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Nanocarrier System for Oral Anticancer Drug Delivery Using Styrene Maleic Acid Micelles
Significant limiting factors are associated with the oral administration of anticancer drugs, such as their low bioavailability and local toxicity to the GI tract. The encapsulation of these anticancer drugs into a nanomicelle carrier should decrease the toxicity to the GI tract. Also, nanosized formulations can selectively accumulate in the tumor tissue, in turn improving the therapeutic efficacy and safety of these drugs. Poly(styrene-co-maleic acid) micelles were synthesized and loaded with epirubicin in this study of oral uptake and transport.