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FROM THE EDITOR: Times are Changing

Authors:

As you all sit down to read this issue of the CRS Newsletter to get a dose of excellent controlled release science it is opportune to reflect on the world as we know it and the potential impact of some recent decisions. Ruth Schmid, the CRS President, has penned a statement in respect of the…

From the Editor: Salamanders, Zebrafish, and CRS

Authors:

Roderick B. Walker

This issue of the CRS Newsletter contains a fascinating summary of five published articles that have some focus on animals as a source of compounds with the potential to treat human conditions or as models to facilitate understanding of disease and biological functions. Of particular interest are…

From the President: Products!

Authors:

Art Tipton

I jotted notes for this update as I flew back from the Partnership Opportunities for Drug Delivery (PODD) conference in Boston. CRS was well represented at this conference. The conference, now in its fourth year, was again chaired by Board of Scientific Advisors (BSA) member Barbara Lueckel.…

Interview: Biomaterial and Drug Delivery Focused Research with Samir Mitragotri at University of California, Santa Barbara

Authors:

Vishwas Rai and Bozena B. Michniak-Kohn

Samir Mitragotri is a prominent leader in the field of drug delivery and biomaterials. His contribution in the field of transdermal drug delivery was noticed by the community when his group successfully published the delivery of vaccines (proteins), insulin (peptides), and siRNA via skin into the…

Investigation of the Permeability, Stability, and Toxicity of a Food-Derived Antihypertensive Peptide

Authors:

John P. Gleeson, Joanne Heade, Sinead M. Ryan, and David J. Brayden

Introduction Ile-Pro-Pro (IPP) is a bioactive peptide found in bovine milk when casein is hydrolyzed by gastrointestinal enzymes. It has an angiotensin-converting enzyme inhibitory potency of 5µM with the potential to reduce blood pressure, if orally administered.1 Although IPP is stable in…

Alkaline Protease Enzymen as a Biological Skin Permeation Enhancer: Breaking Down the Barrier

Authors:

Mohamed I. Nounou,a,b,c Nehal A. Ahmed,d Labiba K. El-Khordagui,b Amira Abouelfetouh Eid,e and Taha I. Zaghlould

Introduction Microorganisms are contributing to a great degree nowadays in the field of biotechnology, with increasing demand as they provide a wide range of by-products that show promising economic importance and value in many specialized branches of…