Year
2010
Institutions
Department of Bioengineering, University of Maryland, College Park, MD 20742, USA; Center for Nanomedicine & Cellular Delivery & Department of Pharmaceutical Sciences, University of Maryland, Baltimore, MD 21201, USA; Departments of Pharmaceutics and Pharmaceutical Chemistry & Bioengineering, Center for Nanomedicine, Nano Institute of Utah, University of Utah, Salt Lake City, UT 84108, USA
Summary
PAMAM dendrimers have shown potential as oral drug delivery carriers due to their ability to translocate across epithelial cell monolayers and open tight junctions. In this work, we demonstrate that dendrimer uptake and transcytosis is governed by dynamin-dependent vesicular mechanisms including clathrin- and caveolin-mediated endocytosis and that cellular internalization is a requisite step for dendrimer modulation of tight junction integrity.
