Target Specific Systemic Delivery of siRNA and Interferon a Using Gold Nanoparticles for the Treatment of Liver Diseases

Category

Bioactive Materials: Inorganic Nanosystems

Year

2012

Authors

Min-Young Lee, Kitae Park, Jeong-A Yang, Sei Kwang Hahn

Institutions

Department of Material Science & Engineering, School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Kyungbuk 790-784, Korea

Summary

Gold nanoparticles (AuNPs) and hyaluronic acid (HA) have been extensively investigated for various drug delivery applications. In this work, we successfully developed a cysteamine modified AuNPs (AuCMs) / siRNA / polyethyleneimine (PEI) / HA complex using the layer-by-layer method for the target specific intracellular delivery of siRNA by HA receptor mediated endocytosis. In addition, interferon α (IFN α) and thiol end group functionalized HA (HA-SH) were complexed to AuNPs, which were successfully exploited for the target specific systemic treatment of hepatitis C virus infection. Taken together, we could confirm the feasibility of the smart nanomedicines using the hybrid materials of AuNPs and HA for the treatment of liver diseases.