Category
Bioactive Materials: DNA and RNAi Delivery
Year
2012
Institutions
University of Utah, Salt Lake City, Utah, 84112,USA, Department of Pharmacology and Toxicology; University of Utah, Center for Controlled Chemical Delivery, Department of Pharmaceutics and Pharmaceutical Chemistry; University of Utah, Department of Surgery, Cardiothoracic Division
Summary
A novel bioreducible polymer was used to transfect rat hearts with anti-apoptotic siRNA in vivo immediately after transient myocardial infarction. siRNA towards BNIP3, a potent hypoxia-inducible pro-apoptotic Bcl-2 family member, was delivered directly to the infarcted myocardium of Sprague Dawley rats. siBNIP3 therapy in this model protected rats from loss of heart function as evidenced by global left ventricular ejection fraction and chamber volume.
