Drug Delivery and Translational Research

CRS members receive a free online subscription   

Drug Delivery and Translational Research is a journal published by CRS, providing a unique forum for scientific publication of high-quality research that is exclusively focused on translational aspects of drug delivery. The journal is published 6 times a year and will be available online to CRS members as part of their annual dues.

Access DDTR Online                Editor-in-Chief Article                Enjoy Articles of DDTR

We welcome research focused on the following areas of translational drug delivery research:

  • Designing and developing novel drug delivery systems, with a focus on their application to disease conditions
  • Preclinical and clinical data related to drug delivery systems
  • Drug distribution, pharmacokinetics, clearance, with drug delivery systems as compared to traditional dosing to demonstrate beneficial outcomes
  • Short-term and long-term biocompatibility of drug delivery systems, host response
  • Biomaterials with growth factors for stem-cell differentiation in regenerative medicine and tissue engineering
  • Image-guided drug therapy
  • Nanomedicine
  • Devices for drug delivery and drug/device combination products

In addition to original full-length papers, communications, and reviews, the journal will also include editorials, reports of future meetings, research highlights, and announcements pertaining to the activities of CRS.

DDTR Research Editors          DDTR Editorial Board


Best Paper of the October 2020 Issue of DDTR: Local anesthesia enhanced with increasing high-frequency ultrasound intensity

Summary: The effect of local anesthetics, particularly those which are hydrophilic, such as tetrodotoxin (TTX), is impeded by tissue barriers that restrict access to individual nerve cells. Insonation has been used to disrupt vascular and cell membranes, which can facilitate transport of substances across biological barriers. Using an in vivo model of local anesthetic delivery, we investigated the effect of acoustic intensity on insonation-mediated delivery of local anesthetics to the peripheral nerve. We found that insonation at acoustic intensity greater than 0.5 W/cm2 was capable of enhancing TTX delivery to the peripheral nerve but not bupivacaine, a more hydrophobic local anesthetic. The finding here suggests that the effect of insonation on local drug delivery to the peripheral nerve depends on the hydrophilic/hydrophobic balance of the drug.


Inspirational Note from Dr. Jeff Hrkach and Prof. Bob Langer: "From micro to nano: evolution and impact of drug delivery in treating disease"  

"As editor-in-chief of DDTR, I am honored to bring such inspiration to the DD community. Many thanks to Bob and Jeff!"
Prof. Maria José Alonso, Editor-in-Chief of the Drug Delivery and Translational Research (DDTR) Journal, Past President of the Controlled Release Society


2019 DDTR Best Paper of the Year: Depletion of collagen by losartan to improve tumor accumulation and therapeutic efficacy of photodynamic nanoplatforms


2019 CRS Nanomedicine and Nanoscale Delivery (NND) Best Paper of the Year: Tumor growth inhibition by mSTEAP peptide nanovaccine inducing augmented CD8+ T cell immune responses


2019 DDTR CRS Oral Drug Delivery Focus Group Paper of the Year Award: Loratadine self-microemulsifying drug delivery systems (SMEDDS) in combination with sulforaphane for the synergistic chemoprevention of pancreatic cancer

Read DDTR's First Inspirational Note: Contraceptive technologies for global health: ethically getting to safe, effective and acceptable options for women and men

ISSN: 2190-3948

Maria José Alonso, PhD - University of Santiago de Complotela, Spain