Year
2011
Institutions
Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology, Karl-Franzens Universität Graz, Universitätsplatz 1, 8010 Graz, Austria; Arab International University, Faculty of Pharmacy, Ghabaghib, Daraa, Syria Arab Republic jana.pardeike@uni-graz.at
Summary
Coenzyme Q10-loaded NLC, Coenzyme Q10 nanocrystals and Coenzyme Q10 suspension for oral application with an active content of 4.8% were developed and compared with regards to in vitro drug release, mucoadhesion and permeation through porcine intestine. The two nanoparticlulate formulations showed a faster drug release, a higher mucoadhesion and a higher permeability through porcine intestine compared to the microparticulate suspension making them promising systems for oral application of Coenzyme Q10.
