Patent Watch
This article summarizes selected patents in the area of controlled release or delivery that were issued from September 15, 2020 through December 29, 2020. Greater detail on each of these patents is given on the U.S. patent website http://patft.uspto.gov.
Industrial Applications
US-10870794- Using brine resistant silicon dioxide nanoparticle dispersions to improve oil recovery
The invention utilizes a brine-resistant silicon dioxide nanoparticle dispersions to extend an oil and gas system reservoir volume and increase initial production rates of an oil well by over 20.0% over wells not treated with the same technology.
US-10843243-Method of remediation of organic toxins using supported lipid bilayer nanoparticles
Accomplishes water treatment and environmental remediation using lipid bilayers supported by silica.
US-10836953-Polysaccharide coated nanoparticle compositions comprising ions
Enhancement of downhole fluid hydrocarbon recovery using a nanoparticle with cross-linked carbohydrate coating with an ion (+1 or +2 charge).
US-10836918- Microparticles and apparatus for smart ink production
Description of a Janus microparticle formulation used in smart ink as a covert security feature in printing inks.
US-10828578- Reversible control of solution solubility using functionalized nanoparticles
Description of the use of nanoparticles to alter a solution’s dissolved components. Nanoparticles with specific functional groups create supersaturated states in solution causing specific solutes to fall out for removal or further purification. The crystallization is reversible as well resulting in a powerful separation and purification method.
US-10822470- Polyolefin materials with reduced oxygen permeability
Polymer compositions using a nanoparticle filler to reduce oxygen permeability. Potential application in roofing systems to protect the insulation layer from weather degradation.
US-10816142- Methods for protecting pipelines
A method for inhibiting corrosion in pipelines for transporting oil and gas is described. A nanoparticle with covalently-bound corrosion inhibitor is flowed through the pipe. The Corrosion inhibitor is released at the site of corrosion.
US-10801305- Use of nanoparticles in cleaning well bores
Description of the use of fluids containing nanoparticles to remove drilling fluid residue from surfaces.
US-10793684- Method of reducing an organic pollutant in contaminated water
A method of producing and using a metal nanoparticle-loaded biopolymer microgel. The microgel can then be used to catalytically reduce an organic pollutant in water using a reducing agent.
Diagnostic/Sensing
US-10876150- Nanoprobe compositions and methods of use thereof
Describes the use of gold “nanorattle” probes for in vitro and in vivo surface-enhanced Raman scattering (SERS) applications. They can be loaded with a range of dye molecules that exhibit SERS in various spectra including the “tissue optical window” for in vivo studies.
US-10837045- Optical nanosensors for hydrolytic enzyme characterization
The sensor assembly probe includes one or more fluorescent hydrophobic semi-conductive nanoparticles disposed in an aqueous medium along with an amphiphilic polymer coating that includes a substrate for a predetermined enzyme.
US-10786582- Gd(III)-dithiolane gold nanoparticle conjugates
Description of Gd(III)-dithiolane gold nanoparticle conjugates used for in vivo imaging such as MRI.
US-10781480- Method of detecting nucleic acids with amplified signal using nanoparticles
Provides a method using nanoparticles bound to nucleic acid capture probes and a second nanoparticle with a second nucleic acid probe that binds to the primary nanoparticle to amplify the signals of the reporter probes.
US-10780185- Multifunctional nanoparticle bioconjugates for photoacoustic-based recording of cellular membrane potential
A system that uses a nanoparticle bound to a peptide to allow for insertion into a cell membrane. Through a series of electron transfers, a photoacoustic emission can be measured and correlated to membrane potential.
US-10780184- Fluorescent solid lipid nanoparticles composition and preparation thereof
Description of a solid lipid nanoparticle with an alkaline-earth complex and a fluorescent dye. The SLN’s hae a long circulating half-life and improved fluorescence signal to be used in diagnostics.
US-10775304- Fluorescent nanosensors and uses thereof
Fluorescent nanosensors for extracellular ion concentration measurements made up of a photoluminescent nanostructure disposed on a substrate surface is disclosed. Nanoparticles with a fluorescent metallic core in a silica shell containing a fluorophore. The nanosensor emits a fluorescence emission based on the extracellular ion concentration.
Pharma
US-10874737- Influenza nanovaccine
Universal influenza vaccine made up of bioerodible nanoparticles (1,8-bis(p-carboxyphenoxy)-3,6-dioxaoctane (CPTEG) and 1,6-bis(p-carboxyphenoxy)hexane (CPH) copolymers )containing immunogenic proteins and an adjuvant.
US-10857105- Compounds and compositions for intracellular delivery of therapeutic agents
Nanoparticles made of novel lipids, phospholipids, structural lipids, and PEG lipids for delivery of therapeutics/prophylactics such as RNA to mammalian cells or organs for various applications.
US-10864270- Nanostructured carriers for guided and targeted on-demand substance delivery
Description of fabricating and implementing nanoscale and microscale structured carriers to provide guided, targeted, and on-demand delivery of molecules and biochemical substances for a variety of applications including diagnosis and/or treatment (theranostics) of diseases in humans and animals.
US-10843159- Apparatus for a mass production of monodisperse biodegradeable polymer-based microspheres and a multi-channel forming device incorporatable therein
Description of an apparatus for the large-scale production of monodisperse microspheres. It appear to make use of micro channels and fluid focusing to accomplish this.
US-10842876- Statin-containing nanoparticle preparation for enhancing function of stem cells for treating inflammatory disease, and functionally enhanced stem cells containing same for treating inflammatory disease
A nanoparticle made from a bioresorbable polymer such as PLA or PLGA containing a statin is described. The authors suggest that the statin formulation could be used enhance function s of stem cells that can then be used for treating inflammatory diseases.
US-10842755- Nanoparticles for brain targeted drug delivery
A nanoparticle formulation that includes a polymeric or inorganic core material and an active agent. The nanoparticle is enrobed in a shell comprising a membrane derived from a brain metastatic cancer cell that facilitates transport across a blood-brain barrier.
US-10835605- Preparations of poly(lactic-co-glycolic acid)/polydopamine core/shell hybrid nanoparticle for photothermal applications
Described is a biodegradable and biocompatible hybrid nanoparticle for use in photothermal, disease detection, treatment, and monitoring applications
US-10835493- Platelet-like proteo-microparticles and method of using such in drug delivery
Description of the use of liposomes that include platelet membrane proteins that are able to bind to monocytes, neutrophils, or other circulating blood cells capable of migrating to an injured site as a targeted delivery vehicle.
US-10828083-Lactoferrin-conjugated nanoparticle complex and use thereof
A lactoferrin-conjugated metallic nanoparticle complex for targeted delivery to brain tumor tissues with improved stability over traditional nanoparticles.
US-10821175- Lipid nanoparticle vaccine adjuvants and antigen delivery systems
A lipid nanoparticle formulation containing cationic lipids for vaccine/antigen delivery systems.
US-10806754- Engineered metal nanoparticles and methods thereof
A formulation with potential in treatment of cancer or an anosmia-related disease made up of metal nanoparticles.
US-10806715- Gold nanoparticle based formulation for use in cancer therapy
Description of a formulation of gold nanoparticles conjugated to fusion proteins for the delivery of anticancer drugs and nucleic acids.
US-10799601- Method of making peptide-tagged PEGylated chitosan nanoparticles
Description of a chitosan non-viral nanoparticle that contains a targeting/penetrating peptide for targeted delivery of nucleic acids or active pharmaceutical ingredients.
US-10799463- Compounds and compositions for intracellular delivery of agents
Description of nanoparticle formulations made up of an amino lipids as well as additional lipids. The payload of these nanoparticles can include therapeutic and/or prophylactic agents such as RNA and are useful in the delivery of actives to mammalian cells or organs for a variety of applications/treatments.
US-10799456- Multiple drug lipid nanoparticle composition and related methods for extended drug levels in blood and lymph tissue
Describes the use of lipid nanoparticles to enhance the circulating half life of multiple small molecule drugs.
US-10793853- Targeted delivery system
A targeted delivery system for siRNA or antisense technology is described. One specific application given involves a method of treating cancer by administering HerPBK10 combined with siRNA, resulting in the inhibition of Her2 expression and cell death.
US-10786569- Lithographically defined nanoparticles for microwave absorption
Description of a formulation of micro/nano particles that exhibit enhanced heat properties under microwave radiation which can be used for diagnosis and therapeutic purpose in cancer treatment.
US-10786527- Nanoparticle-stabilized nanocapsules and methods of preparation and use for nucleic acid delivery
The invention describes a formulation of nanoparticle-stabilized nanocapsules used to delivery payloads such as nucleic acids.
US-10781446- RNA nanoparticle for treatment of gastric cancer
An RNA-based composition and method to treat gastric cancer is described. The formulation contains a multiple branched RNA nanoparticle with a gastric cancer-targeting module, and a therapeutic agent.
US-10780164- Multifunctional nanoparticle compositions and uses thereof
Descripton of nanoparticle formulations for the treatment of cancer by enhancing the anti-tumor effectiveness of radiation directed to a tissue, cell or a tumor. The formulation consists of a metal oxide nanoparticle core with a coating embedded in a matrix carrier.
US-10780099- Injectable neurosteroid formulations containing nanoparticles
IV-injectable nanoparticles with a neoursteroid payload are described. Specific ailments mentioned include seizure disorder, stroke, or traumatic brain injury.
US-10780057- Casein-based silica dual drug-loading composite microcapsule and preparation method therefor
This invention presents a method for preparing casein-based silica dual drug-loaded composite microcapsule. The authors use interfacial polymerization with drug-loaded casein is the shell on a silica-based core. This hollow silica core can be loaded with a second drug. Multiple drug loadings in a single formulation has the potential to enhance the therapeutic effect beyond that of a single drug treatment.
US-10772883- Diketopiperazine microparticles with defined specific surface areas
Described are diketopiperazine microparticles that can comprise a drug such as insulin.
Bio
US-10874751- Nanoallergens and uses thereof
Description of the use of lipid-based nanoparticles containing IgEs specific to mimotopes of allergens to be used for identifying, evaluating and studying allergens. They can be used to identify specific sensitivities to a set of epitopes in the patient as well.
US-10874612- Biodegradable polymer microsphere compositions for parenteral administration
Description of microsphere formulations that contain a biodegradable polymer and therapeutic agent along with a cellulose-derived material. These microspheres exhibited a narrower size distribution, improved dug entrapment and improved stability over other formulations studied.
US-10864549- Half-coating method for nanoparticles
This patent provides a description of Janus nanoparticle preparation using a kit for half coating of the nanoparticles.
US-10864171- Solid nanoparticle with inorganic coating
Description of a nanoparticle with solid core of biologically active substance encapsulated by an inorganic coating.
US-10849924- Compositions and methods for restoring endothelial glycocalyx
Description of the use of liposome nanoparticles in restoration of the glycocalyx.
US-10842908- Polyphosphate-functionalized inorganic nanoparticles as hemostatic compositions and methods of use
A nanoparticle with polyphosphate polymer bound to it that acts as a hemostatic agent that can be used in medical devices to promote blood clotting.
US-10793889- Method of packing polynucleotides
A nanoparticle formulation made up of polynucleotides as a way to enhance stability.
US-10787523- Nanoparticle-protein complex for intracellular protein delivery
Various embodiments disclosed relate to a nanoparticle-protein complex for intracellular protein delivery. In various embodiments, the present invention provides a nanoparticle-protein complex including a nanoparticle including an amine-containing ligand. The nanoparticle-protein complex also includes a protein comprising a carboxylic acid-containing tag.
Consumer Products/ Cosmetics
US-10822741- Scent booster compositions
A scent booster composition having a pastille formulation and optionally a sodium chloride system. The pastille formulation contains a fragrance in its microcapsule core.
US-10813851- Color-changing microcapsule comprising pigment core and pressure breakable wall layer, and preparation method therefor
Description of microcapsules with a colorant core with a pressure sensitive destructible wall layer. The capsules are easily ruptured during cosmetic application but enhances storage stability and “color hiding” prior to use.
US-10808208- Organic compounds
The invention is described as a microcapsule containing a fragrance oil. The shell of the capsule is positively charged and is comprised of the reaction product of a modified isocyanate with an amine or alcohol, preferably a polyamine.
