2022 Archives Power Points

Speaker Presentations

Monday July 11th

Session: Basic Concepts of Oral Drug Delivery; What you Need to Know, What I Wish I Knew When I Started Many Years Ago and Paid the Price for Not Knowing Part 1- 8:00 am - 12:00 pm 

• Lipid-Based- Drug Delivery Systems-  Annete Mullertz
• Multiparticulates: Flexible Oral Solid Dosage Formulations- Maura Murphy
• Innovation in Functional Excipients for Oral Drug Delivery Sandip Tiwari, Ph.D.
• Basic Concepts of Oral Drug Delivery- Daniel Bar-Shalom
• Large Molecule Administration by  the Oral Route: Challenges and Current Status-  David Brayden

Session: Biodegradable LAII, a Patient-friendly and Sustainable Technology for Human Healthcare

• STRATEGIES AND CONSIDERATIONS FOR DEVELOPMENT AND (CGMP) MANUFACTURING OF (PRE)CLINICAL SUPPLIES OF LAI HOT MELT EXTRUDED IMPLANTS - Tony Listro
• Next generation bioresorbable injectable contraceptive implant- Rob Steendam
• Long-Acting Contraceptives for Low and Middle-Income Countries- Dennis Lee of  Bill and Melinda Gates Foundation

Tuesday, July 12th

Tech Forum: Adare Pharma Solutions - Diversifying Contraceptive Options with Stratum Technology-9:00 am -10:00 am

• Sustained Drug Release Injectables-Brad Minrovic, Ph.D
• Biodegradable Polyesteramide (PEA) Materials- An Elegant Solution to Acidic Microclimate Challenge- Dr. George Minov

Tech Forum: Lubrizol Life Science Health - Solubility Enhancement: Accelerate Development with Efficient Excipient-Led Approaches- 10:00 am - 11:00 am

• Solubility Enhancement: Accelerate Development with Efficient Excipient-Led Approaches- Elena Draganoiu & Joey Glassco

Tech Forum: Secant Group - Oral Gand Injectable Microsphere Dosage Forms-10:00 am - 11:00 am

• Elastomeric and Biodegradable HydraleseTM (PGSU) Facilitates Novel Long-acting Oral Gastroretentive Devices and Injectable Microspheres- Manasi Chawathe Baker, Ph.D

Tech Forum: Wyatt Technology - Biophysical Characterization and Quality Control of LNP and Viral Vectors with Light Scattering-10:00 am - 11:00 am

• Biophysical Characterization and Quality Control of LNP and Viral Vectors with Light Scattering Thomas H. Scheuermann, Ph.D.

Tech Forum: Colorcon - Challenges and solutions for modulating drug release in OSDF- 11:00 am - 12:00 pm 

• Challenges and solutions for modulating drug release in OSDF-  Rexit Mehta & John Pare

Tech Forum: NOF Corporation - COATSOME® SS-Lipids: Biodegradable Lipid Nanoparticles for Gene Therapy and Vaccines with Room Temperature Stability-11:00 am - 12:00 pm 

• COATSOME® SS-Lipids: Biodegradable Lipid Nanoparticles for Gene Therapy and Vaccines with Room Temperature Stability  - Syed Reza

Tech Forum: Precision NanoSystems - Accelerating the Development of RNA-Based Medicines Using the Genomic Medicine Toolkit: A Case Study on Developing a COVID-19 mRNA-LNP Vaccine-11:00 am - 12:00 pm 

• Accelerating the Development of RNA-Based Medicines Using the Genomic Medicine Toolkit: A Case Study on Developing a COVID-19 mRNA-LNP Vaccine-Serra Gurcan & Martin Rabel

 

Tech Forum: Agilent Technologies - Overcoming Dissolution Challenges with Low-Dose Pharmaceuticals and Medical Devices-12:00 pm - 1:00 pm

• Tech Forum: Agilent Technologies - Overcoming Dissolution Challenges with Low-Dose Pharmaceuticals and Medical Devices- Dan Spisak (Agilent Technologies)

Tech Forum: Evonik Corporation - Functional Ready-to-fill capsules for delayed release-12:00 pm - 1:00 pm

• Functional Ready-to-fill Capsules for Delayed Release- Kamlesh Oza (Evonik Corporation)

Tech Forum: Simulations Plus - Complex Delivery Routes and Generics: The Next Frontier for PBBM/PBPK Modeling-12:00 pm - 1:00 pm

• Simulations Plus - Complex Delivery Routes and Generics: The Next Frontier for PBBM/PBPK Modeling - Jessica Spires (Simulations Plus)

Plenary Session I 4:30 pm - 5:30 pm

Biodegradable Polymers: From Drug Delivery to Everyday Plastics- Kinam Park

Wednesday, July 13th

Plenary Session 2 -9:00 AM - 10:00 AM

Advances in Antibody-based Therapies for Oncology Applications- Puja Sapara

Tech Session 1: AI and Big Data in Drug Delivery-11:00 am - 1:00 pm

• AI and Big Data in Drug Delivery-Giovanni Traverso
• Artificial Intelligence Strategies for Improving Nanomedicine Formulation Development- Thomas Moore

• Machine Learning Directed Design of Polymer-Protein Hybrids- Adam Gormley

• Predicting Long-Term Drug Release Kinetics from One Week of Elution Data in Poly(Ethylene-co-Vinyl Acetate) Drug-Eluting Implants: A Method to Accelerate Product Development- Jeff Haley, PhD

• Machine Learning Directed Drug Formulation Development- Zeqing Bao, Leslie Dan

Tech Session 1: Bioinspired and Biomimetic Delivery-11:00 am - 1:00 pm

• BIOMIMETIC NANOPARTICLES FOR BIOMEDICAL APPLICATIONS- Helder A. Santos
• A theranostic platform for Joint Repair- Chiara Mancino
• Bio-Inspired Nanopolymer-Based Photodynamic Immunotherapy with Protection Against Tumor Recurrence - Junho Byun
• mRNA Encapsulating Biomimetic Nanoparticles for Treating Rare Pediatric Diseases-Assaf Zinger 

TECH SESSION 1: Biologics Delivery- 11:00 am - 1:00 pm

• Anti-miR-96 and Hedgehog Pathway Inhibitor MDB5 Synergistically Ameliorate Alcoholic Liver Injury in Mice-Virender Kumar           
• Harnessing Synthetic Cells to Support Regenerative Medicine- Gal Chen
• VITAL Dose® Sustained Release of Biotherapeutics from a Solid Parenteral Dosage Form- Harsh Patel
• Harnessing Synthetic Cells to Support Regenerative Medicine- Natalie Orr
• Lipid-metal Hybrid Nanoparticle-mediated Delivery of CRISPR/Cas9 for Restructuring of Tumor Immune Microenvironment- Dongyoon Kim

• Nanoparticles for Transmucosal Delivery of CRISPR-based Gene Editing Tools in the Lung-  Belal Tefech

Tech Session 1: Cancer- 11:00 am - 1:00 pm

• Cancer immunotherapy based on image-guided STING activation by nucleotide nanocomplex-decorated ultrasound microbubbles- Wen Jiang
• A Rationally-designed Polypeptide-based Combination Conjugate for Treatment of Breast Cancer Brain Metastasis- Maria Vicent 
• Engineering Immunity Using Biomaterials- Natalie Arzi

• Mechanotherapeutics optimizes the efficacy of Nano Immunotherapy in Preclinical Breast Cancer Tumor Models- Fotios MPerkris 

• Targeted chemoradiotherapy of prostate cancer using gold nanoclusters with protease-activatable monomethyl auristatin E- James Basilion

• Regulation of Tumor Immune Microenvironment Using Advanced Nano-Immunotherapy- Helena Florindo

Tech Session 1: Local Chapters 1-11:00 am - 1:00 pm

• Fluorescent Ratiometric Micro-tattoos for Monitoring Applications- David Brambilla
• Engineered Therapeutics to Reprogram the Tumor Microenvironment-Jai Prakash
• PARTICLE-STABILIZED LIPID-BASED FORMULATIONS FOR 3D PRINTING OF SOLID LIPID TABLETS BY SEMI-SOLID EXTRUSION- Amanda Brun

Tech Session 1: Nervous System Delivery-11:00 am - 1:00 pm

• MRI-Targeted Drug and Gene Delivery to the CNS with Focused Ultrasound-Richard J. Price.

• Blood-Brain Barrier-Penetrating MnO₂-Loaded Polymer-Lipid Nanoparticles Remodel Tumor Microenvironment and Enhance Radiation Therapy of Glioblastoma- Charles Yen

• Brain-Derived Extracellular Vesicles as Molecular Probes and Therapeutic Vehicles In Neonatal Brain Injury-Phuong Nguyen

• Ultrasound-responsive barbiturate nanodroplets for localized anesthesia across the blood-brain barrier- Harriet Lea Banks

• Development of Targeted Liposomal Nanocarriers for Delivery of siRNA to Neuroblastoma- Amy Logan

PLENARY Session 3- 2:00 PM- 3:00 PM

Controlling in Vivo Drug Transport with Pharmaceutical Nanotechnology - Ijeoma F. Uchegbu

Tech Session 2: Delivery Technologies in Consumer and Diversified Industrial Products(C&DP 1) - 4:30-6:30 PM

• BIODEGRADABLE MICROCAPSULES- Jiten Dihora 
• ENGINEERING CONTROLLED FRAGRANCE RELEASE SYSTEMS FOR SUPERIOR PERFORMANCE- Yabin Lei
• Microencapsulation of Nicotine for Tobaccoless Oral Administration- Dr. Cuie Yan
• Inspired by Nature: Biomimetic stabilizers for Smart Cosmetic Active Ingredient Encapsulation-Damien Dupin
• Antibiotic discovery for Resistant Acne Infections: Novel topical formulation development - Fatima Abid

Tech Session 2: JCR Session- 4:30-6:30 PM

• Overcoming Biological Barriers using Stimuli-Responsive Silica Nanoparticles- Amirali Popat
• Alleviation of aorta atherosclerosis by Antibody-coated Mesoporous silica nanoparticles- Jong Oh Kim, PhD
• Local Delivery of Immunoactive Complex for Systemic Therapy of Solid Tumors- Yoon Yeo
• From Prodrugs to Self-Assembling Prodrugs: Pros and Cons- Honggang Cui

• Analytical and Programmable Drug Delivery Systems- Siowling Soh

• Stability of Drug-Loaded Polymeric Micelles- Wim E. Hennink

Tech Session 2: Nanomedicine and Nanoscale Delivery- 4:30-6:30 PM

• Nanoparticle Mediated in Situ Molecular Reprogramming of Immune Checkpoint Interactions for Cancer Immunotherapy- Professor Khuloud Al-Jamal
• A Novel RNA Lipid Nanoparticle Platform: Gene-Edited CAR T Cells for Off-the-Shelf Cancer Therapy- Samuel Clarke
• Formulation of a drug with novel antifibrotic activity as a sustained-release injection- Rachel Shapiro

• Harnessing Synthetic Cells to Support Regenerative Medicine- Gal Chen

• LIGHT-TRIGGERED NANOBOMBS FOR NANOPROJECTILE-MEDIATED DELIVERY OF BIG MACROMOLECULES-  Juan C. Fraire

• The high drug load delivery system enabling the next generation long-acting injectables through atomic layer precision- Joel Hellrup

• Overcome Hepatic Challenge for a Better Efficacy of IV Administered Therapeutics- Matthieu GERMAIN

• mRNA Nanomedicine for Precision Cancer Immunotherapy- Jinjun Shi

• Nanomedicine and Nanoscale Delivery- Dr. Naomi Benne

• Nanoscale Coherencies in RNA and Drug Delivery Vehicles- Heinrich Haas

Tech Session 2: Ocular Delivery- 4:30-6:30 PM

• An Ion-Paired Moxifloxacin Nanosuspension Eye Drop Provides Improved Treatment and Prevention of Ocular Infection- Matthew Appell
• Injectable Capsule for Tunable Extended Therapeutic Delivery- Katelyn E. Swindle-Reilly

• Mucoadhesive Micelles For Anterior Segment Drug Delivery -Heather Sheardown 

• Novel treatments for retinal degeneration: Ocular bio-distribution and Treatment Efficacy of lipid Nanocapsules and Liposomes- Gustav Christensen

• Ocular Drug Delivery Companies Spun Out of the Center for Nanomedicine at the Wilmer Eye Institute- Justin Hanes

• Photoporation of the Corneal Epithelium by Laser-Induced Nanobubbles-Félix Sauvage

Tech Session 2: Special Populations- 4:30-6:30 PM

• Development of Functionalized Nanocarriers for Drug Targeting in Tuberculosis- Zsuzsa Baranyai

• Development of Human Milk for the Delivery of Poorly Water-Soluble Drugs in Neonatal and Paediatric Patients- Ellie Ponsonby-Thomas

• Extracellular Vesicles from Gardnerella Vaginalis and Mobiluncus Mulieris Induce Host Immune Response from the Cervicovaginal Epithelium- Andrea Joseph

• Ferring and Reproductive Medicine and Maternal Health A Single Commitment: Dual Approaches- Gaurang Daftary

• Lactoferrin Nanoconjugates For Topical Attenuation of Psoriasis- Marwa A. Sallam

Tech Session 2: Vaccine Delivery- 4:30-6:30 PM

• Dendritic Cell-Targeted Nano-Vaccine: A tool for sensitizing cancer to immunotherapies- Ron Kleiner

• Engineering the STING Protein for a Peptidecancer Vaccine- Celestine Hong

• Freeze Drying to Enable the Long-Term Storage of mRNA Lipid Nanoparticles- Sofie Meulewaeter

• Delivering mRNA Vaccines- Yvonne Perrie

• Intradermal Cancer Vaccine: Engineering an Automated Nano-Droplet Dispensing System to Fabricate HPV Peptide-TLR2 Conjugate Loaded Dissolving Microneedles-  Koen van der Maaden, PhD

• mRNA Vaccine Delivery- Shrirang Karve

   

PhD Thesis Award Presentation- 6:30-7:30 PM

• Developing Novel STING-activating Immunotherapy-Xiaoqi (Kevin) Sun
• Polymeric Nanocarriers for the Delivery of Ionizable Therapeutics: Formulation, Internal Structure, and Large-Scale Process Development- Kurt Ristroph

Thursday, July 14th

Tech Session 3: Immuno Delivery- 11:00 am - 1:00 pm

• Engineering (metallo)prodrugs for cancer nano-(Immuno Therapy)- Quim Peña

• Delivery of Genetic Medicines with  Non-Viral Polymer Nanoparticles-  Kunwoo Lee

• Near-Infrared Light-Mediated Multifunctional Hydrogel for Cancer Photo-Chemo-Immunotherapy- M.-Ali Shahbazi

• Ace-DEX Microparticles for Broadly Active Influenza Vaccination- Dylan Hendy

• METRONOMIC ADMINISTRATION OF NANOMEDICINE INDUCES TUMOR MICROENVIRONMENT NORMALIZATION AND IMPROVES IMMUNOTHERAPY-TRIANTAFYLLOS STYLIANOPOULOS

• Tailored drug delivery systems: Treating Cancer & Preventing Device/Graft Rejection- Joshua C. Doloff

Tech Session 3: Local Chapters 2- 11:00 am - 1:00 pm

• FROM THE LAB TO THE MARKET TO MAXIMIZE IMPACT- María de la Fuente
• On-Demand Surface-Triggered In Situ Gelation (STIG) for Coating of Therapeutic Cells and Biomedical Devices- Jee-Heon Jeong
• Building Drug Depots Within the Heart- Eduardo Merino Asumendi
• Delivering Antisense Oligonucleotides to the Murine Brain using Image-Guided Focused Ultrasound- Dr. Kara L. Vine-Perrow 
• Metal Oxide Nanosystems for Targeted Chemotherapy- Thashree Marimuthu

TECH SESSION 3: NEW TECHNOLOGY FOR DRUG DELIVERY- 11:00 am - 1:00 pm

• Biomimetic Nanoformulations for Targeting Inflamed Vasculature- Francesca Taraballi
• Towards Microfluidics Manufacturing of Next-Generation Polyester Microparticles- Jack Bufton
• DEXAMETHASONE INTRAVITREAL IMPLANTS: CHARACTERIZATION AND ELUCIDATION OF DRUG RELEASE MECHANISMS- Mark Costello
• Histopathological Biomarkers to Predict the Accumulation of  Cancer Nanomedicine in Murine and Human Tumors- Jan-Niklas May
• Microfluidic production of monodisperse phase-change nanodroplets for enabling ultrasound imaging and therapy: In vitro and in vivo assessment- Samir Cherkaoui

• PharmaShell^® The high drug load delivery system enabling the next generation long-acting injectables through atomic layer precision-  David Westberg

Tech Session 3: Precision Medicine- 11:00 am - 1:00 pm

• A Novel RNA Lipid Nanoparticle Platform: Gene-Edited CAR T Cells for Off-the-Shelf Cancer Therapy- Samuel Clarke
• mRNA Lipid Nanoparticles for Treating Disease Before Birth -Michael J. Mitchell, PhD
• Precision Nanomedicine-based Immunotherapy to Overcome Immunosuppression Against Melanoma Brain Metastasis- Helena F. Florindo
• Selective Blood Cell Hitchhiking in Whole Blood with Ionic Liquid-Coated PLGA Nanoparticles to Redirect Biodistribution After Intravenous Injection- Chistine Hamadani

Tech Session 3: Success stories - From Bench to Clinical Trials - Lessons Learned- 11:00 am - 1:00 pm

• Bridging early academic research & clinical development on polypeptide-based nanomedicines- Maria Vicent

• Microneedle technology: From bench to clinic- Mark R. Prausnitz

• Starting a career in start-ups (during a global pandemic)- Laura Ensign

Tech Session 3: Transdermal and Mucosal Delivery- 11:00 am - 1:00 pm

• Exosome-Encapsulated Pirfenidone and Its Effects on Wound Healing- Jin Wang
• Stimulus Responsive Nanosystem to Manage Inflammatory Bowel Disease- Andreia Sofia Barros
• Gastrointestinal auto-injectors for the oral delivery of biologics- Stephen T Buckley
• Superswelling Microneedle Arrays for Dermal Interstitial Fluid Proteomics- Davide Brambilla
• Tackling Antibiotic Resistance Using Hydrogel-Forming Microneedle Technology to Deliver Antibiotics Transdermally- Li Zhao
• Tough drug delivery, let’s GUTting it out!-Bruno Sarmento

 

Tech Session 4: Additive Manufacturing- 3:00 PM -5:00 PM

• APPLICATION OF 3D PRINTING TO MICRONEEDLE-MEDIATED DRUG DELIVERY AND INTERSTITIAL FLUID EXTRACTION- Ryan F. Donnelly
• Leveraging Additive Manufacturing to Assay Ultrasound Enhanced Permeability - Jun Xu 
• A 3D-Printed Polymer–Lipid-Hybrid Tablet towards the Development of Bespoke SMEDDS Formulation- Bryce W. Barber

• The effect of a plasticiser on the printability and solubility of a poorly soluble drug in a 3D printed tablet -  Maria Inês E. Barreiros

• Development and Characterization of 3D-Printed Silicone Scaffolds for Antibiotic Release to Treat Bacterial Vaginosis-  Anthony Kyser

Tech Session 4: Gene Delivery & Gene Editing- 3:00 PM -5:00 PM

• Developing Antibody/siRNA Nanocarriers to Regulate Wnt Signaling in  Triple-Negative Breast Cancer- Emilly Day
• Environmentally-sensitive Polymer-based Nanoparticles for Intravitreal Gene Delivery- Gijung Kwak

• Multi-epitope- and siRNA- based Dendritic cell-targeted nano-vaccine against SARS-CoV-2- Ron Kleiner

• Optimization of Lipid Nanoparticles for Self-Amplifying RNA Expression & Cellular Activation Using a DoE Approach - Dr. Anna Blakney

• Peptide-targeted Polymers for Duchenne Muscular Dystrophy Gene Therapy - Jessica Hersh

• Stretch-based cell stimulation for Non-Viral Gene Delivery- Beatrice Ruzzante

Tech Session 4: Global Health- 3:00 PM -5:00 PM

•   Active Targeting of Nanoparticles to the Brain for Treating Parkinson's Disease- Mor Sela
• Colonic Capsules for Bacterial Suspensions- Fatma Abdi
• Homogeneous Surrogate Virus Neutralization Assay to Rapidly Assess Neutralization Activity of Anti-SARS-CoV-2 Antibodies - Morgan Marsh
• Versatile, Topical Antibiotic Delivery with Glutathione-conjugated Hydrogels- Angeliki Andrianopoulou
• Liposome‐Display of Antigens: A Versatile Approach for Vaccine Development- Jonathan Lovell
• Novartis Global Healthcare: Meeting Patient Needs- Manuel Sanchez-Felix

Tech Session 4: New Developments in Characterization and Process Scale-up (C&DP 2)- 3:00 PM -5:00 PM

• Comparing Labelling Methods to Study the in Vivo Pharmacology of Nanomaterials - Sabrina Roussel
• Microfluidics for Automated LNP Screening and Scale Up- Richard Gray
• Scalable Fabrication of Monodisperse Microparticles Using in-air Microfluidics- Jenny Párraga
• Terminal sterilization of Controlled Release Coated Azacitidine Using Gamma Irradiation
• Transitioning from a Lab-scale PLGA Microparticle Formulation to Pilot-Scale Manufacturing- Andrew Otte

Tech Session 4: Oral Delivery- 3:00 PM - 5:00 PM

• Transient Opening of Epithelial Tight for the Oral Delivery of Biologics- Dr. Alistair Taverner
• Oral Delivery Gone Wild: Considerations for Wildlife Species- Arlene McDowell
• Nanomedicine Implementations of Dietary Supplements in Breast Cancer Therapy- Marwa Sallam  
• Modulating Epithelial Drug Delivery through Controlled NanoInterfaces- Tejal A. Desai, PhD
• Gastroresistant Microcapsules for Intestinal Delivery of Biomolecules-Tanya Saxena
• Engineered Inulin Gel Formulation for Gut Microbiota Modulation and Immunotherapy - Kai Han

Tech Session 4: Overcoming Tissue Barriers- 3:00 PM - 5:00 PM

• Effects of Lipid Vehicles on Cannabidiol Delivery to Brain Regions after Oral Administration- Alice Brookes

• Ionic Liquid Mediated Topical Delivery of BCL-2 Inhibitors can Treat Scleroderma and Early- stage Melanoma- Md Nurunnabi

• Mechanisms of Translocating an Intact Blood-Brain Barrier- Daniel A. Heller, PhD

• Quantifying the Transport of Biologics Across Intestinal Barrier Models in Real-Time by Fluorescent Imaging- Arjen Weller, PhD