Pulmonary Delivery of Liposomal Ciprofloxacin

This study tests the efficacy of inhalable liposomes of fasudil, a novel Rho-kinase inhibitor, in providing sustained pulmonary vasodilation in monocrotaline induced rat model of pulmonary arterial hypertension (PAH), thus eliminating the need for multiple dosing. The results indicated that a single administration of inhalable liposomes produced a significant decrease in mean pulmonary arterial pressure (MPAP) for up to 3 hrs, while keeping the systemic pressure in the normal range.