July 25 - 29, 2021
CRS is the home for experts dedicated to delivery science, including delivery scientists, engineers, clinicians, and technical professionals. CRS members are creating the future of delivery science and technology through fundamental delivery research, development, regulatory science, and clinical translation. Research published in CRS journals and presented during the Annual Meeting & Exposition offers a breadth of scientific knowledge covering new technologies and science in the multi-disciplinary delivery field.
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New This Month
CRS 2021 Annual Meeting
Drug Delivery and Translational Research (DDTR)
In this Inspirational Note, Dr. Andrew Lewis and coauthors feature an amazing and innovative discovery that is changing the paradigm of oral peptide delivery.
In this Inspirational Note, Drs. Lara Milane and Mansoor Amiji share their insights and reflections on the impact of the recently approved SARS-CoV-2 mRNA vaccines on the present and future of translational nanomedicines.
"A timely and truly insightful Inspirational Note by one of the fathers of nanotechnology & pharmaceuticals.” -Jung Soo Suk, Ph.D., Assistant Professor, The Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine
"In this 'Inspirational Note' you will be inspired by the way industry sees advances in drug delivery and Nanomedicine. Dr. Marianne Ashford talks about the 'increasing momentum'. You should not miss this note if you are interested in translational research." -Prof. Maria José Alonso, Editor-in-Chief of the Drug Delivery and Translational Research (DDTR) Journal, Past President of the Controlled Release Society
Best Paper of the August 2021 Issue of DDTR: Drug Delivery for Fighting Infectious Diseases: A Global Perspective. Guest Editors: Brigitta Loretz, Yu‑Kyoung Oh, Sarah Hudson, Zhen Gu, and Claus‑Michael Lehr.
Summary: The use of natural polysaccharides in nanovaccine carriers impacts immunogenicity and antigen delivery efficacy. In this work, novel carboxymethyl β-glucan:chitosan nanoparticles were developed to deliver ovalbumin (OVA) to immune cells in lymph nodes. Fluorescently labelled OVA-loaded nanoparticles accumulated in the medullary and interfollicular areas of the popliteal lymph node, 12 hours post-subcutaneous injection into the footpad of C57/BL6 mice. The ability of β-glucan to interact with the dendritic cell receptor Dectin-1 is likely responsible for efficient immune cell targeting observed with our formulation. Thermostability was also achieved through lyophilization of antigen-loaded carriers, which remained stable in a powder form for up to one month at 40 °C. Moreover, subcutaneous immunization of mice with a single dose of the OVA-loaded nanoparticles led to induced T cell proliferation and antibody responses, comparable to those achieved with alum-adsorbed OVA, illustrating the potential of these novel nanocarriers in vaccination.
2019 DDTR Best Paper of the Year: Depletion of collagen by losartan to improve tumor accumulation and therapeutic efficacy of photodynamic nanoplatforms
The Best Paper is chosen by the DDTR Editorial Board.
2019 CRS Nanomedicine and Nanoscale Delivery (NND) Best Paper of the Year: Tumor growth inhibition by mSTEAP peptide nanovaccine inducing augmented CD8+ T cell immune responses
2019 DDTR CRS Oral Drug Delivery Focus Group Paper of the Year Award: Loratadine self-microemulsifying drug delivery systems (SMEDDS) in combination with sulforaphane for the synergistic chemoprevention of pancreatic cancer
Drug Delivery and Translational Research is a journal published by CRS, providing a unique forum for the scientific publication of high-quality research that is exclusively focused on translational aspects of drug delivery. The journal is published 6 times a year and will be available online to CRS members as part of their annual dues.
Women In Science
Celebrate International Day of Women and Girls in Science 2021 by watching an update from CRS WIS
The CRS WIS ran two very successful sessions during the virtual CRS2020 Annual Meeting. Prof. Alonso delivered a very inspirational talk about her career in science that prompted a lively Q&A session where participants could ask their questions live, triggering a collegial and warm atmosphere. We are super proud to announce that this year we had over 150 participants of different nationalities and seniorities, of which a fair amount were men, which we warmly welcome. This allowed a virtual mingling with women CRS past presidents, past Women in Science Award Winners, and peers.
Thank you all for making these sessions an outstanding success and especially thanks to Prof. Alonso for willingly sharing her legacy in science and her path to get there. We are looking forward to welcoming your ideas and experiences and to keep us all engaged. Please contact Ruth Schmid with any questions. We also hope to see you face-to-face in Montreal in 2021!