Patent Watch
This article summarizes selected patents in the area of controlled release or delivery that were published from December 31, 2024 through April 15, 2025. Greater detail on each of these patents is given on the U.S. patent website Patent Public Search | USPTO
General/Industrial Applications
US- 12275896- Catalytic Hydrotreating of Feedstocks
A process for hydrotreating recycled or renewable feedstocks with a catalytic microparticle slurry, and a process for manufacturing the catalytic microparticle slurry, are disclosed.
US- 12263459- Composition And Method to Form a Composite Core Material
A composite core material for use as a panel, molded product, sheet, or reinforcing material made up of a microsphere discontinuous portion.
Agriculture
Diagnostic/Sensing
US- 12275880- Gold Nanoparticle-fluorescent Hybrid Material and Method for Preparing the Same
The present invention relates to a gold nanoparticle-fluorescent hybrid material with improved fluorescence intensity and stability. Applications from biosensing to light emitting device for displays are described.
US- 12268756- Biocompatible Magnetic Materials
A biocompatible magnetic material containing an iron oxide nanoparticle and one or more biocompatible polymers with application as a contrast agent. Also disclosed in a method of preparing the biocompatible magnetic material.
US- 12241118- Assay For the Rapid Detection Of Nucleic Acids Via A Modified Lamp Reaction Coupled With
Colorimetric Reporter Utilizing A Gold Nanoparticle : Peptide Nucleic Acid (AuNp-PNA) Probe System
An assay is provided for the rapid detection of nucleic acids via a modified LAMP reaction coupled with colorimetric reporter utilizing a gold nanoparticle—peptide nucleic acid (AuNP-PNA) probe system.
US- 12226496- Polymeric Core-shell Particles
A nanoparticle with a lipid core, linked to a glucose molecule, and chelating agents for use in imaging a tumor.
US- 12186436- Triblock Copolymer Stabilizers for The Formation Of Nanoparticles Encapsulating Soluble
Biologics, Therapeutics, And Imaging Agents
Methods for the formation of a core-shell-brush nanoparticle from an A-B-C triblock copolymer that can contain a biologic. The particles can be tuned for release based on process parameters triblock characteristics.
Pharma
US- 12263248- Compounds And Compositions for Intracellular Delivery of Therapeutic Agents
Nanoparticles with both novel and traditional lipids such as phospholipids, structural lipids, and PEG lipids used for encapsulation of therapeutic and/or prophylactics such as RNA to regulate polypeptide, protein, or gene
expression.
US- 12263228- Lipids And Compositions Thereof
Lipid nanoparticle (LNP) compositions comprising a capsid-free, non-viral vector (e.g., ceDNA) as targeted delivery vehicles.
US- 12257294- Therapeutics For Autoimmune Disease: Synthetic Antigens
Describes a nanoconjugate complex for delivery of therapeutics for autoimmune diseases. Formulation has at least one specific antigen component recognized by autoantibodies, a helper moiety, and a nanoparticle carrier.
US- 12258384- Fusion Albumin Nanoparticle and Application Thereof
A fusion albumin nanoparticle for biomedicine. The nanoparticle is formed by self-assembly of the shell material entrapping the API during the formation process. The fusion albumin has targetability, pH and enzyme-sensitive functional groups.
US- 12257344- Polymersomes Functionalized with Multiple Ligands
A nanoparticle or microparticle for binding to the surface of a cell, with multiple different ligand types on its external surface and a polymer brush on its external surface as a delivery vehicle for vaccines and therapeutics.
US- 12251471- Inhalable Therapeutics
A nanoparticle comprised of an ionizable lipid, cholesterol or a derivative thereof, a structural lipid, and a PEG lipid suitable for delivering a therapeutic agent to a subject by nebulization.
US- 12245993- Vitamin K2 Microcapsule, Preparation Method Thereof and Use Thereof in Manufacture Of
Medicament For Preventing Or Treating Cardiovascular And Cerebrovascular Diseases
A vitamin K2 microcapsule, for preventing and treating cardiovascular and cerebrovascular diseases. The microcapsule has good water solubility, stability and high bioavailability, with broad application prospects.
US- 12239687- Sustained Release Formulations Using Non-Aqueous Membrane Emulsification
Non-aqueous membrane emulsion methods for producing polymeric and polymer-coated microparticles are provided.
US- 12239703- Composite-type Nano-vaccine Particle
The present invention discloses a composite-type nano-vaccine particle, with an active selected from spike RBD protein of COVID-19, two adjuvants, and an amphiphilic alginate-based nanocarrier.
US- 12233165- Microsphere Formulations Comprising Ketamine and Methods for Making And Using The Same
Extended-release, injectable microsphere formulations comprising ketamine are provided.
US- 12233161- Lipids And Lipid Nanoparticle Formulations
Relates generally to lipids, lipid nanoparticle formulations, and methods of using the same for delivering nucleic acids, such as mRNA.
US- 12226523- Method For Preparing Self-Assembled Nanoparticle Releasing Soluble Microneedle Structure
A self-assembled nanoparticle-releasing soluble microneedle structure made by mixing a biocompatible amphiphilic block copolymer and a hydrophobic drug in a solvent. The solvent is evaporated forming a film that is then suspended in an aqueous solution of an additive and a hydrophilic drug. The suspension is then poured in a microneedle mold and allowed to solidify allowing for delivery via the intradermal or transdermal route via the microneedles.
US- 12226491- Nano-satellite Complexes
A nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core with a plurality of antigenic peptides conjugated to, or absorbed to, said satellite particles ; and at least one additional property. In some embodiments, administration of the nanosatellite complexes to a subject with cancer achieves long-term
cancer remission (e.g., when combined with an immune checkpoint inhibitor, such as αPD1).
US- 12209115- Exosome-targeted DNA Vaccine
Describes the use of exosomes expressing a fusion antigen of an exosome-constituent protein and a vaccine antigen to enhance cytotoxic T-cell inducibility.
US- 12208288- Betacoronavirus RNA Vaccines
RNA vaccines and combination vaccines related to RNA betacoronavirus vaccines formulated in a lipid nanoparticle.
US- 12203073- Plant Viral RNA Delivery Nanoparticles and Uses Thereof
A nanoparticle includes an icosahedral-shaped plant virus particle; an RNAi construct; and one or more endolysosomal release agents, wherein the RNAi construct is noncovalently loaded within the icosahedral-shaped plant virus particle.
US- 12194069- Use Of Probiotic Yeast Cells Producing Recombinant Parathormone for Therapeutic Purposes
The use of probiotic yeast cells that produce recombinant parathormone, which are then microencapsulated and orally delivered in gelatin capsules for hypoparathyroidism treatment.
US- 12194055- Solute Carrier Family 46 Member 3 (SLC46A3) As Marker for Lipid-based Nanoparticle Cancer
Therapy and Diagnostics
Describes the use of SLC46A3 to enhance uptake of nanoparticle formulations by cancer cells as a delivery vehicle and diagnostic aid.
US- 12186389- Nucleic Acid Base Vaccine Against Emerging SARS-CoV-2 Variants
Lipid nanoparticle formulation containing nucleic acids suitable for use in treatment or prophylaxis of an infection with a coronavirus.
US- 12186434- Surfactin-based Lipopeptide for MRNA Delivery
Lipid nanoparticles using Surfactin lipopeptides for mRNA delivery. The resulting nanoparticles may be useful as mRNA delivery vehicles.
US- 12178889- Gold Nanoparticle-ligand Conjugates and Methods of Use
Gold nanoparticles are conjugated to phosphatidylserine-specific ligands for targeting and binding to surface- exposed phosphatidylserine on tumor cells and tumor vasculature.
Bio
US- 12274787- Sustained-release Injection Comprising Deslorelin, And Preparation Method Therefor
A sustained-release injection formulation comprising biodegradable polymer microspheres containing deslorelin as an active ingredient for sustained release of up to 6 months for unwanted pregnancy in dogs and cats.
US- 12269096- Method For Preparing Dispersed Metal Nanoparticles and Metal Nanoparticles Prepared Thereby
A dispersed metal nanoparticle synthesis method using Taylor vortex flow even when using a small amount of, or no stabilizer.
US- 12263227- Optimized MRNA Encoding CAS9 For Use in LNPs
A novel lipid nanoparticle (LNP)-based composition useful for, e.g., the delivery of a site-specific endonuclease or a nucleic acid molecule encoding same, into a target cell.
US- 12257363- Medical Device for Neural Repairing of The Spinal Cord or Of a Nerve
A medical device for repairing injuries to the spinal cord or peripheral nerve utilizing nanoparticles that act as a directional scaffold for stem cells withing the matrix containing the nanoparticles allowing for the parallel extension of neurons of the spinal cord or peripheral nerve.
US- 12194113- Microcapsule With a Porous Or Hollow Core And Ph-sensitive Shell And Use Thereof
A microcapsule comprising a hollow or porous core composed of a polymeric material and containing a component of a redox-initiator system and a pH-sensitive shell material. The microcapsule can be used for formulating dental materials.
Consumer Products/ Cosmetics
US- 12274771- Polyurea Capsule Compositions
A system of two microcapsules in which the first microcapsule has a zeta potential of 10 mV or greater, the second microcapsule has a zeta potential of 5 mV or less, with a weight ratio of between 1:10 and 10:1. Also disclosed are consumer products containing such a microcapsule composition.
US- 12274690- System And Method for Incorporating CBD/THC Cannabinoid Nanoparticle Carrier Compositions Into Particulate Foods And Food Additives
A cannabinoid nanoparticle carrier composition for administration to a human in a consumable food product such as herb or spice, sugar, salt, or particulate preservative, mixed into a slurry or suspension, dried, and then ground to a size suitable for human consumption.
US- 12269002- Microcapsule Compositions
A microcapsule dispersed in an aqueous phase. The core contains an active material selected from the group consisting of a fragrance, cosmetic active, malodor counteractant, and combinations thereof. The microcapsule wall is made up of chitosan, a polyisocyanate, and a polyphenol.
US- 12201707- Nano-emulsion Composition for Tooth Whitening and Method For Producing The Same
A nanoemulsion composition for tooth whitening consisting of nanoparticle containing a perfluorocarbon compound, and an oil phase that includes oxygen gas.
