Patent Watch

Title

Patent Watch

Publish Date

This article summarizes selected patents in the area of controlled release or delivery that were issued from January 1, 2021 through Feb 23, 2021. Greater detail on each of these patents is given on the U.S. patent website http://patft.uspto.gov.

Industrial Applications

US-10926485- Light generating microcapsules for photo-curing

A process that utilizes an encapsulated photo initiator incorporated into a photo-curable material. A stimulus is applied to trigger chemiluminescence within the microcapsule bringing about curing of the material.

US-10926252- Plasmonic nanoparticle catalysts and methods for producing long-chain hydrocarbon molecules

A plasmonic nanoparticle catalyst for producing hydrocarbon molecules by light irradiation.

US-10921302- Method for manufacturing chemochromic nanoparticles

Description of a “chemochromic” nanoparticle with application as a hydrogen sensor. The nanoparticle is composed of a core-shell morphology with a core of a transition metal oxide and a shell with a transition metal catalyst.

US-10920127- Method for in-depth profile control and displacement of low-permeability oil reservoirs

The invention provides a method for in-depth profile control and displacement in oil reservoirs by using a combination of styrene-based flexible and elastic particles in combination with a polyacrylamide polymer microsphere. The flexible particles can block cracks and large pore channels of the oil layer, and the polymer microsphere can displace the remaining oil in the oil layer for use in fracking/drilling applications.

US-10892494- Method and apparatus for manufacturing core-shell catalyst

Description of a continuous method and manufacturing apparatus for production of a core-shell catalyst nanoparticle.

 

Diagnostic/Sensing

US-10908138- Device having an array of sensors on a single chip

A device that is comprised of nanoparticles on the surface of a semiconductor resulting in a photoconductive nanostructure sensor enabling light-assisted sensing of an analyte.

US-10908092- Process for making cyano functionalized gold nanoparticles

This invention revolves around a method for making a cyanide-functionalized gold nanoparticle that can then be used as part of a sensing device. The analyte interacts with the cyanide on the surface of the particle.

US-10900067- Nucleic acid nanoparticles for analyte detection

A description of a nanoparticle system containing a set of nucleic acid domains within its nano pores. When exposed to a biological sample, the nucleic acids present interact with those entrapped in the nanoparticle and can be detected by differences in ionic current through the nanopore. This is a multiplex sensor for selected biomarkers.

US-10898595- Core-satellite nanocomposites for MRI and photothermal therapy

The present invention provides methods, compositions, systems, and kits comprising core-satellite nanocomposites useful for photothermal and/or MRI applications.

US-10883984- Method for preparing nanocomposite and label-free aptamer electrochemical sensor of gamma-interferon based on the nanocomposite

A method for preparing an electrochemical sensor of gamma interferon based on a dendrimer/gold nanoparticle/molybdenum disulfide nanocomposite is described. The nanoparticle complex is connected to an electrode where a linear relationship between current intensity and concentration of the analyte is observed.

 

Pharma

US-10925912- Preparation and application of ginseng derived membranous microparticles

This invention discloses a ginseng-derived nanoparticle. The nanoparticle has a membrane structure, a particle size ranging from 150 to 500 nm and a peak particle size of 280 to 350 nm; Areas of application are thought to be in development of drug products that incorporate natural immunopotentiators and natural anti-tumor drugs.

US-10906944- Stabilized coronavirus spike (S) protein immunogens and related vaccines

A description of a nanoparticle vaccine containing stabilized coronavirus spike proteins. Also included is a description of using the vaccine compositions in various therapeutic applications.

US-10905773- Methods and compositions for treating multiple sclerosis and related disorders

This disclosure provides therapeutic compositions and methods for treating multiple sclerosis or a multiple sclerosis-related disorder. The system described is an antigen-MHC-nanoparticle complex wherein the antigen is a multiple sclerosis-related antigen.

US-10905762-Targeted nanoparticle conjugates

A composition for treating a disorder in a subject includes a PEGylated nanoparticle, at least one hydrophobic therapeutic agent coupled to the surface of the nanoparticle; and at least one targeting moiety coupled to polyethylene glycol of the nanoparticle for targeting the composition to a cell associated with a given disorder.

US-10905637- Peptide nanoparticles and uses therefor

Nanoparticle compositions including one or more peptides are described in this patent. The system achieves transdermal delivery of such peptides without the need for peptide modification, or for use of chemical or mechanical abrasion or disruption of skin.

US-10898436- Nanoparticle compositions for generation of regulatory T cells and treatment of autoimmune diseases and other chronic inflammatory conditions

The present invention relates to nanoparticles for the targeted delivery of antigen to liver sinusoidal endothelial cells and/or Kupffer cells, resulting in generation of regulatory T cells. The invention disclosure provides pharmaceutical compositions and methods for the prevention and treatment of autoimmune diseases, allergies or other chronic inflammatory conditions, and for generation of regulatory T cells. The nanoparticles are described as micelles with a peptide T-cell epitope on the surface of the particle. The micelle may or may not comprise a solid hydrophobic core.

US-10894043- Pharmaceutical composition

This invention is described as an endothelial growth factor receptor inhibitor in a nanoparticle as an ophthalmic disease therapeutic.

US-10894020- Hybrid nanoparticles containing boron-doped graphene quantum dots and applications thereof

A description of a nanoparticle containing boron-doped graphene quantum dots. The nanoparticle contains pH-sensitive dendrimers that can be associated with different therapeutics. Targeting molecules can also be included in this platform technology. A method of disassembly of the nanoparticle using high-frequency magnetic fields is provided as well as an application of the system as a tumor-penetrating drug carrier.

US-10888529- Vehicles for the transfection of miRNAs

The invention herein describes a method of generating a nanoparticle comprising a sorbitan ester, a positively charged substance, and a miRNA. Application of this system as a cancer treatment is described.

US-10881720- Nanoparticles for immune stimulation

The invention describes the process of making an immune-stimulating nanoparticle that may include a polymer substrate comprising a biodegradable polymer and may include at least one antigen and/or at least one adjuvant.

US-10881612- Cationic liposomes for cancer immunotherapy

Disclosed are cationic liposomal compositions comprising immune modulators which exhibit enhanced uptake by mammalian cancer cells, and cause increased cancer cell death and/or an increased release of cancer antigens. Also disclosed are nanoparticle-vectored, immunomodulatory compositions that stimulate antigen presenting immune cells and T-cells.

 

Bio

US-10889720- Phosphor integrated dots nanoparticles and labeling agent using same

This is a description of a fluorescent nanoparticle that could be used as in pathological diagnosis. The nanoparticle contains a hydrophobic fluorescent material in a thermosetting resin matrix.

US-10881740- Passivated magnetic nanoparticles for cell targeting and methods of preparation and use

This invention describes a platform technology containing a magnetic nanoparticle with a passivation layer and a surface entity. This entity could be a targeting molecule such as an antibody or cell surface receptor target.

US-10881735- Phase change nanodroplet conjugates for targeted delivery

A description of a delivery system with a lipid mono- or bi-layer or other polymer layer with a gaseous precursor in the interior. The platform technology can contain therapeutics, prophylactics, or diagnostic nanoparticles and can incorporate a targeting moiety. Once at the desired site, the system can be opened (releasing the payload) using ultrasound radiation in the target region resulting in vaporization of the gaseous precursor.

 

Consumer Products/ Cosmetics

US-10901315- Photosensitive microcapsules

Description of a photosensitive microcapsule. The core material can comprise a benefit agent. The core material can be released from the photosensitive microcapsule upon exposure to an electromagnetic radiation such infrared radiation, visible light, ultraviolet radiation or a combination.

US-10881103- Biocide-encapsulated microcapsule for use in paint

Description of a biocide in a microcapsule for use in paint. The biocide is released in the long term in order to prevent biofouling in the dried paint over time

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