Prolonged Pulmonary Vasodilation by Inhaled Liposomes of Fasudil in Monocrotaline (MCT) Induced Rat Model of PAH

SMANCS, (styrene-maleic acid) copolymer conjugated neocarzinostatin, has been used in Japan for treatment of hepatoma. SMANCS in Lipiodol formulation (SX/Lpd) is administered via the hepatic artery, or the tumor feeding artery. For lung cancer, SX/Lpd can be administered via the bronchial artery. For the enhancement of EPR- effect, we examined the NO-releasing agent, isosorbide dinitrate (ISDN), in the advanced lung cancer patients and the clinical effect of SX/Lpd was evaluated. This procedure was found beneficial.