Category
Bioactive Materials: Biomaterials
Year
2012
Institutions
Centre de Biophysique Moléculaire, CNRS UPR4301 and Université d’Orléans, France; INSERM U613, Hôpital Morvan - CHU Brest - I3S, Brest, France; Laboratoire Analyse et Modélisation pour la Biologie et l'Environnement, CNRS UMR8587 Université d'Evry Val d'Essonne, Evry, France
Summary
A new triblock poly (2-methyl-2-oxazoline-btétrahydrofurane- b-2-methyl-2-oxazoline) copolymer have been used to solubilize curcumin in water. When used on F508-CFTR cells lines, curcumin-loaded with this triblock copolymer (BR04) induces a restoration of the expression of the mutated CFTR protein in the plasma membrane. This restoration is correlated with the functionality of the redistributed CFTR chloride channel in the plasma membrane. These results show a great potential of triblock copolymers for Cystic Fibrosis treatment.
