CURRICULUM VITAE
Date: October 13th, 2021
Seung Rim Hwang
College of Pharmacy, Chosun University, 309 Pilmun-daero, Dong-gu, Gwangju 61452, Korea
TEL (Lab in Chosun Univ) : +82-62-230-6365
C.P : +82-10-6301-6130
E-mail : srhwang@chosun.ac.kr
EDUCATION
2013 Feb (PhD), College of Pharmacy, Seoul National University
2002 Feb (MSc), College of Pharmacy, Seoul National University
1999 Feb (BSc), College of Pharmacy, Seoul National University
WORK EXPERIENCES
2021 Aug ~ Visiting Scholar at Korea Institute of Science and Technology (KIST)
2019 Sept ~ (Associate Professor)
2018 Jul ~ 2020 Jul (Chair of the Department of Pharmacy)
2015 Oct ~ 2021 Aug (concurrently with) Department of Biomedical Sciences, Graduate School
2013 Sept ~ 2019 Aug (Assistant Professor) College of Pharmacy, Chosun University
2013 Feb ~ 2013 Aug (Postdoc) Center for Theragnosis, KIST
GRANT
- “스트레스 과립-엑소좀 커뮤니케이션 표적화를 통한 항암면역요법 시너지 효과
연구” (NRF 2019R1F1A1057702)
- KB BIOMED Inc. “엑소좀을 이용한 약물전달시스템 개발” (2019)
- “초저분자량 헤파린의 선택적 탈황화 기술을 이용한 경구용 류마티스 관절염 치료제
개발” (NRF 2016R1D1A1B03933693)
- “엑소좀 표적성 헤파란 설페이트 유사물질을 이용한 전이성 폐암 치료 연구”
(NRF 2014R1A1A2057483)
LIST OF PUBLICATIONS
1. Jeong Man An, SM Shatil Shahriar, Yong Hwa Hwang, Seung Rim Hwang, Dong Yun Lee, Sungpil Cho, Yong-Kyu Lee. Oral delivery of parathyroid hormone using a triple-padlock nanocarrier for osteoporosis via an enterohepatic circulation pathway (2021). ACS Applied Materials & Interfaces, 13(20), 23314-23327
2. Na-Kyeong Lee, Vinoth Kumar Kothandan, Sangeetha Kothandan, Youngro Byun, Seung-Rim Hwang*. Exosomes and cancer stem cells in cancer immunity: current reports and future directions (2021). Vaccines (Basel), 9(5), 441
3. Jooho Park, Yong-Kyu Lee, In-Kyu Park, Seung Rim Hwang*. Current limitations and recent progress in nanomedicine for clinically available photodynamic therapy (2021). 2Biomedicines, 9(1), 85
4. Jeong Uk Choi, In-Kyu Park, Yong-Kyu Lee, Seung Rim Hwang*. The biological function and therapeutic potential of exosomes in cancer: exosomes as efficient nanocommunicators for cancer therapy (2020). International Journal of Molecular Sciences, 21(19), 7363
5. Vinoth Kumar Kothandan, Sangeetha Kothandan, Do Hee Kim, Youngro Byun, Yong-Kyu Lee, In-Kyu Park, Seung Rim Hwang*. Crosstalk between stress granules, exosomes, tumour antigens, and immune cells: significance for cancer immunity (2020). Vaccines (Basel), 8(2), 172
6. Md. Asadujjaman, Dong-Jin Jang, Kwan Hyung Cho, Seung Rim Hwang, Jun-Pil Jee. Extracellular vesicles: The next frontier in regenerative medicine and drug delivery (2020). Advances in Experimental Medicine and Biology, 1249, 143-160
7. Do Hee Kim, Vinoth Kumar Kothandan, Hye Won Kim, Ki Seung Kim, Ji Young Kim, Hyeon Jin Cho, Yong-Kyu Lee, Dong-Eun Lee, Seung Rim Hwang*. Noninvasive assessment of exosome pharmacokinetics in vivo: a review (2019). Pharmaceutics, 11(12),
649
8. Sumeet Manandhar, Jooho Park, Vinoth K. Kothandan, Joomin Lee, Farzana Alam, Jun-Pil Jee, Jinsu Hwang, Youngro Byun, Seung Rim Hwang*. Properties of heparinoids premixed with tumor-derived extracellular vesicles (2018). Bioconjugate Chemistry, 29(11), 3757-3767
9. Sumeet Manandhar, Vinoth Kumar Kothandan, Jiyun Oh, Sung Hyun Yoo, Jinsu Hwang, Seung Rim Hwang*. A pharmaceutical investigation into exosomes (2018). Journal of Pharmaceutical Investigation, 48(6), 617-626
10. Jooho Park 1 , Seung Rim Hwang 1 , Jeong Uk Choi, Farzana Alam, Youngro Byun. Self-assembled nanocomplex of PEGylated protamine and heparin-suramin conjugate for accumulation at the tumor site (2018). International Journal of Pharmaceutics, 535(1-2), 38-46
11. Jin Woo Park 1 , Seung Rim Hwang 1 , In-Soo Yoon. Advanced growth factor delivery systems in wound management and skin regeneration (2017). Molecules, 22(8), pii: E1259
12. Hasan Al Faruque, Jin Hee Kang, Seung Rim Hwang, Shijin Sung, Md. Mahmudul Alam, Keum Hee Sa, Eon Jeong Nam, Young Ro Byun, Young Mo Kang. Stepwise inhibition of T cell recruitment at post-capillary venules by orally active desulfated heparins in inflammatory arthritis (2017). PLoS One, 12(4), e0176110
13. Seung Rim Hwang, Dong-Hyun Seo, Youngro Byun, Jin Woo Park. Preparation and in vivo evaluation of an orally available enteric-microencapsulated parathyroid hormone (1-34)- deoxycholic acid nanocomplex (2016). International Journal of Nanomedicine, 11, 4231-4246
14. Farzana Alam, Seung Rim Hwang, Taslim A. Al-Hilal, Seung Woo Chung, Hak-Soo Kim, Boo-Hyun Kang, Hu-Song Zhang, Seo-Ho Shin, Joo-Young Lee, Min-Soo Kang, Geum-Hee Kwon, Ok-Cheol Jeon, Sang Yoon Kim, Youngro Byun. Safety studies on intravenous infusion of a potent angiogenesis inhibitor: taurocholate-conjugated low molecular weight heparin derivative LHT7 in preclinical models (2016). Drug Development and Industrial Pharmacy, 42(8), 1247-1257
15. Farzana Alam, Taslim A. Al-Hilal, Jooho Park, Jeong Uk Choi, Foyez Mahmud, Jee-Heon Jeong, In-San Kim, Sang Yoon Kim, Seung Rim Hwang * , Youngro Byun * . Multi-stage 3 inhibition in breast cancer metastasis by orally active triple conjugate, LHTD4 (low molecular weight heparin-taurocholate-tetrameric deoxycholate) (2016). Biomaterials, 86, 56-67
16. Ji-Young Kim, Ok-Cheol Jeon, Hyun Tae Moon, Seung Rim Hwang * , Youngro Byun * . Preclinical safety evaluation of low molecular weight heparin-deoxycholate conjugate as an oral anticoagulant (2016). Journal of Applied Toxicology, 36(1), 76-93
17. Jooho Park, Ji-young Kim, Seung Rim Hwang, Foyez Mahmud, Youngro Byun. Chemical conjugate of low molecular weight heparin and suramin fragment inhibits tumor growth possibly by blocking VEGF165 (2015). Molecular Pharmaceutics, 12(11), 3935-3942
18. Seung Rim Hwang 1 , In Jae Kim 1 , Jin Woo Park. Formulations of deoxycholic for therapy: a patent review (2011-2014) (2015). Expert Opinion on Therapeutic Patents, 25(12), 1423-1440
19. Farzana Alam, Seung Woo Chung, Seung Rim Hwang, Ji-young Kim, Jooho Park, Hyun Tae Moon, Youngro Byun. Preliminary safety evaluation of a taurocholate-conjugated low-molecular-weight heparin derivative (LHT7): a potent angiogenesis inhibitor (2015). Journal of Applied Toxicology, 35(1), 104-115
20. Abid Mehmood Yousaf, Jun-Pil Jee, Seung Rim Hwang, Han-Joo Maeng, Young-Joon Park, Jong Oh Kim, Chul Soon Yong, Han-Gon Choi, Kwan Hyung Cho. Development of direct compression entecavir 0.5 mg-loaded tablet exhibiting enhanced content uniformity (2014). Powder Technology, 267, 302-308
21. Seung Rim Hwang, Youngro Byun. Advances in oral macromolecular drug delivery (2014). Expert Opinion on Drug Delivery, 11(12), 1955-1967
22. Jung Min Shin 1 , Seung Rim Hwang 1 , Roun Heo, G. Saravanakumar, Jae Hyung Park. Amphiphilic hyaluronic acid derivative with the bioreducible bond: Synthesis and its implication for intracellular drug delivery (2014). Polymer Degradation and Stability, 109, 398-404
23. Jin Hee Kang, Seung Rim Hwang, Shijin Sung, Ji Ae Jang, Md. Mahmudul Alam, Keum Hee Sa, Sang-Yeob Kim, In San Kim, Young Ro Byun, Young Mo Kang. Intracellular delivery of desulfated heparin with bile acid conjugation alleviates T cell-mediated
inflammatory arthritis via inhibition of RhoA-dependent transcellular diapedesis (2014). Journal of Controlled Release, 183, 9-17
24. So Jin Lee 1 , Aeju Lee 1 , Seung Rim Hwang, Jong-Sung Park, Jiyeon Jang, Myung Sook Huh, Dong-Gyu Jo, Soo-Young Yoon, Youngro Byun, Ick Chan Kwon, Inchan Youn, Kwangmeyung Kim. TNF-alpha gene silencing using polymerized siRNA/thiolated glycol chitosan nanoparticles for rheumatoid arthritis (2014). Molecular Therapy, 22(2), 397-408
25. Seung Rim Hwang, Sook Hee Ku, Min Kyung Joo, Sun Hwa Kim and Ick Chan Kwon. Theranostic nanomaterials for image-guided gene therapy (2014). MRS Bulletin, 39(1), 44-50
26. Seung Rim Hwang, Kwangmeyung Kim. Nano-enabled delivery systems across the blood-brain barrier (2014). Archives of Pharmacal Research, 37(1), 24-30
27. Ok-Cheol Jeon 1 , Seung Rim Hwang 1 , Taslim A. Al-Hilal, Jin Woo Park, Hyun Tae Moon, Seulki Lee, Jae Hyung Park, Youngro Byun. Oral delivery of ionic complex of ceftriaxone with bile acid derivative in non-human primates (2013). Pharmaceutical Research, 30(4), 959-9674
28. Jin Woo Park 1 , Seung Rim Hwang 1 , Ok-Cheol Jeon, Hyun Tae Moon, Youngro Byun. Enhanced oral absorption of ibandronate via complex formation with bile acid derivative (2013). Journal of Pharmaceutical Sciences, 102(2), 341-346
29. Asarasin Adulnirath, Seung Woo Chung, Jooho Park, Seung Rim Hwang, Ji-Young Kim, Victor C. Yang, Sang Yoon Kim, Hyun Tae Moon, Youngro Byun. Cyclic RGDyk-conjugated LMWH-taurocholate derivative as a targeting angiogenesis inhibitor (2012).
Journal of Controlled Release, 164(1), 8-16
30. Seung Rim Hwang, Dong-Hyun Seo, Taslim A. Al-Hilal, Ok-Cheol Jeon, Jin Hee Kang, Sung-Hyun Kim, Han Sung Kim, Young-Tae Chang, Young Mo Kang, Victor C. Yang, Youngro Byun. Orally active desulfated low molecular weight heparin and deoxycholic acid conjugate, 6ODS-LHbD, suppresses neovascularization and bone destruction in arthritis (2012). Journal of Controlled Release, 163(3), 374-384
31. Seung Rim Hwang, Soo-Jeong Lim, Jeong-Sook Park, Chong-Kook Kim. Phospholipid-based microemulsion formulation of all-trans-retinoic acid for parenteral administration (2004). International Journal of Pharmaceutics, 276(1-2), 175-183
PATENT
Uses of a desulfated heparin-bile acid derivative for the prevention and treatment of inflammatory diseases Young Mo Kang, Youngro Byun, Jin Hee Kang, Seung Rim Hwang (WO2012138003)
INVITED TALK
1. “Exosome-based technologies for regenerative medicine”, 제11차한국조직공학재생의학회, Nov 20th (2020)
2. “Heparan sulfate analogues as pharmaceutical polymers”, 2019 한국고분자학회국제학술대회, Oct 9th (2019)
3. “Development of nano-vehicles using milk-derived exosomes”, 한국약제학회국제학술대회, Nov 23th (2018)
4. “Drug delivery for the treatment of rheumatoid arthritis”, 2014 International Conference of the Korean Society of Pharmaceutical Sciences and Technology (KSPST), Nov 28th (2014)
5. “Application of chemically modified heparins in rheumatoid arthritis”, 2014 The Korean Society for Biotechnology and Bioengineering (KSBB) Spring Meeting and International Symposium, Apr 10th (2014)
