Patent Watch


Patent Watch

Publish Date

Ken Carson, Southwest Research Institute, U.S.A.

This article summarizes selected patents in the area of controlled release or delivery that were issued from March 1, 2019 through June 1, 2019. Greater detail on each of these patents is given on the U.S. patent website

US10224068-Magnetic storage media including nanotubes containing magnetic nanoparticles

A magnetic storage medium of magnetic nanoparticles that are encapsulated within nanotubes, arranged in a substrate to facilitate the reading and writing of information.

US10258579-Process for the preparation of polysaccharide nanoparticles

A process for the preparation of nanoparticles from polysaccharides and derivatives thereof.

US10253166-Flame-retardant microcapsule containing cyclic phosphazene

A process for making a flame-retardant microcapsule with a shell containing a cyclic phosphazene molecule.


A method for the production of a spherical microcapsule using a suspension of particulate cementitious material in a solvent that is emulsified in another phase such that the particulate material of the suspension adsorbs at least partially at a phase boundary.

US10274504-Encoded microcapsules and microarray fabricated therefrom

Describes a microcapsule that has a hydrophilic liquid core including the target substance and a hydrophobic shell surrounding the liquid core. The microcapsule includes graphical codes introduced on the surface of the shell

US10278284-Laminate materials with embedded heat-generating multi-compartment microcapsules

A composite material that incorporates multi-compartment microcapsules that produce heat when subject to a stimulus such as a compressive force or a magnetic field for use in multi-layer printed circuit boards.

US10287470-Microcapsules and macrocapsules having low remnant free formaldehyde microcapsules and methods of making same

Description of capsules of melamine formaldehyde with lower levels of free formaldehyde.

US10220378-Semiconductor-metal nanoparticle hybrids with natural and artificial proton pump for hydrogen production

Using a cell-free expression system, a transmembrane proton pump was generated and incorporated with semiconductor nanoparticles to generate hydrogen gas in water with methanol as a sacrificial electron donor.

US10312463-Light emitting microcapsule, method of preparing the same and OLED display device comprising the same

Description of an OLED (organic light emitting diode) display device made of a microcapsule containing a phosphorescent material as a core material to protect the material from self-quenching, water, and oxygen to improve display quality and life of service.

US10316873-Method and apparatus for forming multiple emulsions

Method and apparatus for making double, and triple emulsions resulting in capsules, liposomes and the like that contain smaller droplets in an immiscible solvent.

US10317397-Microparticle Separation Chip, and Microparticle Separation System and Microparticle separation method which employ said microparticle separation chip

Description of a microparticle separation system capable of continuously separating microparticles from a solution in a short period.  

US10322452-Metal Nanoparticles

The present specification relates to a metal nanoparticle with a cavity.


US-10222319-Method and device for optically detecting nanoparticles in a fluid sample

A device for optically detecting nanoparticles moving in a fluid sample using optical microscopy.

US10241026-Target analyte sensors utilizing microspheres

A microsphere-based analytic chemistry system using encapsulated bioactives for detection of analytes.

US10254268-Method for detecting toxic metal ions in sample

Describes the use of functionalized gold nanoparticles for detection of toxic metal ions by binding of the ions, aggregation and collection of the gold nanoparticles and analysis of the aggregates for the toxins.

US10274431-Method of evaluating pH using an inorganic-oxide nanoparticle based optical pH sensor

Optically active nanoparticles on a substrate are used detect changes in pH.


US10233277-Polymeric nanoparticles useful in theranostics

Use of polymethacrylic acid grafted starch (PMAA-g-St) pH-responsive nanoparticles with various molar ratio of starch synthesized by a new one-pot method that enabled simultaneous grafting of PMAA and nanoparticle formation in an aqueous medium.

US10245319-Lymph node-targeting nanoparticles

Method to make nanoparticles made up of heparin, chitosan, and at least one cytokine and using them to modulate the immune response to an antigen or vaccine.

10245322-Nanostructured carriers for guided and targeted on-demand substance delivery

Methods, systems, and devices used to make nanoscale and microscale structured carriers that can be used in theranostics. This includes nanoparticles and “nanobowls” that can be functionalized and loaded with active for targeted controlled release.

US10252289-Nanoparticle coating of surfaces

Description of a method of electrospraying nanoparticles on to a surface includes providing a drug and polymer combination in solvent to an inner capillary of a coaxial dual capillary spray nozzle.

US10258563-Encpasulation of microbubbles within the aqueous core of microcapsules

Describes the use of microcapsules containing microbubbles, imaging the tissue in a subject, and a method of delivering a therapeutic to treat ta disease or disorder.

US10265407-Modular nanodevices for smart adaptable vaccines

Describes the use of nanoparticles to as controlled release of vaccines involving antigens, adjuvants, immune regulators, and targeting/transport mediation attributes.

US10278926-Statin- encapsulated nanoparticle preparation for enhancing stem cell function, stem cell with enhanced function containing statin-encapsulated nanoparticle, and method for producing same

A preparation containing a statin-encapsulated nanoparticle made of a bio-resorbable polymer with the goal of enhancing stem cell function.

S10279036-Antibody-albumin nanoparticle complexes comprising albumin, bevacizumab, and paclitaxel, and methods of making and using the same

A nanoparticle complex with antigen-binding specificity (e.g., VEGF binding specificity), for cancer (e.g., VEGF-related cancer) treatments.

US10285934-Administration of a drug through the blood brain barrier using stimuli-responsive nanoparticles

Describes the use of a magneto-electric nanoparticle for drug delivery across the blood brain barrier (BBB). The nanoparticle attaches to the blood-brain barrier (BBB) and a non-alternating electric or magnetic field is applied to increase permeability and uptake through the BBB.

US10286004-Targeting-enhanced anticancer nanoparticles and preparation methods of same

Description of nanoparticles with porphyrin compounds for targeting to tumors.

US10293077-Polyphosphate-functionalized inorganic nanoparticles as hemostatic compositions and methods of use

Description of a nanoparticle with hemostatic agent, and polyphosphate polymer attached.  

US10307482-Nanoparticles complexes of paclitaxel, cetuximab, and albumin

Nanoparticle complexes comprising paclitaxel, albumin and anti-EGFR antibodies for treatment of cancers that express EGFR.


US10260022-Microcpasules imparting intense vanilla odor note

Description of a microcapsule with10-30% active that has a vanilla-based odor note which can be used in perfuming compositions and perfuming consumer products.


US10266820-RNA/DNA nanoparticle for siRNA target-specific delivery and vehicle including the same

Description of a nanoparticle made of nucleic acids for encapsulation of siRNA. The particle can be made by self-assembly without the need for a polycationic agent. The incorporation of folate targeting for cancer therapies is given.

US10272126-Nanoparticle-stabilized microcapsules, dispersions comprising nanoparticle-stabilized microcapsules, and method for the treatment of bacterial biofilms

Description of a microcapsule made up of shell of amino-functionalized inorganic nanoparticles around a liquid hydrophobic core. Specific application for prevention of biofilm.

US10273269-High potency immunogenic Zika Virus compositions

Uses a cationic lipid nanoparticle to encapsulate and deliver mRNA encoding Zika Virus antigens for vaccination

US10273367-Biocidal protective formulations

Description of biocidal self-healing coating materials containing microcapsules with a hydrophobic film forming agent and a biocidal agent.

US10273269US10300022-Nanoparticle Delivery Compositions

Nanoparticle delivery systems for use in targeting biologically active agents to the central nervous system using a metal or semiconductor core with a shell containing ligands specific to the application.

US10300145-Synthetic nanoparticles for delivery of immunomodulatory compounds

A synthetic nanoparticle made of peptide nucleic acid oligomer conjugated to a lipid, that complexes with an immunomodulatory compound, thereby forming a nanoparticle.

US10300152-Enzyme-encapsulated nanoparticle platform

Presents methods, systems, and devices for implementing nanoparticles to encapsulate biomolecules such as enzymes. The system includes a porous outer surface to allow substrate into the interior while not allowing the enzyme to exit.

US10307490-Lipid nanoparticle compositions for antisense oligonucleotides delivery

Describes the use of a lipid nanoparticle that incorporates a macromolecule conjugated to a polymer and a targeting agent. The system can be used to encapsulate an antisense oligonucleotide to modulate gene expression.

US10322089-Nanoparticles, nanoparticle delivery methods and systems of delivery

Description of technology for nanoparticle compositions  and methods for sustained release such as siRNA.


US10292915-Antiperspirant compositions

An anhydrous antiperspirant containing an antiperspirant, perfume, and a microcapsule of polymerized acrylate amine with less than 100ppm of residual metal catalyst and/or metal ion.

US10316219-Thermally releasable adhesive member and display apparatus including the same

A system of microcapsules dispersed in a base resin. The microcapsule core comprises an organic solvent. The resulting system causes adhesive release at elevated temperature.

US10308902-Microencapsulation of detergent components

Description of a microcapsule composition produced by crosslinking of a poly-branched polyamine, which is used for stabilizing non-enzymatic detergent components.