Patent Watch August 2025 - November 2025
Ken Carson, Southwest Research Institute, U.S.A.
This article summarizes selected patents in the area of controlled release or delivery that were published from
August 1, 2025 through November 20, 2025. Greater detail on each of these patents is given on the U.S. patent
website Patent Public Search | USPTO
General/Industrial Applications
US- 20250352969- PREPARATION METHOD FOR POLYURETHANE MICROCAPSULE SHELL WITH CONTROLLED-RELEASE CHARACTERISTIC INFLUENCED BY MECHANICAL STIMULUS
A method to create polyurethane microcapsule shells with controlled-release properties influenced by mechanical stimuli involves emulsifying 4,4′-methylenediphenyl diisocyanate in an aqueous polyvinyl alcohol solution, reacting it in another aqueous phase with catalysts, vacuum filtering, ethanol washing, and air-drying. The release speed can be adjusted via external mechanical triggers.
US- 20250353077- GOLD NANOPARTICLE-CONTAINING COMPOSITION, GOLD NANOPARTICLE-CONTAINING COMPOSITION DISPERSION, INK, AND TONER
A nanoparticle-containing composition excellent in storage stability that includes gold nanoparticles, and a zwitterionic compound with an HLB value of 12 or less. Cited use in inks and toner applications.
US- 20250334359- NOVEL DAYTIME PASSIVE RADIATIVE COOLING CERAMIC WITH SELF-CLEANING PROPERTIESAND ITS MANUFACTURING PROCESS
Pertains to the field of refrigeration materials using a novel ceramic designed for daytime passive radiative cooling endowed with a self-cleaning capability, along with its preparation method.
US- 20250296087- MICRO-FLUIDIC CHIP AND HIGH-THROUGHPUT NANO-PARTICLE SYNTHESIS SYSTEM BASED ON MICRO-FLUIDIC TECHNOLOGY
A microfluidic chip-based nanoparticle synthesis system enables high-throughput and small-volume production. Using a pressure controller and distribution assembly connected to flow channels, it ensures precise nanoparticle size, distribution, and consistency. Efficient synthesis avoids reagent waste from dead volume, and throughput is scalable by adding chips or parallel channels.
US- 20250277362- PHASE CHANGE MATERIAL (PCM) INSULATED PANELS WITH PCM AND METHODS OF
MANUFACTURING THE PCM INSULATED PANELS
Insulated panels that incorporate phase-change material (PCM) into the insulation material. The PCM is a solid-to- solid phase change material that is microencapsulated into insulation for building applications.
US- 12378458 PHASE CHANGE MICROCAPSULE FOR DRILLING FLUID COOLING AND ITS PREPARATION METHOD AND APPLICATION
A phase change microcapsule for drilling fluid cooling in the field of oilfield chemistry technology.
US- 20250277116- POLYMER-COATED IMIDACLOPRID COMPOSITE MICROSPHERE, PREPARATION METHOD AND APPLICATION THEREOF, AND CABLEA polymer-coated imidacloprid composite microsphere with a heat deflection temperature of 70° C. to 200° C for use in coating underground cables to inhibit destruction by insects.
Agriculture
US- 20250248396, 20250248397- CHITOSAN ENCAPSULATION OF ABSOLUTE (ESSENTIAL) ROSEMARY,
PEPPERMINT, AND COTTONSEED OILS
Chitosan-encapsulated nanoparticle pesticides containing essential oils (e.g., tea tree oil) designed for slow release to control Black and Yellow Sigatoka in bananas.
Diagnostic/Sensing
US- 20250354984- NANOPARTICLE BODY, COMPOSITE CONTAINING NANOPARTICLE BODIES, AND METHOD FOR FORMING POLYMER MEMBRANE CONTAINING NANOPARTICLE BODY
A metallic nanoparticle, coated with a polymer film that contains a bondable substance that bonds to a test substance, and a fluorescent substance for visualization
US- 20250356522- IMMUNOASSAY
A method for determining positions of microspheres in an image of an immunoassay based on an observed luminescence of a microsphere (bead) as observed by a microscope.
US- 20250345465- DUAL T1/T2 MRI CONTRAST AGENTS FOR PHOTOTHERMAL THERAPY
A photothermal MRI enhancement agent features composite nanoparticles with a porous dielectric core, magnetically responsive nanoparticles, and a metallic outer layer. The synthesis involves creating a porous substrate, loading magnetic nanoparticles, attaching linkers and metal nanoparticles, and forming a controllable- thickness metallic layer to improve imaging and therapeutic applications.
US- 20250341518- MAGNETIC MICROGEL BEADS, METHODS OF MAKING AND USES THEREOF
Magnetic microgel beads encapsulating magnetic nanoparticles in a polymer hydrogel, used for biofunctionalization in biosensing assays. The beads, paired with an electrochemical chip, detect target analytes by generating electrochemical, electroluminescent, or photoelectrochemical signals upon biorecognition agent binding, enabling sensitive and functional diagnostic applications.
US- 20250312493- FLUOROPHORE-LOADED GELATIN-BASED NANOPARTICLES FOR NEAR-INFRARED IMAGING
Fluorescent nanoparticles with a gelatin matrix encapsulating an ionically bound fluorophore. This provides quenching inside the matrix but ensures substantial fluorescence upon release. These nanoparticles are used for imaging tumors, offering controlled fluorescence for enhanced diagnostic applications.
US- 20250314649- RAMAN-ACTIVE NANOPARTICLE FOR SURFACE-ENHANCED RAMAN SPECTROSCOPY AND METHOD OF PRODUCING THE SAME
A Raman-active nanoparticle with a spherical plasmonic metal core; a plasmonic metal shell having surface irregularities.
US- 20250314647- SACCHARIDE COUPLED MICROSPHERE, METHODS OF PREPARATION AND APPLICATIONS THEREOF
A non-covalent method for coupling polysaccharides to microspheres while preserving their structure and epitope
conformation. The microsphere aid in determining immunogenicity, antigen content, and antibody concentrations.
US- 20250339845- CHROMATOGRAPHY MEDIUM AND CHROMATOGRAPHY APPARATUS
This invention describes a chromatography medium made of crosslinked polymer materials with rigid nanoparticles forming an ordered structure. Used as a stationary phase, it enhances separation speed, peak symmetry, and column efficiency.
US- 20250332293- METHOD FOR MANUFACTURING BIOCOMPATIBLE NANOPARTICLES WITH A PEPTIDE CORE EXHIBITING SECOND- AND THIRD-HARMONIC SIGNAL GENERATION
A method for preparing an aqueous suspension of biodegradable, water-suspendable nanoparticles with a peptide core and a polymer shell, wherein the nanoparticles provide a second-harmonic signal and a third-harmonic signal
upon illumination.
US- 20250270638- MICROPARTICLE PROBE FOR SINGLE NUCLEOTIDE POLYMORPHISM ANALYSIS
Microparticle probe for single nucleotide polymorphisms comprising a microparticle with capture probes on the surface of the microparticle that contain a complementary sequence to a target nucleic acid, and reporter nucleic acids.
Pharma
US- 20250352666- LIPID NANOPARTICLE COMPOSITIONS AND USES THEREOF
A lipid nanoparticle (LNP), a therapeutic nucleic acid (TNA) and at least one pharmaceutically acceptable excipient, wherein the LNP can deliver the TNA to a retinal cell.
US- 20250352486- NANOPARTICLES FOR USE IN THE TREATMENT OF INFECTIONS CAUSED BY BIOFILMS
A nanoparticle comprising a therapeutic agent, a molecular drill comprising a compound with catalytic activity, and a self-propulsion system. This system allows breaking the matrix of biofilms formed by infectious microorganisms and release of the therapeutic agent from the nanoparticle under specific conditions (acidic environment of an infection).
US- 20250354140- CALCIUM SALTED SPHERICAL NUCLEIC ACIDS
Calcium salted spherical nucleic acids (SNAs) which comprise a nanoparticle core surrounded by a shell of oligonucleotides.
US- 20250352483- BIOMIMETIC DRUG DELIVERY PARTICLES
A biodegradable microparticle with one or more types of endogenous peptides that are bonded to a surface of the microparticle in an amount ranging from about 15% to about 50% coverage of the surface of the microparticle.
US- 20250345456- TARGETED POLY(BETA-AMINO ESTER)S
Utilization of click chemistry to attach targeting moieties (e.g., aptamers, antibodies) to non-toxic poly beta-amino esters (PBAEs) and their nanoparticles enabling precise nanoparticle localization, facilitating gene therapy or
targeted therapeutic delivery.
US- 20250345286- COMPOSITE LIPID NANOPARTICLE AND PREPARATION METHOD THEREOF, RNA VACCINE, DRUG AND USE
A composite lipid nanoparticle of a lipid composition and a recombinant antibody protein with a streptavidin tag. biotin-streptavidin interactions enable adaptive replacement of recombinant antibodies for targeted RNA vaccines or drug delivery.
US- 20250346904- CCR5 And CD4 SiRNA-TARGETED PHOSPHOLIPID NANOSOMES THERAPEUTICS FOR
TREATMENT OF HIV-1 AND OTHER DISEASES
Nanoencapsulation of siRNA and biologics in phospholipid nanosomes for targeted delivery to diseased cells or organs. It uses novel siRNAs to downregulate CCR5, CD4, and CXCR4 receptors, and targeted delivery using ligands on the surface of the nanosomes. The process employs supercritical or near-critical fluids for improved efficiency.
US- 20250339379- POLYMERIC MICROPARTICLES HAVING PORE CHANNELS OF TWO SIZES AND PREPARATION METHOD THEREFOR
Polymeric microparticles with dual-sized pores with internal structural ordering. Formed using cross-linked oligomers and rigid nanoparticles, some non-spherical, these microparticles enhance permeability and expand separation capabilities.
US- 20250339514- SINGLE-AND MULTI-EPITOPE PEPTIDE AND MRNA VACCINES TO GENERATE TOLEROGENIC EFFECTS FOR ALLERGIC AND AUTOIMMUNE DISEASE BY TARGETING LIVER SINUSOIDAL ENDOTHELIAL CELLS
Tolerogenic nanoparticles designed to induce immune tolerance or suppress immune responses to specific antigens. The nanoparticles carry antigens or their encoding nucleic acids and include targeting moieties that bind liver scavenger receptors.
US- 20250339546- GLIOBLASTOMA TUMOR GROWTH INHIBITON BY SAT1 KNOCKDOWN
Lipid nanoparticles (LNPs) for RNA delivery, with ionizable cationic lipids and neutral surface charge at physiological pH. LNP-encapsulated siRNA targeting SAT1 inhibits glioblastoma cell proliferation. Formulation also incorporates a cadherin-binding peptide for delivery across the blood-brain barrier.
US- 20250339517- LIPID NANOCARRIER VACCINE
Lipid nanoparticle formulation carrying an antigen. The present disclosure also relates to an immunogenic composition comprising the antigen. The immunogenic composition may be a vaccine composition. The present disclosure further relates to methods and uses of the carrier and immunogenic composition.
US- 20250339507- MRNA VACCINE FOR BANDAVIRUS DABIEENSE AND PREPARATION METHOD THEREOF
An mRNA vaccine for Bandavirus dabieense (DBV) containing an optimized DBV glycoprotein Gn sequence followed by transcription, capping, and poly(A) tail addition. The mRNA is encapsulated in lipid nanoparticles for effective delivery.
US- 20250332234- S100A9 VACCINES FOR CANCER AND ATHEROSCLEROSIS
Compositions and methods that contain a nanoparticle and a peptide target for cardiovascular disease and cancer.
US- 20250332278- MULTIVALENT DISPLAY OF APOAI PEPTIDE ON NANOPARTICLES AGAINST ATHEROSCLEROSIS
A nanoparticle-peptide conjugate that reduces LDL concentration in a subject, reduces reactive oxygen species in the subject, or increases cellular healing rate.
US- 20250332104- DENDRON-LIKE LIPID COMPOUND, LIPOSOME, LIPID COMPLEX, AND LIPID NANOPARTICLE AND USE THEREOF
Dendron-like lipid compounds used to create liposomes and lipid nanoparticles. Additionally, porous hydrogel microspheres are prepared via microfluidics and UV curing, offering stable morphology and a porous structure ideal for cell proliferation and expansion.
US- 20250332089- WATER-SOLUBLE MEDICINE DELIVERY FORM
A delivery method using a water-soluble base with nanoparticle clusters containing hydrophobic nanoparticles and active agents. The clusters penetrate the skin while the base forms a lather or residue. The residue can be removed with water.
US- 20250332279- PHARMACEUTICAL COMPOSITION AND METHOD FOR TREATING GLIOBLASTOMAS
Bioengineered virus-like nanoparticles with Qβ capsids with an RNA scaffold integrating siRNA elements, a light-up aptamer, and TAT peptides. These nanoparticles enhance cellular uptake and gene silencing efficiency.
US- 20250332233- REPLICANT / STAV FOR DISEASE TREATMENT AND METHODS OF USE
Lipid nanoparticles containing STING activators (STAVs) and mRNA replicants for targeting antigen-presenting cells enhancing anti-tumor immunity. This boosts cytotoxic T-cell activity and humoral responses in the tumor microenvironment.
US- 20250332116- CARBON-BASED ANTI VIRAL NANOPARTICLES
Carbon-based antiviral nanoparticles, medical use of these NP’s as coating on surfaces and devices and methods of preparation are described.
US- 20250326712- IONIZABLE LIPIDS
Description of novel ionizable lipids used in nanoparticles containing nucleic acids for vaccine and pharmaceutical applications.
US- 20250325513- CABAZITAXEL PRODRUG ANTI-TUMOR PREPARATION
Cabazitaxel prodrug nanoparticles with branched fatty alcohols, improving efficacy and reducing toxicity compared to straight-chain variants. The NPs with the prodrug improve anti-tumor activity and reduce side effects.
US- 20250325480- LIPID NANOPARTICLE COMPOSITIONS AND METHODS FOR FORMULATING INSOLUBLE DRUGS
Novel compositions of lipid nanoparticles for enhancing delivery and bioavailability of poorly soluble drugs, including cannabinoid drugs
US- 20250325695- NANOPARTICLE FOR USE IN A PROPHYLAXIS OR IN A TREATMENT OF A CALCIFICATION OF BRUCHS MEMBRANE AND DRUSEN
A nanoparticle-based method to treat or prevent calcification in Bruch's membrane and adjacent eye tissues. The biodegradable NP contains a targeted antibody and anti-calcifying agent.
US- 20250325490- LIPID COMPOUND, LIPID NANOPARTICLE COMPRISING SAME AND USE THEREOF
Lipid nanoparticles for delivering nucleic acid-based therapies via intramuscular injection. The nanoparticles ensure high activity at the injection site with low visceral expression, enhancing efficacy while minimizing toxicity.
US- 20250325567- COADMINISTRATION OF POLYCANNABINOID WITH AMINE/AMIDE ANESTHETICS TO
ENHANCE EFFICACY AGAINST PAIN
Biodegradable microspheres containing a cannabinoid compound are combined with an amine/amide anesthetic for the treatment of pain are described.
US- 20250319024- TARGETED NANOPARTICLES AND THEIR USES RELATED TO INFECTIOUS DISEASE
Targeted liposome nanoparticles with C-Type Lectin polypeptides on their surface to bind pathogen antigens. These nanoparticles enable precise diagnosis, treatment, or prevention of infectious diseases.
US- 20250319023- METHODS AND COMPOSITIONS FOR MODULATING FIBRINOGEN
A lipid nanoparticle comprising an siRNA molecule (with modified or unmodified nucleotides) against fibrinogen alpha chain.
US- 20250319051- TUMOR CELL-DERIVED MICROPARTICLE LOADED WITH SUCCINIC ACID, PREPARATION METHOD THEREFOR, AND USE THEREOF
These microparticles show enhanced therapeutic effects on tumors, prolonging survival in mice while providing practical production advantages and increased drug-loading capacity for cancer therapy.
US- 20250319035- CATIONIC LIPID NANOPARTICLE HAVING HIGH TRANSFECTION EFFICIENCY AND PREPARATION METHOD THEREFOR
A nucleic acid-loaded calcium-containing cationic lipid nanoparticle, comprising a cationic lipid, a neutral lipid, a PEGylated lipid, and cholesterol and/or a cholesterol ester. The cationic lipid nanoparticle can be used for local or systemic delivery of a nucleic acid.
US- 20250319037- METHODS OF DELIVERING THERAPEUTIC AGENTS, AND LIPID COMPOSITIONS
A lipid nanoparticle system for efficiently delivering therapeutic agents to endothelial, mesenchymal, or cancer cells, targeting organs beyond the liver.
US- 20250319034- MICROSPHERE PRODUCTION METHOD
A method to encapsulate hormones in a hydrogel using methacrylate hyaluronic acid (MHA). MHA precursor solution is extruded into an alginate bath, forming core-shell microparticles. UV light crosslinks the inner core, creating stable hydrogel microparticles. The outer alginate shell can be removed later.
US- 20250320231- AMPHIPHILIC LIPID COMPOUND WHICH CONTAINS ZINC(II)-DIPICOLYLAMINE COMPLEX FOR NUCLEIC ACID BINDING AND LIPID NANOPARTICLE COMPOSITION COMPRISING THE SAME
An amphiphilic lipid compound with a Zn(II)-dipicolylamine complex for nucleic acid binding. The water-soluble linker and hydrophobic terminal group, improve water solubility while enhancing delivery of nucleic acid drugs via lipid nanoparticles.
US- 20250312287- LIPID NANOPARTICLES COMPRISING AN IMIDAZOLIUM-BASED CATIONIC LIPID
Lipid nanoparticle formulations for delivering nucleic acids, particularly mRNAs, into target cells. The LNPs are made up of ionizable lipids, phospholipids, sterols, PEG-lipids, and imidazolium-based cationic lipids.
US- 20250312430- COMPOSITIONS OF LIPID NANOPARTICLES FOR PLASMID DNA DELIVERY TO THE LIVER AND METHODS FOR PREPARING THE SAME
Lipid nanoparticle formulations with cell type specific transfection activity and capable of producing Th1 and/or Th2 response in vivo and their use for plasmid DNA or mRNA delivery is disclosed.
US- 20250312482- LIPID NANOPARTICLES FOR THE TREATMENT OF VASCULAR DISEASES
Lipid nanoparticles (LNPs) designed to target vascular smooth muscle cells (vSMCs). Peptides targeting vSMC surface receptors (e.g., IL-6R, CD63, GAL-3) or extracellular matrix proteins (e.g., Col-IV) further improve uptake.
US- 20250312455- PLASMONIC METAL-COLLAGEN HYBRID NANOPARTICLES FOR PROTEIN DELIVERY AND METHOD OF PREPARATION THEREOF
A plasmonic metal-collagen hybrid nanoparticle that has excellent protein loading efficiency and biocompatibility for protein delivery.
US- 20250332275- BRANCHED POLYPEPTIDE CARRIER FOR EFFICIENT NUCLEIC ACID DELIVERY AND ITS VARIANTS
Description of branched polypeptide carriers that bind nucleic acids through electrostatic interactions. This enables targeted delivery, controlled intracellular release, and enhanced therapeutic efficacy for nucleic acid-based drugs.
US- 20250333567- APPARATUS AND METHOD FOR PREPARING POLYLACTIC ACID MICROSPHERES
Description of an apparatus and method for producing polylactic acid microspheres using emulsification, solvent evaporation, and solidification of polylactic acid droplets in polyvinyl alcohol solution.
US- 20250325491- POLYVALENT MOLECULE BASED LIPID NANOPARTICLES FOR NUCLEIC ACID DELIVERY
Nanoparticles for nucleic acid delivery that have a dendrimer-like structure. The invention further relates to manufacturing nanoparticles, and uses of such nanoparticles in the treatment of a disease.
US- 12447131- ENCAPSULATED RESERATROL (RSV) NANOPARTICLES
Resveratrol nanoparticles with a resveratrol core, a gum acacia shell, and a polyvinyl alcohol coating with average size of 195-210 nm.
US- 20250312430- COMPOSITIONS OF LIPID NANOPARTICLES FOR PLASMID DNA DELIVERY TO THE LIVER AND METHODS FOR PREPARING THE SAME
Lipid nanoparticle formulations with cell type specific transfection activity and capable of producing Th1 and/or Th2 response in vivo and their use for plasmid DNA or mRNA delivery is disclosed.
US- 20250312288- LIPIDS AND LIPID NANOPARTICLE FORMULATIONS
The present disclosure relates generally to lipids, lipid nanoparticle formulations, and methods of using the same for delivering nucleic acids, such as mRNA.
US- 20250312411- TREATMENT OF MULTI-DRUG-RESISTANT CANCERS USING NANOPARTICULATE DRUG CELIVERY VEHICLES
Nanoparticle-based formulations to treat solid tumors by inhibiting communication within the tumor environment (tunneling nanotubes and extracellular vesicles)that leads to multi-drug resistance (MDR) and metastasis.
US- 20250302767- TREATMENT OF CANCER AND AUTOIMMUNE DISORDERS USING NANO POLYMERS OF
HISTONE DEACETYLASE INHIBITORS
Histone deacetylase inhibitors (HDACi), such as romidepsin or vorinostat, encapsulated in mPEG-PDLLA nanoparticles to treat HDACi-sensitive conditions by inhibiting growth, proliferation, and metastasis.
US- 20250302766- FORMULATIONS FOR ORAL DELIVERY OF POLYPEPTIDES, ANTIBODIES AND PROTEINS AND USES THEREOF
A bioerodible nanoparticle containing polypeptides heavier than 50,000 g/mol (e.g. IgY antibodies).
US- 20250304547- SULFUR-CONTAINING LIPIDS
Novel sulfur-containing lipids that may be formulated in a lipid nanoparticle for use in the delivery of charged cargo such as nucleic acids for use in the targeting of a non-liver organ, tissue or cell.
US- 20250304922- METHODS AND COMPOSITIONS OF VIRUS-LIKE PARTICLES OF CYTOPLASMIC TYPE CITRUS LEPROSIS VIRUS FOR NANOTECHNOLOGY APPLICATIONS
A nanoparticle comprising a cytoplasmic type citrus leprosis virus-like particle (CiLV-C) p29 protein coat and an optional agent encapsulated with the protein coat for delivery to cells or tissues.
US- 20250302990- ENHANCING NON-VIRAL DNA DELIVERY AND EXPRESSION
Intracellular DNA delivery using nanoparticles combined with a type 1 interferon receptor pathway inhibitor. To reduce immune responses triggered by the DNA.
US- 20250302991- NOVEL LIPIDS BASED ON OLIGO-y-GLUTAMIC ACID DERIVATIVES AND LIPID NANOPARTICLES CONTAINING THE SAME, AND USES THEREOF
A lipid derivative with oligo-γ-glutamic acid for forming lipid nanoparticles. Replacing PEGylated lipids avoids side effects like anaphylaxis while enhancing in vivo stability.
US- 20250295806- IMMUNOSTIMULATORY NANOPARTICLE
Immunostimulatory nanoparticles with a biocompatible lipid shell and a core containing a TLR9 agonist and a nucleic acid inhibitor of VISTA for cancer therapy.
US- 20250295778- MATERIALS AND METHODS FOR REPEATABLE MAGNETIC NANOPARTICLE-BASED HEATING FOR TUMOR ABLATION
This invention outlines a system for thermal treatment using a precipitated hydrophobic injectable liquid (PHIL) embolic agent enhanced with magnetic nanoparticles. Delivery to a target area allows for imaging in situ, and heat generation via applied impulses to thermally ablate or induce hyperthermia to the target area.
US- 20250288535- INSTANT NANOPARTICLE COMPOSITION AND PREPARATION METHOD THEREFOR
A nanoparticle containing an active ingredient (e.g., paclitaxel or docetaxel), albumin, a particle stabilizer, and lyoprotectant for rapid suspension to addresses poorly water-soluble ingredients in formulations.
US- 20250288682- DEVELOPMENT OF NANO-ENCAPSULATED FATTY-ACYL CONJUGATED COLCHICINE
Colchicine conjugated to behenic acid in liposomes to target inflammatory and cardiovascular diseases.
US- 20250288534- COMPOSITIONS AND METHODS FOR PEPTIDE OR PROTEIN DELIVERY TO THE CENTRAL NERVOUS SYSTEM
Lipid nanoparticles made of ionizable lipids, helper lipids, sterols, and mRNA encoding a secretory polypeptide for treating, preventing, or diagnosing central nervous system (CNS) conditions.
US- 20250281588- PREVENTION AND TREATMENT OF INFECTIONS WITH INTRACELLULAR BACTERIA
A method and composition for prevention and treatment of infections from intracellular bacteria. It provides an intracellular delivery of an active agent (nucleic acid) using a nanoparticle formulation with an iNKT cell agonist.
US- 20250281418- LIPID NANOPARTICLE FORMULATIONS AND METHODS OF SYNTHESIS THEREOF
Stabilized formulations of lipids and nucleic acids, including lipid nanoparticles.
US- 20250281604- MRNA VACCINE FOR PORCINE DELTACORONAVIRUS, PREPARATION METHOD AND
APPLICATION THEREOF
An mRNA vaccine encapsulated with lipid nanoparticles for PDCoV.
US- 20250281647- STEALTH LIPID NANOPARTICLE COMPOSITIONS FOR CELL TARGETING
A bispecific stealth lipid nanoparticle (LNP) engineered to target specific tissues or cell-types, e.g., immune effector cells to modify the cells with a therapeutic nucleic acid.
US- 20250281421- COMPOSITIONS FOR SUPPLEMENTING PRODUCTS WITH THERAPEUTIC AGENTS AND
METHODS OF USE THEREOF
Nanoparticle-based compositions used in delivery of active agents with enhanced stability and bioavailability.
US- 20250276055- VISCO-ELASTIC SOLID FORMULATION FOR ORAL DELIVERY OF A BIOLOGGICALLY ACTIVE AGENT
An oral vaccine formulation using Bacillus subtilis as an antigen expression vehicle. The expression system, in a visco-elastic solid carrier, delivers recombinant viral protein antigens.
US- 20250276054- AVIAN INFLUENZA NANOPARTICLE IMMUNOGENIC COMPOSITIONS
A vaccine nanoparticle containing an H5N1 hemagglutinin glycoprotein with a hydrophobic C-terminus linked to a Matrix-M adjuvant in a particle that provides an effective vaccine composition against avian influenza.
US- 20250269053- LIPID NANOPARTICLES COMPRISING MANNOSE OR USES THEREOF
Mannose-containing lipid nanoparticles targeting liver tissues and LSEC.
US- 20250269083- HOLLOW EMBOLIC MICROSPHERE, PREPARATION METHOD THEREFOR, AND
PHARMACEUTICAL COMPOSITION AND USE THEREOF
Hollow embolic microspheres for transcatheter arterial embolization. The microspheres are made through a simple, mild process and enable controlled release, effective embolization, and support heat-sensitive drugs.
US- 20250268836- MICROSPHERE FORMULATIONS COMPRISING MULTIPLE NON-IDENTICAL PEPTIDES AND METHODS FOR MAKING THE SAME
Polymer microspheres containing at least two distinct peptides and a biodegradable polymer that may include an
adjuvant for therapeutic or vaccine applications.
US- 20250269035- INHALABLE LIPID NANOPARTICLE, LIPID-CHARGED MOLECULE CONJUGATE, AND LIPID-ZWITTERIONIC MOLECULE CONJUGATE
Inhalable lipid nanoparticles including ionizable lipids, phospholipids, cholesterol, and PEG-lipids that enhance nucleic acid delivery and mRNA vaccine stability.
US- 20250262291- MICROPARTICLES FROM STREPTOCOCCUS PNEUMONIAE AS VACCINE ANTIGENS
An isolated Streptococcus pneumoniae membrane vesicle microparticle (MP) used in immunization.
US- 20250255815, 20250255988- NUCLEIC ACIDS ENCODING A CONSTITUTIVELY ACTIVE CYCLIC GMP-AMP SYNTHASE AND IMMUNOGENIC DELIVERY VEHICLES FOR SAME
Formulations leading to expression of a constitutively active cyclic GMP-AMP synthase in cells for enhancing
immunogenicity of lipid particle mRNA vaccines. Formulations may also include one or both of a lysophosphatidylcholine (LPC) compound and a pathogen recognition receptor agonist.
US- 20250255816- POLYSULFIDE MICROPARTICLES AND USES THEREOF
Polysulfide microparticles with tunable monomer compositions, such as propylene sulfide and ethylene sulfide, to
control properties like crystallinity with applications in treating inflammatory diseases.
US- 20250255984- MNO NANOMATERIAL BASED INHIBITORS OF INFLAMMATION AND CANCER METASTASIS
Biodegradable anionic scavengers with low cytotoxicity, which scavenge cell-free nucleic acids for treatment of various medical conditions including inflammation or cancer.
US- 20250248928- NANOPARTICLES AND NANOPARTICLE-RELEASING VAGINAL RINGS
Drug-loaded nanoparticles with a PEG coating that enables mucus penetration, then converts to adhesive, allowing for tissue distribution and prolonged retention, for vaginal drug delivery.
US- 20250250227- AMINO LIPID COMPOUND, PREPARATION METHOD THEREFOR, COMPOSITION THEREOF AND USE THEREOF
An amino lipid compound, used in lipid nanoparticles that enables efficient delivery of therapeutics.
US- 20250248926- AN INJECTABLE MICROPARTICLE SYSTEM AND METHOD OF PREPARING THEREOF
An injectable microparticle system for prolonged brain drug delivery. Comprising drug-loaded polymeric microparticles with a gel coating, it enables deep tissue penetration and sustained drug release (up to 30 d).
Bio
US- 20250354122- EXTRACELLULAR VESICLE MASS PRODUCTION METHOD USING CELL SPHEROID EMBEDDED WITH MICROPARTICLE HAVING DIFFERENTIATION STIMULATING FACTOR SUPPORTED THEREIN
A method for mass-producing extracellular vesicles using cell spheroids embedded with microparticles carrying differentiation factors. The vesicles promote tissue regeneration, particularly cartilage.
US- 20250345455- BISPECIFIC NANOPARTICLE BIOCONJUGATES
Nanoparticle bioconjugates with proteins for binding to a cancer cell and an antigen of an immune cell.
US- 20250345493- ANTIMICROBIAL COMPOSITIONS: METHODS OF MAKING AND USING THE SAME
This invention presents antimicrobial compositions combining metallic nanoparticles and photosensitizers, effective even in dark conditions, methods for preparing and incorporation in encapsulated forms.
US- 20250345481- NANOCOMPOSITE HYDROGELS AND RELATED METHODS AND APPLICATIONS
Nanocomposite hydrogels for bone regeneration, comprising a serum albumin scaffold, cell adhesion promoters, polyethylene glycol crosslinkers, and nanoparticles. Precursors are combined to form a hydrogel, upon injection.
US- 20250339091- HONEY BEE-DERIVED BIOACTIVE WOUND DRESSING WITH SUSTAINED ANTIMICROBIAL RELEASE
A smart wound dressing using honeybee-derived compounds in a hydrogel matrix with biosensors delivering sustained antimicrobials, monitors healing phases, and adjusts release based on pH, temperature, and exudate.
(Literally too cool not to include in this patent review!)
US- 20250333692- NANOCOMPOSITE INCLUDING MAGNETIC NANOPARTICLE COATED WITH PEPTIDE-
IMPRINTED POLYMER, METHOD OF PREPARING THE SAME, AND USE THEREOF
A nanostructure with magnetic nanoparticles and peptide-imprinted polymers for efficient extracellular vesicle (EV) isolation. The peptide-based imprinting ensures selective capture of cell-specific EVs.
US- 20250325593- ENGINEERED MESENCHYMAL STEM CELL AND ITS USE THEREOF
Engineered mesenchymal stem cells containing iron-core nanoparticles with functionalized shells. These MSCs are designed for treating or preventing regenerative diseases.
US- 20250327028- ENGINEERED PLATELETS AS TARGETED PROTEIN DEGRADERS
Engineered platelets or platelet-derived microparticles loaded with an HSP90 anchoring chimera that binds a protein of interest (POI)with potential uses in targeting disease sites and degrading intra- or extracellular POIs.
US- 12447234- EXTRACELLULAR MATRIX HYDROGEL MICROSPHERE, AND PREPARATION METHOD AND
APPLICATION THEREOF
Extracellular matrix hydrogel microspheres created via microfluidics and activated with DMTMM for bone regeneration. Combining stem cell-derived extracellular matrix with hydrogel, the microspheres improve biocompatibility, promote bone formation, and inhibit osteoclast differentiation.
US- 20250320489- DOUBLE-LAYER MICROSPHERE WITH OLIGONUCLEOTIDE SEQUENCE FOR SINGLE-CELL SEQUENCING
Double-layer microspheres for single-cell sequencing. The outer dissolvable hydrogel layer can be dissolved under certain conditions, and the magnetic inner layer carries oligonucleotide barcodes so as to enhance sequencing accuracy and reproducibility.
US- 20250320489- PREPARATIONS FOR CONTROLLED-RELEASE OF HYPOCHLOROUS ACID
Anti-microbial compositions of a solution of hypochlorous acid encapsulated in a nanoparticle for controlled release.
US- 20250313860- EXPRESSION OF EXOGENOUS PROTEINS IN DONOR PLATELETS TREATED WITH LIPID
NANOPARTICLES
This invention describes lipid nanoparticle (LNP) compositions for transfecting platelet cells with mRNA encoding exogenous proteins.
US- 20250311740- HIGH-THROUGHPUT METHODS OF SYNTHESIZING BIOFUNCTIONAL MICROPARTICLES AND RELATED COMPOSITIONS
A high-throughput method of synthesizing biofunctional microparticles by casting biofunctional precursors onto a microporous template to form microparticles and liberating the microparticles.
US- 20250281637- AU, AG AND RICH PHYTOCHEMICAL PAYLOAD NANOMATERIALS, ANTIVIRAL/ANTIBACTERIAL PRODUCTS AND SYNTHESIS METHODS
Gold or silver nanoparticles coated with extracts from sweet gum leaves, including polyphenols, flavonoids, and alkaloids exhibiting strong antiviral and antibacterial efficacy.
US- 20250281416- COATED NANOPARTICLE AGGREGATES COMPOSED OF A HYDROLYZED METAL SALT AND METHODS OF USE THEREOF
Coated nanoparticle aggregates of hydrolyzed metal salts with a glycosaminoglycan coating that prevent biofilm formation and oxidative tissue or bone damage with enhanced stability.
US- 12409234- NANOPARTICLES COMPRISING A FUNCTIONAL AGENT AND METHOD OF PREPARATION AND USE THEREOF
PEG-functionalized nanoparticles with a hydrophobic core containing a functional agent (e.g., drugs or diagnostic
agents) and a hydrophilic PEG outer layer. These nanoparticles have versatile biomedical applications, including therapy, imaging, and immune stimulation.
Consumer Products/ Cosmetics
US- 20250345251- IMPROVEMENTS IN OR RELATING TO ORGANIC COMPOUNDS
A microcapsule slurry composition containing 25-50 wt% core-shell microcapsules with functional material cores. The aqueous phase includes inorganic salts with conductivity above 5000 μS/cm, ensuring stability and efficiency for various applications.
US- 20250345262- LOW-SUBSTITUTED CELLULOSE ETHER SPHERICAL MICROPARTICLE, AND COSMETIC
COMPOSITION USING THE SAME, AS WELL AS METHOD OF PRODUCING LOW-SUBSTITUTED CELLULOSE SPHERICAL MICROPARTICLE
A low-substituted cellulose ether spherical microparticle having an average particle size of 1 to 30 μm, a sphericity of 0.75 to 1.0, and a surface smoothness of 75% to 100%.
US- 12467016- AIR PURIFICATION CANDLE
A candle for air purification with a blend of long-chain waxes, medium-chain waxes, and short-chain waxes. The candle also includes a plurality of metal alloy nanoparticles and a wick.
US- 20250338873- PREPARATION OF DUAL CROSS-LINKED ZEIN-CARBOXYMETHYL CHITOSAN NANOPARTICLES FOR IMPROVING THERMAL STABILITY OF POLYPHENOL
Cross-linked zein-carboxymethyl chitosan nanoparticles for enhancing polyphenol thermal stability. Tannic acid and calcium ions further stabilize quercetin during thermal processing resulting in an eco-friendly natural food additive.
US- 20250332075- POLYAMIDE MICROCAPSULES
A new process for the preparation of polyamide microcapsules. And their use in perfumes and consumer products including home care or personal care products.
US- 20250325947- DOUBLE EMULSION AND CAPSULES
A method for the manufacture of a water-in-oil-in-water double emulsion. Also, a water-in-oil-in-water double emulsion method for preparing solid microcapsules from a water-in-oil-water double emulsion having oligomers and/or monomers in the oil phase.
US- 20250312286-METHOD FOR PREPARING MICROCAPSULE, MICROCAPSULE AND COMPOSITION CONTAINING THE SAME
A method for preparing microcapsules with dual wall materials, using separate heat treatments for dispersions of the first and second wall materials. The approach enhances microcapsule stability and water solubility.
US- 20250302759-BIODEGRADABLE, CONTROLLED RELEASE MICROCAPSULES
Biodegradable, controlled release microcapsules whose microcapsule walls comprise the reaction product of fractured plant proteins with isocyanates and/or bis- or poly-chloroformates.
US- 20250302713- PRODUCT AND METHOD FOR PREPARING OF CATIONIC NANOPARTICLE FORMULATION FOR DERMAL TREATMENT
A skin care formulation combining cationic nanoparticles, a film-forming ingredient, and non-encapsulated cationic
ingredients. Optional active ingredients enhance its anti-aging, moisturizing, and protective effects for skin.
US- 20250255827- BIODEGRADABLE MICROCAPSULES AND A METHOD FOR THEIR PREPARATION
A method for preparing microcapsules and their compositions, along with their uses in creating formulated products.
Observations/Thoughts/Trends/Musings
This was one of the largest patent review articles I’ve written since joining the committee. This is because of the shear volume of patents released during this time. I guess it just shows no matter what is going on in the world,
the work on encapsulation and controlled release never stops and there is no shortage of innovations to explore in
this fascinating discipline. As the days become shorter and longer, have a happy holiday season.
