Targeted Nano-NRTI Formulations for Suppression of HIV-1 Infection in the Brain

Category

Challenges Around Brain Delivery: Sampling Site Issues and Interspecies Extrapolations

Year

2013

Authors

Serguei V. Vinogradov, Santhi Gorantla, Thulani Senanayake, Edward Makarov, Yaman Lu

Institutions

University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha NE 68198-6025

Summary

A brain-targeted antiviral nanoformulations of triphosphorylated nucleoside reverse transcriptase inhibitors (nano-NRTI) were developed and evaluated using several in vitro and in vivo models. These drug formulations demonstrated the ability to penetrate the blood-brain barrier (BBB), accumulate in infected macrophages, and inhibit the HIV-1 activity in humanized mouse model of HIV-1 infection in the brain.