Category
Bioactive Materials/C&DP: Imaging Diagnostics for Material Characterization
Year
2012
Institutions
Laboratory of Pharmacotechnology and Biopharmacy, Katholieke Universiteit Leuven, Belgium;Laboratory of Biophysics and Surface Analysis, School of Pharmacy, The University of Nottingham, United Kingdom
Summary
The influence of heat and humidity on the surface characteristics of spray-dried PLGA/PVP microspheres was investigated. The observations were linked to the intrinsic thermal characteristics of these two polymers. It could be concluded that the surface characteristics, of chemical composition, phase behaviour and topography, of spray-dried PVP/PLGA microparticles were affected by exposure to heat and humidity, resulting in a surface enrichment of PVP.