This article summarizes selected patents in the area of controlled release or delivery that were published from November 27, 2025 through February 26, 2026. Greater detail on each of these patents is given on the U.S. patent website Patent Public Search | USPTO
General/Industrial Applications
US- 20260054456- THREE-PHASE COMPOSITE, AND PREPARATION METHOD AND USE THEREOF
The disclosure provides a three-phase composite comprising hollow glass microsphere foam filled with carbon fiber tubes. The tubes are arranged in a 2D closest packing manner, with center-to-center spacing of 29.9-34 mm, wall thickness of 0.45-1 mm, and sealed ends.
US- 20260035575- NANOCOMPOSITE STRUCTURES
A functional coating comprised of nanoparticle layers forming two primary surfaces with an interior pore volume between oxide nanoparticles. A binder in the pore volume is covalently bonded to some nanoparticles.
Agriculture
US- 20250386822- MICROCAPSULES CONTROLLING THE DIFFUSION OF AN ACTIVE ORGANIC COMPOUND
The microcapsule features a lipophilic core containing an active organic compound, surrounded by a gelled shell. It has potential uses in various areas including crop/seed treatment, nutrition, cosmetics, pharmaceuticals, decontamination, and care products.
US- 20250386827- PESTICIDES WITH METAL NANOPARTICLE AND CELLULOSIC NANOMATERIAL COMPLEX
A nanocellulose scaffold with modified cellulose nanocrystals (CNCs) and metal nanoparticles conjugated via diamine or quaternary amine. This improves nanoparticle adhesion to plant surfaces, enhancing antibacterial, antifungal, and antiviral effects while reducing reapplication frequency.
Diagnostic/Sensing
US- 20260056190- ULTRASENSITIVE PROTEIN DETECTION USING A PROXIMITY IMMUNOASSAY WITH NUCLEIC ACID TARGET AMPLIFICATION AND PHOTONIC RESONATOR ABSORPTION MICROSCOPY (PINATA)
A highly sensitive assay for detecting and quantifying proteins in a sample. It utilizes a bridge sequence, reporter sequence, proximity probes, solution, antibody-tethered adapters, and a gold nanoparticle (AuNP) probe. A system and method for applying the assay are also provided.
US- 20260035732- METHODS, SYSTEMS, AND COMPOSITIONS FOR DETECTION OF NUCLEIC ACIDS
The disclosure provides methods, compositions, and systems for detecting nucleic acids using nanoparticles with oligonucleotides.
US- 20260014283- ULTRASOUND-SENSITIVE PEPTIDE PARTICLES FOR SPATIALLY RESOLVED MOLECULE DELIVERY AND METHODS OF USING THE SAME
The disclosure provides compositions of cells containing peptide-based nanoparticles with a perfluorocarbon liquid core, their preparation methods, and their use in cellular tracking.
US- 20250375545- COMPOSITIONS OF AND METHODS OF MAKING FERRITIN-BASED IMAGING AGENTS
Imaging agents with a recombinant ferritin fusion protein and a magnetic nanoparticle core used in measuring nephron numbers, and/or imaging organs using modalities like MRI, PET, or SPECT.
US- 20250361547- DIAGNOSTIC MICROPARTICLE PROBE COMPRISING MAGNETIC PARTICLE AND INACTIVATED GENETIC SCISSORS, AND MULTI-DIAGNOSTIC SYSTEM AND METHOD INVOLVING PROBE
The invention provides a diagnostic microparticle probe with a magnetic particle and inactivated genetic scissors, enabling rapid, accurate, and multi-diagnostic capabilities.
US- 20250361569- MULTIPLEXED PATHOGEN DETECTION USING NANOPLASMONIC SENSOR FOR URINARY TRACT INFECTIONS
A nanoplasmonic sensor for molecular characterization of urinary tract infections, usable at point-of-care. Using localized surface plasmon resonance (LSPR) between metal nanoparticles and a dielectric, it detects bacterial nucleic acids.
Pharma
US- 20260055429- POLYMER-BASED NANOPLATFORM FOR MRNA DELIVERY TO MULTIPLE CANCER CELL TYPES AND HUMAN INDUCED PLURIPOTENT STEM CELLS
The disclosure details a nanoparticle for mRNA delivery, featuring a polyethylenimine core with fluorinated groups and an mRNA all within a shell of heparin. It includes targeting agents binding specifically to tumor cells, stem cells, T cells, or MHC antigens. Methods for cell transfection and pharmaceutical compositions are also provided.
US- 20260053731- MICRONEEDLE PARTICLES FOR ENHANCED TOPICAL TRANSDERMAL DRUG DELIVERY
The disclosure describes a microneedle particle for rolling on the skin to penetrate the stratum corneum. It includes a support body with microneedles under 100 μm in length and sharpness under 20 μm. Applications include skin treatment and drug delivery.
US- 20260053954- BENZALDEHYDE ACETAL ACID-DEGRADABLE AMPHIPHILIC LIPID AND SELF-ASSEMBLING PEPTIDES
Compounds comprising a benzaldehyde acetal acid-degradable amphiphilic lipid and self-assembling peptides are incorporated in lipid nanoparticle (LNP) and used to transfect cells.
US- 20260053768- SUSTAINED NITRIC OXIDE RELEASING DRUG DELIVERY SYSTEMS
The disclosure describes drug delivery compositions comprising lipid nanoparticles, a nitric oxide donor, and a hydrogel. Methods for preparation and use in treating diseases addressable with nitric oxide are described.
US- 20260054242- CONTINUOUS PROCESSING SYSTEM AND METHODS FOR INTERNAL AND EXTERNAL
MODIFICATIONS TO NANOPARTICLES
A system for continuous nanoparticle processing with sensors monitoring quality attributes, actuators for adjustments, and a controller ensuring attributes stay within a target range coupled to a software interface.
048022- ENDOTHELIAL DAMAGE AND NANOPARTICLE TARGETING: COMPOSITIONS, PROCESSES, USES
The disclosure presents a nanoparticle-based targeting process to improve drug delivery to tumors and other sites. The invention utilizes the resulting activated platelets present near damaged endothelial cells resulting in binding of the fibrinogen- coated nanoparticles, enhancing delivery efficiency to the target site.
US- 20260048021- NEUTRAL LIPID AND LIPID NANOPARTICLE
Formulation of a lipid nanoparticle containing a neutral lipid capable of suppressing the phase transition of endosomal membranes caused by phosphatidylcholine from being inhibited; and a lipid nanoparticle containing the neutral lipid.
US- 20260048142- METAL-CHELATED POLYPHENOL COMPLEX NANOPARTICLE, DRUG-LIPID PARTICLE,
PREPARATION METHODS FOR THE SAME, AND USES THEREOF
The disclosure presents metal-chelated polyphenol complex nanoparticles as drug carriers. These nanoparticles enable high-efficiency systemic delivery with reduced toxicity compared to cationic lipid-based carriers, ensuring safer and more effective treatments.
US- 20260048023- LIPID NANOPARTICLE COMPRISING A DNA-BINDING PROTEIN
The present disclosure relates to lipid nanoparticles for delivery of DNA, the lipid nanoparticle comprising therein a DNA-binding protein or peptide bound to the DNA and uses thereof.
US- 20260048128- SELF-THERAPEUTIC DRUG DELIVERY SYSTEM FOR NEURODEGENERATIVE DISEASES
Disclosure of a gold nanoparticle core coated with a PEG hydrophilic polymer and linked to a therapeutic agent via a functional linker. It treats Huntington's disease (HD) and enables targeted delivery.
US- 20260041638- MODIFIED APOLIPOPROTEINS WITH A TARGETING BODY FOR LIPID NANOPARTICLES
The invention features modified apolipoproteins with targeting bodies, such as antibodies, enabling delivery to specific cells, tissues, or organs. They serve as carriers for payloads, either alone or in lipid nanoparticles, for disease treatment or targeted payload delivery.
US- 20260041644- LIPID NANOPARTICLES FOR DRUG DELIVERY AND METHODS OF USE THEREOF
The disclosure describes lipid nanoparticles composed primarily of phosphatidic acid (PA), monogalactosyldiacylglycerol (MGDG), and digalactosyldiacylglycerol (DGDG) in specific ratios. These nanoparticles are drug delivery systems for treating diseases like inflammatory bowel disease, cancer, and coronavirus infections via oral, intravascular, or intramuscular administration.
US- 20260041643- STEALTH LIPID NANOPARTICLE COMPOSITIONS FOR CELL TARGETING
The present disclosure provides stealth lipid nanoparticle (LNP) compositions engineered to target specific tissues or cells to genetically modify the cells with therapeutic nucleic acid encapsulated in the LNP.
US- 20260042732- SULFUR-CONTAINING COMPOUNDS AND COMPOSITIONS THEREOF FOR DELIVERY OF
NUCLEIC ACIDS
Lipid nanoparticle compositions (LNPs) for treatment of certain diseases and disorders, including liver disorders, as well as kits for the delivery of nucleic acids to various types of cells, including T-cells and hepatocytes, in vivo, ex vivo and in vitro.
US- 20260041778- SHEAR RESPONSIVE APTAMER-BASED CONJUGATE FOR TARGETED DRUG DELIVERY
The invention describes a shear-responsive drug delivery system with a microparticle, aptamer, antibody, and drug for precise therapeutic release. Pathological shear forces trigger aptamer conformational changes, releasing the drug at targeted sites. Antibody functionalization ensures selective drug accumulation for effective localized treatment.
US- 20260034198- NANOZYME-LOADED NUCLEUS PULPOSUS MATRIX HYDROGEL MICROSPHERE
The disclosure presents a nanozyme-loaded nucleus pulposus matrix hydrogel microsphere for treating intervertebral disc degeneration. It utilizes a two-stage temperature-controlled microfluidic system.
US- 20260035338- AMINO LIPID COMPOUND AND LIPID NANOPARTICLE FOR DELIVERING BIOACTIVE
INGREDIENT
Provided are an amino lipid compound for preparing a lipid nanoparticle for delivering an active ingredient and a preparation method.
US- 20260034072- COATED NANOPARTICLES FOR THE TREATMENT OF PERIPHERAL ARTERY DISEASE
A nanoparticle-based composition for treating peripheral artery diseases. The nanoparticle features an exterior cellular membrane coating with an ICAM1 binding ligand for targeted delivery.
US- 20260035410- THERAPEUTIC PEPTIDES AND METHODS OF PEPTIDE DESIGN
The disclosure details TIGIT-binding peptides with dendrimer-based nanoparticle systems. It describes methods for identifying and optimizing peptides through phage display, chemical synthesis, binding affinity testing, and computational modeling to enhance peptide-target binding for therapeutic applications.
US- 20260028310- LIPID COMPOUND AND USES THEREOF
The invention provides a compound, lipid nanoparticle, or nucleic acid nanoparticle complex with good biocompatibility, high transfection efficiency, and low toxicity.
US- 20260014075- IONIZABLE LIPID CONTAINING BIODEGRADABLE ESTER BOND AND LIPID NANOPARTICLES COMPRISING SAME
The disclosure presents an ionizable lipid with a biodegradable ester bond for lipid nanoparticles, enabling stable anionic drug delivery, particularly for nucleic acids, with applications in gene therapy and related fields.
US- 20260015311- AMINO LIPID COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF
The disclosure presents an amino lipid compound, used as a component in lipid nanoparticle preparations for delivering therapeutic agents. Related to another patent by the same inventor (20260015315).
US- 20260014259- PEG TARGETING COMPOUNDS FOR DELIVERY OF THERAPEUTICS
The disclosure provides targeting compounds and lipid nanoparticle (LNP) compositions containing them, which may include ionizable lipids, PEG-lipids, phospholipids, or structural lipids.
US- 20260014094- METHOD FOR PRODUCING A LIQUID COMPOSITION INCLUDING A NANOPARTICLE, AND FORMULATION THEREOF
The method produces a nanoparticle-containing composition with nucleic acids and ionizable lipids by combining reactants in a reactor at specific flow rates. It uses single-pass tangential flow filtration and sterile filtration to isolate and purify the nanoparticles.
US- 20260014077- NOVEL METHODS TO ENHANCE GENE DELIVERY
Nanoparticle preparations with nucleic acids, PEG-lipids, phospholipids, and cholesterol, along with methods for preparation and treatment of diseases.
US- 20260008821- MODIFIED HIV ENVELOPE ANTIGENS AND METHOD OF USE THEREOF
Disclosed herein are modified HIV envelope immunogens, engineered nanoparticle vaccines comprising modified HIV envelope immunogens and methods of use thereof for HIV vaccines.
US- 20260000624- IONIZABLE LIPID CONTAINING BIODEGRADABLE DISULFIDE BOND AND LIPID NANOPARTICLES COMPRISING SAME
An ionizable lipid with a biodegradable disulfide bond for lipid nanoparticles, enabling stable anionic drug delivery including nucleic acid delivery, with applications in lipid nanoparticle-mediated gene therapy.
US- 20260000626- POLYMERIC NANOPARTICLES FOR LONG-ACTING DELIVERY OF A PEPTIDE AND METHODS OF MAKING AND USING THEREOF
The disclosure describes polymeric nanoparticles for sustained peptide delivery, releasing less than 20% initially. It includes methods for micronizing peptides and nanoencapsulation using tailored solvent systems, optimizing particle size, encapsulation efficiency, and release profiles.
US- 20260000612- SUSTAINED-RELEASE MICROPARTICLES CONTAINING DRUG AND PAMOIC ACID
The disclosure provides a sustained-release microsphere with a drug, pamoic acid, and biocompatible polymer for treating diseases like hepatitis B, cancers, endometriosis, and Alzheimer's.
US- 20260000611- HYALURONIC ACID DERIVATIVE PHARMACEUTICAL COMPOSITION AND PHARMACEUTICAL COMPOSITION
A pharmaceutical composition that includes an micro or nanoparticle active ingredient suspended in an aqueous carrier containing a hyaluronic acid derivative, in which the active ingredient has a molecular weight between 100 g/mol and 8000 g/mol.
US- 20260000627- NOVEL LIPID NANOPARTICLE COMPOSITIONS AND USES THEREOF
The invention presents lipid nanoparticles (LNPs) containing sialic acid lipids for targeting Siglec-expressing cells, enabling effective transfection in vitro and targeting in vivo.
US- 20250387530- RADIOPAQUE MONOMER AND EMBOLISATION MICROSPHERES COMPRISING SAME
The invention describes radiopaque embolization microspheres made of hydrophilic monomers, a radiopaque monomer, a hydrophilic crosslinking monomer, and a transfer agent for targeted embolization treatments.
US- 20250387333- CARBON NANOPARTICLE, METHOD FOR PRODUCING THE SAME AND USE OF THE SAME
The disclosure provides a carbon nanoparticle, produced via pyrolysis of sodium alginate and a C₄-C₁₀ diamine. It includes methods for alleviating ocular angiogenesis and for producing the nanoparticle.
US- 20250381213- METHODS FOR LIPID NANOPARTICLE DELIVERY OF CRISPR/CAS SYSTEM
The disclosure describes cancer treatment using lipid nanoparticles delivering a CRISPR/Cas system to target and edit specific cancer genes in cancer cells.
US- 20250375393- PROTEIN-BASED NANOPARTICLE FOR SELF-PACKAGING AND DELIVERING MRNA,
PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION
The method prepares protein-based nanoparticles for mRNA delivery by using three recombinant baculoviruses to infect producer cells, leading to self-assembly of nucleocapsid proteins, envelope proteins, and target RNA into nanoparticles for efficient mRNA packaging and delivery.
US- 20250367127- MICROCAPSULE LOADED WITH AN ACTIVE SUBSTANCE AND COMPRISING A MICROMETRIC OPENING
The disclosure describes a bio-assimilable polymer microcapsule with micrometric openings, loaded with active substances, and its production method. It is designed for treating pathologies like cancer or myopathy.
US- 20250367322- NUCLEOBASE EDITING SYSTEM AND METHOD OF USING SAME FOR MODIFYING NUCLEIC ACID SEQUENCES
The disclosure describes lipid nanoparticle (LNP) compositions for delivering TnpB-based nucleobase editing systems, including TnpB polypeptides, engineered ncRNAs, and optional accessory tools like deaminases or reverse transcriptases.
US- 20250367129- LIPID COMPOUNDS AND USES THEREOF
The disclosure provides compounds for lipid nanoparticle formulations to deliver nucleic acids, including their compositions, preparation methods, and therapeutic applications.
US- 20250367319- TARGETED NANOMEDICINE FOR TREATING FIBROTIC LUNG DISORDERS
The disclosure presents nanoparticle compositions targeting TXNDC5, to deliver inhibitors for treating pulmonary fibrosis and other lung disorders.
US- 20250367329- GENE THERAPY FOR TREATING MITOCHONDRIAL STRESS
Nanoparticles with human UBL5 or its encoding nucleic acid for treating mitochondrial stress-related diseases. It includes expression vectors, pharmaceutical compositions, and methods for gene therapy and targeting CD44 expressing cells.
US- 20250367333- LIPID NANOPARTICLE FOR RADIATION THERAPY, MANUFACTURING METHOD, COMBINATION COMPOSITION, AND KIT
The disclosure describes radiotherapy lipid nanoparticles with a biodegradable lipid core and an external radioactive material as the active ingredient.
US- 20250367008- COMPOSITE HYDROGELS FOR TREATING VASCULAR DEFECTS
The disclosure provides hydrogel compositions for treating vascular defects using non-covalently crosslinked silicate nanoparticles and synthetic polymers with anionic functional groups, enabling electrostatic interactions for stability and therapeutic applications.
US- 20250360172- MICROGEL-ENCAPSULATED IPSC-DERIVED NOTOCHORDAL CELLS FOR TREATMENT OF INTERVERTEBRAL DISC DEGENERATION AND DISCOGENIC PAIN
The disclosure provides iPSC-derived notochordal cell (iNC)-loaded microgels for treating intervertebral disc degeneration and low back pain.
US- 20250361511- NANOPARTICLE COMPOSITIONS CONTAINING SIRP-ALPHA SIRNA FOR TREATMENT OF
CANCER
The disclosure provides nanoparticle compositions with SIRPα siRNA for ovarian cancer treatment, either alone or combined with platinum-based chemotherapy.
Bio
US- 20260055363- A MICROCAPSULE AND METHODS OF MAKING AND USING SAME
The disclosure describes a microcapsule with a polyhydroxy core, a semi-permeable polyampholyte gel shell, and covalent cross-links.
US- 20260041646- NANOPARTICLES AND METHOD FOR TARGETING THE NANOPARTICLES TO BACTERIAL BIOFILMS USING BACTERIAL SURFACE PROTEINS
The disclosure describes a thermally responsive nanosphere with a gold core, functionalized polyethylene glycol, and an R2ab fusion protein. It treats biofilms by binding nanospheres to the biofilm prior to laser irradiation.
US- 20260035423- PLATELET LYSATE-BASED MICROPARTICLES, METHODS AND USES THEREOF
The disclosure describes a process to create protein-based bioactive microparticles from platelet lysates by controlled precipitation. Use cases cited include tissue engineering, disease modeling, and others
US- 20260014273- RNA ROOM-TEMPERATURE STORAGE STABILIZER, RNA PRODUCT, AND PREPARATION
METHOD AND USE THEREOF
An RNA room-temperature storage stabilizer using functionalized polystyrene microspheres, enabling stable RNA storage without ultra-low temperatures. Recovery of the RNA using water is described.
US- 20260000810- KAOLIN-BASED HEMOSTATIC MATERIAL WITH ANTI-INFLAMMATORY FUNCTION AND
PREPARATION METHOD AND USE THEREOF
The disclosure describes a low-cost kaolin-based hemostatic material with anti-inflammatory properties, using CeO₂ nanoparticles.
US- 20260002303- PROCESS FOR MANUFACTURING A POTENTIATING PROTEIN COMPOSITION WITH INCREASED EFFICIENCY AND LONGEVITY AND USES THEREOF
A nanoparticle composition with nanoparticles, polymers, and proteins. It is manufactured through a two-step process and can incorporate a variety of materials for different actives and applications.
Consumer Products/ Cosmetics
US- 20260047711- RUG CORNER PET-CHEWING PREVENTION DEVICE
The pet-chewing prevention device features a durable, flexible body fitting rug or furniture corners. It incorporates encapsulated repellents, textured surfaces, and non-slip features for stability, along with fasteners for secure installation on various floor types.
US- 20260035566- MICROENCAPSULATED GARDENIA YELLOW PIGMENT AND A PREPARATION METHOD
THEREOF
The invention presents a pH-responsive microencapsulation method for gardenia yellow pigment. The microcapsule enhances light and heat resistance while regulating release, slowing it in acidic conditions.
US- 20260021030- FRAGRANCE-CONTAINING MICROPARTICLES
The disclosure describes fragrance-containing polymer microparticles with enhanced hair substantivity for longer- lasting fragrance retention.
US- 20250387771- COMPOSITION COMPRISING BIODEGRADABLE MICROCAPSULES
A microcapsule composition with a biodegradable encapsulating material and preservation agents, resisting microbial growth and leakage during production and storage, while ensuring controlled delivery of functional materials in consumer products.
US- 20250380709-PROCESSING AID FOR THE PREPARATION OF DOUGHS FOR BAKERY PRODUCTS
The disclosure describes a dough aid with microcapsules containing viable lactic acid bacteria, enclosed in a gellable biopolymer casing for use in baked food preparation.
US- 20250359580- DOUBLE-LAYER COATED MICROPARTICLES AND PREPARATION THEREOF
A double-layer coated microparticle for protecting bioactive substances, featuring a bioactive core, a hydrophobic antioxidant inner layer, and a solid fat outer layer.
US- 20250360088- CHARGE MODIFIED CHITOSAN CROSS-LINKED ENCAPSULATE
A polyurea-chitosan core-shell delivery particles with a modified chitosan shell. Modifications improve release, compatibility, and degradation, achieved through reactions with compounds like epoxides or aldehydes, forming covalent bonds with chitosan's amine groups.
