Patent Watch


Patent Watch

Publish Date

This article summarizes selected patents in the area of controlled release or delivery that were issued from May19, 2020 through September 8, 2020. Greater detail on each of these patents is given on the U.S. patent website

 Industrial Applications

US-10731103- Low ash and ash-free acid neutralizing compositions and lubricating oil compositions containing same

An oleaginous nanoparticle dispersion of nanoparticles having a core of an organic base material immobilized within a surfactant layer for use in lubricating oil compositions.

US-10726981- Functionalized magnetic nanoparticles and a method for preparation thereof

Description of a method to generate covalently-functionalized coated magnetic nanoparticles by forming a shell of a hydrophilic polymer coating layer on top of a magnetic metal core. The product is to be used in water treatment applications.  

US-10703834- Light generating microcapsules for self-healing polymer applications

A self-healing polymeric material that includes a polymeric matrix material, microcapsules containing chemiluminescent light emitting materials and microcapsules containing photo-activated reactants that polymerize when exposed to the wavelength of light emitted by the light emitting capsules.


US-10758633- Nanoparticles for magnetic resonance imaging applications

A method of preparing a coated nanoparticle that can be used in magnetic resonance imaging.

US-10738174- Aqueous soluble ferrimagnets stabilized by block copolymers

A water-soluble polymer complex that includes a water-soluble block copolymer (diblock or triblock) and a magnetic nanoparticle. The water-soluble complexes may be derivatized with reactive groups and conjugated to biomolecules.

US-10732115- Mesoporous oxide nanoparticles and methods of making and using same

The nanoparticles have an average size of less than 15 nm and a narrow size distribution. The formulation can be used in imaging applications as well as a controlled release/delivery system for pharmaceuticals.

US-10718693- Compositions comprising nanomaterials and method for using such compositions for histochemical processes

Description of nanoparticle-based systems used for histochemical evaluation of tissue samples. The use of nanoparticles versus conventional staining reduces the average number of spots per slide that result from standard sample staining protocols. Nanoparticles of various materials such as metals, metal alloys, metal oxides, ceramics, functionalized metals or metalloids, and other miscellaneous nanoparticles, such as carbon nanoparticles and diamond nanoparticles are described.

US-10705085- Tethered lipoplex nanoparticle biochips and methods of use

Disclosed are compositions and methods for the use of lipoplex nanoparticle chips and arrays in the detection of/diagnosis of a disease or condition.


US-10765755- Preparation and characterization of methylene blue nanoparticles for Alzheimer's disease and other tauopathies

A delivery system of coated and uncoated nanoparticles (NP) for delivery of methylene blue (MB). The delivery system utilizes PLGA as the encapsulation material. The parameters of synthesized NPs were within the suitable range and charge for BBB permeation upon intravenous administration.

US-10765741- Methods for treating VEGF-expressing cancer using preformed nanoparticle complexes comprising albumin-bound paclitaxel and bevacizumab

Descriptions of methods and materials relating to the use of a composition containing albumin-containing nanoparticle/antibody complexes are provided.

US-10765637- RGD and transferrin nanoparticle composition

Description of a nanoparticle formulation appropriate for penetration of the blood-brain barrier with low cytotoxicity. The nanoparticles described have two materials bound to their surface. Both substances impart a tumor cell-binding specificity (a peptide rich in arginine-glycine-aspartic-acid, the other an iron-binding protein).

US-10765634- Controlled release formulations for the induction and proliferation of blood cells

Description of a Treg-inducing microparticle providing a predictable controlled release for combinations of cytokines and drugs that show potential as an in vivo Treg induction and expansion therapy.

US-10758520- Glutathione-coated nanoparticles for delivery of MKT-077 across the blood-brain barrier

Description of a nanoparticle formulation made up of glutathione-coated, pegylated PLGA for delivery of MKT-077. Suggested use is as a tauopathy therapy.

US-10758485- Amphiphilic entity nanoparticles

Description of AE nanoparticles for pharmaceutical controlled release.

US-10751291- Nanoparticulate compositions comprising interferon gamma and losartan for immunotherapy

Description of multiple formulations containing several different actives ranging from being  loaded into, attached to the surface of and/or enclosed within “nanolipogels” or biodegradable polymeric PLGA nanoparticles. Typically, the actives are immune-modulators. The particles can be further functionalized with targeting moieties.

US-10736972- Methods of treatment using ultra small nanoparticles to induce cell death of nutrient-deprived cancer cells via ferroptosis

Description of a method to induce cell death by ferroptosis using nanoparticles delivered to and taken up by cancer cells.

US-10736943- Silk microspheres for encapsulation and controlled release

A method to prepare microspheres made of silk fibroin proteins using a lipid vesicle template.

US-10729786- Mucus penetrating gene carriers

A description of a nanoparticle formulation for encapsulation of nucleic acids in one or more biocompatible, polycationic polymer. Specifically, these formulations are for diffusion through cystic fibrosis mucous for patients suffering from CF.

US-10729719- Fruit-derived core-shell nanospheres

Core-shell nanospheres that are generated using silver nitrate and Pouteria caimito extract as a method for the green synthesis of silver nanoparticles, followed by coating the nanoparticles with silica. The core-shell nanospheres show activity against oral cancer.

US-10723692- Lipids and lipid nanoparticle formulations for delivery of nucleic acids

This patent involves description of several lipid compounds and lipid nanoparticle formulations for delivery of nucleic acids.

US-10717825- Cationic mucic acid polymer-based delivery system

Describes the use of polymers with charged and uncharged segments (polyalkylene glycol and a cationically- charged segment with at least one polyhydroxy linkage) to generate nanoparticle delivery systems for biological molecules.

US-10709795- Method for delivering pharmaceutical nanoparticles to cancer cells

This breast cancer therapy formulation is described as a nanoparticle made up of a PLA-PEG-PLA copolymer with polyvinyl alcohol and bovine serum albumin on the surface of the nanoparticle. The formulation incorporates a surface targeting moiety and a therapeutic encapsulated within.

US-10695288- Reactive oxygen species (ROS)-responsive compositions and methods thereof

This formulation is comprised of an injectable microsphere loaded with a biologically active agent for targeted delivery to a site with elevated reactive oxygen species. An emulsion-based process is used to generate the microspheres.

US-10688125- Nanoparticles and their use in cancer therapy

Description of a nanoparticle with a metal in the core and a set of ligands on the surface including ethylene glycol, amine, and carbohydrate groups for the treatment of skin cancer. The patent also included methods of treatment alone or in combination with radio therapy.

US-10682421- Nanoparticle composition for use in targeting cancer stem cells and method for treatment of cancer

The formulation described in this patent involves a nanoparticle with a magnetic core that acts as a heat source when exposed to a magnetic field, a cancer therapeutic, and a silica shell that incorporates targeting antibodies specific to cancer cells. The therapeutic is a heat shock protein inhibitor that is released upon activation of the heat source.

US-10682396- Controlled release system for pulmonary delivery of surfactant protein D

A controlled release system made up of PLGA and a payload of surfactant protein D (SPD) is described for pulmonary delivery. The patent also includes a method for the treatment of disorders associated with decreased SPD in the subject.

US-10675250- Nanoparticle, preparation process and uses thereof

The present disclosure provides the preparation of a nanoparticle, as a method for enhancing the effect of a liver cancer drug, and a method for ameliorating tumor hypoxia.

US-10668151- Nanoparticle complexes of albumin, paclitaxel, and panitumumab for treatment of cancer

This invention relates to antibody-albumin nanoparticle complexes including a surface antibody with binding specificity for a cancer antigen (e.g. panitumumab), a therapeutic (paclitaxel), for cancer (e.g. EGFR-related cancer) treatments.

US-10660861- Glutaminase inhibitor discovery and nanoparticle-enhanced delivery for cancer therapy

This invention describes a nanoparticle formulation aimed at addressing the poor stability and solubility of glutaminase inhibitors for their use in cancer therapy. The formulation uses sub-100 nm nanoparticles to package the drug in a colloidal suspension of the particles.


US-10717788- Cyclodextrin functionalized nanoparticles for quenching bacterial communications

Description of attachment of a polymer onto the surface of a nanoparticle where the polymer comprises a cyclic arrangement of saccharides for the purpose of quenching bacterial communications.

US-10716878- Nanoparticle-based scaffolds and implants, methods for making the same, and applications thereof

The invention is described as a silver nanoparticle/PLGA coating for stainless steel alloys used as implants to enhance antimicrobial properties on the surfaces of the implants while promoting osteogenesis of pre-osteoblasts.  

US-10688175- NSP10 self-assembling fusion proteins for vaccines, therapeutics, diagnostics and other nanomaterial applications

Describes the use of the NSP10 protein and fusions of NSP-10 with other proteins that self assembles into higher order structures. These structures could be nanoparticles used to encapsulate and transport the fusion protein (or other therapeutics) for targeted delivery. Potential applications ranging from vaccine formulations to cancer, to biosensing are mentioned.

US-10669534- Nanocaged enzymes with enhanced catalytic activity and increased stability

This invention disclosure describes a nanoparticle comprising a three dimensional DNA “nanocage” and a payload consisting of a biological macromolecule.

Consumer Products/ Cosmetics

US-10729624- High-ultraviolet absorption lignin/chemical sun-screening agent microcapsule and preparation method therefor

This invention makes use of lignin as an encapsulation material for chemical sun-screening agents. 

US-10723981- Laundry detergent

Description of a microcapsule formulation used in liquid laundry detergent made up of a cationically charged coating and a fluorescent brightener unit in order to enhance phase stability and improve delivery efficiency of microcapsules and brightening of fabric.

US-10722857- Encapsulated perfume compositions

A positively charged, encapsulated perfume composition comprising a perfume-containing aminoplast core-shell microcapsule dispersed in an aqueous suspension medium.

US-10695272- Compositions containing microcapsules coated with deposition proteins

A description of and method for making microcapsules coated with a deposition protein, e.g., a protein-silanol copolymer, a protein-silane copolymer, a protein-siloxane copolymer, or a cationically modified protein, for use in rinse-off consumer products.

US-10662400- Microencapulation using small amines

Description of and method for producing microparticles by crosslinking of a polybranched polyamine and a small amine, used for stabilizing detergent components.