Antitumor effect of lipopolysaccharide by pulmonary inhalation combined with chemotherapeutic agent

Year
2011
Authors
R. Suzuki, K. Hirota, , Y. Ohishi, H. Taniguchi, H. Inagawa, C. Kohchi, G-I. Soma, H. Terada,
Institutions
Faculty of Pharmaceutical Sciences and Center for Physical Pharmaceutics, Research Institute for Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan j3b07062@ed.noda.tus.ac.jp
Summary

A new drug delivery device using cylindrical block copolymer nanochannels was successfully developed for controlled protein drug delivery applications. According to the hydrodynamic diameter of the protein drugs, the pore size in cylindrical nanochannels could be controlled precisely down to 6 nm by Au deposition. Zero-order release of bovine serum albumin (BSA) and human growth hormone (hGH) by single-file diffusion was realized for up to 2 months without protein denaturation. Furthermore, a nearly constant release of hGH from the drug delivery nanodevice implanted to Sprague Dawley (SD) rats was demonstrated longer than 3 weeks, reflecting the feasibility for long-term controlled delivery of therapeutic protein drugs.

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