Year
2010
Institutions
Department of Pharmaceutics and Pharmaceutical Chemistry, Center for Nanomedicine, Nano Institute of Utah, Department of Bioengineering, University of Utah, Salt Lake City, UT, 84108, USA, robert.a.price@utah.edu
Summary
The in vivo transfection efficiency of matrix-mediated viral gene delivery by two distinct classes of polymers, namely silk-elastinlike recombinant protein polymers (SELPs) and polyoxypropylene-polyoxyethylene copolymers (poloxamers), was compared in a head and neck squamous cell carcinoma model. Viruses entrapped in SELPs showed higher expression levels in the tumors through day 11, and had statistically significant higher expression levels at day 21. The poloxamer group no longer showed any expression from day 21, while select animals in the SELP group showed expression until day 35.
