Category
Bioactive Materials: Stem Cell and Regenerative Medicines
Year
2012
Institutions
Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, Ontario, M5S 3E5, Canada, Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, Ontario, M5S 3G9, Canada, 3Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario, M5S 3H6, Canada
Summary
Sustained, bioactive release of the oligodendrocyte differentiation factor PDGF-AA was achieved using PLGA nanoparticles dispersed in a hyaluronan/methyl cellulose hydrogel. The encapsulation and release was tuned by controlling protein loading and excipients. Delivery of this system in combination with neural stem/progenitor cells is a promising therapy for the treatment of spinal cord injury.
