Scientifically Speaking

Introduction Long-acting injectable (LAI) (pro)drug nano-/microsuspensions—aqueous dispersions of pure (pro)drug nano-/microcrystals—have shown potential as a drug delivery strategy over the past decade and are now recognized as an attractive formulation option for poorly water-soluble drug…
Introduction Figure 1. (A) Schematic of a human knee joint showing the development of fibrotic scar tissue and an arthrofibrotic joint post injury or surgery. (B) Representative images of normal healthy goat knee (bottom left) and arthrofibrotic goat knee (bottom right). Images courtesy of David…
Introduction In non-small cell lung cancer (NSCLC), the level of oxygenation surrounding the cancerous cells is low compared with normal tissue owing to the rapid growth of the tumor cells. The decreased blood circulation results in development of pockets of lower oxygen levels, resulting in…
Introduction Fibrin hydrogels are protein-based scaffolds frequently used in tissue engineering for delivery of bioactive payloads (e.g., growth factors). Conventional fibrin scaffolds enable very limited spatial and temporal control of payload release, especially after implantation. This is…
Introduction Electrospinning is an electrostatic fiber fabrication technique producing homogeneous fibers in the nanometer range. The process involves dropping a polymer solution in an electric field in such a way that the electric forces overcome the polymer solution surface tension and the drop…
Introduction Grapholita molesta insects (GM) inhabit fruit trees (e.g., peach, apple, and pear), and their larvae destroy fruit.1 Although various pesticides have been used for prevention of GM, the larvae cannot be prevented from entering fruit.1 Sex-pheromone-mediated mating disruption (MD) has…