Patent Watch - Ken Carson, Southwest Research Institute, U.S.A.


Patent Watch - Ken Carson, Southwest Research Institute, U.S.A.

Publish Date

This article summarizes selected patents in the area of controlled release or delivery that were issued from March 3, 2020 through May 19, 2020. Greater detail on each of these patents is given on the U.S. patent website

US-10654020- Preparation method of carbon-coated ceria hollow sphere

Method of preparing a carbon-coated ceria hollow sphere, by first coating a silica sphere with ceria, then coating that sphere with a carbon source and etching the carbon-coated ceria microsphere to create a hollow sphere.

US-10624860- Method to generate microcapsules with hexahydrotriazine (HT)-containing shells

Description of a microcapsule with walls that have hexahydrotriazine (HT) and/or hemiaminal (HA) structures cross-linked with NH4Cl along with a copolymer.

US-10618023- Formation of a janus microcapsule

This patent is a description of a method for generating microcapsules with multiple functionalities on the surface.

Industrial Applications

 US-10653134- Microcapsule composition containing water-soluble amine and a process for the preparation thereof

This patent is a description of an encapsulated reactive amine composition of approx. 100 microns or less in size with a water-soluble amine; polymeric surfactant/stabilizer; poly-isocyanate; and fumed silica; wherein, the reactive amine is released in aqueous and non-aqueous environment, for use in industries such as painting, cosmetics, paper, lubricants, printing, plastics, petrochemicals etc.


US-10646472- Composition comprising a photosensitive compound in a polymeric nanoparticle, and a method of using the composition

This includes a description of a photosensitive compound and a polymer nanoparticle. A targeting moiety may also be included. Upon irradiation with near infrared light, the composition may be used as a fluorescent imaging agent and/or as a phototherapeutic agent. Treatment of cancer was specifically mentioned in the description.

US-10640674- Autonomic damage indication in coatings

Description of a product utilizing microcapsules in a polymer coating having free and/or residual amines. The microcapsules contain a color indicator, upon release and reaction provides a visual indicator of surface damage.

US-10610607- Magnetic graphene-like nanoparticles or graphitic nano- or microparticles and method of production and uses thereof

Description of a graphene or graphene-like nanoparticle that can be used as an MRI contrast agent.


US-10639372- Nucleic acid, medical nanoparticle, and pharmaceutical composition thereof

This patent describes a formulation of a nanoparticle with an outer and inner lipid layer, a photosensitizer and nucleic acid.

US-10631564- Enterically coated microparticle compositions and methods for modified nutrient delivery

A microcapsule or microparticle with a nutrient core is described. The formulation includes an enteric coating for oral delivery.

US-10624934- Prebiotic formulations

Description of a biocompatible microsphere, a biofilm-generating probiotic bacterium, a prebiotic, and/or a “prebiofilmic”. Methods for preparing and formulating the compositions and methods for treating or preventing a disease using the compositions are also provided.

US-10624905- Corticosteroids for the treatment of joint pain

A method to generated corticosteroid-loaded microparticles to be administered locally as a sustained dosage form.

US-10624854- Method for preparing degradable drug-loaded microsphere for embolization, and product obtained therefrom

Description of encapsulation using a degradable polymer by precipitation in a solution of  poly-vinyl alcohol. The patent describes the application of the targeted microspheres to embolized blood vessels.

US-10610493- Detoxification using nanoparticles

This patent describes the use of nanoparticles with an outer surface made up of a source cell. The toxin is bound to the nanoparticle surface membrane instead of the cell of the host. A specific used cited is that of acetylcholinesterase inhibitors such as organophosphates.

US-10603383- High capacity diketopiperazine microparticles and methods

Here is described a microparticle made of diketophperazine capable of adsorbing a large amount of active. Specifically, this can be sued for pulmonary delivery via oral inhalation.

US-10596124- Lipid nanoparticle compositions and methods as carriers of cannabinoids in standardized precision-metered dosage forms

This disclosure describes the use of lipid-based formulations for the encapsulation and delivery of cannabinoids across hydrophobic mucosa resulting in increased bioavailability and therefore lower, more efficient dosing.

US-10590417- RNA ligand-displaying exosomes for specific delivery of therapeutics to cell by RNA nanotechnology

This is a description of exosomes displaying an RNA nanoparticle on their surface for cellular targeting. The extracellular vesicle can potentially be used in treatment or diagnostics.

US-10588985- Compositions and methods relating to RAD6 inhibition

This is a description of a therapeutic agent coupled to a gold nanoparticle.

US-10588860- Poly(vinyl benzoate) nanoparticles for molecular delivery

This is a description of poly(vinyl benzoate) nanoparticle suspensions as molecular carriers for coumarin-6 as an extended release formulation. The formulation method is described as a nanoprecipitation in water with Pluronic F68 surfactant. It is stated that the nanoparticles are suitable carriers for molecular delivery of lipophilic small molecules such as drugs pharmaceutical and imaging agents.

US-10584114- RNA nanoparticles for brain tumor treatment

This patent describes the use of an RNA nanostructure containing a “multiple-branched RNA nanoparticle” along with a tumor-targeting moiety and therapeutic agent. Specifically, a treatment for brain tumors is described.

US-10583104- Tuneable delivery of nanoparticle bound active plasmin for the treatment of thrombosis

This is a description of nanoparticles used in thrombus dissolution. The surface of the particles is reversibly conjugated to a molecule used to dissolve the clot. By changing the surface protein, the particles can be used to induce clot formation.


US-10653786- Silk microspheres and methods for surface lubrication

This is the description of a phospholipid-coated silk microsphere can be used for lubrication of a surface. In some cases, this could be used for joint lubrication and thus arthritis treatment.

US-10653768- Method for producing RNA compositions

This is a description of a method to produce a liquid slurry of nanoparticles containing at least one RNA and at least one cationic or poly-cationic compound at such a scale as to be applicable to pharmaceutical applications such as vaccine production.

US-10588986- Biofunctionalized nanoparticles and uses thereof in adoptive cell therapy

Here is described a nanoparticle coupled to an antigen and an antibody to a B cell receptor for use in immunotherapy.

US-10583156- Nanoparticle formulations

This disclosure describes a biologically active nanoparticle formulation of MYC protein and its use in treatment.

Consumer Products/ Cosmetics

US-10646416- Microcapsules containing a gas-releasing photolabile compound and uses thereof

Description of a photolabile capsules that can be used to release a fragrance.

US-10617609- Composition comprising microcapsules containing reflective particles

The patent describes the use of microparticles containing reflective materials applied to the surface of the skin for a cosmetic application.

US-10610466- Products containing charged polymer complex microcapsules and method of use

This is a description of formulations of microcapsules that bind to protein-containing surfaces (hair or fur) with payloads for the purpose if enhance health of the hair (rehydration, reduction of “split ends”).