Evaluation of Antibiotic-releasing Porous Polymethylmethacrylate Space Maintainers in an Infected Composite Tissue Defect

Category

Bioactive Materials: Stem Cell and Regenerative Medicines

Year

2012

Authors

P.P. Spicer, A.M. Henslee, L.A. Kinard, B.M. Watson, J.D. Kretlow, K. Bevil, L. Katchee, J.A. Jansen, M.E. Wong, F.K. Kasper, A.G. Mikos

Institutions

Rice University, Houston, Texas, 77005, USA; Baylor College of Medicine, Houston, Texas, 77030, USA; Radboud University Nijmegen Medical Centre, Nijmegen, 6500 HB, The Netherlands; University of Texas Health Science Center at Houston, Houston, Texas, 77030, USA

Summary

Antibiotic releasing porous space maintainers were evaluated in an infected rabbit mandibular composite tissue defect model. Temporal release and magnitude of release were varied to evaluate their effects on clearance of the infection, soft tissue healing and inflammatory response. Additionally the safety of the local delivery was measured via serum blood markers for kidney function and histology. Results showed an effect on gross soft tissue healing in response to temporal delivery changes and local delivery resulted in no decreased kidney function as measured by serum markers.