Multifunctional Cargo Systems: Polyelectrolyte Based Multilayer Microcapsules.

Year
2009
Authors
G.B. Sukhorukov, M. Bedard, A.G. Skirtach, O. Kreft, A. Muñoz Javier, B.G. de Geest, W.J. Parak
Institutions
School of Engineering and Material Sciences, Queen Mary University of London, E1 4NS, London, UK; MPI of Colloids and Interfaces, Potsdam, 14424, Germany; Center for Nanoscience, LM University, Munich, Germany; Department of Pharmaceutics, Ghent University, 9000 Ghent, Belgium; Department of Physics, Philipps University Marburg, Marburg, Germany, g.sukhorukov@qmul.ac.uk
Summary

Layer-by-layer assembled capsules are owing to their ability to encapsulate a wide range of chemicals, for their permeability to be modified and their responsiveness to different factors and functionalities to be tailored in one capsule entity. Current research leads to the fabrication of carriers with remote guiding and activation by optical, magnetic and ultrasound addressing, what envisages unique applications as multifunctional biomaterials invivo. Submicron sized capsules are good model to mimicking bio-chemical processes in a confined geometry imitating cell organelles, whilst delivered inside cell and tissues the capsules could serve as intracellular reporter or enzymatic reactor.