino ester)-poly (lactic-co-glycolic acid) nanoparticles
Presenter: H Oya Alpar Authors: H Oya Alpar, M Koray Gok, S Ozgumus, G Sinani, E Cevher.
UCL Scholl of Pharmacy, Instanbul Kemerburgaz University, England

112 Injectable PLGA Implants for Controlled Release of Bevacizumab
Presenter: Rae Sung Chang Authors: R Chang, S P Schwendeman.
University of Michigan, U.S.A.

114 Internalization of radical-scavenging metallothionein for cytoprotection of transplanted pancreatic islets from xenogeneic immune reactions
Presenter: Min Jun Kim Authors: M Kim, Y Lee, D Lee.
Hanyang University, Korea

115 Intestinal regional localisation of coated SmPill® beads in rats: proof of principle using X-ray imaging
Presenter: Tanira Aguirre Authors: T A Aguirre, M Rosa, S S Guterres, A R Pohlmann, I Coulter, D J Brayden.
University College Dublin, Brazil

116 Intranasal Delivery of mRNA Vaccine Using Cyclodextrin-PEI As A Carrier Elicits Both Systemic and Mucosal Immunity
Presenter: Man Li Authors: M Li, Z Zhang, X Sun.
Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan, 610041, P.R China, China

118 Investigating of Protein-Coated Nanoparticles for Controlled Release Films
Presenter: Jason McConville Authors: A Le, A Padilla, J O Morales, J T McConville.
University of New Mexico, U.S.A.

119 Investigation of the effect of thermal and shear stress on the stability of the monoclonal antibody Infliximab
Presenter: Jihad Alsaddique Authors: J Alsaddique, R Pabari, Z Ramtoola.
The Royal College of Surgeons in Ireland, Ireland

120 Liposome-based vaccines for lung cancer treatment
Presenter: Cristina Loira Pastoriza Authors: C Loira Pastoriza, C Herin, M Machado, K Vanvarenberg, R Vanbever.
Université catholique de Louvain, Belgium

121 Local Delivery of Brain-Derived Neurotrophic Factor to the Brain For Functional Recovery Following Stroke
Presenter: Jaclyn Obermeyer Authors: J M Obermeyer, M S Shoichet.
University of Toronto, Canada

122 Measles and Rubella Vaccination Using a Microneedle Patch
Presenter: Jessica Joyce Authors: J C Joyce, C Edens, M L Collins, P A Rota, M R Prausnitz.
Georgia Institute of Technology , U.S.A.

123 Nanoencapsulation of an hTS inhibitor octapeptide against ovarian cancer in solid lipid matrix
Presenter: Valentina Iannuccelli Authors: F Sacchetti, C Marraccini, R Guerrini, G Cannazza, V Iannuccelli, M Hanuskova, E Maretti, M Costi, E Leo.
University of Modena and Reggio Emilia, Italy

124 Nano-polyplex MK2 Inhibitory Peptide Delivery Inhibits Vascular Graft Intimal Hyperplasia by Blocking Inflammation and Maintaining the Contractile VSMC Phenotype
Presenter: Thomas Werfel Authors: B C Evans, K M Hocking, M J Osgood, I Voskresenksy, J Dmowska, K V Kilchrist, C M Brophy, C L Duvall.
Vanderbilt University, U.S.A.

125 Nanosized Phytosomes for Ocular Delivery of the Histidine Dipeptide Drug L-Carnosine
Presenter: Hamdy Abdelkader Authors: H Abdelkader, R Alany, B Pierscionek, M Carew.
Kingston University London, United Kingdom

127 New Intrinsically Enteric Two-Piece Capsule Drug Delivery System
Presenter: A Sivert Authors: J Vertommen.
Capsugel Dosage Form Solutions, France

128 Novel approach to enhance the oral absorption of peptide and protein drugs through an endogenous pathway
Presenter: Khaled Almansour Authors: K Almansour, I Eggleston, R Mrsny.
Univ of Bath, United Kingdom

130 Novel in vitro instrument for estimating formulation performance of subcutaneously administered therapeutics
Presenter: Karl Box Authors: K J Box, H Kinnunen, R Mrsny.
Sirius Analytical, United Kingdom

133 PEGylated interferon shows differences in plasma clearance and bioavailability between male and female mice and between female immunocompetent C57Bl/6J and athymic nude mice
Presenter: Lisa Kaminskas Authors: L M Kaminskas, C Landersdorfer, S M Caliph, D M Shackleford, D B Ascher.
Monash Institute of Pharmaceutical Sciences, Australia

134 PEGylated TRAIL as an efficient biotherapeutics on rheumatoid arthritis model
Presenter: Sung Mook Lim Authors: S Lim, H Eom, K Lee.
SungKyunKwan University, Korea

135 Peptide Post Encapsulation onto Porous Polymeric and Inorganic Microparticles
Presenter: sarah eilleia Authors: s Y eilleia, m E Soliman.
department of pharmaceutics and industrial pharmacy faculty of pharmacy ain shams university, Egypt

136 Photocrosslinked microgels for oral delivery of macromolecular based-therapeutics
Presenter: Paolo Marizza Authors: P Marizza, A Faralli, R V Mateiu, A Müllertz, S S Keller, N B Larsen, M Grassi, A Boisen.
Technical University of Denmark (DTU), Denmark

138 Polymeric nanocarries delivery of protein through epithelial cells
Presenter: Ruiying Li Authors: R Li, R Mrsny.
Univ of Bath, United Kingdom

139 Polymeric, Cytokine-Aided Cell Recruitment & Histological Analysis
Presenter: Vérida Léandre Authors: V Léandre, E Atherton, S Furtado, P Weston, A Guennoun, H Bauer, J Chang, S Choo, S Kurial, R Lee, R Makani, S Bakhru, E Darling, L Chouchane, E Mathiowitz.
Brown University, U.S.A.

140 PolySTAT: A peptide-based, synthetic injectable hemostat that reduces bleeding in trauma models
Presenter: Suzie Pun Authors: L W Chan, X Wang, H Wei, L D Pozzo, N J White, S H Pun.
University of Washington, U.S.A.

141 Porous silicon microparticle potentiates anti-tumor immunity by enhancing antigen cross-presentation and inducing type I interferon response
Presenter: Haifa Shen Authors: H Shen, X Xia, M Ferrari.
Houston Methodist Research Institute, U.S.A.

142 Preparation, Characterization, and In Vitro Release Study of Stromal Cell-Derived Factor-1-Loaded Chitosan Membrane
Presenter: Kuo-Yu Chen Authors: K Chen, M Zheng, C Yao.
Department of Chemical and Materials Engineering, National Yunlin University of Science and Technology, Taiwan

146 Redox-Sensitive Dextran Nanogels aimed for Intracellular Delivery of Antigens
Presenter: Dandan Li Authors: D Li, C F van Nostrum, T Vermonden, W E Hennink.
Utrecht University, China

147 Self-Assembled Excipient-Free Enzyme Formulations For Oral Administration
Presenter: Mircea Mateescu Authors: M A Mateescu, P Ispas-Szabo, I Bustos.
Université du Quebec a Montreal, Canada

148 Self-assembled nanoparticles of a peptide-drug conjugate for targeted cancer therapy
Presenter: Hyungjun Kim Authors: H Kim, Y Lee, J Kim, S Jon.
KAIST, Korea

149 Self-Assembling MMP-2 Cleavable Hydrogel for On-demand Peptide Delivery
Presenter: Kyle Koss Authors: K M Koss, L D Unsworth.
University of Alberta, Canada

151 Simultaneous Delivery System of Antigenic Protein and Cytokine Gene Based on pH-Sensitive Polymer-Modified Liposomes for Induction of Antigen-Specific Immune Responses
Presenter: Eiji Yuba Authors: E Yuba, Y Kanda, A Harada, K Kono.
Osaka Prefecture University, Japan

152 Size effects of gold nanoparticles on induction of cellular immune response toward cancer immunotherapy
Presenter: Sukmo Kang Authors: S Kang, S Ahn, J Lee, E Shin, S Jon.
Korea Advanced Institute of Science and Technology, South Korea

154 Surface charge of adjuvant-modified PLGA microspheres can differently skew the immune response
Presenter: Manoli Igartua Authors: A Salvador, J Pedraz, R Hernandez, M Igartua.
NanoBioCel Group, Laboratory of Pharmaceutics, University of the Basque Country, Faculty of Pharmacy, Vitoria-Gasteiz, 01006, Spain;, Spain

155 Sustained Gelatin Release from Injectable Polymer Hydrogel System
Presenter: Bo-Bae Seo Authors: B Seo, C Kim, S Song.
Korea Institute of Science and Technology, South Korea

156 Sustained release formulations of biologics composed of cross-linked HA hydrogels
Presenter: Ole Dall Authors: M J Maltesen, O M Dall.
Novozymes A/S, Denmark

158 Targeting Skin Immune Cell Subsets for Intradermal Immunisation Against Influenza
Presenter: Matthew Ivory Authors: M O Ivory, S Llewellyn-Lacey, D A Price, M Kim, S Kang, S A Coulman, V Piguet, J C Birchall.
Cardiff University, Wales

159 The evaluation of therapeutic peptide as an anti-cancer drug Using BRET system
Presenter: Sang Kyoon Kim. Authors: Gabbine Wee, Seonggon Kim, Sang Joon Park, Choong-Yong Kim.
Laboratory Animal Center, Daegu-Gyeongbuk Medical innovation Foundation, Daegu, Republic of Korea,

162 Thermoresponsive Nano/Micro-Particles Based on PEGylated α-elastin for Protein Delivery
Presenter: Youn Jae Jung Authors: Y Jung, Y Cho.
Hanyang University, Korea

165 Tuning Physical Properties of Sustained BMP-2 Releasing Hydrogel:
Presenter: Bo-Bae Seo Authors: B Seo, C Kim, S Song.
Korea Institute of Science and Technology, South Korea

855 Characterization of DNA complexes with cyclodextrin and polyethylene gycol bisphenol A as potential formulations for gene therapy
Presenter: Yanerit Rosales Morgan Authors: Y G Rosales Morgan, O Al Meanazel, L Ali, A A Elkordy.
UnIversity of Sunderland, United Kingdom
collapse Delivery of Vaccines

12 Mucosal delivery of particulate vaccines
Presenter: Ed Lavelle Authors: E C Lavelle.
School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland

13 Vaccine delivery – depot or not?
Presenter: Dennis Christensen Authors: D Christensen.
Statens Serum Inst, Denmark

73 Biomimetically Engineered Demi-bacteria Potentiate Vaccination Against cancer
Presenter: Wei Wei Authors: W Wei, D Ni, H Yue, G Ma.
National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences. Beijing, China

126 Needle-Free Transdermal Vaccine Delivery Systems Using Hyaluronate-Vaccine Conjugates
Presenter: Sei Kwang Hahn Authors: S Hahn, H Kim, K Kim, S Yun.
POSTECH, South Korea

145 Rabies vaccination in dogs using a dissolving microneedle patch
Presenter: Jaya Arya Authors: J Arya, K Dewitt, M Scott-Garrard, Y Chiang, M R Prausnitz.
Georgia Institute of Technology, U.S.A.

161 Therapeutic Tumor Lysate Vaccine for B cell lymphoma: Efficacy and Mechanistic properties of Soluble vs Particulate Tumor Lysate Formulations
Presenter: Krishnendu Roy Authors: P Pradhan, J Leleux, J Liu, K Roy.
Professor, U.S.A.
collapse Delivery Science in Cosmetics, Personal Care, and Household Products

36 Encapsulation of oil in Ca-alginate microcapsules by inverse gelation technique
Presenter: Denis Poncelet Authors: D Poncelet.
GEPEA, France

37 Engineering Controlled Fragrance Release Systems for Superior Performance
Presenter: Yabin Lei Authors: Y Lei, L Xu, M Popplewell, J brahmas.
International Flavors and Fragrance, U.S.A.

506 Cell Toxicity and Ocular Tolerability of Chitosan Nanoparticles Loaded with OTZ
Presenter: Ali Al-kinani Authors: A A Al-kinani, A Vangala, G Calabrese, B Pierscionek, D Naughton, R G Alany.
School of Pharmacy and Chemistry, Kingston University London, United Kingdom

507 Coffee silverskin as new cosmetic ingredient: in vitro and in vivo evaluation
Presenter: Francisca Rodrigues Authors: F Rodrigues, C Pereira, F B Pimentel, R C Alves, M Ferreira, B Sarmento, M Amaral, M Oliveira.
Requimte, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, Porto, Portugal

508 Controlled Release of Encapsulated Bioactive Volatiles by Rupture of the Capsule Wall through the Light-Induced Generation of a Gas
Presenter: Damien Berthier Authors: D L Berthier, N Paret, A Herrmann, A Trachsel.
Firmenich SA, Switzerland

509 Criopass Laser Efficiency as an Enhancer of Caffeine and Caffeisilane C permeation: 3D Human Skin Equivalent as a Model Barrier
Presenter: Patricia Lopes Authors: P S Lopes, D P Luco, P G Oliveira, I M Rufino, E B Herbst, G Grecco, M B Mathor, H D Silva, M A Andreo, V R Leite-Silva.
Federal University of São Paulo, Brazil

510 Hyalgel(R): A novel hybrid system for dermo-cosmetic applications
Presenter: Daniel Morelló-Bolumar Authors: D Morelló-Bolumar, V J Nebot, M J Vicent.
Polymer Therapeutic Solutions S.L., Spain

511 In Vitro Skin Permeation of Octyl Methoxycinnamate Encapsulated in a New Gelatin Capsule System
Presenter: Vania Leite-Silva Authors: V R Leite-Silva, A M Ramos, L M Matheus, C P Monção, H Okigami, P S Lopes, H D Silva, T M Kaneko, J E Grice, M S Roberts.
UNIFESP- Universidade Federal de Sao Paulo, Brazil

512 Morphological Changes in Polycaprolactone/Oil Systems
Presenter: Christopher Baker Authors: E Atherton, C Baker, R Lee, D Austin, E Mathiowitz.
Brown University, U.S.A.

514 The effect of a damaged skin barrier on percutaneous absorption of SDS and skin hydration investigated by confocal Raman spectroscopy
Presenter: Magdalena Hoppel Authors: M Hoppel, K Kwizda, D Baurecht, C Valenta.
University of Vienna, Austria

515 Visualization and Quantification of Delivery in Hair Care Products
Presenter: David Scurr Authors: D J Scurr, M R Alexander, M C Davies.
University of Nottingham, United Kingdom

517 Controlled Release of Menthol from Polycaprolactone
Presenter: Christopher Baker Authors: C M Baker, N Jain, K Munoz, E Atherton, E Mathiowitz.
Brown University, U.S.A.
collapse Drug Delivery in Tissue Engineering

45 Designer Nanoneedles for Regenerative Medicine and Biosensing
Presenter: Molly Stevens Authors: M Stevens.
Imperial College, United Kingdom

46 Collagen-Based Scaffolds For Therapeutic Delivery To Enhance Tissue Regeneration
Presenter: Fergal O'Brien Authors: F J O'Brien.
Royal College of Surgeons in Ireland, Ireland

96 Engineering a Bioartifical Pancreas: Tuning Device Geometry Prevents Foreign Body Immune Responses and Fibrosis to Enable Prolonged Efficacy in Diabetic Rodents
Presenter: Omid Veiseh Authors: O Veiseh, R Langer, D Anderson.
David H. Koch Institute for Integrative Cancer Research at MIT, U.S.A.

105 Identification of a Lung Carcinoma-specific Peptide for in vivo Targeting
Presenter: JeongHeon Yu Authors: J Yu, M Oh, M Yang, Y Nam.
KAIST, South Korea

129 Novel Bone Targeting Parathyroid Hormone Analogues Impart Significantly Improved Peptide Hormone Delivery and Efficacy upon Osteoporotic Bone Surfaces
Presenter: Yang Yang Authors: Y Yang, A Panahifar, K Tang, F Wuest, M R Doschak.
Pharmaceutical Orthopaedic Research Lab, Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Canada

137 Polymeric electrospun scaffolds: Neuregulin encapsulation and biocompatibility studies in a rat model of myocardial ischemia
Presenter: Maria Blanco-Prieto Authors: T Simon-Yarza, A Rossi, K Heffels, E Garbayo, F Prosper, J Groll, M J Blanco-Prieto.
University of Navarra, Spain

857 Chitosan-pDNA Nanoparticles Facilitate Controlled Gene Delivery on Collagen Scaffolds for Orthopaedic Tissue Engineering Applications
Presenter: Rosanne Raftery Authors: R M Raftery, C M Curtin, S Cryan, F J O'Brien.
Tissue Engineering Research Group, Royal College of Surgeons in Ireland, Dublin 2, Ireland; Trinity Centre of Bioengineering, Trinity College Dublin, Dublin 2, Ireland; Advanced Materials and Bioengineering Research Centre (AMBER), Dublin, Ireland, Irelan
collapse Drug Delivery to the Brain

1 Polymer Nanoparticles Delivered by Convection-Enhanced Delivery For Treatment of Brain Tumors
Presenter: W. Mark Saltzman Authors: W Saltzman.
Yale Univ, U.S.A.

2 Targeted CNS delivery of cGMP analogue preventing inherited retinal degeneration
Presenter: Pieter Gaillard Authors: P J Gaillard, H Genieser, M Valeria, P Ekström, F Paquet- Durand.
2-bbb medicines BV, Netherlands

157 Targeted Delivery of GDNF to Brain by Novel V-SmartTM Nanovesicles and its Efficacy in Parkinson's Disease Animal Model
Presenter: Susan Rosenbaum Authors: E Heldman, M Popov, C Linder, E Shaubi, V Kas'yanov, I Hollander, S Grinberg.
Lauren Sciences LLC, U.S.A.

439 Delivery of Brain-Penetrating Nanoparticles Across the Blood-Brain Barrier with Focused Ultrasound: Brain Tumor and Neurodegenerative Disease Applications
Presenter: Richard Price Authors: B Mead, K Timbie, W Miller, P Mastorakos, C Zhang, J Suk, J Song, J Hanes, R Price.
University of Virginia, U.S.A.

459 Image-guided Drug Delivery across the Blood-Brain Barrier using Theranostic Microbubbles
Presenter: Twan Lammers Authors: T Lammers, P Koczera, F Kiessling.
RWTH Aachen University, Germany

489 Selective Accumulation of PEG-liposomes in Brain after Traumatic Brain Injury
Presenter: Ben Boyd Authors: B J Boyd, A Galle, J Rosenfeld, R Medcalf.
Monash Institute of Pharmaceutical Sciences, Australia

692 Lactoferrin-bearing Polypropylenimine Dendrimer for Targeted Gene Delivery to the Brain
Presenter: Sukrut Somani Authors: S Somani, G Robb, B Pickard, C Dufès.
University of Strathclyde, United Kingdom
collapse Encapsulation for Industrial Applications

3 Does size matter? Navigating the path from milli through micro to nano in the packaging of bioactives.
Presenter: Ronald Neufeld Authors: R J Neufeld.
Queen's Univ, Canada

4 Invited Speaker - Robert Kent
Presenter: Robert Kent Authors: R Kent.
AnaBio Technologies Ltd., Ireland

249 Scaling up a high shear granulation process to gain granules suitable to formulate orally disintegrating tablets
Presenter: Thorsten Cech Authors: S Fros, T Agnese, A Zakhvatayeva, F Cembali, G Mondelli, T Cech, C Funaro.
BASF SE, Germany

516 Antibacterial coating of catheters with solid lipid nanoparticles using physical plasma sources
Presenter: Gerold Lukowski Authors: G T Lukowski, R Brandenburg, J Ehlbeck.
Institute of Marine Biotechnology, Germany

518 Development of Stable Polymersomes Encapsulating Bacteria for Release of Metabolites
Presenter: Jacob Barlow Authors: J Barlow, K Gozzi, A Van De Ven-Moloney, Y Chai, S Sridhar.
Northeastern University, U.S.A.

519 Dry Polymer Coating for Improving Physical Stability of Amorphous Drug Formulations
Presenter: Rajesh Dave Authors: M Capece, R Dave.
New Jersey Instiute of Technology, U.S.A.

522 Enzymatically Triggered Release from Zein Particles for Antimicrobial Coatings and Plasters
Presenter: Nicole Papen-Botterhuis Authors: M Nieuwland, N E Papen-Botterhuis, W C Drost, T M Slaghek, J Eversdijk, B Erich.
TNO Materials Solutions, Netherlands

523 HYDROGELS-BASED SYSTEMS FOR CONTROLLED RELEASE IN AGRICULTURAL APPLICATIONS
Presenter: Annalisa Dalmoro Authors: D Caccavo, P Apicella, S Cascone, A Dalmoro, G Lamberti, A A Barba.
University of Salerno, Italy

524 Multidrug Encapsulation Using PDMS Microfluidic Devices for Pulmonary Drug Delivery
Presenter: Hélder A. Santos Authors: R Vasiliauskas, D Liu, H Zhang, L Mazutis, H A. Santos.
Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014, Helsinki, Finland

525 Novel Encapsulation System for Water Soluble Powder
Presenter: Fideline Tchuenbou-Magaia Authors: F L Tchuenbou-Magaia, P Gomez-Pereira, N Young, Z Zhang.
University of Birmingham, United Kingdom

526 OBSERVATION OF PHASE SEPARATION IN POLYACRYLAMIDE HYDROGELS WITH VARIATION IN CROSS-LINKER CONCENTRATION: A RHEOLOGICAL STUDY
Presenter: SIDHARTHA JENA Authors: S Khandai, S S JENA.
NIT Rourkela, India

527 Optimization of dry coating formulation for improvement of acid-resistance and stability of probiotics by 3-factor, 3-level Box-Behnken Design
Presenter: Hee Jun Park Authors: H Park, J Jun, M Son.
Dong-A ST Research Institute, South Korea

529 Preparation of poly(ε-caprolactone) microcapsules containing thyme oil
Presenter: Young Jin Kim Authors: Y Kim, M Lee, K Lee.
Cnungnam National University, Korea

530 Stimuli-responsive organo-silica/polyurea composite microcapsules
Presenter: Juan Yang Authors: J Yang, M Pilz, C Simon.
SINTEF Materials and Chemistry, Norway

531 Taste Masking Active Pharmaceutical Ingedients using a Novel Acoustic Mixing Process
Presenter: Rosaleen McLaughlin Authors: R T McLaughlin, A P Parker, S A Howes, C Smith, T Brown.
collapse European Technology Platform on Nanomedicine: Translation of Nanomedicines

42 Invited Speaker - Liam Good
.

43 Invited Speaker Dan Palmer
Presenter: Dan Palmer Authors: J Barry.
Midatech Pharma , United Kingdom

44 Nanomedicine in Ophthalmology: Myriocin loaded Lipid Nanoparticles for therapy in Retinitis Pigmentosa
Presenter: Paolo Gasco Authors: P Gasco.
Nanovector srl, Italy
collapse Formulating Oral Solid Dosage Forms to Enhance Oral Drug Delivery

47 Modifying the solid state of drugs to enhance oral drug delivery
Presenter: Thomas Rades Authors: T Rades, H Grohganz, P Priemel, A Mullertz, K Loebmann.
Univ of Copenhagen, Denmark

48 The effect of plasticizer used in hot melt extrusion on drug product intermediate properties
Presenter: Susanne Page Authors: S Page.
F. Hoffmann-La Roche Ltd, Switzerland

299 Development of local controlled-release fenretinide as a chemopreventive therapy for oral squamous cell carcinoma (OSCC)
Presenter: Kari Nieto Authors: K J Nieto, S Schwendeman, S Mallery.
University of Michigan, U.S.A.

339 Infacort® - Development and Clinical Evaluation of a Taste Masked Multiparticulate Oral Hydrocortisone Formulation for Paediatric Use
Presenter: Daniel Margetson Authors: D N Margetson, G Neal, R Ross, H Huatan, D Eckland, D Digweed, A Grave, A Foerg, N Poellinger, M J Whitaker.
Diurnal Ltd, United Kingdom

383 The synergistic effect of silica and polymer in establishing improved lipid-based solid dosage forms for poorly water soluble drugs
Presenter: Clive Prestidge Authors: C A Prestidge.
University of South Australia, Australia
collapse Get Up! Get Educated! Choosing the Best Animal Model for Your Drug Delivery Studies

Choosing the Best Animal Model for Your Drug Delivery Studies
Presenter: Marcel Bally.
Centre for Drug Research and Development (CDRD)

Choosing the Best Animal Model for Drug Delivery Study
Presenter: Tamara Minko.
Rutgers, The State University of New Jersey
collapse Get Up! Get Educated! Trends in Protein Delivery

Protein Delivery Reality or Myth?
Presenter: Edith Mathiowitz.
Brown University
collapse In vivo Nucleic Acid Delivery

23 Invited Speaker - Uta Griesenbach
.

24 Genome Editing with Zinc Finger Nucleases
Presenter: Michael Holmes Authors: M C Holmes.
Sangamo BioSciences, U.S.A.

853 Cell Derived Nano-Ghosts: A Novel Targeted Gene Delivery System For Cancer Therapy
Presenter: Limor Kaneti Authors: L Kaneti, M Machluf.
Technion, Israel

856 Chitosan coated PLGA Nanoparticles for Pulmonary Delivery of mRNA encoding a Zinc Finger Nuclease: An in-vivo proof of concept study for somatic genome editing
Presenter: Brigitta Loretz Authors: B Loretz, E Malaeksefat, A J Mahiny, A Dewerth, L E Mays, M Alkhaled, B Mothes, J Rottenberger, D M Brosch, P Reautschnig, P Surapolchai, F Zeyer, A Schams, M Carevic, M Bakele, M Griese, M Schwab, B Nürnberg, S Beer-H.
Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Saarland University, Germany

881 Gene Delivery to the Brain Using Brain Penetrating DNA Nanoparticles
Presenter: Panagiotis Mastorakos Authors: P Mastorakos, C Zhang, E Song, S Berry, J Suk, J Hanes.
Johns Hopkins University Medical School, U.S.A.

891 Mannosylated Polyion Complexes for In Vivo Gene Delivery into CD11c+ Dendritic Cells
Presenter: Ayelet David Authors: L Raviv, M Jaron-Mendelson, M Golan, A David.
Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel, Israel

915 Ultrasound-mediated gene transfer to the brain
Presenter: Suzie Pun Authors: J Y Tan, D Sellers, H Wei, N Coulsen, D O Maris, P Mourad, P J Horner, S H Pun.
University of Washington, U.S.A.
collapse Industry Roundtable

Drugs, Delivery, and Patients - How Will We Bring It All Together In the New World?
Presenter: Debra Bingham.
Valeo Partners
collapse Manufacture, Characterization, Measurement & Stability

14 Invited Speaker - Alastair Florence
.

15 Assessing how excipients properties as well as the manufacturing process would influence solid oral dosage form performance and overall cost of manufacturing.
Presenter: Amina Faham Authors: A Faham.
Dow Chemical, Switzerland

167 A combined spectroscopic and thermal methods for ketoprofen inclusion in cyclodextrins in solid state and analysis of the profile dissolution
Presenter: Manuel Vueba Authors: M L Vueba.
Universidade Agostinho Neto, Angola

168 A Mathematical Approach for Assessing Release Kinetics of Nanosized Formulations by Application of a Novel Dialysis Apparatus
Presenter: Li Xie Authors: L Xie, S Beyer, V Vogel, M G Wacker, W Mäntele.
Institute of Biophysics, Goethe University, Frankfurt (Main), Germany

169 A New Solvent System for Electrospinning Polycaprolactone
Presenter: Andrew McLaughlin Authors: A W McLaughlin, A Berretta, A Clarkson, G F Walker.
University of Otago, New Zealand

170 A Systematic Investigation of Surface Properties and Compression Profiles of Milled D-Mannitol
Presenter: Jasdip Koner Authors: J S Koner, A Rajabi-Siahboomi, J Bowen, Y Perrie, D Kirby, A Mohammed.
Aston University, United Kingdom

171 Amorphous Solid Dispersions: A Comparison Between Hot Melt Extrusion and Supercritical Fluid Impregnation
Presenter: Atif Madi Authors: A M Madi , G P Andrews, D S Jones.
Mr , Northern Ireland

172 Analyzing lipid nanoparticles by Solid Phase Extraction
Presenter: Alexis Guillot Authors: A Guillot, A Couffin, C Draheim, X Séjean, F Navarro, M Limberger, C Lehr.
PHAST GmbH, Germany

173 Application of Polymer Coating on Size M “Mouse” Capsules Containing Immediate and Delayed Release Formulations
Presenter: Ian McIntosh Authors: I McIntosh, P Sabo, J Vaughn, M Gosselin.
Patheon, U.S.A.

174 Aqueous Based Enteric Coating Formulation Containing Hypromellose Acetate Succinate (HPMCAS)
Presenter: Anisul Quadir Authors: A Quadir, S Obara.
Shin-Etsu Chemical Co. Ltd., U.S.A.

175 Aqueous Ethyl Cellulose Coatings for Pharmaceutical Dosage Forms
Presenter: Jurgita Kazlauske Authors: J Kazlauske, A Larsson.
Chalmers University of Technology, Sweden

176 Assessing PLGA microsphere porosity by means of fluid imaging microscopy techniques
Presenter: Ahmad Sediq Authors: A S Sediq, S Waasdorp, M Nejadnik, J Meulenaar, R Verrijk, W Jiskoot.
MSc, Netherlands

177 Biomimetic Barrier PermeapadTM: an innovative tool for passive drug permeabilities investigation
Presenter: Massimiliano Pio di Cagno Authors: M di Cagno.
Arctic University of Norway, Norway

178 Cell cytotoxic effects of clioquinol and prepare of a gellam gum/glucosamine hydrogel carrier for oral cancer therapy
Presenter: Ming Wei Lee Authors: M Lee.
School of Medical Laboratory and Biotechnology, Chung Shan Medical University, , Taiwan

179 Cell Sheet Engineering for Primary Rabbit Corneal Epithelial Cell under Serum-free Culture Condition
Presenter: How TSENG Authors: C TAI, W CHENG, H TSENG.
Taipei Medical University, Taiwan

180 Characterisation of polymeric films with thermal methods: measurement of critical humidity and glass transition temperature
Presenter: Asma Buanz Authors: A Buanz, S Gaisford.
UCL School of Pharmacy, Univeristy College London, United Kingdom

181 Characterization of Self-Assembling PEG-PLGA Nanoparticles Encapsulating Semiconducting Conjugated Polymers
Presenter: Thais Abelha Authors: T F Abelha, M Green, L Dailey.
King's College London, United Kingdom

182 Computer-Assisted Drug Formulation: Computational tools for dosage form design
Presenter: Rania Hathout Authors: A A Metwally, R M Hathout.
Department of Pharmaceutics and Industrial Pharmacy - Faculty of Pharmacy-Ain Shams University, Egypt

184 Controlling Polymeric Particle Size and Distribution by Adjusting the Applied Mechanical Force
Presenter: Aharon Azagury Authors: A Azagury, E Atherton, S Furtado, E Mathiowitz.
Brown University, U.S.A.

185 Deconstructing the tumor microenvironment - The role of fibronectin
Presenter: Frankie Vanterpool Authors: F A Vanterpool, M Cantini, P Seib, M Salmerón-Sánchez.
University of Glasgow and University of Strathclyde, United Kingdom

186 Designing a Permeation Model of the Gram Negative Bacterial Cell Envelope
Presenter: Florian Gräf Authors: F Gräf, S Gordon, C Lehr.
Helmholtz Institute for Pharmaceutical Research Saarland, Germany

188 Determination of the Crystalline State of Ritonavir in Medium Chain Triglyceride Softgel Fill Formulations by X-ray Powder Diffraction
Presenter: Nidhi Mahajan Authors: I Vitez, R Vladyka.
Catalent Pharma Solutions, U.S.A.

189 Development and Application of a Stability Indicating HPLC Method for the Estimation of Lidocaine Release from Poly Ethylene co-Vinyl Acetate (EVA) Melt Extrudates
Presenter: Prabhat Bhusal Authors: P Bhusal, M Sharma, J Harrison, G Procter, D S Jones, A G Hill, D M Svirskis.
School of Pharmacy, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand, New Zealand

194 Effect of polyethyleneglycol bisphenol A epichlorohydrin copolymer and gluconolactone on trypsin biological activity
Presenter: Ala' Salem Authors: A Salem, A Vesseur, P Bhatia, A A Elkordy.
University of Sunderland, United Kingdom

195 Effect of Processing Methods on Physical Stabilities of Amorphous Solid Dispersions Consisting of Naproxen and Povidone
Presenter: Tony Listro Authors: T Listro, A Miller, F Zhang, M Crowley, L Acquarulo.
Foster Corporation, U.S.A.

196 Encapsulation of antifungal agents into solid lipid nanoparticles: Physicochemical characterization and biocompatibility studies
Presenter: Rohan Shah Authors: R M Shah, D S Eldridge, E A Palombo, I H Harding.
Department of Chemistry and Biotechnology, Faculty of Science, Engineering and Technology, Swinburne University of Technology, Melbourne, Vic 3122, Australia, Australia

197 Evaluation of a Co-processed Excipient for Orally Disintegrating Tablets
Presenter: Anisul Quadir Authors: Y Hirama, M Fukasawa, S Obara, N Maruyama.
Shin-Etsu Chemical Co., Ltd., U.S.A.

198 Evaluation of Swelling and Erosion of HPMC Based Captopril Tablets
Presenter: Roderick Walker Authors: S Y Mukozhiwa, S M Khamanga, R B Walker.
Rhodes University, South Africa

199 Evaluation the palatability of ebastine orally disintegrating tablets using OD-mate; as new apparatus of detecting disintegration time and electronic tongue system
Presenter: Takahiro Uchida Authors: T Uchida, T Haraguchi, M Yoshida.
Mukogawa Women's University, Japan

200 Fabrication of Nanoparticles By A Versatile And Robust Microfluidic Platform For Drug Delivery
Presenter: Dongfei Liu Authors: D Liu, S Cito, Y Zhang, C Wang, T M Sikanen, H A Santos.
University of Helsinki, Finland

201 Formation of Lipid and Polymer Based Gold Nanohybrids for Intracellular Trafficking
Presenter: Dominik Witzigmann Authors: D Witzigmann, J Huwyler.
Division of Pharmaceutical Technology, University of Basel, Switzerland

202 Formulation and Characterization of Lipid Particles with Nephroprotective Properties
Presenter: Rachel Donaghey Authors: R Donaghey, V A Ferro, D A Lamprou.
Strathclyde Institute of Pharmacy and Biomedical Sciences, Scotland

207 Impact of cationic polymer coatings on PLGA nanoparticle characteristics and immunogenicity
Presenter: Nicole Kunschke Authors: N Kunschke, A de Groot, B Loretz, E Sijts, C Lehr.
Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Germany

209 Importance of Osmotic Effects for the Control of Drug Release from Kollicoat SR Coated Pellets
Presenter: Julie Fahier Authors: J L Fahier, S Muschert, G Byrne, J Willart, F Siepmann, J Siepmann.
University of Lille, College of Pharmacy, INSERM U1008, France

210 Infacort® - Manufacturing Process Scale Up and Characterisation of a Taste Masked Multiparticulate Oral Hydrocortisone Formulation for Paediatric Use
Presenter: Greg Neal Authors: G Neal, M J Whitaker, A Grave, A Foerg, N Poellinger, D N Margetson.
Diurnal Ltd, United Kingdom

211 Influence of CO2 Laser Irradiation on the Physical, Mechanical and Contact Angle Properties of Treated Enteric Coating Films
Presenter: Varin Titapiwatanakun Authors: V Titapiwatanakun, A Basit, S Gaisford.
UCL school of pharmacy, United Kingdom

212 Injection Moulding of Controlled Release Solid Dispersions
Presenter: Adrian Kelly Authors: A L Kelly, S Deshmukh, A Paradkar, S Abrahmsén Alami, J Booth.
Centre for Pharmaceutical Engineering Science, University of Bradford, Bradford, BD7 1DP, United Kingdom

214 International Acceptability Study of Orally Disintegrating Tablets (ODTs) in Children and Yong Adults
Presenter: Hamad Alyami Authors: H Alyami.
Aston University, United Kingdom

215 Investigation of the stabilizer elimination during the washing step of charged PLGA microparticles utilizing a novel HPLC-UV-ELSD method
Presenter: Markus Riehl Authors: M Riehl, M Harms, A Hanefeld, K Mäder.
Merck Serono, Darmstadt, Germany

216 Key Parameters and Limits for Quantification in Optical Imaging
Presenter: Johannes Stelzner Authors: J J Stelzner, H Caysa, S Hoffmann, K Mäder.
Wolfgang-Langenbeck-Str. 4, Germany

220 Mechanical activation – milling induced solid state interaction as a mechanism to mitigate process induced amorphisation
Presenter: Kieran Gallagher Authors: K H Gallagher, D R Lopez, A Healy.
Trinity College Dublin, Ireland

221 Microfluidics liposome formulation and investigation of liposome-cell interactions by Atomic Force Microscopy (AFM)
Presenter: Olivia Kemp Authors: O Kemp, D Lamprou, H M Grant.
University of Strathclyde, United Kingdom

222 Microfluidics-Controlled Manufacturing of Drug-loaded Nanoparticles in a Scalable and High-throughput Setup
Presenter: Elisabeth Kastner Authors: E Kastner, A Ingham, Y Perrie.
Aston University , United Kingdom

223 Microwave-Assisted Process For The Preparation of Microneedle Arrays
Presenter: Eneko Larrañeta Authors: E Larrañeta, R E Lutton, A J Brady, E Vicente-Pérez, A Woolfson, T Raj Singh, R F Donnelly.
School of Pharmacy Queen's University Belfast, United Kingdom

224 Modeling in vitro Microsphere Settling Through Mucin
Presenter: Vérida Léandre Authors: V Léandre, B Pavlov, S Rege, H Yang, A Tripathi, E Mathiowitz.
Brown University, U.S.A.

225 Modelling Physical Stability of Amorphous Systems
Presenter: Dolores Serrano Authors: D R Serrano, P O'Connell, N McSweeney, A Healy.
School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Ireland

227 Monitoring the dissolution mechanisms of amorphous solid dispersions by real time Raman mapping and on-line UV-vis
Presenter: Francesco Tres Authors: F Tres, S Wren, J Aylott, J Burley.
University of Nottingham, United Kingdom

228 Mucoadhesive characterization and in vitro antifungal activity of liquid crystal systems for buccal release of curcumin
Presenter: Giovana Calixto Authors: G Calixto, J Bernegossi, R Salmazi, M Ramos, T Bauab, M Chorilli.
State University of Sao Paulo, Brazil

231 Nanotoxicity Testing UsingThe Zebrafish Embryo Assay
Presenter: Susanne Golombek Authors: S K Golombek, L Y Rizzo, L Novo, W E Hennink, W Jahnen-Dechent, F Kiessling, T Lammers.
Experimental Molecular Imaging, UKA Aachen, Germany

233 Non-steroidal anti-inflammatory drugs encapsulated into solid lipid nanoparticles: Characterization, cytotoxic and anti-inflammatory studies
Presenter: Rohan Shah Authors: R M Shah, D S Eldridge, E A Palombo, I H Harding.
Department of Chemistry and Biotechnology, Faculty of Science, Engineering and Technology, Swinburne University of Technology, Melbourne, Vic 3122, Australia, Australia

234 Optimelt™ Technology: Unique Approach To Development & Scale-up Of Melt Extruded Oral Dosage Forms
Presenter: Nidhi Mahajan Authors: S B Upadhye, N Mahajan, X Meng, A Gryczke, U Hanenburg, S Juenkering, R S Vladyka.
Catalent Pharma Solutions, U.S.A.

235 OPTIMIZING THE LOADING OF DIAGNOSTIC AND THERAPEUTIC AGENTS INTO THE SHELL OF PBCA-BASED MICROBUBBLES FOR IMAGE-GUIDED DRUG DELIVERY
Presenter: Lia Appold Authors: L Appold, S Fokong, C Böhnke, C Sparatelu, F Kiessling, T Lammers.
Institute for Experimental Molecular Imaging, RWTH Aachen University Clinic, Germany

236 Pellet Distribution Analysis by UV Imaging and HPLC: A Comparative Study
Presenter: Anna Novikova Authors: A Novikova, A Sakmann, J M Carstensen, T Rades, C S Leopold.
University of Hamburg, Germany

237 Physicochemical Characterization of Liposome-Peptides Complexes
Presenter: Patrizia Iavicoli Authors: P Iavicoli.
European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Ispra (VA), 21027, Italy, Italy

239 Polyethyleneimine-based liquid crystal precursor vehicle with in situ gelling for buccal administration: development and characterization
Presenter: Giovana Calixto Authors: G Calixto, F Victorelli, M Chorilli.
State University of São Paulo, Brazil

240 Predicting in-vitro cumulative 28-day dapivirine release from a cured disc by modeling: A novel critical quality attribute
Presenter: Levi Kanu Authors: L N Kanu, N Ni, W Blanda, C Gilmour, M E Russell.
University of Pennsylvania School of Medicine, U.S.A.

241 Preparation and Evaluation of Chrysosplenol C-loaded Solid Dispersion with Hydrophilic Carriers
Presenter: Choon Lian Ng Authors: C Ng, B Kang, S Lee, J Park.
College of Pharmacy, Chungnam National University, Korea

244 Protein-polyelectrolyte complexation kinetics monitored by nanoparticle tracking analysis and flow imaging microscopy
Presenter: Ahmad Sediq Authors: A S Sediq, M Nejadnik, I El Bialy, G Witkamp, W Jiskoot.
MSc, Netherlands

245 Quality by Design Approach to Formulation of Rebamipide Gastro-retentive Tablet
Presenter: Kyu-Mok Hwang Authors: K Hwang, J Seo, S Lee, E Yi, S Kim, S Seok, E Park.
Sungkyunkwan University, South Korea

246 Quality evaluation of ibuprofen and quinine sulphate formulations sold on the market in Angola, using differential scanning calorimetry technique
Presenter: Manuel Vueba Authors: M L Vueba.
Universidade Agostinho Neto, Angola

250 Simultaneous Enhancement of Dissolution and Tribo-electrification of Solid Dispersions
Presenter: Kofi Asare-Addo Authors: K Asare-Addo, A Nokhodchi, E Supuk, B Conway.
University of Huddersfield, United Kingdom

251 Softgel Capsules Low Batch Size Optimization on Industrial Equipment
Presenter: Vincent Plassat Authors: G Enderlin, V Plassat.
Catalent Pharma Solutions, France

252 Sol-gel Transition Study of Thermosensitive Chitosan Hydrogels Using Low-field NMR
Presenter: Rong Yu Authors: Y Li, x Li, C Chen, R Yu, Z Su.
Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education,West China School of Pharmacy, Sichuan University, China

253 Sol-gel Transition Study of Thermosensitive Chitosan Hydrogels Using Low-field NMR
Presenter: Rong Yu Authors: Y Li, X Li, C Chen, R Yu, Z Su.
Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, Sichuan University, China

254 Solubility Improvement of Novel Antimicrobial Compounds, NCL812 and NCL099
Presenter: Yunmei Song Authors: Y Song.
University of South Australia , Australia

255 Stabilization of Influenza Vaccine in Microneedle Patches for Room-Temperature Storage
Presenter: Matthew Mistilis Authors: M J Mistilis, A S Bommarius, M R Prausnitz.
Georgia Institute of Technology, U.S.A.

256 Structural analysis of nanosystems: Solid Span Nanoparticles (SSN) as a case study
Presenter: Inés Fernández Piñeiro Authors: A Pensado, I Fernández Piñeiro, M Martín Pastor, A Sánchez, B Seijo.
University of Santiago de Compostela, Spain

257 Surface Characterisation of Composite Particles Produced using a Novel Isothermal Particle Coater
Presenter: Eman Dahmash Authors: E Z Dahmash, A U Mohammed, C J Bailey.
Aston University, United Kingdom

258 Swellable/erodible capsular devices for oral pulsatile release prepared by 3D printing
Presenter: Alice Melocchi Authors: A Melocchi, F Parietti, G Loreti, A Maroni, L Zema, A Gazzaniga.
Università degli Studi di Milano, Italy

260 The Development of hot melt-injection moulding technique buccal patches for enhanced delivery of felodipine
Presenter: Muqdad Alhijjaj Authors: M Alhijjaj.
School of Pharmacy / University of East Anglia, United Kingdom

261 The Effect of Surfactants and Polymers on the Dissolution of Amorphous Indomethacin
Presenter: Timo Laaksonen Authors: P T Mah, L Peltonen, T Rades, C J Strachan, T Laaksonen.
Faculty of Pharmacy, University of Helsinki, Finland

262 The NanoAssemblr™ Platform for the Scalable, Microfluidics-based Manufacture of Lipid-Based Nanoparticles for the Controlled Release of Therapeutics
Presenter: Colin Walsh Authors: C Walsh, A Thomas, K Ou, T Leaver, A Wild, E Ramsay, P Cullis.
Precision NanoSystems, Canada

263 Tight Junctions as a Barrier in the Hair Follicle - Relevance for Drug Delivery
Presenter: Christiane Mathes Authors: C Mathes, J M Brandner, M Laue, S S Raesch, S Hansen, S Vidal, I Moll, U F Schaefer, C Lehr.
Saarland University, Germany

264 Utilization of SoluPath Flex™ to Provide Data-Driven Choices in Preclinical Formulation Development
Presenter: Paul Sabo Authors: P Sabo, I McIntosh, J Vaughn, M Gosselin.
Patheon, U.S.A.

265 UV Imaging of the Dissolution Mechanism of HPMC Extended Release Tablets
Presenter: Karl Box Authors: K J Box, R Taylor, D Matthews.
Sirius Analytical, United Kingdom
collapse Manufacture, Characterization, Measurement, and Stability

187 Designing of some floating tablets
Presenter: Amal Elkordy. Authors: Sheikh Aniqa Rezwana.
University of Sunderland, Faculty of Applied Sciences, Department of Pharmacy, Health and Wellbeing, SR1 3SD, UK

192 Docetaxel Nanosuspension: Preparation and optimization using Quality by design approach
Presenter: Kamalinder Singh Authors: P Kedia, K K Singh.
University of Central Lancashire, PRESTON, United Kingdom

217 Manufacturing, Characterization and Evaluation Controlled-Release Formulation Using Hypromellose by Continuous Granulation
Presenter: Edmont Stoyanov. Authors: Zhuoyang “John” Lian, Adam Bell, Divya Tewari, Joshua Hullen, Jessica Zombek, Andrew Birkmire, Thomas Dürig.
Ashland Specialty Ingredients, Wilmington, DE, 19808, USA

219 Measuring the Water-Excipients Flory-Huggins Interaction Parameters Using Dynamic Vapor Sorption
Presenter: Yiwei Tian. Authors: Yiwei Tian, David S Jones, and Gavin P Andrews.
School of Pharmacy, Queen’s University Belfast, BT9 7BL, Belfsat

238 Physicochemical Study of Countercharged Polymers in Soft Gelatin Capsules for an Extended Release Application
Presenter: Yinyan. Zhao. Authors: C. Burris, G. Vamvakas.
Banner Life Sciences, High Point, North Carolina, 27265, USA
collapse Micro- and Nanoparticle Delivery

532 3D alginate micro-scaffolding for cumulus-oocyte complex in vitro culture: formulation and stability evaluation
Presenter: Bice Conti Authors: B Conti, R Dorati, I Genta, T Modena, V Merico, S Garagna, M Zuccotti.
University of Pavia, Department . of Drug Sciences, Italy

533 5-fluorouracil liposomes targeted with cetuximab for skin squamous cell carcinoma: characterization studies
Presenter: Raquel Petrilli Authors: R Petrilli, J O Eloy, R J Lee, R F Lopez.
School of Pharmaceutical Sciences of Ribeirao Preto, Brazil

534 A biodistribution study of albumin-lyophilisomes
Presenter: René Raavé Authors: R Raavé, E van Bracht, I Perevyazko, E Versteeg, T Hafmans, U Schubert, E Oosterwijk, T van Kuppevelt, W Daamen.
Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, Netherlands

537 A Doxorubicin Nano Drug Delivery System for Postoperative Treatment of Ovarian Cancer Residual Disease
Presenter: Raquel De Souza Authors: S Eetezadi, R De Souza, M Vythilingam, R L Cataldi, C Allen.
Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, M5S 3M2, Canada, Canada

540 A New Precipitation/Self-Assembly Method to Fabricate Monodisperse and Biodegradable Smart Microgels for Drug Delivery
Presenter: Todd Hoare Authors: D Sivakumaran, E Mueller, T Hoare.
McMaster University, Canada

543 A Novel BBB-Penetrating Peptide Improves pBAE-Mediated Gene Delivery into Brain Endothelial Cells
Presenter: Anna Cascante Authors: P Brugada, I Porcar, P Dosta, G Molins, V Ramos, A Cascante, S Borrós.
Sagetis Biotech and Institut Químic de Sarrià (Universitat Ramon Llull), Spain

544 A Novel Oxalipatin Derivative Showed Enhanced Efficacy in a Xenograft Model of Pancreatic Cancer
Presenter: Aiman Abu Ammar Authors: A Abu Ammar, T Nassar, R Raveendran, D Gibson, S Benita.
The School of Pharmacy, Faculty of Medicine, the Hebrew University of Jerusalem, Jerusalem, 9112102, Israel, Israel

547 A safe and efficient hepatocyte-selective carrier system based on myristoylated preS1/21-47 domain of hepatitis B virus
Presenter: Quan Zhang Authors: Q Zhang, C Deng, Z Zhang, T Gong.
Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, China

548 A Simple and Effective Numerical Method for Quantifying Real-Time
Presenter: Xiao Yu Wu Authors: Y Zhou, A Abbasi, C He, J Ni, Y Cai, X Guo, X Wu.
University of Toronto, Canada

551 Active Macropinocytosis Induction Potentiates Exosome-mediated Intracellular Delivery
Presenter: Ikuhiko Nakase Authors: I Nakase, N Bailey Kobayashi, T Takatani-Nakase, T Yoshida.
Osaka Prefecture University, Japan

552 Active Targeting of Hepatocytes via Asialoglycoprotein-Receptor – Evaluation of Expression Level
Presenter: Dominik Witzigmann Authors: D Witzigmann, J Huwyler.
Division of Pharmaceutical Technology, University of Basel, Switzerland

553 Adipose-Derived Stem Cells Adhered To PLGA Microparticles Containing Neuregulin-1 Improved Heart Tissue Regeneration In A Rat Model
Presenter: Paula Díaz-Herráez Authors: P Díaz-Herráez, E Garbayo, T Simón-Yarza, G Abizanda, F Prósper, M Blanco-Prieto.
University of Navarra, Spain

554 Advantages of fluorescent nanoprobes for tumor imaging and photo-dynamic therapy (PDT) and pitfalls of PDT in earlier studies
Presenter: Hiroshi Maeda Authors: H Maeda.
Institute of DDS, Sojo University, Japan

555 Aerosol Nanocomposites Microparticles Capable of Penetrating Pulmonary Physiological Barriers
Presenter: Samantha Meenach Authors: Z Wang, E Torrico, S A Meenach.
University of Rhode Island, U.S.A.

557 An AS1411 aptamer-conjugated liposomal system containing a bubble-generating agentfor tumor-specific chemotherapy that overcomes multidrug resistance
Presenter: Hsing-Wen Sung Authors: H Sung, L Zi-Xian, C Er-Yuan, L Chia-Chen, L Kun-Ju, C Po-Yuan.
Department of Chemical Engineering, National Tsing Hua University, Taiwan

558 Antibody-mediated targeting of nanoparticles to human endothelium;
Presenter: Gregory Tietjen Authors: G T Tietjen, A J Engler, J Cui, D Deep, J S Pober, M Saltzman.
Yale University, U.S.A.

560 Anti-inflammatory Mechanism of Liposomal Bisphosphonates: The Effect on CD11b++ Monocytes
Presenter: Gershon Golomb Authors: M Gurina, K Ostrovsky, E Grad, N Kourokhov, A Giterman, O Feldman, G Golomb.
The Hebrew University of Jerusalem, Israel

562 Application of Nanoparticles for Oral Delivery of Acid Labile Lansoprazole: In Vitro and In Vivo
Presenter: Wen Jen Lin Authors: W Lin.
School of Pharmacy, National Taiwan University, Taiwan

563 Axitinib-loaded Nanohybrid Liposomal Nanoparticles for Hypoxic Tumor
Presenter: Jong Oh Kim Authors: J Kim.
Yeungnam University, Korea

564 Bacteriophage loaded liposomes for controlling Salmonella colonization in broilers
Presenter: Mary Cano-Sarabia Authors: M Cano-Sarabia, J Colom, J Otero, P Cortes, D Maspoch, M Llagostera.
Institute Catalan of Nanoscience and Nanotechnology ICN2, Spain

565 Barley Protein based Nanoparticles for Vitamin B12 Delivery
Presenter: Guangyu Liu Authors: G Liu, Z Tian, L Chen.
Department of Agriculture, Food and Nutrition Science, University of Alberta, Canada

567 Biodegradable Theranostic Agent of Melanoidin for Non-Invasive Photoacoustic Imaging and Photothermal Therapy
Presenter: Ho Sang Jung Authors: H Jung, M Lee, C Lee, C Kim, S Hahn.
POSTECH, South Korea

569 Biodistribution Study of Cationic Polymeric Biodegradable Nanoparticles by Optoacoustic Imaging
Presenter: Manoli Igartua Authors: S Egusquiaguirre, N Beziere, J Pedraz, R Hernandez, V Ntziachristos, M Igartua.
NanoBioCel Group, Laboratory of Pharmaceutics, University of the Basque Country, Faculty of Pharmacy, Vitoria-Gasteiz, Spain

570 Bio-inspired silica nanoparticles as drug delivery vehicles
Presenter: Scott Davidson Authors: S Davidson, S V Patwardhan, D A Lamprou, M H Grant.
University of Strathclyde, United Kingdom

571 Bioreducible Shell-Cross-Linked Hyaluronic Acid Nanoparticles for Efficient Intracellular Drug Delivery
Presenter: Hwa Seung Han Authors: H Han, S Son, H Ko, M Lee, J An, J Park.
Sungkyunkwan University, Korea

572 Brain Tumor Targeting of Nano Curcumin via LDLr-mediated Pathway
Presenter: Malay Das Authors: M K Das, K Husain, Y Pathak.
Dibrugarh University, India

573 Buprenorphine Nanoparticles for Long Term Pain Relief and the Treatment of Addiction
Presenter: Yuh-Jing Lin Authors: Y J Lin, Y P Lee, W R Ravis.
Auburn University, U.S.A.

574 Carbon nanotubes uptake in brain after intravenous injection in mice
Presenter: Khuloud Al-Jamal Authors: K T Al-Jamal.
King's College London, United Kingdom

575 Carbon onion as a porous carrier for amorphous drug delivery
Presenter: Nikhila Miriyala Authors: N Miriyala, H Ye, D Ouyang, D Lowry, D Kirby.
Aston University, United Kingdom

576 Carboxymethyl dextran-based self-assembled nanoparticles for hypoxia-triggered drug delivery
Presenter: Soyoung Son Authors: S Son, T Thambi, H Yoon, H Han, M Lee, J Park.
Sungkyunkwan University, South Korea

577 Cationic Lipid-Free Cationic Nanoemulsions with Dexamethasone Acetate and Poylmyxin B Sulfate
Presenter: Cornelia Keck Authors: X Li, N A Bou-Chacra, C M Keck, R H Müller.
University of Applied Sciences Kaiserslautern, Germany

578 Cationic nanosystems enhance melatonin ocular delivery: insights from a human corneal epithelial cell line model
Presenter: Jasmina Lovric Authors: A Hafner, J Lovric, M Duvnjak Romic, M Juretic, I Pepic, B Cetina-Cizmek, J Filipovic-Grcic.
University of Zagreb, Faculty of Pharmacy and Biochemistry, Department of Pharmaceutical Technology, Croatia

580 Characterisation and comparison of DOPE:DOTAP and DOPE:DC-Chol liposomes
Presenter: Fraser Crofts Authors: F J Crofts, E Kastner, H R Griffiths, L A Brito, Y Perrie.
Aston University, United Kingdom

581 Characterisation of Biofilm Conditions Towards the Prevention of Urinary Catheter Biofouling
Presenter: Nicola Irwin Authors: C P McCoy, N J Irwin, C Brady, S P Gorman, D S Jones, L Carson.
Queen's University Belfast, United Kingdom

582 Chitosan and its derivatives as appropriate nanocarriers for ocular release
Presenter: Dimitrios Bikiaris Authors: D Bikiaris.
Aristotle University of Thessaloniki, Greece

583 Chitosan coated nanostructured lipid carriers for brain delivery of proteins by intranasal administration
Presenter: Rosa Maria Hernandez Authors: O Gartziandia, E Herran, J Pedraz, E Carro, M Igartua, R Hernandez.
NanoBioCel Group, Laboratory of Pharmaceutics, University of the Basque Country, Faculty of Pharmacy, Vitoria-Gasteiz, 01006, Spain, Spain

584 Chitosan lipid nanocapsules as tunable systems for antigen delivery
Presenter: José Crecente-Campo Authors: J Crecente-Campo, N Csaba, M Alonso.
Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela, Santiago de Compostela, CP 15782, Spain, Spain

585 Co-Delivery of Curcumin Analog and Paclitaxel with Reduction Sensitive Micelles to Treat Drug Resistant Cancer
Presenter: Joshua Reineke Authors: L Cheemalakonda, J Reineke.
Wayne State University, U.S.A.

586 Co-Delivery of Curcumin and Doxorubicin by Temperature-Responsive Hollow Microspheres
Presenter: Yu-Ru Su Authors: Y Su, F Mi, S Yu, A Chao.
PH.D.Program in Materials and Chemical Engineering, National United University, Miaoli, Taiwan, Taiwan

587 Combined effects of PLGA and vascular endothelial growth factor promote healing in non-diabetic and diabetic wounds
Presenter: Kiran Kumar Chereddy Authors: K Chereddy, G Vandermeulen, V Preat.
Université catholique de Louvain, Belgium

588 Combined treatment with CXCR4 antagonist and liposomal doxorubicin for enhancing antitumor and anti-metastasis efficiency
Presenter: Qin He Authors: L Mei, Y Liu, Q He.
Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, China

590 Comparative Study of Folate Receptor-Targeted Delivery Systems: Dosing Regimens and Therapeutic Index
Presenter: Anna Scomparin Authors: A Scomparin, S Salmaso, A Eldar-Boock, D Ben-Shushan, S Ferber, G Tiram, H Shmeeda, N Landa-Rouben, J Leor, P Caliceti, A Gabizon, R Satchi-Fainaro.
Department of Physiology and Pharmacology, Sackler School of Medicine, Room 607, Tel Aviv University, Tel Aviv 69978, Israel, Israel

594 Curcumin-loaded Nanoparticles made of Comb-like PEG-PLA Copolymers as a Potential Drug Delivery System for Neurodegenerative Diseases
Presenter: Jimmy Faivre Authors: J Faivre.
Faculty of Pharmacy, University of Montreal, Canada

596 Customizable Protein Microparticles as Carriers for Controlled Drug Delivery
Presenter: Kwok Kei Lai Authors: K Lai, J Lademann, R Renneberg, W Mak.
The Hong Kong University of Science and Technology, Hong kong

598 Cytotoxic T cells as transport vehicles for targeted nanoparticle delivery to the tumor
Presenter: Koen Raemdonck Authors: L Wayteck, H Dewitte, K Breckpot, J Demeester, S C De Smedt, K Raemdonck.
Laboratory of General Biochemistry and Physical Pharmacy, Belgium

600 Delayed-Release Silica-Coated Nanocapsules
Presenter: Tom Haber Authors: T Haber, G Copeland, J M Berlin.
Department of Molecular Medicine, Beckman Research Institute at City of Hope, 1500 East Duarte Road, Duarte, California 91010, United States, U.S.A.

601 Delivery Enhancement of Cisplatin Using Non-Ionic Surfactant Vesicles
Presenter: Manal Alsaadi Authors: M M Alsaadi, K C Carter, A B Mullen.
University of Tripoli, Libya

602 Delivery of Indocyanine Green to Cancer Cells by Chitosan-Based Nanocarriers
Presenter: Fwu-Long Mi Authors: F Mi, Y Su, S Yu, A Chao.
Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan, ROC, Taiwan

603 Design and Evaluation of Lipid-Polyethylene Glycol-Polymer Hybrid Nanoparticles for Intranasal Delivery of Farnesylthiosalicylic Acid Against Glioblastoma
Presenter: Emine Sekerdag Authors: E Sekerdag, S Bozdağ Pehlivan, B Yavuz, A Kara, N Öztürk, A Kaffashi, I Vural.
Hacettepe University, Turkey

605 Design of Fiber-Shaped Nanovectors for Neurosurgically-Precise Gene Knockdown: The Case of Peptide Nanofiber-siRNA mediated Gene Silencing in the Brain
Presenter: Mariarosa Mazza Authors: M Mazza, M Hadjidemetrou, I De Lazaro, C Bussy, K Kostarelos.
University of Manchester, United Kingdom

609 Developing and assessing a combinatorial dietary phytochemical based polymeric micellar drug delivery system as a chemotherapeutic strategy
Presenter: Deepa Rao Authors: D A Rao, B Cote, A W Alani.
Pacific University, U.S.A.

610 Development of a multimodal fluorescence probe for easy diagnosis of diseases
Presenter: Yudai Narita Authors: Y Narita, Y Takeuchi, K Ikemoto, K Shimizu, M Ogawa, Y Magata, N Oku.
University of Shizuoka, Japan

611 Development of a Resveratrol Solid Dispersion with Soluplus
Presenter: Bruno Sarmento Authors: T Vasconcelos, S Marques, B Sarmento.
I3S / INEB -Instituto de Engenharia Biomédica, University of Porto, 4150-180 Porto, Portugal; CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Instituto Superior de ciências da saúde-Norte, 4585-116; Portugal, Portu

612 Development of Aspherical Nanoparticles Functionalised with Invasion Moieties for Studying the Influence of Particle Shape on Cellular Uptake
Presenter: Arianna Castoldi Authors: A Castoldi, P Dersch, S Gordon, C Lehr.
Helmholtz Institute for Pharmaceutical Research Saarland, Germany

613 Development of Bauhinia purprea agglutinin-modified liposomes for treatment of prostate cancer
Presenter: Kosuke Shimizu Authors: K Shimizu, K Ikemoto, K Ohashi, Y Takeuchi, M Shimizu, N Oku.
University of Shizuoka School of Pharmaceutical Sciences, Japan

614 Development of Liposomal Delivery Systems that Target the Lymphatics
Presenter: Swapnil Khadke Authors: S K Khadke, R K Singh Badhan, Y Perrie.
Aston University, UK , United Kingdom

615 Development Of Multifunctional Gold Nanostructures For Cancer Phototherapy
Presenter: Catarina Silva Authors: C P Reis, M Neves-Petersen, S B Petersen, C O Silva, L Ascensão, P M Rijo, J P Coelho, P Vieira.
Universidade Lusófona de Humanidades e Tecnologias, Portugal

616 Development of Nanobody Targeted-Liposomes Directed Against Tumors for Image-Guided Drug Delivery
Presenter: Michiel Bolkestein Authors: M Bolkestein, D Drabek, T L ten Hagen, W van Weerden, M de Jong, A M Eggermont, F G Grosveld, G A Koning.
Erasmuc Medical Center, Netherlands

617 Development of peptide based imaging probe for drug efficacy monitoring.
Presenter: Dongkyu Kim Authors: D Kim, T Lee, H Kim, B Lee, R Park, C Kim.
Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Korea

618 Development of pH-dependent Endosome-Destabilizing High-Density Lipoprotein Nanoparticles
Presenter: Hyungjin Kim Authors: H Kim.
Institue for Cell-Material Sciences (WPI-iCeMS), Kyoto University, Japan

620 Development of sustained release systems with alendronate based on mesoporous silica MCM41
Presenter: Lacramioara Ochiuz Authors: L Ochiuz, M Popa, A Grigoras, A Stefanache, A M Tomoiaga.
University of Medicine and Pharmacy “Grigore. T. Popa”, Romania

622 Development of untoxic cyclic ester/polyester solution-based biodegradable microspheres
Presenter: Daris Grizic Authors: D Grizic, A Lamprecht.
Laboratory of Pharmaceutical Technology and Biopharmaceutics, University of Bonn, Germany

623 Development, Optimization and In-vitro Characterization of Lazaroid Nano-structured Lipid Carriers
Presenter: Prajakta Gadgil Authors: P Gadgil, D Chow.
University of Houston, U.S.A.

624 Development, physicochemical characterization and cytotoxicity evaluation of bone-targeted pH-sensitive liposome based formulation containing doxorubicin
Presenter: Diêgo Ferreira Authors: D S Ferreira, S D Faria, C S Teixeira, J D Filho, B L Oliveira, A S Guimarães, P Caravan, R J Alves, M C Oliveira.
Universidade Federal de Minas Gerais, Brazil

625 Dexamethasone Releasing Novel Three-Layered Monolithic Scaffold
Presenter: Derya Algul Authors: D Algul, G F Yener.
Yeditepe University, Turkey

629 Dose- and surface protein dependency of extracellular vesicle-mediated drug delivery
Presenter: Heikki Saari Authors: H Saari, E Lazaro-Ibañez, P Siljander, M Yliperttula.
University of Helsinki, Division of Pharmaceutical Biosciences, Centre for Drug Research, Faculty of Pharmacy, Finland

630 Droplet Based Microfluidics for Drug Delivery Applications
Presenter: Hongbo Zhang Authors: H Zhang, M Hai, D Liu, V Balasubramanian, B Herranz-Blanco, X Qu, M Shahbazi, P Almeida, E Makila, J Salonen, J Hirvonen, H Santos.
Harvard University, U.S.A.

631 Drying of b-galactosidase by Electrospinning Followed by Tableting and Scaling-up Experiments.
Presenter: Geert Verreck Authors: G Verreck, I Van Assche, M E Brewster, Z K Nagy, I Wagner, G Marosi.
Janssen Pharma R&D, Belgium

632 Dual pH-sensitive liposomes for enhanced liposomal membrane stability and potential tumor targeted drug delivery
Presenter: Zimei Wu Authors: Z Wu, M Kanamala, B Wilson.
The University of Auckland, New Zealand

633 Dual receptor recognizing cell penetrating peptide modified liposomes for anti-glioma therapy
Presenter: Qin He Authors: Y Liu, L Mei, Q He.
Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, China

634 Dual Stimuli-Responsive Charge-Convertible Nanoparticles for Intracellular Delivery of Doxorubicin
Presenter: Hyewon Ko Authors: H Ko, J Jeon, J Park.
Sungkyunkwan University, South Korea

635 Dual Stimuli-Responsive Nanogel Assemblies for Intracellular Drug Delivery
Presenter: Wen-Chia Huang Authors: W Huang, W Chiang, Y Chang, H Chiu.
Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Taiwan

636 Effect of Methyl Substitution on the Redox Response and Biological Impact of Aniline Based Nanostructures Used for Cancer Therapy
Presenter: Mohammad-Ali Shahbazi Authors: M Shahbazi, N Shrestha, J Hirvonen, H Santos.
Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Finland

638 EFFICIENT DELIVERY OF NEUREGULIN INTO INFARCTED HEARTS USIGN POLYMERIC MICROPARTICLES
Presenter: Simon Pascual-Gil Authors: S Pascual-Gil, T Simón-Yarza, E Garbayo, F Prosper, M Blanco-Prieto.
Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Spain

639 Electrostatic interaction and reversibility of adsorption on the loading of therapeutic peptide GLP-1 into porous silicon nanoparticles
Presenter: Martti Kaasalainen Authors: M Kaasalainen, J Rytkönen, E Mäkilä, A Närvänen, J Salonen.
University of Turku, Finland

640 Embedding of gefitinib eluting microspheres in polyurethane stent coatings
Presenter: Weiluan Chen Authors: W Chen, J Clauser, L Thiebes, T Lammers, W Hennink, R J Kok.
Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands, Netherlands

641 Encapsulation of Didanosine within Polymeric Particles for Enhanced Oral Bioavailability in HIV: Spray-drying versus Coaxial Electrohydrodynamic Atomization
Presenter: Alejandro Sosnik Authors: K Seremeta, A Sosnik.
Technion-Israel Institute of Technology, Israel

643 Enhanced solubility and dissolution rate of gatifloxacin by solid dispersion technique
Presenter: Raida Al-Kassas Authors: R Al-Kassas, J Wen, W Ho, S Lin, D Cho, Y Y Ly, Y Li.
University of Auckland, New Zealand

644 Enhanced water solubility and tumor selectivity for polymeric photosensitizers in cancer treatment
Presenter: Songhee Jeong Authors: S Jeong, K Na.
Department of biotechnology, The Catholic University of Korea, Bucheon, Gyeonggi do, 420-743, Republic of Korea , South Korea

645 Enteric shell-core microparticles production by coupling ultrasonic atomization and polyelectrolytes complexation
Presenter: Annalisa Dalmoro Authors: A Y Sitenkov, R I Moustafine, A Dalmoro, G Lamberti, A A Barba.
University of Salerno, Italy

647 Evaluation of a nanotechnological approach for treatment of neurological diseases
Presenter: Secil Caban Authors: S Caban, R Novoa-Carballal, R Riguera, E Fernandez-Megia, P Couvreur, T Dalkara, Y Capan.
Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey, Turkey

648 Ex Vivo Diffusion Model of Microparticles Crossing Intestinal Mucosa and Epithelium
Presenter: Soham Rege Authors: S Rege, V Léandre, B Pavlov, H Yang, H Bauer, J Chang, S Choo, S Kurial, G Lee, R Makani, C Baker, S Furtado, E Mathiowitz.
Brown University, U.S.A.

649 Exploring computational approach for optimizing polymeric nanoparticles for biomedical applications
Presenter: Anomitra Dey Authors: A P Dey, U B Koli, V H Dalvi, P Dandekar, R Jain.
Institute of Chemical Technology, Mumbai, India, India

650 External Manipulation of Nanostructure in Photoresponsive Lipid Depot Matrix to Control Drug Release In Vivo
Presenter: Wye-Khay Fong Authors: W Fong, C B Landsdorfer, B J Boyd.
ETH Zürich and Monash University, Switzerland

654 Fibrillar pH-responsive micelles loading succinobucol suppresses lung metastasis of breast cancer
Presenter: Zhiwen Zhang Authors: Z Zhang, Y Li.
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China

655 First In Vitro Characterization of Novel Nucleic Acid-Based Nanocomplexes for the Treatment of Antibiotic Resistant Pathogens
Presenter: Alan Hibbitts Authors: A Hibbitts, J Bruniaux, M Menneteau, D Jary, A Marin Menendez, M McArthur, K Hatzixanthis, F Navarro.
1. CEA, LETI, MINATEC Campus, Commissariat à l'Énergie Atomique et aux Énergies Alternatives (CEA), Technologies for Biology and Healthcare Division, Grenoble, F-38054, France 2. Univ. Grenoble Alpes, Grenoble, F-38000, France , France

656 Fluconazole-loaded chitosan nanoparticles is an effective alternative to topical treatment of vaginal candidiasis
Presenter: Guilherme Gelfuso Authors: T A Reis, B N Matos, T Gratieri, G M Gelfuso.
University of Brasília, Brazil

657 Fluorescent Stability and Imaging of Liposomal Quantum-Dots in Carotid-Injured Rats
Presenter: Gershon Golomb Authors: G Aizik, N Waiskopf, E Grad, U Banin, G Golomb.
Institute for Drug Research, Faculty of Medicine and the Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Israel

658 Folate-conjugated Reducible Polyethylenimine Passivated Carbon dots Complexation with siRNA as Theranostic Nanoagent for Lung Cancer Therapy
Presenter: Tzu-Wei Wang Authors: T Wang, Y Wu, H Wu.
National Tsing Hua University, Taiwan

660 Folate-Targeted Liposomes for Co-delivery of Paclitaxel and Imatinib: Combined Antitumoral Properties on Cytotoxicity and VEGF Expression
Presenter: Eliana Lima Authors: M J Peres-Filho, E M Lima.
Universidade Federal de Goias, Brazil

661 Folic acid-Polyethylene glycol-Photosensitizer for Photodynamic Tumor Theragnosis
Presenter: Ji Young Kim Authors: J Kim, K Park, I Kwon, K Kim, K Na.
Department of Biotechnology, The Catholic University of Korea, Bucheon, Gyeonggi-do, 420-743, Republic of Korea, South Korea

662 Formulation and In vitro Cytotoxicity of pH-sensitive Liposomes for a Novel Hypoxia-activated Prodrug
Presenter: Mimi Yang Authors: M M Yang, Z Wu, W R Wilson, B D Palmer.
School of Pharmacy, University of Auckland, New Zealand

664 Gelatin/Aminolyzed PDLLA Nanoparticles for Delivery of Hydrophobic Drugs
Presenter: Tze-Wen Chung Authors: T Chung, T Chou, W Jhuang.
Dept. of Biomedical Engineering, National Yang-Ming Univ., Taiwan

665 Gelatinized core liposomes: Towards an advanced carrier for hydrophilic drugs formulation
Presenter: Rania Hathout Authors: R M Hathout, S M Abdel-Hafez, A A Metwally.
Department of Pharmaceutics and Industrial Pharmacy- Faculty of Pharmacy - Ain Shams University, Egypt

668 Herceptin Conjugated Liposome Encapsulating Metformin for Targeting Breast Cancer Stem Cell
Presenter: Ji Yeon Lee Authors: J Lee, D Shin, J Kim, S Lee, J Kim.
Sookmyung Women's University, Korea

669 High Shear mixing : An alternative approach for the size reduction of liposomes
Presenter: Peter Stone Authors: P Stone, A Rozhin, D Allaer, Y Perrie.
School of Life and Health Sciences, Aston University, United Kingdom

670 High Throughput Approach to the Elucidation of the Role of Lipid Geometry in the Design and Development of Liposomal Drug Delivery Systems
Presenter: Ehsan Suleiman Authors: E Suleiman, A Wagner, Y Perrie.
University of Veterinary Medicine, Vienna / Polymun Scientific GmbH / Aston University, Birmingham, UK , Austria

672 Hyaluronan-immobilized Magnetic Bioceramic Nanocrystals for Active Targeting and Intracellular Hyperthermia
Presenter: Hsi-Chin Wu Authors: H Wu, S Hsieh, T Wang, J Sun, P Kang.
Department of Materials Engineering, Tatung University, Taiwan

673 Hyaluronic acid nanogel systems for poorly water-soluble drugs
Presenter: Takashi Nakai Authors: T Nakai, T Kanei, Y Tampo, K Yasugi, T Hirakura, T Shimoboji, M Ishigai.
chugai Pharmaceutical Co Ltd, Japan

675 Improved Circulation Time of Imageable Mesoporous Silicon Nanocarrier
Presenter: Vesa-Pekka Lehto Authors: V Lehto, S Näkki, T Nissinen, J Riikonen, H Santos, H Zhang, J Rytkönen, A Närvänen, T Liimatainen, M Kettunen.
University of Eastern Finland, Finland

676 Improved Tumor Specific Drug Accumulation by Polymer Therapeutics with pH-sensitive Drug Release overcomes Chemotherapy Resistance
Presenter: Anne-Kathrin Heinrich Authors: A Heinrich, H Caysa, T Etrych, L Schindler, P Chytil, S Hoffmann, K Mäder, T Müller.
Institute of Pharmacy, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany

677 In vitro characterization and real-time label-free monitoring of cell interactions of pH responsive gold nanoparticles
Presenter: Tapani Viitala Authors: S Bisso, A Kartal-Hodzic, C Brazzale, C Alexander, G Mantovani, M Yliperttula, P Caliceti, S Salmaso, T Viitala.
Centre for Drug Research, Division of Pharmaceutical Biosciences, University of Helsinki, Finland

678 In vitro digestion of cetyl palmitate SLN monitored with two different readouts: Are the pH-stat and HPTLC results equivalent?
Presenter: Martha Heider Authors: M Heider, K Mäder.
Institute of Pharmacy, Martin-Luther-University Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120 Halle, Germany, Germany

681 In vivo Evaluation of Etoposide Polymeric Nanoparticles for Brain Delivery by Nasal Route
Presenter: Nayanabhirama Udupa Authors: N Udupa, A T Alex, J V Rao, A Joseph.
Professor, India

682 In vivo mitochondrial delivery of coenzyme Q10 via MITO-Porter prevents ischemic reperfusion injury in the liver
Presenter: Yuma Yamada Authors: Y Yamada, K Nakamura, H Harashima.
Hokkaido University, Japan

683 Inhalable Microparticles Encapsulating the Immunomodulator, All-trans-Retinoic Acid, for the Treatment of Mycobacterium tuberculosis (Mtb) Infection.
Presenter: Gemma O'Connor Authors: G O'Connor.
Royal College of Surgeons in Ireland, Ireland

684 Injectable doxorubicin thermosensitive hydrogels incorporated with docetaxel mixed micelles for localized cancer therapy
Presenter: Chia yu Su Authors: C Su.
Taipei Medical University, Taiwan

685 Injectable Microspheres for non-invasive in vivo Oximetry using Electron Paramagnetic Resonance (EPR)
Presenter: Juliane Frank Authors: J Frank, D Gündel, O Thews, K Mäder.
Martin-Luther-University Halle-Wittenberg, Germany

687 Integrin-nanoparticles regenerate collapsed alveoli
Presenter: Michiko Horiguchi Authors: M Horiguchi.
Department of Pharmaceutics and Drug Delivery, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Japan

690 Invasin-functionalized Liposomes for Intracellular Delivery of Anti-infectives
Presenter: Sarah Gordon Authors: S Menina, H Labouta, R Geyer, P Dersch, S Gordon, C Lehr.
Helmholtz-Institute for Pharmaceutical Research Saarland, Germany

691 Investigating the performance and interactions of conjugated polymer nanoparticles with primary human blood cells
Presenter: Raha Ahmad Khanbeigi Authors: R Ahmad Khanbeigi, Z Hashim, A Woods, T Fedatto Abelha, B Forbes, H Collins, S Pitchford, M Green, L Dailey.
King's colleg London, England

693 Layer-by-Layer Nanoparticles with PEGylated Polyelectrolytes for Systemic Delivery of Multiple Anticancer Drugs
Presenter: Jong Oh Kim Authors: J Kim.
Yeungnam University, Korea

694 LbL-Microcarriers for the Treatment of Chronic Inflammation: Interaction, Uptake and Viability Studies of LbL-Drug Delivery Systems
Presenter: Mandy Fichtner Authors: M Fichtner, U Reibetanz.
Institute for Medical Physics and Biophysics, University of Leipzig, Germany

696 Light-triggered internalization of nanocomplex for effective gene delivery to hMSCs
Presenter: Jieun Han Authors: J Han, K Na.
Department of Biotechnology, The Catholic University of Korea, Bucheon, Gyeonggi do, 420-743, Republic of Korea, South Korea

697 Lipid based Nanocarriers for Carbamazepine
Presenter: Silki Kumar Authors: S P Kumar.
UIPS, Panjab University, Chandigarh, India

698 Lipid Platforms For Gene Therapy: The Bridge Between siRNA Silencing Efficiency and Intracellular Delivery
Presenter: Mafalda Videira Authors: M Videira, D Rafael, L Pereira.
Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy of the University of Lisbon, Portugal

699 Lipid-Based Nanoparticulate Formulation of Copper-Diethyldithiocarbamate: The Active Agent When Using Disulfiram for Treating Cancer
Presenter: Moe Wehbe Authors: M Wehbe, M Anantha, I Backstrom, A Malhotra, M Bally.
BC Cancer - Experimental Therapeutics, Canada

701 Looking into Blood Trash: Searching for Low Molecular Weight Biomarkers using Polyacrylic Acid Coated Gold Nanoparticles
Presenter: Luai Khoury Authors: L R Khoury, J Kost, G Enden.
Ben-Gurion University of the Negev, Israel

705 Magnetic-Guiding pH-responsive Co-delivery Nanomedicine System to Enhance Cancer Therapy
Presenter: San-Yuan Chen Authors: S Chen, W Li, P Chang.
National Chiao Tung University, Taiwan

706 Melatonin-loaded chitosan/Pluronic® F127 microspheres as in situ forming hydrogel: an innovative approach toward improved wound healing
Presenter: Anita Hafner Authors: M Duvnjak Romic, M Segvic Klaric, J Lovric, I Pepic, B Cetina-Cizmek, J Filipovic-Grcic, A Hafner.
University of Zagreb, Faculty of Pharmacy and Biochemistry, Department of Pharmaceutical Technology, Croatia

707 Mesoporous Phospholipid Particles: A Novel Drug Delivery Platform
Presenter: Kohsaku Kawakami Authors: K Kawakami, S Zhang, L Shrestha, G Jayakumar, M Fukushima, J Hill, K Ariga.
National Institute for Materials Science, Japan

709 Micellar formulation of crizotinib and dasatinib for the treatment of glioblastoma multiforme
Presenter: Hayley Nehoff Authors: H L Nehoff, S Taurin, K Greish.
University of Otago, New Zealand

710 Micellar Raloxifene improves its pharmacokinetics and cellular uptake with enhanced activity for the treatment of castrate-resistant Prostate cancer
Presenter: Khaled Greish Authors: K Greish, T Pritchard, R Rosengren, S Taurin.
Department of Pharmacology, University of Otago, New Zealand

714 Microfluidics-formulated Drug Nanocrystals for Pulmonary Delivery
Presenter: Maria Pereira Authors: M Pereira, D Vllasaliu, N Blagden.
University of Lincoln, United Kingdom

715 Microgels for Hydrophilic Drug Delivery to the Brain
Presenter: Todd Hoare Authors: J Piazza, N Smeets, R K Mishra, T Hoare.
McMaster University, Canada

716 Micro-scale liposome formulation via dual centrifugation
Presenter: Thomas Fritz Authors: T Fritz, M Voigt, V Schulz, U Massing, M Helm.
Institute of Pharmacy, University of Mainz, Germany

717 MIL100 nanoparticles as a Busulfan delivery system
Presenter: Teresa Simon-Yarza Authors: T Simon-Yarza, L L Leuseur, A Seck, T Baati, M Chiper, A Paci, P Couvreur, C Serre, R Gref, P Horcajada.
Institute Lavoisier, UVSQ, France

718 Mitigating Tacrolimus Nephrotoxicity By PLGA Nanoparticles: A Comparative In Vivo Study With Prograf®
Presenter: Aws Alshamsan Authors: A Alshamsan, Z Binkhathlan, A Alomrani, I Aljuffali, M Alghonaim, H Kfoury, S Almuhsen.
King Abdullah Institute for Nanotechnology, Saudi Arabia

719 MMP-sensitive size-shrinkable “raspberry-type” nanoparticles for tumor microenvironment-response penetration and pH triggered doxorubicin release in breast cancer
Presenter: Qin He Authors: S Ruan, Y Liu, H Gao, Q He.
Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, China

721 Molecular dynamics simulation as a tool in drug delivery liposome development
Presenter: Alex Bunker Authors: A Bunker, A Magarkar, T Rog.
University of Helsinki, Finland

722 MP-SPR New Characterization Method for Targeted Drug Delivery Systems and Controlled Release
Presenter: Annika Jokinen Authors: A Jokinen, N Granqvist, W M Albers, J Sadowski.
BioNavis Ltd., Finland

723 Multimodal imaging of metastasis targeting and antimetastatic therapy using polymeric, liposomal and micellar nanomedicines
Presenter: Larissa Rizzo Authors: L Y Rizzo, R Pola, C Rijcken, G Storm, F Kiessling, T Lammers.
ExMI (Uniklinik RWTH Aachen), Germany

724 Multiple Bioreducible Disulfide Linkage-Containing Poly(ethylene glycol)-b-Poly(ε-caprolactone) Nanoparticles for Intracellular Doxorubicin Delivery
Presenter: Jong-Ho Kim Authors: S Moon, J Kim, H Kang.
Kyung Hee University, Korea

726 Nanobubbles Combined with Extracorporeal Shock Waves for Enhanced Targeted Intracellular Delivery of Doxorubicin
Presenter: Roberta Cavalli Authors: M Argenziano, F Marano, M Catalano, R Frairia, R Cavalli.
Department of Drug Science and Technology, University of Turin, Italy

728 Nanomedicine in Obstetrics: Evaluation of a Novel Tocolytic Therapy Preventing Drug Passage to the Fetus
Presenter: Biana Godin Authors: J S Refuerzo, J F Alexander, F Leonard, M Leon, M Longo, B Godin.
Department of Nanomedicine, Houston Methodist Research Institute, Houston, Texas, U.S.A.

729 Nanoparticles Containing Lipopolysaccharide for Immunotherapeutic Inhibition of Tumour Cells Growth
Presenter: Mona Abdel-Mottaleb Authors: M M Abdel-Mottaleb, M Shetab, A Lamprecht.
University of Franche Comte, France

730 Nanoparticles in cancer immunotherapy: towards a systemic application of resiquimod
Presenter: Cedric Thauvin Authors: C Thauvin, J Widmer, I Mottas, C Bourquin, F Delie, E Allémann.
University of Geneva, Switzerland

731 Nanoparticles loading a natural anticancer agent tetrandrine for improving drug delivery
Presenter: Marc Schneider Authors: C Shi, M Schneider.
Department of Pharmacy, Biopharmaceutics and Pharmaceutical Technology, Saarland University, Germany

732 Nanoparticulate Delivery of Growth Factors for Fracture Healing
Presenter: Onyinyechi Udo-Chijioke Authors: O C Udo-Chijioke, Y Perrie, L Marshall, D Lowry.
Aston University, United Kingdom

734 New strategies based on gold nanorods to facilitate endosomal release
Presenter: Josep Garcia Authors: J Garcia, M Teixido, E Giralt.
Institute for Research in Biomedicine, Spain

735 Novel Polylysine PEG-Peptides Inhibit Scavenger Receptor Mediated Uptake of Nanoparticles by the Liver
Presenter: Kevin Rice Authors: K Rice.
Department of Pharmaceutical Sciences, College of Pharmacy, University of Iowa, Iowa City, IA 52242, U.S.A.

736 On-demand Release of Entrapped Bioactive Nanoparticles from Alginate
Presenter: Cathal Kearney Authors: C J Kearney, H Skaat, S M Kennedy, J Hu, M C Darnell, D J Mooney.
Royal College of Surgeons in Ireland, Ireland

738 Optimization of the Formulation of Photoluminescent Semi-Conducting Polymer Nanoparticles for Diagnostics and Bioimaging
Presenter: Laura Urbano Authors: L Urbano.
Institute of Pharmaceutical Science, School of Biomedical & Health Sciences, King’s College London, Franklin-Wilkins Building, Stamford Street, London SE1 9NH, U.K., United Kingdom

739 Oral Bile Salt Stabilised Vesicles for the Treatment of Parasitic Diseases
Presenter: Aikaterini Lalatsa Authors: A Lalatsa, E Kritza, M Mauger, D R Serrano Lopez, M A Dea-Ayuela.
University of Portsmouth, United Kingdom

740 Overcoming Multi-drug Resistance by Ultrasound Actuated Delivery to the Cytosol
Presenter: William Pitt Authors: W G Pitt, J B Williams, G A Husseini.
Brigham Young University, U.S.A.

741 Oxidation-Responsive Polymers: Tailored Sensitivity to Reactive Oxygen Species for Drug Delivery Purposes
Presenter: Richard d'Arcy Authors: R d'Arcy, N Tirelli.
University of Manchester, United Kingdom

742 Paclitaxel-Lapatinib loaded F127 Pluronic micelles; an in vitro- in vivo evaluation
Presenter: Farid Dorkoosh Authors: P Dehghankelishadi, F Dorkoosh, E Saadat, F Ravar.
Department of Pharmaceutics, Tehran University of Medical Science, Iran

743 PAMAM Dendrimer Interactions with Model Membranes
Presenter: Marleen Wilde Authors: M Wilde, R J Green, F Greco.
University of Reading, United Kingdom

744 Pegylated Docetaxel loaded Human serum albumin nanoparticles: Quality by design optimization, characterization, cytotoxicity and pharmacokinetics
Presenter: Shilpa Pawar Authors: S B Pawar, N P Saini, K K Singh.
C. U. Shah College of Pharmacy, S.N. D. T. Women’s University, Santacruz (W), Mumbai 400049, India , India

746 PEGylated Silk Nanoparticles for Drug Delivery Applications
Presenter: Thidarat Wongpinyochit Authors: T Wongpinyochit, P Seib.
University of Strathclyde, United Kingdom

747 PEGylation and CPP-Bioconjugation of Diatomite Nanoparticles for Enhanced Stability,Biocompatibility and Cellular Internalization in Cancer Cells
Presenter: Monica Terracciano Authors: M Terracciano, M Shahbazi, A Correia, I Rea, L De Stefano, H Santos.
Institute for Microelectronics and Microsystems, National Research Council, Italy

748 pH responsive vesicles with controlled cell penetrating activity for intracellular anticancer drug delivery
Presenter: Stefano Salmaso Authors: M Barattin, S Bersani, E Ambrosio, A Mattarei, C Paradisi, S Salmaso, P Caliceti.
Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Italy

750 pH-Controlled Morphology of Cationic Lipid Assemblies within Polyelectrolyte Gel Surface Layer Enclosing Superparamagnetic Core Particle for Co-Delivery of Theranostic Agents
Presenter: Hsin-Cheng Chiu Authors: H Chiu, Y Huang, W Huang, W Chiang.
Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Taiwan

752 pH-sensitive fliposomes based on a conformational flip
Presenter: Warren Viricel Authors: W Viricel, A Mbarek, J Leblond-Chain.
Faculty of pharmacy of Montréal, Canada

753 pH-sensitive liposomes for the delivery of therapeutic proteins: potential application for the treatment of bladder cancer
Presenter: Stefano Salmaso Authors: M Vila-Caballer, G Codolo, F Munari, S Bersani, M Fassan, M Rugge, P Caliceti, M de Bernard, S Salmaso.
Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Italy

755 Polymeric Micelles with Endosomal Buffering Function Reverse Multidrug Resistant of Tumor
Presenter: Qi Yin Authors: Q Yin, J Su, Y Li.
Shanghai Institute of Meteria Medica, Chinese Academy of Sciences, China

756 Polymeric Nanomedicine for Tumor-Targeted Combination Therapy to Elicit Synergistic Genotoxicity against Prostate Cancer
Presenter: Qingqing Yang Authors: Q Yang, Y Yang, Y Huang.
Sichuan University, China

757 Polymeric Smart Nanoparticles for the treatment of EGFR overexpressing diseases:
Presenter: Bice Conti Authors: B Colzani, R Dorati, B Conti, T Modena, E Zagato, L M Vermeulen, G R Dakwar, K Braeckmans, I Genta.
University of Pavia, Italy

758 Post-insertion Technique effect on pH-responsiveness, Cytotoxicity and Long-circulation of PEGylated Liposomes
Presenter: Zimei Wu Authors: H Xu, J W Paxton, Z Wu.
The University of Auckalnd, New Zealand

759 Preclinical CT, BLI and PET imaging with 18F-FDG and 64Cu-liposomes for detection of metastatic lesions in mice
Presenter: Raquel De Souza Authors: R De Souza, J Zheng, L C Ayub, G Francia, R Kerbel, C Allen, D Jaffray.
Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, M5S 3M2, Canada, Canada

760 Preparation and Characterization of Dexamethasone – PAMAM Dendrimer Complexes
Presenter: Burçin Yavuz Authors: B Yavuz, S Bozdağ Pehlivan, N Ünlü.
Hacettepe University Faculty of Pharmacy, Pharmaceutical Technology Department, Turkey

762 Preparation and Characterization of Reactive Oxygen Species-Sensitive Nanoconjugates as the Imaging Agent
Presenter: Eun Sook Lee Authors: E Lee, D V.G., D You, W Um, J Park.
SungKyunKwan University, South Korea

764 Preparation of polymer micelle-based fluorescent probe to image nitric oxide-producing macrophages
Presenter: Yasuhiko Tabata Authors: M Tatsutomi, J Jo, Y Tabata.
Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, Japan

765 Preparation, Optimization, In-vitro and In-vivo Evaluation of a Liposomal Formulation for Co-Delivery of Paclitaxel and Lapatinib
Presenter: Farid Dorkoosh Authors: F Ravar, F Dorkoosh, E Saadat, P Dehghankelishadi.
Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Tehran, P.O. Box 14155-645, Iran, Iran

766 Prevention of endotoxin-induced acute lung injury by intrapulmonary administration of platinum nanoparticles as reactive oxygen species scavengers
Presenter: Hidemasa Katsumi Authors: H Katsumi, K Fukui, K Kusamori, T Sakane, A Yamamoto.
Kyoto Pharmaceutical University, Japan

767 Probing the diffusive characteristics of silica nanoparticles functionalized with pharmaceutically relevant polymers through gastric mucus
Presenter: Edward Mansfield Authors: E Mansfield, V V Khutoryanskiy.
University of Reading, United Kingdom

768 Production of polyaspartamide based nanovectors by the method of solvent evaporation from ultrasound-made multiple emulsions
Presenter: Annalisa Dalmoro Authors: A Dalmoro, G Cavallaro, E F Capraro, C Sardo, G Lamberti, A A Barba.
University of Salerno, Italy

769 Pullulan bioconjugate for selective targeting to the hepatocyte
Presenter: Anna Balasso Authors: A Balasso, S Salmaso, A Malfanti, S Quarta, P Pontisso, P Caliceti.
Università degli Studi di Padova, Italy

770 Pure Nanocrystals of a Poorly Water-Soluble Protease Inhibitor Sustain the Release by the Oral Route: A New Generation of Nanocarrier-less Nano-Delivery Systems
Presenter: Alejandro Sosnik Authors: J C Imperiale, A Sosnik.
Technion-Israel Institute of Technology, Israel

771 Quality by Design Approach for the formulation of Resveratrol lipid nanoparticles: Multivariate design for optimizing process and product parameters
Presenter: Chahinez Houacine Authors: C Houacine, D Adams, P Roberts, K Singh.
School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston, PR1 2HE, United Kingdom, United Kingdom

773 Rapamycin liposomes functionalized with trastuzumab: development and characterization
Presenter: Josimar Eloy Authors: J O Eloy, R Petrilli, R Brueggemeier, R J Lee, J M Marchetti.
University of Sao Paulo - College of Pharmaceutical Sciences of Ribeirao Preto, Brazil

775 Redispersible microparticles composed of nanoparticles by spray drying with mannitol
Presenter: Afra Torge Authors: A Torge, M Schneider.
Philipps University Marburg, Germany

776 Re-examining the EPR Effect to Improve Nanomedicine Translatability
Presenter: Jennifer Hare Authors: J I Hare, H Barjat, S Puri, G Storm, M B Ashford, S T Barry.
AstraZeneca, United Kingdom

777 Remote control hybrid nanoparticles as a thermoresponsive drug carrier for pancreatic cancer therapy
Presenter: Maryam Malekigorji Authors: M Malekigorji, P Kong Thoo Lin, A D Curtis, C Hoskins.
PhD student in nanopharmaceutics, United Kingdom

779 ROS-induced Degradable Polymeric Nanoparticles for Intracellular Delivery of Paclitaxel
Presenter: Jee Seon Kim Authors: J Kim, G Seah, I Kim, J Yu, Y Nam.
Korea Advanced Institute of Science and Technology (KAIST), Korea

780 Rutin smartCrystals for Improvement of the Skin Appeal
Presenter: Rainer Müller Authors: S Pyo, R H Müller.
Freie Universität Berlin, Germany

782 Self-Assembled Nanoconjugate of Amphotericin B and Water Soluble Chitosan
Presenter: Akhil Krishnan R. Authors: R Krishnan, S Dyawanapelly, R Jain, P Dandekar.
Institute of Chemical Technology, Mumbai, India, India

785 Size exclusion chromatography: a useful method to determine peptide loading of nanoparticles
Presenter: Svenja Sladek Authors: S Sladek, M Eskander, L Tajber, D J Brayden.
University College Dublin, Ireland

786 Smart Chlorin e6 Tetraether Lipids Based Liposomes for Photodynamic Therapy
Presenter: Gihan Mahmoud Authors: G F Mahmoud, J Jedelská, B Strehlow, U Bakowsky.
Department of Pharmaceutical Technology and Biopharmacy, Germany

787 Smart gold nanoparticles for enhanced tumour targeting
Presenter: Stefano Salmaso Authors: C Brazzale, F Mastrotto, G Mantovani, C Alexander, P Caliceti, S Salmaso.
Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Italy

788 Solid lipid nanoparticles as intracellular drug transporters: An investigation of the uptake mechanism and pathway in epithelial cells
Presenter: Rohan Shah Authors: D Rajasekaran, R M Shah, M Ludford-Menting, D S Eldridge, E A Palombo, I H Harding.
Department of Chemistry and Biotechnology, Faculty of Science, Engineering and Technology, Swinburne University of Technology, Melbourne, Vic 3122, Australia, Australia

789 SP-D loaded PLGA nanoparticles as drug delivery system for premature infant's lung diseases
Presenter: Shani Attias Authors: S Attias, R Goldbart, T Traitel, J Kost, P Kingma, J Whitsett.
Ben Gurion University, Israel

790 Squalenoylation of chitosan: a new platform for anti-infectives delivery?
Presenter: Elise Lepeltier Authors: E Lepeltier, B Loretz, D Desmaele, J Zapp, J Herrmann, P Couvreur, C Lehr.
Dept. of Drug Delivery (DDEL) Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Germany

792 Stimuli Responsive Phospholipid-based Nanomaterials for On-demand Drug Delivery
Presenter: Joanne Du Authors: J D Du, S Caliph, B J Boyd.
Monash Institute of Pharmaceutical Sciences, Australia

793 Styrene-maleic acid copolymer conjugated pirarubicin, an anticancer nanomedicine with good stability and tumor-targeting property
Presenter: Jun Fang Authors: J Fang, K Tsukigawa, L Liao, H Nakamura, K Greish, M Otagiri, H Maeda.
Institute for Drug Delivery Science, Sojo University, Japan

794 Super stealth liposomes for the delivery of anticancer drugs.
Presenter: Katia Maso Authors: K Maso, A Grigoletto, A Mero, E Canato, C Celia, D Paolino, M Fresta, O Schiavon, G Pasut.
University of Padua, Italy

797 Surfactant protein A-mediated targeting of alveolar macrophages using surface-modified biodegradable nanoparticles
Presenter: Elias Fattal Authors: E Fattal, C Ruge, H Hillaireau, N Tsapis, J Nicolas, M Beck-Broichsitter, O CAÑADAS BENITO, C Casals.
Université Paris Sud, France

798 Synthesis of Redox-Sensitive Polymeric Nanoparticles with Potential Drug and Gene Delivery Applications
Presenter: Chi-Hwa Wang Authors: P Davoodi, C Wang, M Srinivasan.
Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore

799 Synthesis of Triblock Co-Polymeric Micelles for Delivery of Anticancer Drugs
Presenter: MOHD CAIRUL IQBAL MOHD AMIN Authors: M MOHD AMIN, N KHEN ENG, H KATAS, M AMJAD, A BUTT.
CENTRE FOR DRUG DELIVERY SYSTEM, FACULTY OF PHARMACY, UNIVERSITI KEBANGSAAN MALAYSIA, Malaysia

800 Synthesis, characterization and in vitro release studies of doxorubicin-loaded pH and thermal sensitive nanogels of N-isopropylacrylamide and carboxyalkyl methacrylates
Presenter: Dalia Castro-Vidal Authors: D A Castro-Vidal, A C Vea-Barragán, A Serrano-Medina, J M Cornejo-Bravo.
Autonomous University of Baja California, Mexico

801 Systemic Radionuclide Therapy Using Graphene Oxide Nanoplatelets and Mesoporous Carbon Nanoparticles
Presenter: Junghyun Kim Authors: J Kim, X Lu, K H Kim, M Jay.
University of North Carolina, U.S.A.

802 Systemically Optimized Lipidic Nanoparticles of Berberine with Enhanced Brain Targeting Potential for Alzheimer’s disease
Presenter: Shikha Lohan Authors: S Lohan, S Mehta, P S Sandhu, S K Agrawal, B S Bhoop.
Research Fellow, India

804 Targeted delivery of platinum-taxane combination therapy in ovarian cancer
Presenter: Tatiana Bronich Authors: S S Desale, K S Soni, S Romanova, T K Bronich.
University of Nebraska Medical Center, U.S.A.

805 Targeted gold nanoparticles as sensitizers in ultrasound based cancer treatment
Presenter: Stefano Salmaso Authors: C Brazzale, L Serpe, R Canaparo, L Racca, G Durando, P Caliceti, S Salmaso.
Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Italy

807 Targeting and altering in vivo macrophage responses with modified polymer properties
Presenter: Kaitlin Bratlie Authors: H C Bygd, K D Forsmark, K M Bratlie.
Iowa State University, U.S.A.

809 Targeting Drug Carriers Using Copper Free Click Chemistry and Metabolic Labelling
Presenter: Nicolas Alcaraz Authors: N A Alcaraz, B Boyd, A Johnston, B Graham, T Hanley.
Monash Institute of Pharmaceutical Sciences, Australia

810 The Development of Self-Sterilising Urinary Biomaterials Utilizing a pH-Responsive Surfactant System
Presenter: Johann Trotter Authors: C P McCoy, J L Trotter, N J Irwin, S Gorman, L Carson.
Queen's University Belfast, United Kingdom

811 The NanoAssemblrTM Platform: Scalable, Microfluidics-based Manufacture of Polymeric Nanoparticles
Presenter: Colin Walsh Authors: G Heuck, J Bteich, A Thomas, K Ou, A Ansari, T Leaver, A Wild, E Ramsay, C Walsh, R J Taylor, S Li, M Ernsting.
Precision NanoSystems, Canada

812 The Nanoparticle Corona in Pulmonary Surfactant is composed of Proteins AND Lipids
Presenter: Simon Raesch Authors: S S Raesch, W Storck, S Tenzer, C A Ruge, U F Schaefer, C Lehr.
Department of Pharmacy, Saarland University, Germany

813 The smartLipids® – 3rd Generation of Lipid Nanoparticles after SLN® and NLC®
Presenter: Rainer Müller Authors: C M Keck, R Ruick, R H Müller.
Free University Berlin, Germany

814 The Vacuum SpinSwiper Device for Making PLGA Microparticles
Presenter: Byung Kook Lee Authors: B Lee, Y Yun, S Skidmore, J Garner, K Park.
Purdue University, U.S.A.

816 Thermosensitive liposomes and hyperthermia: Intravascular drug release versus intratumoral particle accumulation
Presenter: Wouter Lokerse Authors: W Lokerse, E Kneepkens, M Bolkestein, A Eggermont, T ten Hagen, H Grüll, G Koning.
Erasmus Medical Center, Netherlands

819 Transport Mechanism Of Coumarin 6 Nanocrystal In MDCK Monolayer and Larval Zebrafish
Presenter: Xiaoqing Miao Authors: X Miao.
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, China

822 Trojan-Horse Nanocapsules – a Multistage Drug Delivery System for Deep Permeation in Tumor Tissue
Presenter: Yen-Ho Lai Authors: Y Lai.
Department of Materials Science and Engineering, National Chiao Tung University , Taiwan

823 Tumor Targeting Efficiency of Hyaluronic acid Based Micelle Containing Paclitaxel
Presenter: Farid Dorkoosh Authors: F Dorkoosh, E Saadat, M Gholami.
Tehran University of Medical Sciences, Iran

824 Tunable Encapsulation and Controlled Release of a Hydrophilic Drug by a New Modified Drop-wise Nanoprecipitation Method
Presenter: Jiang Xu Authors: J Xu, F Gu, A Colin.
University of Waterloo, University of Bordeaux, Canada

825 Ultrahigh Drug Loading and Release from Biodegradable Porous Silicon Aerocrystals
Presenter: Catherin Kelly Authors: D K Nadarassan.
pSiMedica (A pSivida group company), United Kingdom

826 Ultrasonic assisted production of nanoliposomes as peptide delivery vectors
Presenter: Sabrina Bochicchio Authors: A Barba, S Bochicchio, G Lamberti, M Sala, P Campiglia.
University of Salerno, Italy

827 Ultrasound-Responsive Nanobubbles for Enhanced Posterior Eye Drug Delivery
Presenter: Sachin Thakur Authors: S S Thakur, M Parat, N L Barnett, M S Ward, N B Flemming, A Popat, H S Parekh.
University of Queensland, Australia

828 Unintended Tissue Targeting: Is the Accumulation of Nano-DDS in Ovaries and Adrenals a Rather Common Phenomenon or an Artifact?
Presenter: Karsten Maeder Authors: K Maeder.
Martin-Luther-university Halle-Wittenberg, Germany

830 Up-Regulating Autophagy in Attempt to Overcome Insulin Resistance Using Quaternized Starch as PI3P Carrier
Presenter: Nitzan Marelly Authors: N Marelly, T Vodonos, R Chintakunta, R Goldbart, T Traitel, A Rudich, J Kost.
Department of Chemical Engineering, Ben-Gurion University of the Negev, Israel

831 Upsalite®: A Novel Mesoporous Drug Delivery System
Presenter: Peng Zhang Authors: P Zhang, T Gómez de la Torre, J Forsgren, M Strømme.
Uppsala University, China

832 Ursolic Acid Promotes Stabilization of pH-Sensitive and Long-Circulating Liposomes under pH Decrease
Presenter: Diêgo Ferreira Authors: M C Oliveira, S C Lopes, M Novais, D S Ferreira, F C Braga, R Magalhães-Paniago, Â Malachias.
Universidade Federal de Minas Gerais, Brazil

834 Use of synthetic-sick screens to define improved combinations for cancer treatment: PAPSS1 silencing and lipid-based nanoparticulate formulations of DNA damaging agents
Presenter: Ada Leung Authors: A Leung, B Kwok, D Ricaurte, A Ahluwalia, M Qadir, M B Bally.
BC Cancer Research Centre, Canada

836 Virus Mimetic: Bio-inspired Liposomes for Controlled Drug Release
Presenter: Siyuan Chen Authors: S Chen, R Chen.
Imperial College London, United Kingdom

838 Vitamin E-Conjugated Lipid Based Polymeric Micelles for Improved Delivery of Chemotherapeutics in Cancer
Presenter: SWATI BISWAS Authors: O MUDDINETI, P KUMARI, B GHOSH, S BISWAS.
BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE PILANI, HYDERABAD, India

839 What’s the dose? Accumulation of oligoarginine decorated nanoparticles on the surface of Caco-2 cells
Presenter: Ian Tucker Authors: A McDowell, J Z Chiu, A E Radunskaya, I G Tucker.
University of Otago, New Zealand
collapse Micro-and Nanoparticle Delivery

679 In vivo Biodistribution and Anticancer Activity of Cisplatin Delivered by Ultra-short Carbon Nanotube Capsules
Presenter: STUART CORR Authors: S J CORR, A Guven, M Raoof, B T Cisneros, S Phounsavath, J Chak-Shing Ho, S A Curley, L J Wilson.
BAYOR COLLEGE OF MEDICINE, U.S.A.

796 Surfactant coated nanoparticles for Alzheimer: A brain uptake perspective
Presenter: Ola ElNoweam Authors: O ElNoweam, S Soudi, D Alian, A H El-Kamel, M I Nounou.
Faculty of Pharmacy, Alexandria University, Egypt

840 Zein-PCL Electrospun Triple-Layered Nanofibre Matrices For Localised Controlled Delivery of Tetracycline
Presenter: Ian Blagbrough. Authors: Nour Alhusein, and Paul A. De Bank.
University of Bath, Bath BA2 7AY, UK
collapse Modeling and Simulation of Oral Absorption

9 Invited Speaker - Peter Langguth
.

10 Enhanced in vitro inputs for in silico prediction of oral absorption – progress within the Innovative Medicines Initiative OrBiTo project
Presenter: Mark McAllister Authors: M McAllister, R Holm, A Müllertz, J Butler, P Augustijns, B Abrahamsson, H Lennernäs.
Pfizer Inc, United Kingdom

11 Invited Speaker - Xavier Pepin
.
collapse Modulated and Responsive Delivery Systems

5 Photo, pH, and Reduction-Responsive Drug Release Nanosystems: Which is the Best for Targeted Cancer Chemotherapy?
Presenter: Zhiyuan Zhong Authors: Z Zhong.
Soochow Univ, China

674 Hybrid Bioactive Nanoparticles Modulate Tumor Microenvironment and Enhance Radiation Therapy
Presenter: Mohammad Ali Amini Authors: M Amini, A Z Abbasi, C R Gordijo, A Maeda, R S DaCosta, A M Rautth, X Wu.
Leslie Dan Faculty of Pharmacy, University of Toronto, Canada

725 Multistage Stimuli-responsive and Sequential Size-alterable Nanovehicle for Systemic Nuclear-targeted Drug Delivery
Presenter: Lian Li Authors: L Li, Y Huang.
Sichuan University, China

784 Site-Specific Time and Sequential Nanoparticle Delivery of Chemotherapeutics for Synergy Enhancement
Presenter: Elvin Blanco Authors: V Segura-Ibarra, S Wu, F E Cara, F Meric-Bernstam, M Ferrari, E Blanco.
Houston Methodist Research Institute, U.S.A.

806 Targeted Imaging of Cyclooxygenase-2 in Inflammation and Cancer by Fluorocoxib A-Loaded ROS-Responsive Nanoparticles
Presenter: Thomas Werfel Authors: T Werfel, M Uddin, B Crews, M Gupta, L Marnett, C Duvall.
Vanderbilt University, U.S.A.
collapse Nanocarriers for Combined Delivery

49 Dermatan Sulfate, a Silent Actor of a Ternary Gene Delivery System
Presenter: Yoon Yeo Authors: Y Yeo, B Kim, S Kim, I Kwon.
Purdue University, U.S.A.

50 An Injectable 3-drug Nanotherapeutic for Disseminated Angiosarcoma
Presenter: Glen Kwon Authors: G S Kwon.
Univ of Wisconsin, U.S.A.

539 A Lipid Nanoemulsion System for Concurrent Delivery of Chemotherapeutics and Bromotetrandrine (W198) to Overcome Multidrug Resistance in Breast Cancer Therapy
Presenter: Yao Fu Authors: X Cao, T Gong, Z Zhang, Y Fu.
Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, China

680 In vivo evaluation of a novel chemo-immunotherapeutic strategy to treat glioblastoma: paclitaxel and CpG loaded lipid nanocapsules
Presenter: Giovanna Lollo Authors: G Lollo, M Vincent, G Ullio Gamboa, L Lemaire, F Franconi, D Couez, J Benoit.
LUNAM University— Micro et Nanomédecines Biomimétiques, France

713 Microfluidic Fabrication of a Stimulus Responsive Hybrid Nanocomposite for Antitumoral Applications
Presenter: Barbara Herranz Blanco Authors: B Herranz Blanco, D Liu, E Mäkila, M Shahbazi, E Ginestar Nadal, H Zhang, V Aseyev, V Balasubramanian, J Salonen, J hirvonen, H A Santos.
University of Helsinki, Finland
collapse Nano-Sized Carriers for Small Molecule Oncology Drugs

25 Nanotechnology Approaches for Personalized Treatment of Cancer
Presenter: Tamara Minko Authors: T Minko, A Kuzmov, J Sapiezynski, O Taratula, V Shah, M Zhang, O B Garbuzenko, S R Pine, L Rodriguez-Rodriguez.
Rutgers Univ, U.S.A.

26 Invited Speaker - Andre Lieber
.

541 A novel antitumour strategy using bidirectional autophagic vesicles accumulation via combined treatment with TAT-Beclin 1 and liposomal hydroxychloroquine
Presenter: Qin He Authors: Y Wang, Y Liu, Q He.
Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, China

546 A novel vincristine submicron emulsion system with enhanced antitumor effect
Presenter: Ting Zhang Authors: T Zhang, T Gong, Z Zhang.
West China School of Pharmacy, Sichuan University, China

651 Extracellular vesicles as smart carriers for small molecule drugs
Presenter: Gregor Fuhrmann Authors: G Fuhrmann, A Serio, M M Stevens.
Imperial College, Department of Materials, Department of Bioengineering, United Kingdom

815 Theranostic Barcoded Nanoparticles for Personalized Cancer Medicine
Presenter: Zvi Ya'ari Authors: Z Ya'ari.
Technion, Israel
collapse Nano-Systems for Non-Oncology Drug Delivery

51 Macromolecular Dexamethasone Prodrug Prevents And Resolves Lupus Nephritis With Reduced Systemic Toxicities
Presenter: Dong Wang Authors: D Wang.
University of Nebraska Medical Center, U.S.A.

52 Liposomal drug delivery to atherosclerotic lesions in cardiovascular patients
Presenter: Gert Storm Authors: G Storm, J M Metselaar, M E Lobatto, Z Y Fayad, E S Stroes, W J Mulder.
Utrecht University and University of Twente, Netherlands

589 Comparative study of curcumin-loaded lipid-based nanocarriers for inflammatory bowel disease treatment
Presenter: Ana Beloqui Authors: A Beloqui, P B Memvanga, R Coco, S Reimondez-Troitino, M Alhouayek, A Staub, G G Muccioli, M J Alonso, N Csaba, M de la Fuente, V Preat.
Universite catholique de Louvain, Belgium

703 Macromolecular Prodrugs of AZT and Ribavirin - Towards a Treatment of Infection with HIV and HCV.
Presenter: Kaja Zuwala Authors: K Zuwala, A A S. Smith, B M Wohl, M B L. Kryger, P Ruiz-Sanchis, C Guerrero-Sanchez, A Postma, M Tolstrup, A N Zelikin.
Department of Infectious Diseases, Aarhus University Hospital, Skejby, DK-8200, Denmark, Denmark

772 Raltegravir Prodrugs for Improved Nanoparticle Delivery
Presenter: Ian Suydam Authors: I T Suydam, M E Ebner, A M Bever, Y Jiang, K A Woodrow.
Seattle University, U.S.A.

795 Suppression of Inflammatory Cytokines with “Eat-me” Signal Bearing Particles
Presenter: Yoshiki Katayama Authors: Y Katayama, P Kumar, M Hosain, D Funamoto, A Kishimura, T Mori.
Department of Applied Chem., Fuclty of Engineering, Kyushu University, Japan
collapse Next-Generation Vaccine Development and Delivery Technologies

31 Invited Speaker - Lorne Babiuk
.

32 Invited Speaker - Derek O'Hagan
.

33 Invited Speaker - Phil Marsh
.
PHE Porton, UK
collapse Ocular Drug Delivery

27 Non-viral gene therapy for eye diseases: Which perspectives? How to translate to the clinic?
Presenter: Francine Behar-Cohen Authors: F F Behar-Cohen.
Department Ophthalmology department of Lausanne, Jules Gonin Hospital, Inserm UMR1138, Paris, Switzerland

28 Development of Drug Delivery Systems for the Eye: Focus and Team
Presenter: Eugene de Juan Authors: E de Juan.
ForSight Labs, U.S.A.

425 A Physically-Associative, Shear-Responsive Ophthalmic Hydrogel for Anterior and Posterior Segment Drug Delivery
Presenter: Todd Hoare Authors: P Sheikholeslami, B Muirhead, D Baek, H Wang, X Zhao, D Sivakumaran, S Boyd, H Sheardown, T Hoare.
McMaster University, Canada

431 Antioxidant Activity and Real-Time Imaging of HPMC–coated Cerium Oxide Nanoparticles: New Modality for Age-Related Cataract
Presenter: S Patel Authors: A A Al-kinani, S Patel, A Vangala, G Calabrese, B Pierscionek, D Naughton, R G Alany.
School of Pharmacy and Chemistry, Kingston University London, United Kingdom

434 Clinical and Preclinical Demonstration of Continuous and Adjustable Methotrexate Delivery from a Novel Refillable “Port Delivery System” Implant
Presenter: Signe Erickson Authors: S R Erickson, R Campbell, K Farinas, J Horvath, J M Stewart.
ForSight Vision4, U.S.A.

478 Patterned Nanoporous Polypyrrole for Tunable Ocular Drug Delivery
Presenter: Ali Seyfoddin Authors: A Seyfoddin, H Zhang, S Moulton, M Higgins, I D Rupenthal, G I Waterhouse.
School of Pharmacy, University of Auckland, New Zealand
collapse Opening Session

Opening Session
Presenter: Art Tipton.
Southern Research Institute
collapse Oral Delivery for Food

16 Assembly of Karifin Nanoparticles-Based Pickering Emulsions for Nutraceutical Delivery
Presenter: Qingrong Huang Authors: Q Huang.
Rutgers Univ, U.S.A.

17 Invited Speaker - Dolores O'Riordan
.

273 Application of sodium alginate for enteric coated lactoferrin tablets
Presenter: Chiaki Takahashi Authors: C Takahashi, Y Obayashi, A Uchiyama, S Tanaka, H Iwasaki.
Lion Corporation, Japan

277 β-Casein Based Nano-vehicles for Oral Delivery of Chemotherapeutic Combinations Overcoming Multidrug Resistance in Human Gastric Cancer
Presenter: Maya Bar-Zeev Authors: M Bar-Zeev, Y G Assaraf, Y D Livney.
Technion - Israel Institute of Technology, Haifa, 32000, Israel, Israel

340 Intestinal permeation enhancers improve flux of food-derived tripeptides across rat intestinal mucosae in vitro
Presenter: John Gleeson Authors: J P Gleeson, S M Ryan, D J Brayden.
University College Dublin, Ireland

360 Optimization of the Microencapsulation of Anthocyanins from Haskap Berries (Lonicera caerulea L.) in Ca-Alginate Beads for Oral Delivery
Presenter: Giovana Celli Authors: G B Celli, A Ghanem, M S Brooks.
Dalhousie University, Canada

375 Silica Encapsulated Lipid Based Drug Delivery Systems for Reducing the Food Effect of Ziprasidone
Presenter: Tahnee Dening Authors: T J Dening, S Rao, N Thomas, A Tan, C A Prestidge.
Ian Wark Research Institute, University of South Australia, Australia
collapse Oral Delivery for Food & Pharma

314 Enteric Coated Mucoadhesive Nanoparticles for Oral Drug Delivery utilizing Micro Jet Reactor: A Novel Method for Production
Presenter: Akif Emre. Authors: N. G. Türeli, B. Baumstümmler.
MJR PharmJet GmbH, Unikliniken des Saarlandes, Starterzentrum (Geb.7), D-66424 Homburg, Germany,

388 Use of a Fed/Fasted Dog Model to Predict the Effect of Food on the Pharmacokinetics of a BCS IV Compound
Presenter: Mei Wong. Authors: K. Jones, R. Manley and K. Sugano.
Drug Product Design, Pfizer Worldwide Research & Development, Sandwich CT13 9NJ, UK
collapse Oral Delivery for Food and Pharma

266 A bio-inspired delivery system for doxorubicin transport across intestinal epithelial cells
Presenter: Quanlei Zhu Authors: Q Zhu, S Guo, D Xia, Y Gan.
Shanghai Institution of Materia Medica, Chinese academy of science, China

268 A cell penetrating peptide-medium chain fatty acid conjugate increases paracellular permeability across isolated rat intestinal mucosae
Presenter: Fiona McCartney Authors: F McCartney, J Garcia, M Teixido, J Heade, E Giralt, D J Brayden.
University College Dublin, Ireland

270 A Novel Controlled-release Formulation of Carvedilol
Presenter: Lin Tsung-Hsin Authors: L Tsung-Hsin, L Ta-Chien, H Wei-Hua.
Innopharmax Inc, Taiwan

271 A practical approach: A standardized method for investigation of supersaturation and determination of the effect of excipients on this
Presenter: Henrik Palmelund Authors: H Palmelund, C M Madsen, A Müllertz, T Rades.
Department of Pharmacy, University of Copenhagen, Denmark

272 A Study of the Utilization of Starch Micro-Spheres as a Core Material for a Dry Powder Layering of an API to Facilitate High API Loading in Particles Below 250 microns
Presenter: Shawn Engels Authors: S M Engels, B K Jensen, S Freers, C Shipley.
Freund-Vector Corporation, U.S.A.

274 Assessment of pH values, transit conditions and pressure events along the gastrointestinal tract in fasted and fed state using a wireless motility capsule (SmartPill®)
Presenter: Felix Schneider Authors: F Schneider, M Grimm, M Koziolek, C Modeß, A Seekamp, T Roustom, W Weitschies.
Department of Biopharmaceutics and Pharmaceutical Technology, Institute of Pharmacy, University of Greifswald, Germany

276 Automated screening approaches for solid dispersion approach of a poorly soluble compound.
Presenter: Geert Verreck Authors: G Verreck, J Herman, L Wang, T Janssen, J Van Gelder, L Bijnens, A Van Dijck, M Jansens, G Van der Avoort, B Van Hove, A Debunne, I Van Assche, M E Brewster, R Leemans, P Van Remoortere.
Janssen Pharma R&D, Belgium

278 Bioactive protein-based nanofibers promotes transepithelial permeation of intact therapeutic protein by interactions with biological components
Presenter: Karen Stephansen Authors: K Stephansen, M Garcia-Diaz, F Jessen, I S Chronakis, H M Nielsen.
Technical University of Denmark, Denmark

279 Biphasic dissolution studies: Impact of concentration and particle size on partition rate
Presenter: Karl Box Authors: K J Box, J Comer, R Taylor.
Sirius Analytical, United Kingdom

280 Can judicious selection of polymer viscosity improve the GI robustness of HPMC hydrophilic matrices with low polymer contents?
Presenter: Laura Mason Authors: L M Mason, D E Storey, P Gupta, C D Melia.
University of Nottingham, United Kingdom

281 Carrier Peptide-Mediated Transepithelial Permeation of Biopharmaceuticals:
Presenter: Mie Kristensen Authors: M Kristensen, H M Nielsen.
University of Copenhagen, Denmark

282 Casein nanocapsules: a new platform for oral drug delivery
Presenter: Dolores Torres Authors: M Alonso, G Rivera-Rodriguez, D Torres, D Torres.
Dpt Pharmaceutical Technology, Spain

284 Characterization of Orally Disintegrating Tablets Containing Taste-Masked Mirtazapine Granules with Different Coating Ratio
Presenter: Eren Aytekin Authors: S Yıldız, E Aytekin, S Bozdağ Pehlivan, N Ünlü.
Hacettepe University Faculty of Pharmacy Pharmaceutical Technology Department, Turkey

285 Chewing Gum with a Built-in Trigger Mechanism for Drug Delivery
Presenter: Kent Nielsen Authors: K A Nielsen.
Nicotine Science Center, Fertin Pharma A/S, Denmark

286 Chronocort® - a Modified Release Oral Hydrocortisone Formulation Customised to Mimic the Human Circadian Rhythm
Presenter: Daniel Margetson Authors: D N Margetson, G Neal, H Huatan, R Ross, D Eckland, D Digweed, A Grave, A Foerg, N Poellinger, M J Whitaker.
Diurnal Ltd, United Kingdom

287 Circumvent p-glycoprotein-mediated efflux by Lipo- encapsulated pure nanodrug
Presenter: Dengning Xia Authors: D Xia, Y He, Q Li, J Tao, C Wang, Y Gan.
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China

288 Co-loading of Glucagon-like Peptide-1 and Dipeptidyl Peptidase 4 Inhibitor in pH Sensitive Polymer/Porous Silicon Nanomatrix for Type 2 Diabetes Mellitus
Presenter: Neha Shrestha Authors: N Shrestha, M Shahbazi, F Araújo, E Mäkilä, J Raula, B Sarmento, J Salonen, J Hirvonen, H Santos.
University of Helsinki, Finland

289 Combined use of Biofirm Penetration Enhancer and Sublingual Administration for Improving the Bioavailability of BBR
Presenter: Xiaoying Long Authors: X Long, C Liu.
Guangdong Pharmaceutical University, China

290 Controlled Release Coatings of Ethylcellulose on Drug Loaded Multiparticulates:A Comparison of a Novel Rotor Dry Layering Process to a Traditional Wurster Bottom Spray Coating
Presenter: Brian Jensen Authors: B Jensen, S Engels, K Bellach, C Schoener, S Khot.
Freund-Vector Corporation, U.S.A.

291 Controlled Release Formulations of Pelubiprofen Employing Kollidon® SR
Presenter: Boram Chae Authors: B Chae, S Sohn.
Daewon Pharm.Co.,Ltd., South Korea

292 Controlled Release Tablet Formulations: Effect of Hydrophilic Matrix and Fillers on Active Pharmaceutical Ingredient Release
Presenter: Jaime Conceição Authors: J Conceição, S Fernandes, P Costa, J Sousa Lobo.
Faculty of Pharmacy, University of Porto, Portugal

295 Design of a histology score card to standardize the assessment of intestinal toxicity of novel candidate pharmaceutical excipients
Presenter: Fiona McCartney Authors: S Waters, F McCartney, S Bleiel, D J Brayden, S Maher.
Royal College of Surgeons Ireland, Ireland

297 Design of Modified Release Multi-Particulate Floating Drug Delivery System for Levodopa and Carbidopa Combination Based on a Multilayer Structure
Presenter: SHRIKANT CHARDE Authors: P P RAUT, S Y CHARDE.
RESEARCH SCHOLAR, India

298 Determining the azoreductase activity in bacteria residing the lower human gastrointestinal tract
Presenter: Gunnar Glöckl Authors: G Glöckl, K Eggers, J Oberland, M Mahler, W Weitschies.
University of Greifswald, Germany

300 Development of MCC-free pellets with fast release for poorly soluble drugs
Presenter: Natalia Dudzinska Authors: N Dudzinska, M Hahn, K Mäder.
Martin-Luther-University Halle-Wittenberg, Institute of Pharmacy, W. Langenbeck-Str. 4, D-06120 Halle/Saale, Germany, Germany

301 Development of Pharmaceutical Abuse Deterrent Capsule Formulations
Presenter: Simone Wengner Authors: S Wengner.
Catalent Pharma Solutions, Germany

302 Development of Rapid-acting Oral Insulin Formulation
Presenter: Yu-Tsai Yang Authors: Y Yang, P Hsu, Y Huang, L Chang, W Hao, C Hsu.
INNOPHARMAX, INC, Taiwan

303 Development, characterisation and optimisation of PEG-chitosan based nanoparticle system for the oral delivery of insulin
Presenter: Revanth Rayasam Authors: R Rayasam.
Kingston University, LONDON, United Kingdom

304 Dissolution of niacin ER tablets under standard and biorelevant test conditions
Presenter: Bart Milanowski Authors: B Milanowski, G Rappen, G Garbacz, A Urbańska, A Hejduk, J Lulek.
Poznan University of Medical Sciences, Poland

305 Dissolution of Tacrolimus from Modified Release Formulations under Biorelevant Conditions
Presenter: Annalisa Mercuri Authors: A Mercuri, R Sattler, S Stranzinger, S Wu, S Mohr, S Salar-Behzadi, E Fröhlich.
RCPE GmbH, Austria

306 Effect of Bead Size and Counts per Unit in a Multi-Particulate System on Bioavailability.
Presenter: Yogesh Gattani Authors: Y S Gattani, D K Sahoo, P K Ghosh, N Vaya, K K Venkatesh.
1. Dr. Reddy’s Laboratories, Hyderabad, Telangana, 500072, India, India

307 Effect of Citrate Buffer on the Release Rate and Swelling Properties of Fluvastatin Matrix Tablet In Acid and Basic Media.
Presenter: Uloma Ubani-Ukoma Authors: U Ubani-Ukoma, Y Perrie, P Rue.
University of Lagos, Nigeria

308 Effect of pH combined with surfactant on solubility profile of weakly acidic HMG CoA enzyme reductase inhibitor- Atorvastatin Calcium
Presenter: PRITI DOSHI Authors: A ASTHANA, P DOSHI.
Student, India

309 Effect of Talc Particle Size on Drug Release from Modified Release Dosage Forms
Presenter: Basawaraj Chickmath Authors: B Chickmath.
Upsher Smith Laboratories, U.S.A.

310 Enabling Controlled Release Formulations for Once Daily (QD) Dosing of a Poorly Water Soluble Compound
Presenter: Pranav Gupta Authors: P Gupta, S Patel, F Kesisoglou, P Kothari, S Lee.
Merck and Co.,, U.S.A.

311 Encapsulation by modification food protein to increase survival rate of probiotics in the stomach
Presenter: Robert Tromp Authors: R H Tromp.
NIZO food research, Netherlands

313 Enteric coated hard gelatin capsule development for pharmacokinetic studies
Presenter: Paul Evans Authors: P Evans, R Ellis, S Dotan, S Samira, J Fraser, S Brown, J Mains.
Encap Drug Delivery a subsidiary of Capsugel, United Kingdom

315 Enteric-coated tablets containing permeation enhancers improve oral bioavailability of Enoxaparin
Presenter: Morvarid Goharzadeh Authors: M Goharzadeh, M Avadi, A Mir Mohamad Sadeghi.
Faculty of Pharmacy, Azad University of Pharmaceutical Science, Iran

316 Establishment of Virtual Bioequivalence Using Population-Based PBPK Modelling: Application to the Setting of Dissolution Limits
Presenter: Shriram Pathak Authors: S Pathak, N Patel, J Wedagedera, D Turner, M Jamei, A Rostami-Hodjegan.
Simcyp (A Certara Company), United Kingdom

317 Evaluation of Acetaminophen Particle Size and Crystal Morphology on Taste-Masking Performance from Coated Granules and Chewable Tablets
Presenter: Ali Rajabi-Siahboomi Authors: R Y Mehta, C R Cunningham, A R Rajabi-Siahboomi.
Colorcon Inc., , U.S.A.

319 Evaluation of HPMC as a Polymer Carrier in a Celecoxib Amorphous Solid Dispersion
Presenter: Timothy Brannigan Authors: T I Brannigan, D S Jones, G P Andrews.
Queens University Belfast, United Kingdom

321 Film Casting as a Screening Technique in the Selection of API-Polymer Compositions for Amorphous Solid Dispersion Production via Spray Drying
Presenter: Claire Brennan Authors: C Brennan, A Giles, M I Amaro, L Tajber, G P Andrews, A M Healy.
Trinity College Dublin, Ireland

322 Formulating a chewable tablet containing paracetamol and masking the taste of the active pharmaceutical ingredient
Presenter: Thorsten Cech Authors: F Bang, T Cech.
BASF SE, Germany

323 Formulating an orally disintegrating tablet carrying cetirizine HCl and evaluating advantages and disadvantages of different manufacturing procedures
Presenter: Thorsten Cech Authors: T Agnese, T Cech.
BASF SE, Germany

324 Formulating Oils in the Zydis® Freeze Dried Orally Disintegrating Tablet
Presenter: Lisa Garrett Authors: L M Garrett, L P Grother, N M Warren.
Catalent Pharma Solutions, United Kingdom

326 Formulation Development and Preliminary Studies of Decitabine loaded PLGA Nanoparticles for Potential Oral Delivery
Presenter: Nayanabhirama Udupa Authors: N Udupa, P Jain, A Chonkar, M TIWARI, J V Rao.
Manipal University, India

329 High Shear Granulation to Leverage the Full Potential of Delta Polymorph Mannitol
Presenter: Finn Bauer Authors: F Bauer, B Michel, R Ognibene, E Schornick, D Lubda.
Merck Millipore, Germany

330 Hot Melt Extrusion to Improve Dissolution of Itraconazole
Presenter: Piero Piccinni Authors: P Piccinni, J Fraser, D Jones, S Brown, G Andrews.
Queens University Belfast/Encap Drug Delivery , United Kingdom

331 Human in vivo regional intestinal permeability: Quantitation using site-specific drug absorption data
Presenter: David Dahlgren Authors: D Dahlgren, C Roos, E Sjögren, H Lennernäs.
Uppsala University, Sweden

332 HYDROGELS-BASED MATRICES BEHAVIOR: EXPERIMENTAL AND MODELING DESCRIPTION
Presenter: Sabrina Bochicchio Authors: D Caccavo, S Cascone, S Bochicchio, G Lamberti, A Dalmoro, A Barba.
University of Salerno, Italy

333 Impact of monoacyl phosphatidylcholine on the nanoemulsification capacity of self-nanoemulsifying drug delivery systems
Presenter: Thuy Tran Authors: T Tran, X Xi, T Rades, A Mullertz.
University of Copenhagen, Denmark

334 Improved loading of a poorly water soluble drug in Orally Dissolving Films through cyclodextrin inclusion complex.
Presenter: Thu Pham Authors: T Pham, D Ouyang, D Terry, D Lowry, D J Kirby.
Aston University, UK, United Kingdom

335 In silico modeling of drug release from Eudragit® RL/RS coated drug beads using material properties and kinetic parameters of the free polymer films
Presenter: Xiao Yu Wu Authors: K Chen, J Lugtu-Pe, G Lima, B Ramos, A Kane, X Wu.
University of Toronto, Canada

336 IN VITRO AND IN SILICO MODELS IN PHARMACOKINETIC STUDIES
Presenter: Sabrina Bochicchio Authors: S Cascone, S Bochicchio, G Lamberti, G Titomanlio, A Barba.
University of Salerno, Italy

338 Increasing the complexity in epithelial cell culture to assess cytotoxicity of a permeability enhancer (CriticalSorbTM)
Presenter: Robert Cavanagh Authors: R Cavanagh, F Jordan, S Stolnik.
University of Nottingham, United Kingdom

341 Investigating the barrier properties of an intestinal co-culture model of CCD-18co intestinal sub-epithelial myofibroblasts and Caco-2 intestinal epithelial cells
Presenter: Jamie Patient Authors: J D Patient.
University of Nottingham, United Kingdom

342 Investigating the impact of particle size and content of cross-linked PVP onto the resulting tablet characteristics
Presenter: Thorsten Cech Authors: T Agnese, F Bang, T Cech.
BASF SE, Germany

343 Investigation of dimethyl palmitoyl ammonio propanesulfonate as an intestinal permeation enhancer in isolated rat intestinal mucosae
Presenter: Fiona McCartney Authors: F McCartney, J Heade, D J Brayden.
University College Dublin, Ireland

344 Investigation of the cytotoxicity of a sucrose laurate, a novel intestinal permeation enhancer
Presenter: Fiona McCartney Authors: F McCartney, M Rosa, D J Brayden.
University College Dublin, Ireland

345 Lipid co-administration that promotes incorporation into intestinal lipoproteins is critical for efficient lymphatic transport of a bio-mimetic triglyceride prodrug
Presenter: Sifei Han Authors: S Han, L Hu, T Quach, J S Simpson, N L Trevaskis, C J Porter.
Monash University, Australia

346 Lipophilic prodrugs design and in vitro characterization: towards oral chemotherapy
Presenter: Vaskor Bala Authors: V Bala, S Rao, S Wang, B J Boyd, C A Prestidge.
University of South Australia, Australia

347 Liposomal encapsulation of anti-diabetic drugs
Presenter: Sameer Joshi Authors: S V Joshi, D Kirby, Y Perrie.
Aston University, United Kingdom

348 Mass balance: an old concept for the new challenges proposed by personalized medicine
Presenter: Mario Grassi Authors: M Grassi, M Abrami, R Abbiati, B Posocco, A Barba, G Lamberti, D Manca, D Voinovich, G Grassi.
Trieste University, Italy

349 Matrices containing Hydrophilic Excipients: Swelling and Dissolution Studies
Presenter: Kyu-Mok Hwang Authors: K Hwang, J Seo, S Kim, S Seok, E Yi, S Lee, J Kim, E Park.
Sungkyunkwan University, Korea

350 Melt extruded Sirolimus: Effect of TPGS on sirolimus dissolution and stability
Presenter: Parijat Kanaujia Authors: P Kanaujia, P Poovizhi, W K Ng, R B Tan.
Institute of Chemical and Engineering Sciences, Singapore

351 Micellar solubilization of fenofibrate by saponins and classical surfactants
Presenter: Zahari Vinarov Authors: Z Vinarov, D Radeva, S Tcholakova, N D Denkov.
Sofia University, Dept. Chemical and Pharmaceutical Engineering, Bulgaria

353 Modification of Eudragit® L 30 D-55 coated tablets to reduce the effect of residence time in acid on drug release
Presenter: Ann-Kathrin Menge Authors: A Menge, H Steckel.
Kiel University, Germany

354 Mucoadhesive polymers and the application in the food industry: In vivo and in vitro assessments
Presenter: Sarah Smith Authors: V V Khutoryanskiy, L Methven, J K Parker, S L Smith.
University of Reading, United Kingdom

355 Nanocarrier system for oral anticancer drug delivery using Styrene Maleic acid micelles.
Presenter: Neha Parayath Authors: N N Parayath, H Nehoff, S Taurin, K Greish.
University of Otago, New Zealand

356 Nanoscale Phase Separations of immiscible Polymer Blends in Electrospun Nanofibres and their Potential Applications in Controlled Drug Delivery
Presenter: Pratchaya Tipduangta Authors: P Tipduangta.
school of pharmacy university of East Anglia, United Kingdom

357 New Insights into the Stability of SR Lipid Matrix Tablets
Presenter: Yvonne Rosiaux Authors: Y Rosiaux, V Jannin, J Doucet, J Girard, F Desvignes, D Marchaud.
Gattefossé SAS, France

358 New Insights into the Steric and Interactive Barrier of Intestinal Mucus: Impact on Particle Diffusion and Peptide Permeation
Presenter: María García-Díaz Authors: M Boegh, M García-Díaz, A Müllertz, H M Nielsen.
University of Copenhagen, Denmark

361 Optimization of Type I and II Lipid Based Drug Delivery System to limit inter-variability linked to the food effect, an in-vitro study
Presenter: Vincent Plassat Authors: V Plassat, B Hilbold.
Catalent Pharma Solutions, France

362 Oral Absorption of Nanoparticles: Low Copy Number of a T7 Phage Display-derived Peptide Significantly Increases Translocation Across Caco-2 Cell Monolayers
Presenter: Daniel Myers Authors: D R Myers, X Zhang, S R Johnson, R K Prud'homme, Z Szekely, P J Sinko.
E.M. School of Pharmacy, Rutgers University, U.S.A.

363 Performance evaluation of Acryl-EZE® II enteric coated lansoprazole multiparticulates and esomeprazole tablets in low and intermediate pH media
Presenter: Ali Rajabi-Siahboomi Authors: J Teckoe, G Reyes, P Sandoval, A R Rajabi-Siahboomi.
Colorcon Inc., U.S.A.

365 Phase separation in the gel layer of mixed HPMC/PEO hydrophilic matrices
Presenter: Anran Hu Authors: A Hu.
School of Pharmacy, University of Nottingham, United Kingdom

367 Preliminary evaluation of hot melt extrusion for improving the oral bioavailability of substrates of P-glycoprotein (P-gp) efflux pump
Presenter: Alice Melocchi Authors: A Foppoli, M D Del Curto, L Palugan, A Melocchi, U Musazzi, F Selmin.
Università degli Studi di Milano, Italy

368 Preparation and Evaluation of Fast Dissolving Oral Films Containing Lercanidipine HCl Nanoparticles
Presenter: Nayanabhirama Udupa Authors: N Udupa, A Chonkar, P Jain, J V Rao.
Manipal University, India

369 Preparation and physiochemical characterisation of carvedilol-polyethylene glycol solid dispersions: potential for enhanced oral delivery
Presenter: Steven Fallows Authors: S J Fallows, R F Donnelly.
Queen's University Belfast, United Kingdom

370 Production of cocrystals in an amorphous matrix via spray drying
Presenter: David Walsh Authors: D G Walsh, D R Serrano, K Smyth, B A Norris, A Healy.
Trinity College Dublin, Ireland

372 ROLE OF SALTS IN THE MODULATION OF DRUG RELEASE FROM CARBOPOL MATRICES
Presenter: Abdul Fazli Authors: A A Fazli, N A Khan, M K Bavraisatti, R S Barat.
Univeristy of Kashmir, India

373 SANS Analysis of Micellar Structures in the GI Tract during Food Digestion
Presenter: Oljora Rezhdo Authors: O Rezhdo, S Di Maio, P Le, K Littrell, S Chen, R Carrier.
Northeastern University, U.S.A.

374 Self-assembled Nanobubbles as a Carrier for Oral Protein Drug Delivery
Presenter: Lin Po-Yen Authors: L Po-Yen, C Er-Yuan, S Hsing-Wen.
Department of Chemical Engineering, National Tsing Hua University, Taiwan

376 Studies on design, development, and stability of enteric coated HPMC capsules
Presenter: Balaji Kadri Authors: B V Kadri, S P Tatawati, A Puttaswamy, L S Channagiri.
GVK Bio, India

377 Supersaturation of Zafirlukast in simulated intestinal media, and the effect of precipitation inhibitors: Is it possible to predict a negative food effect in vitro?
Presenter: Cecilie Madsen Authors: C M Madsen, J Khan, B Boyd, T Rades, A Mullertz.
University of Copenhagen, Denmark

378 Supersaturation, phase separation and the measurement of drug precipitation rates
Presenter: Karl Box Authors: K J Box, J Comer, R Taylor.
Sirius Analytical, United Kingdom

379 Synthesis of hyaluronic acid-based nanoparticles for oral insulin delivery
Presenter: Peadar Rooney Authors: A Srivastava, P Rooney, J Gleeson, F McCartney, A Pandit, D Brayden.
School of Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland

380 The Effect of Viscosity on the Swelling, Matrix Erosion, Dissolution and Compaction properties of Hypromellose Matrices
Presenter: Muhammad Ghori Authors: M U Ghori, B R Conway.
University of Huddersfield, United Kingdom

381 The Role of Polyethylene Glycols on the Modulation of the Anionic ABCC2 Transporter
Presenter: John Pollard Authors: J Pollard, A Siahboomi, R Badhan, A Mohammed, Y Perrie.
Aston University, United Kingdom

382 The Serosal Layer’s Potential Impact On Rat Intestinal Tissue Viability And Permeability
Presenter: Carl Roos Authors: C Roos, E Sjögren.
Department of Pharmacy, Uppsala University, Sweden

385 Transport of apomorphine and its esters across Caco-2 cell monolayer
Presenter: Nrupa Borkar Authors: N Borkar, L Saaby, A Müllertz, M Yang, R Holm, H Mu.
Department of Pharmacy, University of Copenhagen, Denmark

389 Use of NMR and MRI to probe the in vitro dissolution of amorphous solid dispersions made with coPVP and Felodipine or Bicalutamide
Presenter: Stephen Wren Authors: S Wren, L Hughes, S Coombs, A Phillips, F Tres, J Burley, J Aylott.
AstraZeneca, United Kingdom

390 Utilisation of RapidFACT strategies to evaluate and develop an In Vitro In/Vivo Correlation (IVIVC) for Modified Release Formulations of Lorcaserin HCl
Presenter: Zoe Kane Authors: Z Kane, J Shao, R Christopher, W Shanahan, L Stevens, A Wilby, S Mair.
Quotient Clinical, United Kingdom
collapse Oral Drug Delivery

29 Invited Speaker - Gaisford
.

30 Oral Fixed Dose Combination Products
Presenter: Divyakant Desai Authors: D Desai.
Bristol-Myers Squibb Inc, U.S.A.

267 A Case Study - Formulation Development for Carcinogenicity Study
Presenter: Zahid Nazir Authors: Z Nazir, K Hill, S Horner.
AstraZeneca, United Kingdom

328 Gastroretentive Dosage Form for Once Daily (QD) Dosing of a Compound with a Narrow Absorption Window
Presenter: Pranav Gupta Authors: P Gupta, S Patel, W Lin, L C-Lens, M Rizk, J McDermott, A Connor, R Krishna, R L Smith.
Merck and Co.,, U.S.A.

366 Polymeric microcontainers improve oral bioavailability of a poorly soluble drug
Presenter: Line Hagner Nielsen Authors: L Hagner Nielsen, A Melero, S Sylvest Keller, T Rades, A Müllertz, A Boisen.
Department of Micro- and Nanotechnology, Technical University of Denmark, Denmark
collapse Parenteral Controlled Release

394 Controlled Release Kinetics of Vitamin Loaded Poly(glycerol sebacate)
Presenter: Jeremy Harris Authors: J J Harris, C M Smoot.
Secant Medical, Inc, U.S.A.

395 Delivery of Dexamethasone, VEGF, and PDGF to Prevent the Foreign Body Reaction and Promote Angiogenesis in Subcutaneous Implants
Presenter: Claire Price. Authors: M. Kastellorizios, F. Papadimitrakopoulos and D. J. Burgess.
Department of Pharmaceutical Sciences, 69 N Eagleville Rd, University of Connecticut, Storrs, CT, 06269, USA

397 Development of an Extended-Release Leuprolide Formulation using the FormEZETM Technology
Presenter: Weibin Deng Authors: W Deng, B Perkins, B Hudson, C Davis, K Burton.
Evonik Corporation, U.S.A.

398 Development of Asiatic Acid Loaded Solid Lipid Nanoparticles for Anti-Cancer Therapy
Presenter: Tanem Garanti Authors: T Garanti, M A Alhnan, K Wan.
University of Central Lancashire, United Kingdom

400 Development of electrospun sodium alginate/ethyl cellulose nanofiber scaffolds for urethral reconstruction
Presenter: Bice Conti Authors: R Dorati, I Genta, T Modena, B Conti.
Dept. Drug Science, University of Pavia, Italy

401 Direct injectable, solvent-free biodegradable polymers for parenteral controlled release
Presenter: Alexandre Rodrigues Authors: A G Rodrigues, K Mäder, V M Weiss, H Metz, J Kressler, T Naulou, M H Bilal.
Institute of Pharmacy, Martin Luther University, Germany

403 Effect of Dobutamine on Pancreatic Cancer in 3D Tumour Spheroid Model
Presenter: Bailu Xie Authors: B Xie, E Harvey, R Mrsny.
Univ of Bath, United Kingdom

404 Glucosamine as a carrier for renal drug targeting
Presenter: Yanping Li Authors: Y Li, Y Lin, Z Zhang.
West China School of Pharmacy, Sichuan University, China

405 Improved Cisplatin Efficacy on HCT-116 Colorectal Cancer Cells and Decreased Toxicity in Rats from Tunable Biodegradable Nano-Composite Hydrogel
Presenter: hend Abdel-Bar Authors: h M Abdel-Bar, A Y Abdel-Reheem, R Osman, G A Awad, n mortada.
national organization for drug control and research, Egypt

406 In Vitro-In Vivo Correlation of Risperidone Microspheres
Presenter: Diane Burgess. Authors: Jie Shen, Namita Tipnis, Stephanie Choi, Wen Qu, and Yan Wang.
University of Connecticut, School of Pharmacy, Storrs, CT 06269

407 In Vivo Release of Celecoxib-loaded Acetyl-capped PCLA-PEG-PCLA Thermogels in Rats
Presenter: Maarten Van Dijk Authors: P M Van Midwoud, M Sandker, M Van Dijk, L G De Leede, C H Van de Lest, H Weinans.
InGell Labs BV, Groningen, Netherlands

410 N, N-dimethyl amino group based brain-targeting derivative of dopamine for the treatment of Parkinson’s disease
Presenter: Zhirong Zhang Authors: Y Li, T Gong, X Sun, Z Zhang.
West China School of Pharmacy, Sichuan University, China

412 Oleogels as a New Alternative for Direct Injectable and Parenteral Controlled Release
Presenter: Karsten Maeder Authors: K Maeder, J Kutza, M Windorf.
Martin-Luther-university Halle-Wittenberg, Germany

413 PEG-cholane can successfully enhance the solubility of poorly soluble drugs. A novel formulation for amphotericin B delivery
Presenter: Stefano Salmaso Authors: C Luengo Alonso, M P Ballesteros Papantonakis, S Salmaso, J J Torrado, P Caliceti.
Università degli Studi di Padova, Italy

414 Polymer degradation induced nifedipine precipitation in PLGA implants
Presenter: Christin Nitzschke Authors: C Nitzschke, M Barth, K Mäder.
Institute of Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, Martin-Luther-University Halle-Wittenberg, Germany

415 Polymer Implants for Drug Delivery: The Relation between Structure and Release Kinetics
Presenter: Emilie DUFFAU Authors: E DUFFAU.
Ceva Santé animale / CBMN, France

416 Polyoxazoline coated poly(L-lysine) dendrimers as novel carriers intended for drug delivery
Presenter: Richard England Authors: R M England.
AstraZeneca plc, United Kingdom

420 Targeting ligand conjugated pH-sensitive Polymeric Drug based on Chitosan derivatives for Cancer Therapy
Presenter: Jae-Woon Nah Authors: J Nah, T Kim.
Department of Polymer Science and Engineering, Sunchon National University, South Korea

421 Thermosensitive Hydrogels for Bone Regeneration and Local Drug Delivery
Presenter: Marta Roldo Authors: S Yasmeen, M Kit Lo, S Bajracharya, M Roldo.
University of Portsmouth, United Kingdom
collapse Parenteral Delivery Technologies

38 Controlled Release of an Old Chemotherapeutic Using a Low-Temperature Thermal Sensitive Liposome: A New Paradigm for Drug Release in the Blood Stream of Warmed Tumors
Presenter: David Needham Authors: D Needham.
Duke University and University Southern Denmark, U.S.A.

39 Titania Nanoporous Membranes: Enabling Extended, Constant Delivery from a Rice-Grain-Sized Device
Presenter: Adam Mendelsohn Authors: A D Mendelsohn, K E Fischer.
Nano Precision Medical, Inc., U.S.A.

391 A Novel Fluorescent Assay to Determine the Influence of Oil Type and Surface Composition on Lipid Emulsion Lipoprotein Lipase Mediated Metabolism
Presenter: Paul Dougall Authors: P W Dougall.
University of Nottingahm, United Kingdom

392 An injectable liquid crystal system for sustained delivery of entecavir
Presenter: Min Kyung Joo Authors: J Lim, M Ki, M Joo, S An, E Park.
CKD Research Institute, South Korea

411 Novel Methods for the Evaluation of Drug Release from Drug Eluting Beads
Presenter: Tanya Swaine Authors: T S Swaine, P Garcia, Y Tang.
University of Huddersfield, Biocompatibles UK Ltd, United Kingdom

418 Questioning the rate-limiting drug release and absorption mechanisms from an intramuscular sustained-release nano-/microsuspension: the effect of local macrophage depletion
Presenter: Nicolas Darville Authors: N Darville, M van Heerden, D Mariën, M De Meulder, S Rossenu, A Vermeulen, P Sterkens, S De Jonghe, P Annaert, g Van den Mooter.
Drug Delivery and Disposition - KU Leuven, Belgium
collapse Plenary Sessions

Customized Drug Delivery: A Personal Odyssey
Vincent H. L. Lee.
Chinese University of Hong Kong

Intelligent Polymer Hydrogels: From Obscure Molecular Structures to Useful Multifunctional Systems for Drug and Protein Delivery, Targeting and Molecular Sensing
Nicholas A. Peppas.
The University of Texas at Austin

Global Efforts and Successes in Needle-Free Peptide Delivery
Maria Jose Alonso.
University of Santiago de Compostela
collapse Regional Delivery

423 A Novel Transparent Cyclosporine Eye Drop
Presenter: Ho Seong Jeon Authors: H Jeon, S Hong, D Ko, M Lim, H Kang, S Hwang, K Um.
Huons Co., Ltd, South Korea

424 A Novel ex vivo Assay to Evaluate the Role of Müller Cells in Retinal Drug Delivery
Presenter: Karen Peynshaert Authors: K Peynshaert, T Martens, S De Smedt, K Braeckmans, K Remaut.
Ghent University, Belgium

426 Absorption Kinetics of Dendrimers across the Pulmonary Epithelium: Comparing Degree of PEGylation
Presenter: Joshua Reineke Authors: A Mohammad, B Bharatwaj, S da Rocha, J Reineke.
Wayne State University, U.S.A.

430 Anti-Angiogenic Strategies for Chemoembolization of Liver Tumors
Presenter: Katrin Fuchs Authors: K Fuchs, P E Bize, R Duran, A Denys, O Dormond, G Borchard, O Jordan.
University of Geneva, Switzerland

432 Application of PBBP Modeling to Liver Targeted Drug Delivery Systems
Presenter: Ilse Dubbelboer Authors: I R Dubbelboer, E Lilienberg, E Sjögren, H Lennernäs.
Uppsala University, Sweden

435 Controlled Release of levofloxacin from Vitamin E loaded Silicone Hydrogel Contact Lenses
Presenter: Patrizia Paradiso Authors: P Paradiso, A Serro, B Saramago, R Colaço, A Chauhan.
Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, 1049-001, Portugal, Portugal

436 Controlled Release of Tetracycline From Electrospun Micro/Nanofibrous Zein/PCL Blended Mats:  In Vitro and Ex Vivo Testing
Presenter: Ian S. Blagbrough. Authors: Nour Alhusein, Albert Bolhuis, and Paul De Bank.
University of Bath, Bath BA2 7AY, UK

437 Corneal ulcer amelioration in response to in situ gelling naltrexone hydrochloride (NTX) films: pharmaceutical formulation and clinical evaluation
Presenter: R Alany Authors: R Alany, B Pierscionek, H Mohharam, R Abdelkader.
Kingston University London, United Kingdom

438 Cytotoxicity, Pro-Inflammatory Potential and Drug Permeability Profile of Dapivirine-Loaded Poly(Lactic-co-Glycolic Acid) Nanoparticles
Presenter: José das Neves Authors: J das Neves, B Sarmento.
INEB - Instituto de Engenharia Biomédica, Portugal

440 Design of multifunctional liposomes having target specificity, temperature-sensitivity and imaging for efficient and personalized chemotherapy
Presenter: Kenji Kono Authors: K Kono.
Osaka Prefecture University, Japan

441 Development and Assessment of Thermosetting Ketoconazole (KZ) Vaginal Gel Formulations
Presenter: Roderick Walker Authors: A Ramanah, R B Walker.
Rhodes University, South Africa

442 Development and Characterization of Dexamethasone-Loaded Crosslinked Hyaluronic Acid Films for Ocular Therapy
Presenter: Javier Calles Authors: J A Calles, A López-García, S D Palma, E M Vallés, Y Diebold.
Institute of Applied Ophthalmo-Biology – University of Valladolid, Spain

443 Development and evaluation of brain targeting RVG peptide-modified protein nanocarrier
Presenter: Nobuhito Hamano Authors: N Hamano, M Murata, T Kawano, S Narahara, J Piao, K Ohuchida, M Hashizume.
Department of Advanced Medial Initiatives, Faculty of Medical Sciences, Kyushu University, Japan

445 Development of a mucoadhesive system for release of dexamethasone in oral cavity
Presenter: Ayla Vea-Barragan Authors: A C Vea-Barragan, D A Castro-Vidal, A Serrano-Medina, J M Cornejo-Bravo.
Autonomous University of Baja California, Mexico

446 Development of Mucoadhesive Gels Containing Moxifloxacin for the Treatment of Periodontal Diseases
Presenter: Sevda Şenel Authors: N Zazali, N Azeran, S Doğan, R Sheshala, K Dua, A Özdoğan, S Şenel.
Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 06100, Ankara, Turkey

447 Drug Eluting Beads vs. Lipiodol-based Emulsion regarding Local Drug Release and Effect in Patients with Hepatocellular Carcinoma
Presenter: Elsa Lilienberg Authors: E Lilienberg, I R Dubbelboer, A Karalli, P Stål, C Ebeling Barbier, A Norén, F Duraj, R Nyman, E Sjögren, H Lennernäs.
Department of Pharmacy, Uppsala University, Uppsala, Sweden

448 Effective Fabrication of Tumor-bearing Animal Models by Cancer Cell Sheet Transplantation
Presenter: Masamichi Nakayama Authors: M Nakayama, J Akimoto, M Yamato, T Okano.
Tokyo Women's Medical University, Japan

450 Enhanced pulsatile on-demand drug release from injectable, magnetic 'plum pudding' hydrogels with embedded microgels.
Presenter: Scott Campbell Authors: S B Campbell, D Maitland, T Hoare.
McMaster University, Canada

451 Estrone-1-sulfate (E1S) has impact on the kinetic parameters of transporter mediated taurine glutamate influx to Caco-2 cells
Presenter: Bente Steffansen Authors: B Steffansen, F El-Sayed.
University of Copenhagen, Denmark

453 Development of hydrogels for drug and cell delivery to the distal airways
Presenter: Christina Payne Authors: C M Payne, C L Hastings, H M Kelly, S Cryan.
Royal College of Surgeons in Ireland, Ireland

454 Extended Release of Inhaled Treprostinil-Prodrug Formulation for Prolonged Pharmacokinetics
Presenter: Kuan-Ju Chen Authors: K Chen, F Leifer, D M Konicek, A J Plaunt, Z Li, R W Chapman, W R Perkins, V Malinin.
Insmed Incorporated, U.S.A.

455 Fabrication of characteristically enhanced moldable electrospun scaffolds
Presenter: Wuyong Choi Authors: W Choi, S Lee, G Jin, S Kim, J Jang.
Department of Chemical and Biomolecular Engineering, Yonsei University, Korea

456 Gelatin-based Nanogels in Intravesical Gene Delivery
Presenter: Li-Ching Chang Authors: C Liu, T Tsai, C Tsai, P Chiang, L Chang.
Department of Occupational Therapy, I-Shou University, Taiwan

457 Gellan gum fluid gels as a mucoadhesive nasal delivery system
Presenter: Mohammed Mahdi Authors: M H Mahdi, A M Smith, B R Conway.
university of Huddersfield, United Kingdom

458 Highly ironic acid: divergent properties of high and low molecular weight hyaluronic acid on macrophage polarization and angiogenic function
Presenter: Jamie Rayahin Authors: J E Rayahin, R A Gemeinhart.
University of Illinois at Chicago, U.S.A.

460 Implications of Polymer Properties on the Manufacture of Soft Contact Lens as a Tool for Ocular Drug Delivery
Presenter: shelan mustafa Authors: s mustafa, A ElShaer, B Ghatora, R Alany.
kingston university school of pharmacy and chemistry , United Kingdom

463 In vitro drug release from intra-ocular lenses using a microfluidic device
Presenter: Andreia Pimenta Authors: A Pimenta, D Bozukova, J Mata, R Colaço, B Saramago, A Serro.
Instituto Superior Técnico, Universidade de Lisboa, Portugal

464 In vivo predictive ability of two selected in vitro methods applied on DC Beads
Presenter: Emelie Ahnfelt Authors: E Ahnfelt, E Sjögren, N Axén, H Lennernäs.
Uppsala University, Sweden

466 Inhalable particles containing Nitazoxanide alone and in combination with Isoniazid and Rifabutin for the treatment
Presenter: Anuradha Gupta Authors: A Gupta, D Sharma, P Gupta, U D Gupta, A Misra.
CSIR-Central Drug Research Institute, India

467 In-Situ Forming Implant for Local Delivery of Superparamagnetic Iron Oxide Nanoparticles for Application of Induced Hyperthermia
Presenter: Stella Ehrenberger Authors: S S Ehrenberger, D Bonvin, M Mionic, H Hofmann, G Borchard, O Jordan.
University of Geneva, Switzerland

470 Locally-Controlled Release of Chemotherapeutic Drugs via Palladium-Functionalized Implants
Presenter: Belen Rubio-Ruiz Authors: J T Weiss, B Rubio-Ruiz, N O Carragher, A Unciti-Broceta.
Edinburgh Cancer Research UK Centre, University of Edinburgh, United Kingdom

471 Mechanical Characterization of ECM Hydrogels for CNS Regeneration with Rheometer and Texture Analyzer
Presenter: irina kadiyala Authors: i kadiyala.
Vertex Pharmaceuticals, U.S.A.

472 Microparticle-based Delivery of Clindamycin for Prevention of Mandibular Infection
Presenter: Sarita Shah Authors: S R Shah, A M Tatara, J Lam, S Lu, G N Bennett, J van den Beucken, J A Jansen, M E Wong, A G Mikos.
Rice University, U.S.A.

473 Minimizing the Non-specific Binding of Nanoparticles in the Brain Enables Active Targeting of Fn14-positive Brain Tumors
Presenter: Anthony Kim Authors: C S Schneider, J G Perez, E Cheng, C Zhang, P Mastorakos, J Hanes, J A Winkles, G F Woodworth, A J Kim.
University of Maryland, U.S.A.

474 Modifying Drug Release Kinetics of Enteric Coated Tablets Targeted to the Duodenum by CO2 Laser Irradiation
Presenter: Varin Titapiwatanakun Authors: V Titapiwatanakun, A Basit, S Gaisford.
UCL school of pharmacy, United Kingdom

476 Nanomedicine for prevention of corneal allograft rejection
Presenter: Qingguo Xu Authors: Q Xu, Q Pan, N J Boylan, N W Lamb, D G Emmert, J Yang, C G Eberhart, W J Stark, J Hanes.
Center for Nanomedicine and Department of Ophthalmology, The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, U.S.A.

477 Omentum ECM-based hydrogel as a platform for cardiac cell delivery
Presenter: Michal Shevach Authors: M Shevach, R Zax, A Abrahamov, S Fleischer, A Shapira, T Dvir.
Tel Aviv University, Israel

479 PEG-Polyacetal-Curcumin Conjugate in the Rescue of Acute Rat Spinal Cord Injury
Presenter: Maria Vicent Authors: M Cases-Vilar, R M England, A Alastrue-Agudo, M J Vicent , V Moreno-Manzano.
Polymer Therapeutics Lab. CIPF, Spain

480 Penetration enhancers in transcorneal delivery of riboflavin
Presenter: Vitaliy Khutoryanskiy Authors: P W Morrison, V V Khutoryanskiy.
Reding School of Pharmacy, University of Reading, United Kingdom

481 Perivascular administration of atorvastatin needs to be sustained in order to decrease neointimal hyperplasia in mice carotid artery ligature model.
Presenter: Ioanna Mylonaki Authors: I Mylonaki, F Delie, O Jordan, É Allémann.
University of Geneva, Switzerland

482 PLGA nanoparticles incorporated into a light-responsive gel as novel ocular injectable implant
Presenter: Rohit Bisht Authors: R Bisht, Y Chen, J Jin, I D Rupenthal.
PhD student, New Zealand

483 Porous Conducting Polymer Prepared Through Liquid Crystal for Stimuli Responsive Drug Delivery
Presenter: Dedeepya Uppalapati Authors: D Uppalapati, B J Boyd, J T Sejdic, D Svirskis.
School of Pharmacy, University of Auckland, Auckland, 1023, New Zealand, New Zealand

484 Porous PEDOT Honeycomb Structures for Stimuli Responsive Ocular Drug Delivery
Presenter: Muhammad Naveed Yasin Authors: M Yasin, R K Brooke, A Seyfoddin, G I Waterhouse, D Evans, D Svirskis, I D Rupenthal.
Dept. of Ophthalmology, University of Auckland, New Zealand

485 Preformulation Studies of Silicone Elastomer Type Combination Vaginal Ring of Dapivirine and Levonorgestrel
Presenter: Sandeep Kumar Authors: S Kumar, K Malcolm.
Queen's University BElfast, United Kingdom

488 Scaffolds optimized for the regional release of TGF-β3 and BMP7 induce cartilage formation
Presenter: Marcos Garcia-Fuentes Authors: J Crecente-Campo, E Borrajo, A Vidal, M de la Fuente, M Garcia-Fuentes.
Universidad de Santiago de Compostela, Spain

490 Self-assembling benzothiazole prodrugs for targeted cancer therapy
Presenter: Francesca Citossi Authors: F Citossi, T D Bradshaw, B Kellam, M Marlow.
University of Nottingham, United Kingdom

491 Site-specific simultaneous delivery of metronidazole and clarithromycin in treatment of H. pylori infections
Presenter: Adeola Adebisi Authors: A Adebisi, B Conway.
University of Huddersfield, United Kingdom

492 Spray dried vesicular delivery system targeting pulmonary tuberculosis
Presenter: Amira Hamed Authors: A Hamed, R Osman, S Mansour, A Geneidi.
Faculty of Pharmacy, Ain Shams University, Egypt

493 Stability of Docetaxel in polyurethane matrix and implications on release behavior- A SAXS account
Presenter: Mohsin Shaikh Authors: M Shaikh, N R Choudhury, R Knott, S Garg.
CPID, School of Pharmacy and Medical Sciences, University of South Australia, Australia

494 Sustained Delivery of Local Anesthetic to Address Post-surgical Complications
Presenter: Manisha Sharma Authors: M Sharma, T Yu, G Proctor, D S Jones, G Andrews, J Harrison, A G Hill, D Svirskis.
School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand

495 Sustained Intra-Articular Release of Celecoxib from In Situ Forming Gels Made of Acetyl-capped PCLA-PEG-PCLA Triblock Copolymers in Horses
Presenter: Mike De Leeuw Authors: E M Redout, A Petit, C H van de Lest, M De Leeuw, R Meyboom, P M van Midwoud, T Vermonden, W E Hennink, R van Weeren.
InGell Labs BV, Groningen, Netherlands

496 Synthesis and Evaluation of Hyaluronic Acid Hydrogel as a Biodegradable Polymer
Presenter: Haruka Obata Authors: H Obata, Y Yamazaki, T Matsunaga, T Sato.
SEED CO., LTD., Japan

497 Systematic investigation of the role of extracellular calcium in enhancing stratification of buccal cell cultures to enhance in vitro assessment of transmucosal drug delivery
Presenter: Affiong Iyire Authors: A R Iyire, C Bailey, A U Mohammed.
Aston University, Birmingham, United Kingdom

498 Targeted pulmonary montelukast sodium loaded lecithin based soft agglomerates for treatment of asthma
Presenter: Rihab Osman Authors: R Abdel Gawad, R Osman, G Awad, N Mortada.
faculty of Pharmay, Ain Shams University, Egypt

501 The improvement of Solid Lipid Microparticle breathability for an anti-TB inhalation therapy
Presenter: Valentina Iannuccelli Authors: V Iannuccelli, E Maretti, E Porcheddu, E Leo, E Imbuluzqueta, F Buttini, A Balducci, F Sacchetti.
Department of Life Sciences - University of Modena and Reggio Emilia, Italy

503 Trojan starch-based nanoparticles for the deep lung delivery of IgG1
Presenter: Sarah Barthold Authors: S Barthold, E Lepeltier, B Loretz, C Lehr.
Helmholtz-Institute for Pharmaceutical Research Saarland, Germany

504 Tying up the giant: the influence of cross-linked networks of hyaluronic acid on macrophage function
Presenter: Richard Gemeinhart Authors: R A Gemeinhart, J E Rayahin.
University of Illinois at Chicago, U.S.A.
collapse Respiratory Delivery

18 Technological and pharmacological rationale for regional drug delivery
Presenter: Sevda Senel Authors: S Senel.
Hacettepe Univ, Turkey

19 Extended Release in the Lungs: Challenges and Opportunities
Presenter: Ralph Niven Authors: R Niven.
Novartis, U.S.A.

465 Inhalable nano-embedded microparticles for sustained delivery of cationic antimicrobial peptides: overcoming lung barriers
Presenter: Ivana d'Angelo Authors: I d'Angelo, B Casciaro, M Mangoni, A Miro, F Quaglia, F Ungaro.
DISTABIF, Second University of Naples, Italy

469 Layered Nanoemulsion-based Mucoadhesive Buccal Systems for Controlled Delivery of Oral Cancer Therapeutics
Presenter: Tamer Elbayoumi Authors: A Gavin, N Kim, D Wang, B Brownlow, T A Elbayoumi.
Midwestern University-Glendale, AZ, U.S.A.

500 The Development of All-Trans Retinoic Acid-Loaded Collagen-Hyaluronic Acid Films for Respiratory Tissue Regeneration
Presenter: Cian O'Leary Authors: C O'Leary, F J O'Brien, S Cryan.
Royal College of Surgeons in Ireland, Ireland

535 A comparison of the pharmacokinetics of an inhaled PEGylated dendrimer between rats and sheep and the role of the pulmonary lymphatic system in absorption from sheep lungs.
Presenter: Lisa Kaminskas Authors: L M Kaminskas, G M Ryan, C J Porter, D J Owen.
Monash Institute of Pharmaceutical Sciences, Australia

820 Transport Properties of Liposomes for Pulmonary Drug Delivery depend on the Surface Characteristics of the Liposomes and the Atomization Technique used for Nebulization
Presenter: Ruth Prassl Authors: B Lehofer, P P Jain, F Bloder, R Leber, G Leitinger, L M Marsh, H Olschewski, A Olschewski, R Prassl.
Institute of Biophysics, Medical University of Graz, Austria
collapse RNA and DNA Delivery

843 A Lipid Nanoparticle siRNA Delivery System for Non-Hodgkin Lymphoma
Presenter: Kathryn Whitehead Authors: C M Knapp, K A Whitehead.
Carnegie Mellon University, U.S.A.

844 Albumin-mediated protection, reduced immunogenicity and extended circulatory half-life of cholesterol modified small interfering RNA
Presenter: Konrad Bienk Authors: K Bienk, F Dagnæs-Hansen, J Wengel, U Kragh-Hansen, K A Howard.
The Interdisciplinary Nanoscience Center (iNANO), Aarhus University, 8000 Aarhus C, Denmark, Denmark

848 Attachment of Hydrophobic Tails to Polyamino Alcohols Enhances DNA and siRNA Delivery
Presenter: Yihang Wu Authors: Y Wu, L Li, P Levkin, G Davidson.
Karlsruhe Institute of Technology, Germany

849 Autophagy-related Gene Expression Analysis Of Mouse Embryonic Fibroblast Cells Treated With Polyethylenimine
Presenter: Jung-hua Kuo Authors: J Kuo, M Jan, C Lin.
Chia Nan University of Pharmacy and Science, Taiwan

850 Branched modified R9 cell-penetrating peptide for efficient gene delivery into mammalian cells
Presenter: Jisang Yoo Authors: J Yoo, D Lee, S Arumuganainar, C Jeong, Y Kim.
KAIST, Korea

851 Carrier exchange between the core and shell of PLL- and PEI-DNA nanoparticles
Presenter: Elina Vuorimaa-Laukkanen Authors: E Vuorimaa-Laukkanen, E S Lisitsyna, T Ketola, F M Winnik, M Yliperttula, A Urtti.
Tampere University of Technology, Finland

852 Catechol-conjugated Polymeric Films for the Adeno-associated Virus-mediated Transfection
Presenter: Slgirim Lee Authors: S Lee, M Do, S Kim, H Lee, J Jang.
Yonsei University, South Korea

854 Cell-Penetrating Peptide Mediated Gene Delivery via Polymeric Microneedles; A Platform for DNA Vaccination
Presenter: Joanne McCaffrey Authors: J McCaffrey, C M McCrudden, S Spence, A Kissenpfennig, R F Donnelly, H O McCarthy.
School of Pharmacy, Queen's University Belfast, Northern Ireland

859 Co-delivery with other nucleic acids affects the efficiency of mRNA translation
Presenter: Joke Devoldere Authors: J Devoldere, O Andries, N N Sanders, S C De Smedt, K Remaut.
Laboratory of General Biochemistry and Physical Pharmacy, Belgium

860 Colloidal stability of polymeric nanocapsules in an ex-vivo model of vitreous humor
Presenter: Sonia Reimóndez-Troitiño Authors: S Reimóndez-Troitiño, G R Dakwar, K Peynshaert, T F Martens, K Braeckmans, K Remaut, M De la Fuente, N Csaba, M J Alonso, S De Smedt.
Center for Research in Molecular and Chronic Diseases (CIMUS), Santiago de Compostela, 15706 (A Coruña), Spain, Spain

861 Combinatorial Library of Ternary Polyplexes Enables Identification of Improved siRNA Nanocarriers for Rapid In Vivo Translation
Presenter: Thomas Werfel Authors: T Werfel, M Miteva, T Kavanaugh, K Kirkbride, M Jackson, R Cook, C Duvall.
Vanderbilt University, U.S.A.

862 Comprehensive study of DC-Chol/DOPE liposome for the delivery of siRNA in lung cancer
Presenter: Abdullah Alshehri Authors: A Alshehri, S Stolnik, A Grabowska.
Drug Delivery and Tissue Engineering Division, School of Pharmacy, The University of Nottingham / King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia, United Kingdom

863 Construction of Structural Viral-Mimicry by Peptide/DNA Co-assembly
Presenter: Rong Ni Authors: R Ni, Y Chau.
The Hong Kong University of Science and Technology, Clearwater Bay, Hong Kong, China, Hong kong

865 Cyclodextrin-based co-formulations for targeted delivery of siRNA to prostate cancer
Presenter: Caitriona O' Driscoll Authors: K Fitzgerald, M Malhotra, J Guo, F Sallas, R Darcy, C M O' Driscoll.
University College Cork, Ireland

867 Design Of A Multifunctional Vector For Delivery Of miRNA-34a For Metastatic Prostate Cancer
Presenter: Stephen Loughran Authors: S P Loughran, H O McCarthy, R F Donnelly, C M McCrudden.
Queens University Belfast, United Kingdom

870 Development of Adipocyte-Targeted Oligopeptide Gene Delivery System
Presenter: Hyung Jin Kim Authors: H Kim.
Hanyang University, Korea

871 Development of Functional Viral-Mimicry by Optimization of Peptide/DNA Co-assembly
Presenter: Rong Ni Authors: R Ni.
The Hong Kong University of Science and Technology, Clearwater Bay, Hong Kong, China, Hong kong

872 Development of PGA Based Systems for pDNA Delivery
Presenter: Amaya Niño Authors: A Niño, A Armiñán, E Gallon, C Scholz, P Kos, E Wagner, M Vicent.
Centro de Investigación Príncipe Felipe, Spain

873 Development of Star Shaped Polypeptides As Non-Viral Gene Delivery Vectors to Produce Gene Activated Matrices for Bone Tissue Engineering
Presenter: David Walsh Authors: D P Walsh.
Tissue Engineering Research Group, RCSI, Dublin, Ireland, Ireland

874 Distribution of PEI-PEG-based polyplexes in tumor tissue and possible approach to improve gene delivery
Presenter: Mikhail Durymanov Authors: M O Durymanov, A A Yarutkin, A A Rosenkranz, A S Sobolev.
Institute of Gene Biology of the RAS, Russia

876 Efficient One-step Preparation of siRNA-encapsulated Non-cationic Liposomes
Presenter: Masaharu Somiya Authors: M Somiya, K Yamaguchi, S Kuroda.
Nagoya University, Japan

877 Efficient siRNA delivery system mediated with dendritic gold nanocrystals
Presenter: Min Sang Lee Authors: M Lee, J Jeong, J Park.
Sungkyunkwan University, Korea

878 Elucidation of the Mechanism of Increased Activity of Immunostimulatory DNA by Formation of Polypod-like Structure
Presenter: Kohta Mohri Authors: K Mohri, M Nishikawa, S Toyama, K Nagata, Y Takahashi, Y Takakura, S Sakuma.
Setsunan University, Japan

879 Exosomes underperform compared to liposomes for functional, in vitro siRNA delivery
Presenter: Stephan Stremersch Authors: S Stremersch, K Braeckmans, S C De Smedt, K Raemdonck.
Ghent university, Belgium

880 FORMULATION DEVELOPMENT AND EVALUATION OF ULTRADEFORMABLE CATIONIC LIPOSOMES FOR DELIVERY OF OLIGONUCLEOTIDES
Presenter: Gyati Asthana Authors: G S Asthana, A Asthana.
M. M. College of Pharmacy, M. M. University, Mullana-Ambala, India

882 Heme Oxygenase-1 Gene Delivery using a Polymeric Carrier for the Treatment of Ischemic Stroke
Presenter: Jungju Oh Authors: J Oh, M Choi, M Lee.
Hanyang University, Korea

883 Hyaluronic acid-incorporated calcium phosphate nanoparticles for specific tumor-targeted siRNA delivery
Presenter: Min Sang Lee Authors: M Lee, J Lee, N Kim, J Park, J Jeong.
Sungkyunkwan University, Korea

884 Intracellular redox potential-responsive micelles for enhanced miR-34a delivery
Presenter: li hanmei Authors: l hanmei, s xun.
West China School of Pharmacy, Sichuan University, China

885 Intraperitoneal liposomal-based siRNA delivery: A Systematic Evaluation in the Ascites Fluid
Presenter: George Dakwar Authors: G R Dakwar.
Ghent Research Group on Nanomedicines, Belgium

886 Life prolongation in rats with malignant glioma by intranasal siRNA/drug co-delivery to the brain with cell-penetrating peptide-modified polymer micelles
Presenter: Takanori Kanazawa Authors: T Kanazawa, H Ibaraki, Y Takashima, Y Seta.
Tokyo University of Pharmacy and Life Sciences, Japan

887 Lipidoid siRNA Nanoparticles for Intestinal Disease Therapeutics
Presenter: Rebecca Ball Authors: R L Ball, K Whitehead.
Carnegie Mellon University, U.S.A.

888 Lipoplexes Containing Bipolar Tetraether Lipids for Transfection of Cancer Cell Lines
Presenter: Konrad Engelhardt Authors: K Engelhardt, U Bakowsky.
Philipps-University Marburg, Germany

889 LNA/2’OMe Delivery to Helicobacter pylori within Gastric Mucus
Presenter: Rita Santos Authors: R S Santos, K Forier, E Zagato, G R Dakwar, K Remaut, S Stremersch, S Fontenete, J Wengel, C Figueiredo, S D Smedt, N F Azevedo, K Braeckmans.
University of Porto, Portugal

895 poly(2-dimethylaminoethyl methacrylate)-functionalized graphene oxide nanoflakes for efficient cellular delivery of siRNA
Presenter: Jung Eun Lee Authors: J Lee, M Lee, J Park, S Park, J Jeong.
Sungkyunkwan university, Korea

896 Polymeric and lipidic nanoparticles for targeted siRNA delivery
Presenter: Gershon Golomb Authors: M Naim, M M Nordling-David, A Dagan, G Golomb.
Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, 91120, Israel, Israel

897 Polymeric Nanoparticles For The Pulmonary Delivery Of miRNA To Treat Chronic Obstructive Pulmonary Disease (COPD)
Presenter: Adel Mohamed Authors: A A Mohamed, K Ross, I Y Saleem, G A Hutcheon.
Phd Student, United Kingdom

900 Regression of prostate tumors following intravenous administration of tumor-targeted dendriplexes
Presenter: Christine Dufes Authors: M Al Robaian, K Chiam, D R Blatchford, C Dufes.
University of Strathclyde, United Kingdom

901 Regulation of Osteogenic Genes using microRNA-Activated Scaffolds to Enhance Mesenchymal Stem Cell Osteogenesis
Presenter: Fergal O'Brien Authors: I Mencía Castaño, C M Curtin, G P Duffy, F J O'Brien.
Tissue Engineering Research Group, Dept. of Anatomy, Royal College of Surgeons in Ireland, Dublin 2, Dublin, Ireland, Ireland

902 RNAi and gene delivery mediated via novel Lipopolyplexes
Presenter: Shashank Pinnapireddy Authors: S R Pinnapireddy.
Philipps University, Marburg, Germany

904 Self-destroying Bioreducible Polymer with Agmatine Moiety for Efficient Gene Delivery Systems
Presenter: Tae-il Kim Authors: T Kim, J Choi.
Seoul National University, Korea

905 Simple Method for Preparation of 20-50 nm Lipid Nanoparticles Encapsulating siRNA Using a Y Connector
Presenter: Tine Schrøder Authors: T D Schrøder, P Hervella, L Folke Olsen, J Mollenhauer, D Needham.
University of Southern Denmark, Denmark

906 Span based nanoparticles as efficient non-viral vectors for in vivo PRPF31 gene delivery to treat inherited retinal dystrophy
Presenter: Andrea Pensado Authors: A Pensado, F J Diaz-Corrales, B De La Cerda, L Valdés-Sánchez, B Seijo, S S Bhattacharya, A Sanchez.
University of Santiago de Compostela, Spain

908 Tailoring the Surface of a Gene Delivery Vector with Carboxymethylated Dextran: a Systematic Analysis
Presenter: Charles Fortier Authors: C Fortier, E Louvier, Y Durocher, G De Crescenzo.
Ecole Polytechnique de Montreal, Canada

910 Targeted Gene Delivery into Peripheral Nervous System Mediated by Trimethyl Chitosan Nanoparticles
Presenter: Ana Paula Pego Authors: A Pego.
INEB, Portugal

912 Targeting chitosan oligosaccharide nanoplexes to lung cancer cells for enhanced internalization and improved siRNA delivery
Presenter: UDAY KOLI Authors: U KOLI, R JAIN, P DANDEKAR.
INSTITUTE OF CHEMICAL TECHNOLOGY, India

913 The NanoAssemblr™ Platform: Scalable, Microfluidics-based Manufacture of RNA Lipid Nanoparticles
Presenter: Colin Walsh Authors: A Ansari, C Walsh, A White, K Ou, A Thomas, T Leaver, A Wild, E Ramsay, P Cullis.
Precision NanoSystems, U.S.A.
collapse siRNA and mRNA Delivery

40 Delivery of siRNA with nanoparticles based on PEG-PLA block copolymer for cancer therapy
Presenter: Jun Wang Authors: J Wang, C Xu, A Liu, C Sun, X Yang.
Univ of Science and Technology, China

41 Advances in Polymer Conjugates Designed for siRNA Delivery
Presenter: Stephanie Barrett Authors: S E Barrett, R S Burke, R M Garbaccio, E N Guidry, B J Howell, E A Kemp, A H Latham, A M Leone, S L Colletti.
Merck & Co., Inc, U.S.A.

845 anti-IL8 siRNA Nanoparticles Induce Knockdown in Epithelial Cells-in vitro and in vivo
Presenter: Joanne Ramsey Authors: J Ramsey, A Hibbitts, R MacLoughlin, J Barlow, S Cryan.
School of Pharmacy, Ireland

875 Efficient Expression of mRNA PEG-Peptide Polyplexes in Liver
Presenter: Kevin Rice Authors: K Rice.
Department of Pharmaceutical Science, College of Pharmacy, University of Iowa, Iowa City, IA 52242, U.S.A.

893 Peptide Nanofiber Vectors of siRNA for Glioblastoma Treatment
Presenter: Mariarosa Mazza Authors: M Mazza, L O'Donnell, K Kostarelos.
University of Manchester, United Kingdom

899 Reciprocal dormancy-promoting nanomedicine altering EGFR and TSP-1 for the management of glioblastoma
Presenter: Ronit Satchi-Fainaro Authors: S Ferber, G Tiram, E Yavin, N Almog, J Henkin, M Calderon, R Haag, R Satchi-Fainaro.
Tel Aviv University, Israel

911 Targeted mitochondrial delivery of functional nucleic acids using MITO-Porter
Presenter: Eriko Kawamura Authors: E Kawamura, Y Yamada, H Harashima.
Faculty of Pharmaceutical Sciences, Hokkaido University, Japan
collapse Therapeutic Cancer Nanomedicines

20 Development of Fixed-Ratio Anticancer Drug Combination Nanomedicines That Markedly Improve Clinical Efficacy and Survival Outcomes
Presenter: Lawrence Mayer Authors: L D Mayer, B Liboiron, D Cabral-Lilly, S Xie, P Tardi, K Paulsen, M Chiarella.
Celator Pharmaceuticals, Canada

21 Clinical Experience Combining CRLX101, an Investigational Nanoparticle-Drug Conjugate, With Other Agents: A Translational Research Program
Presenter: Scott Eliasof Authors: S Eliasof, E G Garmey, L Jayaraman, D Lazarus, C G Peters, P Wu.
Cerulean Pharma Inc., U.S.A.

22 Clinical Fact Sheet of Cancer Nanomedicine and Revisiting its Working Mechanisms
Presenter: You Han Bae Authors: Y Bae.
Univ of Utah, U.S.A.
collapse Topical and Transdermal Delivery

408 Investigating the effect of hydrophilic polymers on solvent-induced in situ forming implants
Presenter: Thakur R R Singh Authors: R R Singh, H McMillan, C Gujral, K McAvoy, D Jones.
Queens University, Belfast, United Kingdom

917 A microfludic system using a hollow microneedle for targeted drug delivery of phenyephrine for treatment of fecal incontinence
Presenter: Mee-Ree Han Authors: M Han, M Ahn, J Kim, J Park, J Park.
Chung-Ang University, Korea

918 A novel spraying method for preparing Eudragit® E PO-Soluplus®-Perphenazine thin matrix films
Presenter: Kristiina Korhonen Authors: K Korhonen, M Savolainen, O Korhonen, J Ketolainen, R Laitinen.
University of Eastern Finland, Faculty of Health Siences, School of Pharmacy, Finland

919 Acute Dermal Irritancy and Anti-Arthritic Efficacious study of Alginate Bilayer Film containing Hydroxytyrosol in Freud’s Adjuvant induced-Arthritic Rat Model
Presenter: Shiow-Fern Ng Authors: S F Ng, L Tan, S Tan.
Centre for Drug Delivery Research, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Malaysia

920 Allergen-coated microneedles as a novel way for asthma preventive immunotherapy
Presenter: Akhilesh Shakya Authors: A K Shakya, C H Lee, H S Gill.
Post doc research associate, U.S.A.

921 Antimicrobial hydrogels based on poly(vinyl alcohol)- poly(methyl vinyl ether-alt-maleic anhydride) combinations for wound care applications
Presenter: Enrica Calo' Authors: E Calo'.
University of Reading, United Kingdom

922 Bacterial Nanocellulose as Wound Dressing for Controlled Fast and Prolonged Release of Octenidine
Presenter: Dagmar Fischer Authors: M Dewaldt, S Moritz, D Kralisch, D Fischer.
Friedrich-Schiller-University, Germany

924 Chlorhexidine digluconate nanoemulsions for topical antisepsis
Presenter: Pratibha Kakadia Authors: P G Kakadia, B R Conway.
Researcher, United Kingdom

928 Development and Characterization of Mucoadhesive In Situ Nasal Gelling Systems.
Presenter: Harendra Parekh Authors: P Pandey, B Wallwork, B Panizza, P J Cabot, H S Parekh.
Senior Lecturer, Australia

929 Development and Evaluation of Tocotrienol-based Nanoemulsion Platforms for Dermal Chemoprevention Applications
Presenter: Tamer Elbayoumi Authors: J Pham, C Hoang, B Brownlow, M Joshi, T A Elbayoumi.
Midwestern University-Glendale, AZ, U.S.A.

930 Development of a Novel Transdermal Drug Delivery System using an Atmospheric-pressure Low-temperature Plasma Jet
Presenter: Kosuke Kusamori Authors: K Kusamori, N Hirota, K Hayashida, K Shimizu, H Katsumi, T Sakane, A Yamamoto.
Kyoto Pharmaceutical University, Japan

933 Development of Thermostable Oxytocin-Coated Microneedle Patch for Treatment of Postpartum Hemorrhage
Presenter: Yasmine Gomaa Authors: Y Gomaa, C Kolluru, M Milewski, D Lee, J Zhang, R Saklatvala, M R Prausnitz.
Georgia Institute of Technology, U.S.A.

934 Effect of Photoinitiator Concentration on the Properties of Unmedicated Hydrogels.
Presenter: Rachel Wong Authors: R S Wong, M Ashton, H Wolff, K Dodou.
University of Sunderland, United Kingdom

935 Encapsulation Of Diterpene Parvifloron D In Hybrid Nanoparticles For Cancer Targeted Therapy
Presenter: Catarina Silva Authors: C O Silva, J M García del Pozo, P M Rijo, C P Reis.
CBIOS - Universidade Lusófona, Portugal

936 Enhanced Release and Solubilization of Paclitaxel by Buccal Delivery System based on DMβCD and Pluronic F127
Presenter: Choon Lian Ng Authors: C Ng, S Choi, S Lee, J Park.
College of Pharmacy, Chungnam National University, Korea

937 Evaluating the impact of various additives upon the gel-point temperature of aqueous poloxamer-based formulations
Presenter: Thorsten Cech Authors: F Bang, T Cech, F Soergel.
BASF SE, Germany

938 Evaluation of In Vitro Skin Permeability of Succinylated Type I Atelocollagen
Presenter: Si-Nae Park Authors: M Kim, M Kang, H Cho, S Bae, S Park, I Shim, S Kim.
Dalim Tissen Co., Ltd., Korea

939 Formulation and development of a novel dermal system for the local delivery of the anti-cancer agent MTL-004
Presenter: Mandeep Marwah Authors: M Marwah, Y Perrie, D Lowry.
Aston University, United Kingdom

940 Formulation and evaluation of topical formulation of a local anaesthetic drug for pain management
Presenter: Sujata Sawarkar Authors: S P Sawarkar, T T Jadhav, P Ravikumar.
SVKM's Dr. Bhanuben Nanavati College of Pharmacy, India

941 Formulation and Evulation of Loxoprofen Sodium Containing Topical Gel
Presenter: Cigdem ASIK Authors: C ASIK, Y ERDEM, A Turkyilmaz.
Sanovel Pharmaceuticals, Turkey

943 Hyaluronan-based Dissolving Microneedles for Intradermal Protein Delivery: Protein Stability and Microneedle Dissolution in Skin
Presenter: Juha Mönkäre Authors: J Mönkäre, M Nejadnik, K Baccouche, W Jiskoot, J A Bouwstra.
LACDR, Leiden University, Netherlands

944 Imiquimod Permeation into the Skin to Treat Basal Cell Carcinoma
Presenter: Mohammed AL-Mayahy Authors: M H AL-Mayahy, G G Castro, M J Alonso, M Marlow, D J Scurr.
School of Pharmacy, University of Nottingham, United Kingdom

945 Improve of tyrosinase inhibitor activity by trans-resveratrol-loaded solid lipid nanoparticles
Presenter: Roberta Rigon Authors: R B Rigon, N Fachinetti, P Severino, M A Santana, M Chorilli.
School of Pharmaceutical Sciences, São Paulo State University, Araraquara, São Paulo, 14801-902, Brazil. , Brazil

948 In Vivo Theophylline, Caffeine and Glucose Monitoring Using Hydrogel-Forming Microneedles
Presenter: Ester Caffarel-Salvador Authors: E Caffarel-Salvador, A J Brady, E Eltayib, T Meng, R F Donnelly.
Queen's University Belfast, United Kingdom

949 Influence of fresh or defrosted pig ear tissue upon tape stripping results
Presenter: Cornelia Keck Authors: A Arntjen, E Loris, I Riediger, K Schäfer, C M Keck.
University of Applied Sciences Kaiserslautern, Germany

951 Isotretionin colloidal carriers for topical acne treatment: ATR-FTIR and in vitro cytotoxicity studies
Presenter: M. SEDEF ERDAL Authors: M ERDAL, A GÜRBÜZ, G ÖZHAN, S GÜNGÖR.
ISTANBUL UNIVERSITY FACULTY OF PHARMACY DEPARTMENT OF PHARMACEUTICAL TECHNOLOGY, Turkey

953 Microemulsion Improves Oral and Topical Absorption of Acycovior
Presenter: Jui-Chen Tsai Authors: J Tsai.
National Cheng Kung University, Taiwan

954 Microemulsions for topical Fluconazole delivery
Presenter: Taís Gratieri Authors: C Carnicel, G N Menezes, F A Sá, P C Souto, G M Gelfuso, T Gratieri.
Universidade de Brasilia, Brazil

955 Microneedle-mediated delivery of donepezil: potential for improved treatment options in Alzheimer's disease.
Presenter: Mary-Carmel Kearney Authors: M Kearney, R F Donnelly.
Queen's University Belfast, Northern Ireland

958 Nanofibers Based On Chondroitin Sulfate Intended For Wound Healing
Presenter: Carla Caramella Authors: G Sandri, M Bonferoni, F Saporito, S Rossi, F Ferrari, I Liakos, E Mele, A Athanassiou, C Caramella.
Dep Drug Sciences, Univ Pavia, Italy

959 Nanotechnological approaches for skin regeneration: The topical administration of rhEGF loaded Nanostrucutred lipid carriers enhances healing in a swine wound model
Presenter: Rosa Hernandez Authors: G Gainza, D Celdrán, B Moreno, J J Aguirre, F B Gutierrez, S Villullas, J L Pedraz, M Igartua, R M Hernandez.
University of the Basque Country/Nanobiocel research group, Spain

960 Novel Bioadhesives Based on Gelatin and Alginate with Controlled Release of Antibiotic Drug
Presenter: Maytal Foox Authors: M Foox, Y Ullmann, I Berdicevsky, A Keren, E Cohen, N Goldstein, M Zilberman.
Tel Aviv University, Israel

961 Optimization of Electrospun Nanofiber Mats for Transdermal Delivery
Presenter: Emine Kahraman Authors: A Gençtürk, E Kahraman, G Ozhan, S Güngör, Y Ozsoy, A Sarac.
Istanbul University, Faculty of Pharmacy, Dept. of Pharm. Tech., 34116, Istanbul, Turkey

962 P.L.E.A.S.E.® Fractional Laser Ablation for the Cutaneous Deposition of Triamcinolone Acetonide Loaded PLGA Microparticles
Presenter: Mayank Singhal Authors: M Singhal, S del Río-Sancho, K Sonaje, Y N Kalia.
University of Geneva, Switzerland

963 Pharmacokinetic profile of donepezil hydrochloride microneedle encapsulation for the treatment of Alzheimer’s disease
Presenter: Ji-Yeon Kim Authors: J Kim, M Han, M Ahan, J Park, Y Kim, S Shin, S Nam.
Gachon University, South Korea

964 PLGA/PEI/pH1N1 Polyplex coated Microneedle as an Efficient Transdermal DNA Vaccine Delivery System
Presenter: HaeYong Seok Authors: H H Seok, Y Kim.
Korea advanced institutes of science and technology, Korea

965 Polymer-microneedles coated with a hydrophilic solution
Presenter: HANSOL LEE Authors: H LEE, I CHOI, J PARK.
GACHON UNIVERSITY, South Korea

966 Preliminary Studies on the Design of a Temperature Regulated Patch
Presenter: Kalliopi Dodou Authors: P Karamperopoulos, I Fletcher, A Wheatley, K Dodou.
University of Sunderland, United Kingdom

967 Propranolol and Timolol-Loaded Nanoparticles for Topical Treatment of Infantile Hemangiomas
Presenter: Nicole Brogden Authors: M N Kelchen, K L Stange, H Ciliberto, N K Brogden.
University of Iowa College of Pharmacy, U.S.A.

969 smartPearls for the Dermal Delivery of Physically Stable Amorphous Cyclosporine
Presenter: Cornelia Keck Authors: C M Keck, N Jin, F Monsuur, H H Höfer, R H Müller, S Staufenbiel.
PharmaSol GmbH Berlin, Germany

970 smartPearls-Dermal Delivery System for Cosmetics and Consumer Care based on Amorphous Actives
Presenter: Cornelia Keck Authors: C M Keck, F Monsuur, H H Höfer, W McCarthy, R H Müller.
PharmaSol GmbH Berlin, Germany

971 smartPearlsTM for the Dermal Delivery of Azithromycin against Borreliosis Infection
Presenter: Rainer Müller Authors: R H Müller, N Jin, F Monsuur, H H Höfer, C M Keck, S Staufenbiel.
Free University Berlin, Germany

973 Sterilisation Considerations in the Preparation of Polymeric Microneedle Arrays: Enhancing Controlled Delivery of the Model Protein Ovalbumin
Presenter: Aaron Courtenay Authors: A J Courtenay, M C McCrudden, A Z Alkilani, R F Donnelly.
Queens University Belfast, United Kingdom

974 Studies on a semisolid emulsion of doxycycline for transdermal drug delivery
Presenter: Kalliopi Dodou Authors: N Dewan, B Khalil, S Wilkinson, K Dodou.
University of Sunderland, United Kingdom

975 Sustained Delivery of Peptides and Proteins by High Content Phospholipids-based Phase Separation Gel
Presenter: Tao Gong Authors: T Zhang, Q Peng, Z Zhang, T Gong.
West China School of Pharmacy, Sichuan University, China

977 The antimicrobial activity of silver zeolite loaded bacterial cellulose hydrogels against Staphylococcus aureus and Pseudomonas aeruginosa
Presenter: A Gupta Authors: P K Dosanjh, A Gupta, S T Britland, I Radecke, C Martin.
Univ of Wolverhampton, United Kingdom

978 The hen’s egg chorioallantoic membrane (HET-CAM) test to predict the ophthalmic irritation potential of cysteamine-containing gels: Quantification using Photoshop® and ImageJ
Presenter: Barbara McKenzie Authors: B McKenzie, G Kay, K Matthews, R Knott.
RGU, Scotland

979 Thermosensitive Dendritic Polyglycerol-Based Nanogels for Cutaneous Delivery of Biomacromolecules
Presenter: Katja Obst Authors: K Obst.
Freie Universität Berlin, Germany

980 Transdermal and Dermal Drug Delivery by means of Polyglycerol-based Nanogels
Presenter: Fiorenza Rancan Authors: F Rancan, S Dogan, J Jurisch, S Chatzopoulou, M Asadian-Birjand, M Giulbudagian, C Graf, U Blume-Peytavi, M Calderon, A Vogt.
Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Germany

982 Transdermal Photodynamic Therapy Using Carbon Dot - Chlorin e6 - Hyaluronate Conjugate
Presenter: Songeun Beack Authors: S Beack, H Jung, S Hahn.
Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-ro, Nam-gu, Pohang 790-784, Korea, South Korea
collapse Transdermal Delivery

7 Invited Speaker - Veronica Preat
.

8 Expanding Transdermal Delivery to Biologics
Presenter: Bobby Singh Authors: B Singh.
Corium Intl Inc, U.S.A.

927 Design of a Dissolving Microneedle Platform for Transdermal Delivery of a Fixed-dose Combination of Cardiovascular Drugs
Presenter: Helen Quinn Authors: H L Quinn, L Bonham, R F Donnelly.
Queen's University Belfast, United Kingdom

946 In vitro biocompatibility studies of microneedle arrays for use in the transdermal delivery of ibuprofen sodium.
Presenter: Maelíosa McCrudden Authors: M T McCrudden, A Z Alkilani, C M McCrudden, E McAlister, A D Woolfson, R F Donnelly.
Queen's University Belfast, United Kingdom

947 In vivo Monitoring of Compound Permeation and Age Related Effects in Human Stratum Corneum
Presenter: Nichola Starr Authors: N J Starr, J Wibawa, I Marlow, M Bell, D A Barrett, D J Scurr.
University of Nottingham, United Kingdom

956 Micropore Closure Kinetics are Delayed Following Microneedle Insertion in Elderly Subjects
Presenter: Nicole Brogden Authors: C C Converse, M N Kelchen, M J Farley, G O Holdren, N K Brogden.
University of Iowa, U.S.A.

976 Targeting of skin resident dendritic cells via laser microporation
Presenter: Yoan Machado Authors: Y J Machado, M Mayr, T Thalhamer, V Höpflinger, M Schmid, U Ritter, S Gordon, C Lehr, S Scheiblhofer, J Thalhamer, R Weiss.
University of Salzburg - Department of Molecular Biology, Austria
collapse Young Scientist Workshop: Finding Your Career Edge

Finding Your Career Edge
Presenter: Teresa Virgallito.
Microtek Labs Inc.
collapse Young Scientist Workshop: The Rise, and Rise, of Precision Medicine

Towards Precision Medicine Using PBPK Modeling
Presenter: Devendra Pade.
Simcyp Limited

Production and Development of a Personalized Cancer Vaccine
Presenter: Heinrich Haas.
BioNTech RNA Pharmaceuticals GmbH
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