Patent Watch: June - November 2023
This article summarizes selected patents in the area of controlled release or delivery that were issued from June 1, 2023 through November 30, 2023. Greater detail on each of these patents is given on the U.S. patent website Patent Public Search | USPTO
General/Industrial Applications
US- 11852444- Personal Armor Resistant to Pointed Or Sharp Weaponry
A personal armor system that includes a textile-based layer, and an elastomeric coating. The textile-based layer includes a fiber reinforcement and a resin binder. The elastomeric coating is essentially a strain-rate-sensitivity-hardening elastomer that contains is microparticle-filled. The textile-based layer affords ballistic protection; the elastomeric coating affords protection against sharp/pointed objects.
US- 11851536- Precipitation Process for Preparing Polystyrene Microparticles
A process including combining polystyrene and a first solvent to form a polystyrene solution; heating the polystyrene solution; adding a second solvent to the polystyrene solution with optional stirring whereby polystyrene microparticles are formed via microprecipitation. The polystyrene microparticle formed has a spherical morphology, a particle diameter of greater than about 10 micrometers, and a weight average molecular weight of from about 38,000 to about 200,000 Daltons.
US- 11826721- Metal Nanoparticle-deposited, Nitrogen-doped Carbon Adsorbents for Removal Of Sulfur Impurities In Fuels
Metal nanoparticle-deposited, nitrogen-doped carbon adsorbents are disclosed, along with methods of removing sulfur compounds from a hydrocarbon feed stream using these adsorbents.
US- 11807797- Dynamic Thermal Infrared Stealth Composite Material Based on Dual Phase Change And Preparation Method Thereof
A dynamic thermal infrared stealth composite material based on dual phase change is a phase change thermal storage thin layer composite material composed of a nanoparticle coating and a mica-based phase change thermal storage thin layer. The dynamic thermal infrared stealth composite material can synergistically reinforce thermal infrared stealth performance.
US- 11796517- Multifunctional Magnetic Tags for Mud Logging
Compositions and methods containing a nanoparticle tag including a superparamagnetic iron oxide core, an intermediate layer including a fluorescent dye, and a polymer shell. The nanoparticle tag can be used to determine the origin location of a subterranean sample by mixing the nanoparticle tag into a fluid, flowing the fluid into a subterranean formation, recovering subterranean samples from the subterranean formation, and separating tagged samples from untagged samples using a magnet. The origin location of the subterranean sample can be determined by analyzing the fluorescent signal of the nanoparticle tag.
US- 11754374- Energy Absorbing Nanocomposite Materials and Methods Thereof
Composite materials made up of elastomers and reinforcing nanoparticle materials capable of absorbing and dissipating high energy forces such as ballistic impacts and explosive blasts are described. Composites can be configured as nonwoven webs and can be layered.
US- 11746243- Silicone-based Protective Formulations
Self-healing compositions, method of preparation and uses thereof are disclosed. In an example, a self-healing composition includes two distinct microcapsules. The self-healing composition releases and mixes contents of the first microcapsule and the second microcapsule upon the rupture thereof, imparting a passively initiated repair process.
US- 11739252- Microbicidal Composition and A Method For Mitigating Internal Microbiological Influenced Corrosion In Petroleum Transporting Pipelines
The present invention provides a composition and a method for mitigating formation or activity of a corrosion-associated biofilm on metal surfaces of pipelines. The composition contains corrosion inhibitors, surfactants, biocides and a lignan-based microparticle. The nano particle is functionalized with amine functionalizing agent.
US- 11708274- Synthesis of Polyethyleneimine-silica Janus Nanoparticles
An asymmetrically functionalized nanoparticle and a method for synthesizing it are provided.
US- 11692440- Polymer Nano-clays As Multifunctional Mud Logging Barcode Tracers
A method includes introducing into a drilling fluid a clay nanoparticle with a polymer embedded. The tags are circulated in drilling fluid through a well during a drilling operation such that the tags interact with the formation cuttings, creating tagged cuttings. The returned cuttings are collected at a surface of the well and detected to identify the tagged cuttings.
US- 11685683- High-strength Geopolymer Hollow Microsphere, Preparation Method Thereof and Phase Change Energy Storage Microsphere
A high strength geopolymer hollow microsphere loaded with a phase change material for energy storage is provided.
US- 11667831- Enzyme-encapsulated Hydrogel Nanoparticles for Hydraulic Fracturing Fluid Cleanup
Provided herein is a hydraulic fracturing fluid containing enzyme encapsulated hydrogel nanoparticles and a breaker composition of a viscosities-degrading enzyme encapsulated in the hydrogel nanoparticle to improve transport and placement of the proppant and to facilitate subsequent cleaning of the fracturing fluid.
Agriculture
No patents in this industry area were observed over this time period using the search method employed.
Diagnostic/Sensing
US- 11851592- Quantum Dot-containing Nanoparticle and Method for Manufacturing Same
A quantum dot-containing nanoparticle with improved luminous efficiency (QY) and brightness when detecting a biological sample (biomolecule).
US- 11827920- Nanostructure, A Biosensor Including the Nanostructure, And A Screening Method
Disclosed is a nanoparticle, a probe bound to the surface of the nanoparticle, and a DNA sequence encoding the probe and bound to the surface of the nanoparticle. The nanostructure is used in screening interactions of samples with the specific DNA sequences.
US- 11697838- Oligonucleotide-functionalized Hydrophobic Polymer Nanoparticles
The present invention concerns an oligonucleotide-functionalized hydrophobic polymer nanoparticle. The nanoparticle is a dye-loaded polymeric nanoparticle, functionalized by: (a) target-specific oligonucleotides, and/or (b) non-specific oligonucleotides.
US- 11698372- Near Infrared Fluorescent Biosensors for Steroid Hormones
Corona Phase Molecular Recognition utilizing a template heteropolymer adsorbed onto and templated by a nanoparticle surface to recognize a specific target analyte can be used for macromolecular analytes, including proteins.
Pharma
US- 11851389- Cationic Lipids for Nucleic Acid Delivery and Preparation Thereof
The present invention provides cationic lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their intracellular delivery both in vitro and for therapeutic applications.
US- 11850294- Buffered Microencapsulated Compositions and Methods
A microcapsule composition with a polymer as a semipermeable shell around an aqueous buffered solution with an active suitable for delivery to a mammal.
US- 11844829- Microparticles from Streptococcus Pneumoniae as Vaccine Antigens
An isolated Streptococcus pneumoniae membrane vesicle microparticle is described with uses in immunizations.
US- 11833255- Nanoparticles with PH Triggered Drug Release
Provided is a nanoparticle comprising a pH-responsive polymer, a pH-insensitive polymer, and a payload molecule. The nanoparticle can act as a system for delivery of the payload that releases the payload in a pH sensitive manner.
US- 11833256- Selective RARγ Ligand-loaded Nanoparticles for Manipulation Of Targeted Bone Growth
The invention relates to a pharmacotherapeutic strategy that targets the endochondral ossification process in a pharmacologically selective and site-specific manner. The invention consists of a RARy agonist and antagonist nanoparticle for treating abnormal endochondral ossification and bone growth.
US- 11833132- Method of Synthesis of A Nanocomposite Including Silymarin-loaded Collagen Nanoparticles
A method of synthesizing silymarin-loaded collagen nanoparticles is provided.
US- 11826418- Virus-like Particle (VLP)-based Vaccine Against CVB4
The virus-like particle (VLP)-based vaccine against CVB4 infection includes a virus-like particle (VLP) derived from VP1 of Coxsackievirus B4 (CVB4). The vaccine is devoid of virus RNA. The virus-like particles may be in nanoparticle form and coated with a polymer coating such as albumin.
US- 11820728- Carbonyl Lipids and Lipid Nanoparticle Formulations For Delivery Of Nucleic Acids
Compounds are provided having one of the following structures with potential use as a component of lipid nanoparticle formulations for delivery of a therapeutic agent.
US- 11801304- Formulated And/or Co-formulated Liposome Compositions Containing TFGB Antagonist Prodrugs Useful In The Treatment Of Cancer And Methods Thereof
Formulated and/or co-formulated liposomes (LNP) and solid-lipid nanoparticles (SLNP) comprising TB Prodrugs are disclosed herein to provide a method of treating cancer, immunological disorders, and other disease.
US- 11801308- Drug Delivery Vehicle, Drug Delivery System and Methods Thereof
The drug delivery vehicle includes a lipid nanoparticle core for enclosing a primary drug and a protective shell surrounding the lipid nanoparticle.
US- 11801228- Modified Guanidine-containing Polymers for Biologic Delivery
Provides materials and methods for intracellular delivery of molecules and/or therapeutic agents as well as methods for synthesizing polymeric systems and nanomaterials that enhance or assist the passage of molecules and/or therapeutic agents across biological membranes with potential uses in cancer treatment.
US- 11793756- Anionic Nanocomplexes for Nucleic Acid Delivery
A nanoparticles delivery system with cationic core comprising a peptide having a polycationic nucleic acid binding component, a cleavable spacer element and a cell surface receptor binding component; a nucleic acid and optionally a cationic lipid; and an anionic liposomal coating surrounding the cationic core, said coating comprising lipids from a subject's cells.
US- 11795454- Targeted Delivery System
A targeted delivery system for siRNA or antisense technology for the treatment of cancer using a targeting protein and siRNA to bring about cell death.
US- 11786468- Nanoparticles
A lipid nanoparticle formulation is provided. The release can be triggered by focused ultrasound (FUS) applied to a desired part of the body to induce hyperthermia resulting in controlled release of the drug at the desired site of the body. Lipid nanoparticles can be labelled enabling real time monitoring of the drug in the body.
US- 11786469- Silica Nanoparticle Composition for Delivering Bioactive Material Or Protein Such As A Human Proteasome
A composition for delivering a bioactive material include a porous silica nanoparticle containing pores, loaded with a bioactive material.
US- 11786607- RNA Formulations
This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins.
US- 11786609- Lipid Compound as well as Lipid Vector, Nucleic Acid Lipid Nanoparticle Composition, and Pharmaceutical Preparation Comprising the Same
A formulation exhibiting a pH responsiveness, with high encapsulation efficiency for nucleic acid drugs, and high in-vivo delivery efficiency of nucleic acid drugs with applications in gene therapy is described.
US- 11771676- Method for Preparing High-load Oral Paclitaxel Capsule for Slow Release In Colon
Disclosed is a method for preparing high-load oral paclitaxel capsule for a slow release in colon by encapsulation within a porous starch microsphere.
US- 11766409- Core-shell Polymer Nanoparticle
A method of forming a core-shell polymer nanoparticle encapsulating an active agent is disclosed using a multi-solvent system to generate the formulation allowing for a greater degree of control compared to the use of a single solvent.
US- 11759521- Photo-immunoconjugate Formulations and Methods of Treatment Relating Thereto
Photo-immunoconjugate formulations comprising a nanoparticle carrier comprising first and second therapeutic agents coupled to a nanoparticle carrier, and a photosensitizer molecule for treating cancer via administration of the photo-immunoconjugate formulations.
US- 11752206- Herpes Simplex Virus Vaccine
Herpes simplex virus (HSV) ribonucleic acid (RNA) vaccines formulated as a lipid nanoparticle comprising at least one cationic lipid.
US- 11752104- Oral Composition and Methods for Manufacturing the Same and Treatment
An oral composition includes an immediate-release and an extended-release admixture. The immediate-release component includes an active ingredient and a hydrophilic dispersant, in which the active ingredient is substantially insoluble in water. The extended-release portion includes a nanoparticle-encapsulated active.
US- 11744801- Methods of Making Lipid Nanoparticles
Novel methods of producing nucleic acid lipid nanoparticle (LNP) compositions employing a modifying agent after formation of a precursor nucleic acid lipid nanoparticle with applications in gene therapy.
US- 11744804- Microcapsule Powder Stable in Gastric Acid, Method for Preparing Same, And Use Thereof
The present invention discloses a microcapsule powder stable in gastric acid with a shell that has a melting pointer greater than 42C, is stable under gastric conditions but decomposes when exposed to intestinal digestive enzymes.
US- 11744897- Folate Receptor Targeted Nanoparticle Drug Conjugates and Uses Thereof
The disclosure relates to nanoparticle drug conjugates (NDC) that comprise ultrasmall nanoparticles, folate receptor (FR) targeting ligands, and linker-drug conjugates, and methods of making and using them to treat cancer.
US- 11737979- Method of Making Lipid-encapsulated RNA Nanoparticles
A method of producing a lipid-encapsulated RNA nanoparticle wherein the lipid-encapsulated RNA nanoparticles have a bilayer structure.
US- 11731099- Method for Controlling Encapsulation Efficiency and Burst Release of Water-Soluble Molecules from Nanoparticles And Microparticles Produced By Inverse Flash Nanoprecipitation
An inverted Flash Nano Precipitation (iFNP) process and subsequent processing steps is presented. The encapsulation efficiency of the soluble agent in the particles and the burst release of the soluble agent from the particles can be controlled by the copolymers used, the degree of crosslinking of the nanoparticle core, the incorporation of small molecule or polymeric additives, and/or the processing and release conditions employed.
US- 11730793- Sustained Release Formulations Using Non-Aqueous Emulsions.
Non-aqueous emulsion methods for producing polymeric or polymer-coated microparticles using emulsion-based solvent evaporation/extraction are provided.
US- 11731100- Microparticle Producing System Which Comprises Carrying Fluid, And A Controlling Method Thereof
A microparticle producing system using microfluidics that may stably transport droplets produced using microfluidics without agglomeration or destruction, compared to the conventional art is described.
US- 11717548- Synthetic Oncolytic LNP-replicon RNA And Uses for Cancer Immunotherapy
Relates to synthetic oncolytic viruses comprising a lipid nanoparticle comprising one or more types of lipids and a self-amplifying replicon RNA comprising a sequence that encodes an immunomodulatory molecule.
US- 11717490- Therapeutic Nanocarrier System and Methods Of Use
A nanoparticle for treatment of cancer is provided comprising a poloxamer surfactant, a Vitamin E TPGS and an anticancer compound.
US- 11701433- Complexes for Delivery Of Antigenic Peptides
The present invention provides formulations comprising nano-satellite complexes and/or serum albumin carrier complexes, used for modulating antigen-specific immune response.
The nano-satellite complexes comprise a core nanoparticle complex with a biocompatible coating surrounding a nanoparticle core, at least one satellite particle attached to, or absorbed to, the biocompatible coating, and an antigenic component, and an interferon agonist.
US- 11696959- Nanoparticle-cell Construct with Platinum Anti-cancer Agent
Formulations comprising cell-nanoparticle constructs and drug loaded nanoparticles for the treatment of cancer.
US- 11696901- Curcumin Nanoparticle and Preparation And Application Thereof
Disclosed is a curcumin nanoparticle, including curcumin as core material and a wall material combined with gum arabic and zein. Application of the nanoparticles in a beverage formulation is provided.
US- 11690922- Lipid Compound as Well as Lipid Carrier, Nucleic Acid Lipid Nanoparticle Composition And Pharmaceutical Preparation Containing Same
A series of lipid compounds and a lipid carrier formulation for nucleic acid lipid nanoparticle formulations that exhibits pH response for release of payload with high entrapment efficiency. Additionally, a lipid compound with a specific structure can be chosen as a carrier based on an organ in which the nucleic acid is to be targeted.
US- 11684579- Multi-vesicular Liposomes for Targeted Delivery of Drugs and Biologics For Tissue Engineering
A multivesicular liposome composition wherein each multivesicular liposome includes a carrier liposome particle and at least one sub-chamber liposome nanoparticle.
US- 11679163- Compositions and Methods for Delivery Of RNA
Nano emulsion compositions to deliver a bioactive agent such as a nucleic acid to a subject. The formulation comprises a hydrophobic core based on inorganic nanoparticles in a lipid nanoparticle that allows imaging as well as delivering nucleic acids.
US- 11672825- Acetic Acid and Hypochlorous Acid Compositions for Treatment of Biofilms And Wound Care
Disinfecting compositions containing hypochlorous acid and acetic acid. Compositions may be provided in gel form and may include nanoparticle encapsulated molecules for controlled release.
US- 11672861- Prussian Blue Nanoparticles Functionalized with Immune Signals and Applications Thereof
Nanocomposites comprised of a core nanoparticle formed of Prussian blue materials, a shell obtained by partially or completely encapsulating the Prussian blue core with a biocompatible coating, and at least one biomolecule attached to, or absorbed to, the biocompatible coating and uses thereof.
US- 11666515- Phosphate Crosslinked Starch Nanoparticle and Dental Treatments
A starch nanoparticle crosslinked with STMP is generated in an emulsion process. Negative charges are reduced or reversed by adding cations and/or cationizing the starch. Anionic active agents, such as fluoride or fluorescein, are optionally incorporated into the nanoparticle during the formation process. The nanoparticles may be useful for tooth remineralization, the treatment of dentinal hypersensitivity, to treat caries, or as a diagnostic agent.
Bio
US- 11850263- Nanoparticles Conjugated with Vasoactive Intestinal Peptide Antagonists
Formulations comprising an antagonist of vasoactive intestinal polypeptide signaling coupled to a nanoparticle. In certain embodiments, the nanoparticle is a poloxamer-stabilized polypropylene sulfide nanoparticle.
US- 11851592- Quantum Dot-containing Nanoparticle and Method for Manufacturing Same
The present invention relates to a quantum dot-containing nanoparticle wherein the nanoparticle exhibits improved luminous efficiency (QY) and brightness when detecting a biomolecule.
US- 11844874- Lyophilized Polymer Scaffold Compositions, Processes for Preparation and Use in Anabolic Wound Repair
A lyophilized scaffold with a polysaccharide that when contacted with a neutral aqueous solution, blood, blood derived fluid and/or combination, it forms a microparticle dispersion and stimulates tissue remodeling and anabolic wound repair.
US- 11795502- Method for Multiplying Nucleic Acids
Nanoparticles conjugated with an oligonucleotide used to multiply nucleic acids via PCR.
US- 11788058- Protein-modified PLGA Microsphere and Tissue-engineered Nerve Constructed Therewith
A protein-modified PLGA microsphere used to construct tissue-engineered nerve. The microspheres are loaded with active substances for treating peripheral nerve injury and are bound to tissue-engineered nerves.
US- 11732277- Cellular Production of Pure Iron Oxide Nanoparticles
A method for producing high purity iron oxide nanoparticles using nanoparticle-producing cells.
US- 11731098- Method for Extracting Nerve Tissue-derived Exosomes
Ag—Fe3O4 immunomagnetic microsphere contains poly-D-lysine modified on the surface and S100β and/or MBP antibody linked by an amide bond. The microsphere can capture peripheral nerve tissue-derived exosomes.
US- 11668706- Near-infrared II Polymer Fluorescent Microsphere and Method for Preparing Same
Provided are a near-infrared II polymer fluorescent sub-microsphere formulation. The method includes steps of 1) dissolving fluorochrome in a water-immiscible organic solvent ; 2) distributing a polymer sub-microsphere into a sodium dodecyl sulfonate solution; 3) subjecting a first mixture of the fluorochrome solution and the sub-microsphere solution to ultrasonic treatment; 4) swelling the emulsion such that the fluorochrome solution enters nanopores formed during swelling of the polymer sub-microsphere; and 5) heating the second mixture to volatilize the organic solvent, such that the fluorochrome is crystallized out and encapsulated in the nanopores.
Consumer Products/ Cosmetics
US- 11839622- Consumable Nutraceutical Composition
A formulation of apigenin, phenylethylamine, nicotinamide mononucleotide and/or nicotinamide riboside, and resveratrol, anthocyanin, and/or pterostilbene and piceatannol. The composition may be microencapsulated and selectively added to a consumable substance, such as a fluid, jell, or the like. The composition may be used to increase the consumer's levels of energy, alertness, and activate the body's natural chemical that prevent anxiety and depression.
US- 11826474- Nano-lipid Carrier for Encapsulation Of Bioactive Material, And Method For Producing Same
A particulate nano-lipid carrier for the encapsulation of a bioactive material having excellent nanoparticle stability and improved encapsulation of water-soluble drugs. A specific application in cosmetics to target hair follicles for delivery is described.
US- 11813763- Razor Blades
A razor blade with a coating containing expanded polymer microspheres including a gas encapsulated within a hollow thermoplastic polymer shell. A skincare device.
US- 11793319- Bedding or Seating Product Having Topper With At Least One Thermally Enhanced Foam Component
A bedding or seating product that can be infused with microencapsulated phase change materials to improve thermal conductivity or heat absorption.
US- 11766387- Cosmetic Composition Showing a Natural and a Healthy-looking Appearance
A cosmetic composition comprising a microcapsule containing at least one iron oxide particle, and a coating containing titanium dioxide. The multilayer interference particles being released from the microcapsule(s) when applied on a keratin material such as keratin fibers or the skin.
US- 11724942- Method for Preparing a Self-assembled Porous Three-dimensional Zinc Oxide Nanoparticle Structure Using A Microfluidic Device, Zinc Oxide Nanoparticles, An Aggregate Of Zinc Oxide Nanoparticles, And Zinc Oxide Nanoparticle Structure Prepared Therefrom, And A Bio-ink Including The Same
A method for preparing a self-assembled porous zinc oxide nanoparticle structure using a microfluidic device.
US- 11680232- Laundry Detergent Sheet with Microcapsules
A non-fibrous laundry detergent sheet that may include a microcapsule along with a surfactant, and a film former having a thickness ranging from 0.1 mm to 10 mm.
Observations/Thoughts/Trends/Musings
Overall, the number of patents issued during this time frame was less than those in previous patent summaries I’ve drafted. The search parameters and databases queried remained unchanged, but the number of patens (~175) was down from the ~300 I would expect to review over an almost six-month time frame. While patents in the pharmaceutical space once again dominates the document, I was struck by the number of industrial patents as well as the lack of patents issued in agriculture
