Scientifically Speaking
IntroductionNowadays, most of the currently available ocular drugs are administered topically through eye drops,1 but their residence time in the eye is short, about 2 min…
Macromolecular prodrugs (MP), or polymer–drug conjugates, are successful tools of drug delivery investigated broadly toward optimization of pharmacokinetics of drugs.1 Specific advantage is gained when, for example, the polymer increases solubility of the drug or aids in localizing an enhanced…
Introduction
Ile-Pro-Pro (IPP) is a bioactive peptide found in bovine milk when casein is hydrolyzed by gastrointestinal enzymes. It has an angiotensin-converting enzyme inhibitory potency of 5µM with the potential to reduce blood pressure, if orally administered.1 Although IPP is stable in…
Introduction
Therapeutically relevant proteins such as antibodies, growth factors, and enzymes play an increasing role in the treatment of malignant and autoimmune diseases. However, they often suffer from insufficient stability and poor bioavailability. A suitable method to increase protein…
Introduction
Overexpression of cyclooxegenase-2 (COX-2) is a hallmark of inflammation and an early event in carcinogenesis and cancer progression.1,2 Because COX-2 is expressed in virtually all solid tumors, it represents an ideal biomarker with broad impact for the early clinical detection of…
Introduction
Figure 1. Mechanistic and kinetic analysis of the model system.Food can significantly impact the bioavailability of oral drugs through multiple mechanisms including enhancement of solubility and dissolution kinetics, enhancement of permeation through the intestinal mucosa, and so on.…
