About CRS

CRS is the home for experts dedicated to delivery science, including delivery scientists, engineers, clinicians, and technical professionals. CRS members are creating the future of delivery science and technology through fundamental delivery research, development, regulatory science, and clinical translation. Research published in CRS journals and presented during the Annual Meeting & Exposition offers a breadth of scientific knowledge covering new technologies and science in the multi-disciplinary delivery field.

Learn More

Featured Videos

CRS Leadership Video Series


An Update from the CRS Turkey Local Chapter President, Sevgi Güngör

tuk

An Update from the Bioinspired and Biomimetic Delivery Focus Group Vice Chair, Md Nurunnabi

bbd

An Update from the CRS South Korea Local Chapter President, Jin-Seok Kim

kor

 

New This Month

Congratulations to the 2022 Best Poster Award winners sponsored by Merck!

Click here to see the winners


Congratulations to the first Volunteer of the Year Award Winner!

Click here to see the winner

CRS 2022 Annual Meeting

Drug Delivery and Translational Research (DDTR)

What's New?

September 2022 Special Issue | Regulatory Framework on Nanomedicine

Guest Editors:  Drs. Kathleen Spring, Klaus-M. Weltring, Adriele Prina-Mello, and Ruth Schmid

Best Paper of the September 2022 Special Issue of DDTR: 
Summary: Biodistribution of nanomedicines is primarily determined by the size, shape, chemical composition, and surface properties of the encapsulating nanoparticles, rather than the loaded active pharmaceutical ingredient payloads. In this work, we show that two clinically relevant nanoformulations, one each based on lipids and polymers, behave very differently in vivo in animals. We quantified the encapsulated payloads as proxy for biodistribution of the nanoparticles. One of the most notable differences was the marked (> 50-fold) difference between the lipidic and polymeric formulations in terms of the measured concentrations in tissue vs. blood. Also, we observed an enrichment of the polymer-encapsulated anticancer drugs (cabazitaxel) in the lung tissue, which warrants further studies towards a possible indication for lung cancer therapy.

Perspective

Role of drug delivery technologies in the success of COVID-19 vaccines: a perspective

This newly published DDTR “Perspective” article discusses the roles of drug delivery technologies in developing safe and efficacious vaccines. We thank Drs. Robert Langer, Pieter Cullis, Olivia Merkel and Mark Prausnitz for sharing their perspectives and insights on this important topic.

Inspirational Note

Inspirational Note by Wim H. De Jong, Robert E. Geertsma & Gerrit Borchard: Regulatory safety evaluation of nanomedical products: key issues to refine

This newly released Inspirational Note discusses critical considerations for the clinical implementation of nanomedicine.

Inspirational note by Martin J. Whitaker, Hiep Huatan and Richard J. Ross

Chronotherapy based on modified-release hydrocortisone to restore the physiological cortisol diurnal rhythm

This Inspirational Note features innovative drug delivery technology that replicates the physiological cortisol diurnal rhythm for chronotherapy.

Inspirational note by James Goodson and Dr. Paul Rota

Innovations in vaccine delivery: increasing access, coverage, and equity and lessons learnt from measles and rubella elimination

In this inspirational note, James Goodson and Dr. Paul Rota provide insightful and timely perspective and discussion regarding the importance of vaccine delivery technology and multidisciplinary efforts to achieve global vaccination and ultimately well-being.

Inspirational note by Dr. Andrew L. Lewis

Development and approval of rybelsus (oral semaglutide): ushering in a new era in peptide delivery

In this Inspirational Note, Dr. Andrew Lewis and coauthors feature an amazing and innovative discovery that is changing the paradigm of oral peptide delivery.

Mansoor Amiji

 Inspirational note by Drs. Lara Milane and Mansoor Amiji

Clinical approval of nanotechnology-based SARS-CoV-2 mRNA vaccines: impact on translational nanomedicine

In this Inspirational Note, Drs. Lara Milane and Mansoor Amiji share their insights and reflections on the impact of the recently approved SARS-CoV-2 mRNA vaccines on the present and future of translational nanomedicines.

A. Florence

Inspirational note by Alexander (Sandy) T. Florence  Trajectories in nanotechnology: embracing complexity, seeking analogies

"A timely and truly insightful Inspirational Note by one of the fathers of nanotechnology & pharmaceuticals.”  -Jung Soo Suk, Ph.D., Assistant Professor, The Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine

Inspirational Note from Dr. Marianne Ashford, Senior Principal Scientist in Glocal Advanced Drug Delivery Group in Pharmaceutical Sciences at AstraZeneca "Drug delivery - the increasing momentum"  

"In this 'Inspirational Note' you will be inspired by the way industry sees advances in drug delivery and Nanomedicine. Dr. Marianne Ashford talks about the 'increasing momentum'. You should not miss this note if you are interested in translational research." -Prof. Maria José Alonso, Editor-in-Chief of the Drug Delivery and Translational Research (DDTR) Journal, Past President of the Controlled Release Society

Inspirational Note from Dr. Robert Langer

"From micro to nano: evolution and impact of drug delivery in treating disease"

In this Inspirational Note, Robert Langer and Jeff Hrkach highlight the technological evolution of drug delivery from micro to nano, providing examples of clinically approved medicines that demonstrate the significant impact of the drug delivery field on treating many diseases.


DDTR 2020 Best Paper

2020 DDTR Best Paper of the Year: Translational studies of intravenous and intracerebroventricular routes of administration for CNS cellular biodistribution for BMN 250, an enzyme replacement therapy for the treatment of Sanfilippo type B.

2019 DDTR Best Paper of the Year: Depletion of collagen by losartan to improve tumor accumulation and therapeutic efficacy of photodynamic nanoplatforms

The Best Paper is chosen by the DDTR Editorial Board.

2019 CRS Nanomedicine and Nanoscale Delivery (NND) Best Paper of the Year: Tumor growth inhibition by mSTEAP peptide nanovaccine inducing augmented CD8+ T cell immune responses

2019 DDTR CRS Oral Drug Delivery Focus Group Paper of the Year Award: Loratadine self-microemulsifying drug delivery systems (SMEDDS) in combination with sulforaphane for the synergistic chemoprevention of pancreatic cancer

DDTR Videos

Editor-in-Chief Article

Drug Delivery and Translational Research is a journal published by CRS, providing a unique forum for the scientific publication of high-quality research that is exclusively focused on translational aspects of drug delivery. The journal is published 6 times a year and will be available online to CRS members as part of their annual dues.

Drug Delivery and Translational Research Editors

Drug Delivery and Translational Research Editorial Board

    

 

Women In Science

Visit the WIS Page

Update from Women in Science Chair, Maria Jose Alonso 

mja

 

Annual Meeting Women In Science Keynote 

Women in Science

The CRS WIS ran two very successful sessions during the virtual CRS2020 Annual Meeting. Prof. Alonso delivered a very inspirational talk about her career in science that prompted a lively Q&A session where participants could ask their questions live, triggering a collegial and warm atmosphere. We are super proud to announce that this year we had over 150 participants of different nationalities and seniorities, of which a fair amount were men, which we warmly welcome. This allowed a virtual mingling with women CRS past presidents, past Women in Science Award Winners, and peers.

Thank you all for making these sessions an outstanding success and especially thanks to Prof. Alonso for willingly sharing her legacy in science and her path to get there. We are looking forward to welcoming your ideas and experiences and to keep us all engaged. Please contact Ruth Schmid with any questions. We also hope to see you face-to-face in Montreal in 2021!