Category
Bioactive Materials/Veterinary: Protein and Vaccine Delivery
Year
2012
Institutions
Orbis Biosciences, Inc., Kansas City, KS, 66103, USA; Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS, 66045, USA; Department of Clinical Sciences, Kansas State University, Manhattan, KS, 66506, USA; Department of Anatomy and Physiology, Kansas State University, Manhattan, KS, 66506
Summary
Most analgesics require multiple oral administrations per day which frequently leads to poor compliance and often results in insufficient control over pharmacokinetic profiles. While sustained release injectable formulations offer improved compliance, they typically result in drug ‘burst’, followed by imprecise pharmacokinetics resulting in lack of tight control over the concentration of these drugs in the blood. Here, we explore the possibility of developing a safer, more effective extended pain reliever using Orbis Bioscience’s controlled release technology to reformulate a generic NSAID into a long-lasting injectable depot.
