Stem Cell Derived Nano-Vesicles, A New Delivery Platform for Cancer Targeted Therapy

Category

Emerging Technologies

Year

2013

Authors

Naama Toledano Furman, Limor Sertshuk, Tomer Bronshtein, Yael Lupu, Nitzan Letko, Eyal Winshtein, Limor Baruch, And Marcelle Machluf

Institutions

Faculty of Biotechnology and Food Engineering, Technion – Israel Institute of Technology, Haifa, Israel 32000

Summary

A new delivery system was developed for the targeted treatment of solid tumors. The nano vesicles are derived from mesenchymal stem cells (MSC) plasma membrane, which is specifically recognized by the tumor microenvironment and tumor cells. In vitro and in vivo assays were conducted on a prostate cancer model to reassure that specificity and to evaluate the feasibility of the system to inhibit tumor growth.