Polymeric Nanofibers Co-loaded with Fusidic Acid & Rifampicin for the Prevention of Implant Associated Infections

Category

Bioactive Materials/C&DP: Nanofibers/Nanoparticles

Year

2012

Authors

S.E. Gilchrist, D. Lange, H. Bach, L. Fazli, Y. Av-Gay, and H. Burt

Institutions

Faculty of Pharmaceutical Sciences; Department of Urological Sciences; Division of Infectious Diseases; The University of British Columbia, Vancouver, BC, V6T1Z3, Canada

Summary

Here we report the development of a biodegradable localized nanofiber delivery system using poly(lactic acid-co-glycolic acid) (PLGA) for the combinatorial release of fusidic acid (FA) (or its sodium salt; SF) and rifampicin (RIF). All co-loaded formulations were continuous and defect-free, and allowed the controlled release of FA, SF, and RIF over 35d. The release of drug contents was sufficient to eliminate a number of pathogens associated with prosthetic joint infections, and prevented the colonization of methicillin-resistant S. aureus (MRSA) in vivo using a rodent model of implant infection.