A guanidine-substituted polyamidoamine with outstanding antiviral activity against Herpes Simplex Virus, Papilloma Virus, Cytomegalovirus and probably other DNA viruses

Category

Bioactive Materials: Biomaterials

Year

2012

Authors

Paolo Ferruti, David Lembo, Manuela Donalisio, Elisabetta Ranucci, Amedea Manfredi and Roberta Cavalli

Institutions

Dipartimento di Chimica Organica e Industriale, Università degli Studi di Milano, via Venezian 21, 20133 Milano, Italy; Dipartimento di Scienze Cliniche e Biologiche, Ospedale S. Luigi Gonzaga, 10043 Orbassano, Torino, Italy; Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, via P. Giuria 9, 10125 Torino, Italy

Summary

An amphoteric biocompatible polyamidoamine with guanidine side substituents proved very active in vitro and in vivo against HSV and other DNA viruses without eliciting adverse side effects.