Polyspermine imidazole-4, 5-imine, a Chemically Dynamic and Biologically Responsive Carrier System for Intracellular Delivery of siRNA

Category

Rising Suns in Asia

Year

2013

Authors

Shiyue Duan, Weien Yuan, Fei Wu, and Tuo Jin

Institutions

School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China

Summary

We report a structurally simple yet highly functional cationic polymer, polyspermine imidazole-4,5-imine, which accomplishes four of the total five essential tasks to achieve therapeutically feasible delivery of siRNA.