Speaker Presentations
Monday, July 14th
Recent Advances in Oral Peptide Delivery – From Molecule to Market - 8:30 AM - 4:30 PM
- An Assessment of the Trends in Oral Peptide Administration- David Brayden
- Characterization of Macrocyclic Peptide Drug Interactions with Bile Salts and Biorelevant Colloids in the Context of Oral Delivery- Tahnee Dening, PhD
- Overcoming Barriers to Oral Macromolecule Delivery- Stephen T. Buckley, PhD
- Applications of Physiologically - Based Pharmacokinetic Modelling in Oral Peptide Drug Development- Ricardo Diaz de Leon Ortega
- Global Drug Delivery and Formulation Summit 2025- Thomas von Erlach
- Biological Strategies for the Oral Delivery of Poorly Absorbed Therapeutics - Randy Mrsny
- The Development of the Oral Macrocyclic Peptide Enlicitide (MK-0616), for the Treatment of Hypercholesterolemia- Doug Johns, PhD, FAHA
- Enabling Oral Delivery of Peptides through Molecular and Formulation Design- Sumit Arora, PhD
- Recent Advances in Oral Peptide Delivery – From Molecule to Market- Doug Johns, PhD, FAHA
CRS/IPEC-Americas Biologics Summit 2025: Unlocking the Code: Cutting-Edge Advances in Gene & RNA Delivery 8:30 AM - 1:00 PM
- Unlocking the Code: Cutting-Edge Advances in Gene & RNA Delivery- Beate Bittner, Simon Matoori
- Gene Delivery for Glioblastoma: At the Interface of Immunotherapy and Precision Medicine- Dr. Flávia Sousa, PhD,
- Non-viral Delivery of RNA and Genome Editors- Daniel G. Anderson
Oral Drug Delivery - Technology of Today and Tomorrow- 9:00 AM - 5:00 PM
- Understanding Oral Route for Drug Delivery- Andre Hermans, Merck & Co., Inc.
- Oral Drug Delivery Workshop: Technology of Today and Tomorrow- Ali Rajabi-Siahboomi, Sandip Tiwari, and Daniel Treffer
- Current Trends in Complex Oral Formulations & Digital Developments- Rainer Dobrawa
- SYNT, a Synthetic Polymer Lining, to Unlock the Full Therapeutic Potential of the Small Intestine- Vasu Sethuraman, Ph.D
- Implications of Solution-Phase Phenomena and Nanodroplet Formation Upon Dissolution of Amorphous Dispersions in Aspirated Human Intestinal Fluids- Ahmed Elkhabaz
- Understanding Development and Scale-up Challenges to the Commercialization of Complex Oral Solid Dosage Forms- Anil Kane
- Biological Strategies for the Oral Delivery of Poorly Absorbed Therapeutics - Randy Mrsny
- When Mechanistic IVIVC Falls Short: The Case for IVIVR in Oral Drug Delivery- James Mullin
- Predict the Unpredictable - Physiology-Driven Testing of Oral Medicines- Grzegorz Garbacz
- Effect of Polymer Type and Drug Loading on The Mechanism of Nano-species Generation During Dissolution of Amorphous Solid Dispersions of Aprepitant- Arvind K Bansal
- Formulating Peptides for the Gut: A Case Study on Exenatide in Lipid-Based Formulations using Enteric Capsules- Vincent Jannin
Workshop: Applications of 3D Printing Technology to Accelerate Formulation of Challenging Molecules and Manufacturing- 1:00 PM - 5:00 PM
- 3D Printing of Pharmaceuticals: From Inception to the Present-Xiaoling Li
- In Vivo Applications of 3D Printed Pharmaceuticals: Solutions for Challenging Molecules- Tim Tracy
- 3D Printing in Pharma: Regulatory and Compliance Expectations in the Digital Age- Youmin Wang
Workshop: Diagnostics with Phospholipids - Quality standards and areas of application - 1:00 PM - 5:00 PM
- Phospholipids for Use in Parenteral Applications- Michael Kahn
- The Quality of Phospholipids-Alexander Kreft
- Reactive Oxygen Species-Sensing Liposomal Hydrogel for Molecular Diagnostics in Chronic Wounds- Simon Matoori
- Lipid-Shelled Microbubbles and Nanodroplets for Diagnostic and Therapy Applications- Samir Cherkaoui
- Photodynamics and Phospholipids: Controlled Drug Release and Tumor Permeation with Light- Mans Broekgaarden
Workshop: Development Pathways and Considerations for Subcutaneous Biologic Formulations
Tuesday, July 15th
YSC Meet & Greet with a Luminary- 8:00 AM - 9:00 AM
- Speaker: Antoni Torres Coll
- Speaker: Hagar Labouta
Tech Forum: The Role of a Trusted Partner in Advancing Resorbable Polymers for Controlled Drug Release- 9:00 AM - 10:00 AM
- The Role of a Trusted PLGA Partner in Advancing Resorbable Polymers for Controlled Drug Release - Julien Bérard, Nathalie Gonzalez-Vidal
Tech Forum: Molecular Modeling and Machine Learning for Drug Formulation- 9:00 AM - 10:00 AM
- Molecular Modeling and Machine Learning for Drug Formulation- John Shelley, David Nicholson
Tech Forum: Transforming Nanoparticle Analysis: What Light Scattering Techniques Reveal About LNPs & Liposomes- 9:00 AM - 10:00 AM
- Transforming Nanoparticle Analysis: What Light Scattering Techniques Reveal About LNPs & Liposomes- William Penny
Technical Session I: Artificial Intelligence and Predictive Models -10:00 AM-12:00 PM
- Drug Nanoaggregates for Cancer Therapeutics- Daniel Heller, PhD
- 3D-Bioprinted Cancer Models for Prediction of Nanomedicine Response Driven by H&E-based AI Algorithm- Prof. Ronit Satchi-Fainaro, PhD
- Leverage HTS, HTA, and Predictive Models to Advance Lipid Nanoparticle Formulation Development- Yuchen Fan
- Proton sponge or membrane fusion? – Endosomal Escape of siRNA Polyplexes Unveiled by MD Simulations- Katharina Steinegger
- Multiphysics Modeling Towards a Digital Twin Platform for Drug-Loaded Polyester-Based Implants- Marion Krapez
- Comprehensive Whole-Body Cellular Mapping Technologies: Integrating Advanced Imaging and AI-Driven Analysis- Jie Luo
Technical Session I - Bioengineering I-10:00 AM-12:00 PM
- Optoelectronic Technologies for Leadless Modulation of Cells with Sub-Cellular Resolution- Hemi Rotenberg
- Leveraging a Pulsatile Delivery Platform to Create a Single-injection Rabies Vaccine- Kevin McHugh
- Isolation and Focal Treatment of Brain Aneurysms using Interfacial Fluid Trapping - Maria Khoury, PhD
- Stretching Cell Stimulation Enhances Nonviral Gene Delivery: Internalization Pathways and YAP Dynamic- Flaminia Fruzzetti
- Injectable Devices as Cell Factory Implants for Therapeutic Antibody Production- Marwa Sallam
- Evaluation of a Collagen Type II-Targeted Peptide-Drug Conjugate for Rheumatoid Arthritis Treatment- Laavanya Devarajan
- Poly(β-amino ester) Backpacks for Adoptive Macrophage Transfers in High-Grade Serous Carcinoma- Courtney Bailey
- Biophysical State-Driven Regulation of Biomimetic Nanoparticles: Nanomedicine Applications- Sebastião Mendanha
Technical Session I - Nanomedicine and Nanoscale Delivery (Focus: Immuno)-10:00 AM-12:00 PM
- Subcutaneous Administration of Antibody-Drug-Conjugates- Alexandre Detappe
- Engineering Neutrophil-Targeted Antibiotic Nanoparticles to Prevent Lung Injury in Sepsis- Jacob Myerson
- Self-Assembling Multi-Antigen T Cell Hybridizers for Precision Immunotherapy in Multiple Myeloma- Shannuo Li
- Triazine Lipids as a Platform for Subunit Vaccine Development- Kaysi Lee
- Understanding the Inflammatory Targeting of Lipid Nanoparticles to Deliver Therapeutic RNAs- Riccardo Rampado
- Localized Antitumor Therapy via Mitochondrial Apoptosis with siRNA-loaded Metallo-alginate Hydrogels- Jennifer fernández Alarcón
Technical Session I - Nanomedicine and Nanoscale Delivery (Focus: Gene)-10:00 AM-12:00 PM
- Characterizing CRISPR-Cas Ribonucleoprotein Delivery with Bioreducible Polymer Nanoparticles- Christopher Grigsby
- Gold Nanoparticles as Carriers of MicroRNA Mimics for Cancer Immunotherapy and Muscular Diseases- Álvaro Somoza
- Overcoming Chemoresistance in Colorectal Cancer by FcRn-Driven Nucleic Acid Delivery- Natália Teixeira
- Hybrid LNP Prime Dendritic Cells for Nucleotide Delivery- Riddha Das
- Tunable Surface Charge on Polymer Nanoparticles and the Effect on Endothelial Cellular Drug Delivery- Jianlei Wu
- Targeted-LNPs Capable of Functional DNA Delivery to T-cells Enable in-Vivo CAR-T Generation- Daniel Murphy
- Pulmonary Delivery of Circular RNA Therapeutics for Cystic Fibrosis- Ri Tang
Technical Session I - Skin and Mucosal Delivery I-10:00 AM-12:00 PM
- Engineering Synthetic Mucus Biomaterials for Local Therapeutic Delivery- Gregg Duncan
- Nasal Delivery Redefines Immunity: Fighting Melanoma Brain Metastases with a Cancer Nanovaccine- Bárbara Carreira
- Rapid In Situ Forming PEG Hydrogels for Mucosal Drug Delivery- Taj Kumari Yeruva
- Thermostabilization of a Model Viral-Vectored Oral Thin Film Vaccine using DoE Approach- Annika Yardy
- QbD-Guided Development of Hydrogel-Forming Microneedles with a Reservoir for Enfuvirtide Delivery- Huanhuan Li
Technical Session I - Women's Health II-10:00 AM- 12:00 PM
- Drug Delivery Systems in Women's Health- Gustavo Doncel
- Translating Vaginal Films from Bench to Clinic: Interplay Between User Preferences and Drug Delivery Considerations- Sravan Patel
- Pregnancy-Associated Disease Organ-on-a-Chip Models to Pioneer Targeted Therapies- Hagar Labouta
- Genetic Modification of Bacterial Extracellular Vesicles for Vaginal Drug Delivery- Varunaa Sri Hemanth Kumar
- Impact of Cream Composition on Critical Quality Attributes of Miconazole Nitrate Vaginal Creams- Zizhao Xu
- Enabling the Rational Development of Long-Acting Contraceptive Levonorgestrel Intrauterine Systems- Ashwin Abhang
Technical Session II - Nanomedicine and Nanoscale Delivery (Focus: Imaging)- 2:00 PM- 4:00 PM
- PET Imaging for Developing Nanomedicine-based Drug Delivery Systems- Rafael de Rosales
- Toolbox of Self-propelled Nanomotors for Bladder Cancer Therapy- Samuel Sánchez
- Tumor Microenvironment is a Key Driver for Drug Delivery and Efficacy in HER2+ Breast Cancer- Rahaf Mihyar
- USPIO-5D3-DM1 Nano-conjugates as Optical-MRI Theranostics for PSMA-Positive Prostate Cancer Therapy- Sudath Hapuarachchige
- Theranostic Targeted pH-sensitive Liposomes for Breast CancerBone Metastasis- Amanda Claudia Ferreira Amorim
- Evaluation of Long-Acting Injectable In-Situ Forming Gels through in vivo and in vitro MRI- Julia Rosenberger
- A DNA-Guided Lipid Nanoparticle Platform for Targeted Drug Delivery Beyond the Liver- Karoline Kadletz
Technical Session II - Nanomedicine and Nanoscale Delivery (Focus: Nervous)- 2:00 PM- 4:00 PM
- Development and Clinical Translation of Dendrimer Nanomedicines for CNS and Retinal Disorders- Sujatha Kannan
- SARS-CoV-2 Clearance in the Brain and Lungs of K18-hACE2 Mice after Intranasal Liposomal Remdesivir- Frédéric Frézard
- Blood-brain Barrier Targeted Nanoparticles for Peptide Delivery to Glioblastoma- Pablo Hervella
- NLC for Intranasal Delivery in Alzheimer’s Disease-Pharmacokinetic, Biodistribution, and PD Study- Saif Khan
- Dopamine-modified Exosome: Autophagy Induction and Therapeutic Potential In Parkinson’s Disease- Jeongyun Kim
- H-bonded Organic Frameworks as Ultrasound-programmable Delivery Platform- Huiliang (Evan) Wang
- Rapid Cooling and Neuroprotection: Intranasal Vanilloid Nanodrugs for Acute Brain Injuries- Jorge David Tovar Castro
- Glucose Dendrimer-Cannabidiol Conjugates: Safe and Effective Treatment of Pain and Epilepsy- Durgadas Cherukaraveedu
Technical Session II - Ocular Delivery- 2:00 PM- 4:00 PM
- Regeneron Introduction- Hunter Chen
- Biological Barriers to Lipid Nanoparticle Mediated Messenger RNA Delivery to the Retina- Katrien Remaut
- Evaluation of the Effects of TiO2 Nanoparticles Conjugated with Fluorescein on Retinal Angiography-Sílvia L. Fialho, Ph.D
- Rational Design of Medicated Contact Lenses Using ToF-SIMS for Ocular Drug Delivery- Maria Vivero-Lopez
- CRISPR-Cas Delivery Using Lipid-Polymer Nanoplexes in Microneedle Patches for Corneal Dystrophy- Sonia Guha
- Intravitreal Delivery of A190-loaded Microparticles in a Model of Age-related Macular Degeneration- Sagun Poudel
- Mucoadhesive Micelle Nanoparticles: A New Dosing Paradigm for Glaucoma Treatment- Frances Lasowski
- Nanoscale Activated Carbons for Intrastromal Controlled Drug Release -Tejabhiram Yadavalli, PhD
- Breaking Corneal Barriers: GelMA-Based Hybrid Microneedles for Enhanced Intrastromal Drug Delivery- Sonia Alav
Technical Session II- Immuno Delivery- 2:00 PM- 4:00 PM
- Thermal Focused Ultrasound Ablation Combined with Vascular Normalization Drives Anti-tumor Immunity- Mark Schwartz
- Oral Nanotherapeutics for Precision Targeting of Antigen Presenting Cells in Type 1 Diabetes- Nicholas Hunt
- Intradermal administration of Immune Modulating Spherical Nucleic Acids as Anti-Glioma Therapy- Akanksha Mahajan
- Nanoparticle-Based Immunometabolism Approach to Mitigate Allergic Airway Inflammation- Shruti Dharmaraj
- Treatment of Acute Lung Injury Using One-Component LNP to Deliver TGFβ mRNA to the Lower Lung- Jaclynn Meshanni
Technical Session II - Oral Delivery- 2:00 PM- 4:00 PM
- From Nature to Nanoparticles: Advancing Oral Delivery through Permeation Enhancement- Kathryn Whitehead
- A Model-informed Drug Development (MIDD) Approach to Designing Modified Release Formulations for a BCS Class I Drug- John Gleeson
- Development of a Novel Antibody-Based Oral Factor VIII Mimetic Drug Candidate (Inno8)- Philip Jonas Sassene
- Oral Protein Delivery: Nanoassemblies for Targeted Treatment of Intestinal Diseases- María González Portela
- Formulating Biologics for Buccal Delivery: An Investigation of Feasibility and Stability- Anthony Rajabi
- Optimizing Leuprorelin-Permeability Enhancer Complexes for Oral Release- Deborah Shalev
Technical Session II - Gene Delivery and Gene Editing- 2:00 PM- 4:00 PM
- Nature-Inspired Nanotechnology for RNA Delivery to Myeloid Cells and Bone Marrow Progenitors- Roy van der Meel
- Development of SORT Lipid Nanoparticles (LNPs) for Genome Correction of Disease-causing Mutations- Daniel Siegwart
- Cardiac-tropic Lipid Nanoparticles Provide Selective Vascularization After Myocardial Infarction- Junchao Xu
- Targeting a Novel Oncogene with an Azacitidine-based Prodrug Nanocarrier to Elicit Immunogenic Cell Death for Advanced Cancer Therapy- Bei Zhang
- One-component Janus Dendrimers: a Novel Platform for Efficient mRNA Vaccine Delivery- Wook-Jin Park
Wednesday, July 16th
Technical Session III - Delivery to the Nervous System- 10:00 AM - 12:00 PM
- Blood-Brain Barrier/Glioblastoma Interplay 3D in vitro Model for (Nano-)therapeutic Screening- Claudia Martins
- Modulating the Response of Neurons and Glial Cells for Spinal Cord Injury Recovery- Roberta Censi
- Breaking Barriers: Gold Nanoparticle-Based Strategies for Delivering Biologics to the Brain- Rachela Popovtzer
- Development of Neuron-Derived, Mitochondria-containing Extracellular Vesicles for ALS Treatment- Paromita Paul Pinky
- Peptide-Functionalized Lipid Nanoparticles for Targeted Systemic mRNA Delivery to the Brain- Emily Han
- AI-Validated Brain Targeting mRNA Lipid Nanoparticles with High Neuronal Specificity- Gal Chen
- Novel Biodegradable NanoArtemisinin to Treat Leukemia in Blood and Brain- Charles Dai
- Targeting Axonal Pathways: Advancing Nanoparticle Delivery Strategies for Neuronal Therapeutics- Sahadev Shankarappa
Technical Session III - Skin and Mucosal Delivery- 10:00 AM - 12:00 PM
- Living Delivery System for the Treatment of Skin Infections- Boaz Mizrahi
- Chitosan Nanobubbles as a Combined Chemo-immunotherapy Strategy Against Melanoma- Monica Argenziano
- Thermal Stabilization and Immunogenicity of mRNA Vaccine Delivered by Single-Use Microneedle Patches- Nidhi Sharma
- Biocatalytic Nanobots: Modulating Oxidative Stress in Cellular Models of Inflammatory Bowel Disease- Ezequiel Coscueta
- Branched PEGylation as a Strategy to Overcome the Mucus Barrier to Aerosolized Nanomedicine- Alexa Stern
- Quantifying the Impact of the Mucin Protein Corona on Nanoparticles in the Female Reproductive Tract- Alyssa P. Petersen
- Novel Dissolving and Hydrogel-Forming Microarray Patches for Transdermal Delivery of Apomorphine HCl- Andrew Graham
Technical Session III - Gene Delivery and Gene Editing- 10:00 AM - 12:00 PM
- Enhanced pDNA Delivery Mediated by Backbone-Degradable RAFT Copolymers- Adam Gormley
- DNA-loaded Lipid Nanoparticles (DNA-LNPs): a Platform Technology to Treat Common Chronic Diseases- Jacob Brenner
- Lipid Nanoparticle Delivery for CRISPR Gene Editing in Primary Human T-cells- Joy Chen
- Breaking Barriers: Stabilized Lipid Nanoparticles Transform Oral Nucleic Acid Delivery- Kanika Suri
- The Lipid Nanoparticle Shape and Morphology Affect the Efficiency and Duration of mRNA Transfection-Sara Elsafy
- Optimization of Nanoparticle Delivery of Nucleic Acids to Cells Using Poly(glycerol esters)- Brian Ginn
- Optimized Lipid Nanoparticles for CRISPR/Cas9 Delivery: Advancing Gene Editing in Lung Tumor Cells- Simone Carneiro
Technical Session III - Nanomedicine and Nanoscale Delivery (Bioengineering)-10:00 AM - 12:00 PM
- Delivery of Nanoparticulate Vaccines by Microneedle Patch- Mark Prausnitz
- Supercharging Immunotherapy Through Nanotechnology: Chemical Structure Matters- Natalie Artzi
- Leveraging Cell-Penetrating Peptides and Liposomes to Enhance Nanobody Therapy in Breast Cancer- Giulia Pander
- Programmable Degradable Oxanorbornadiene Hydrogels for Functional Biomolecular Release- Wenting Shi
- Chiral Quantum Dots Enhanced Small Extracellular Vesicles for Gene Delivery- Yichun Wang
- Fabrication and Evaluation of Calcium Polyphosphate-based Graft Materials for Spinal Fusion-FNU VIKAS
- Sweet Encounters: Studying Nanoparticle-Glycan Interactions by Metabolic Labeling and Click Chemistry- Melissa Hendrén
Technical Session III - Nanomedicine and Nanoscale Delivery (Focus: Nano)-10:00 AM - 12:00 PM
- β-cyclodextrin-based Nanomedicines for Cancer Therapy- Anna Scomparin
- Lysine-acetylated Human Serum Albumin: Enhanced Uptake by Cancer Stem Cells and Application-Guojun Xiong
- Improving Tumor-Specific Drug Delivery: The Role of ADAM17 Inhibition in CD44-Targeted Nanoparticles- Sheida Dabiri
- Sustained-Release of Novel Therapies for Treating Opioid Use Disorder- Diane Ingabire
- MUC4-Targeted Nanoparticles Deliver MRTX1133 and MDP5 to Overcome Pancreatic Cancer Chemoresistance-Yashwardhan Ghanwatkar
Technical Session IV - Alternative Methods to Animal Testing-2:00 PM - 4:00 PM
- Stimuli-Responsive Bioengineered Biomaterials: 3D In-vitro Models & Regenerative Medicine Therapies-Silvia Panseri
- 3D(Bio)printed Infection Models of Human Lung Cells and Skin Hair Follicles to Study Nanoantibiotics- Claus-Michael Lehr
- 3D Cell Assemblies to Evaluate Inflammatory Response to Dual-agent Delivery Platforms Targeting BV- Arielle Greiner
- Collagen Microgel 3D Organoid Culture and Extracellular Vesicle Production for Drug Development- Samantha Ali
- mRNA-LNPs Microneedle Delivery in 3D Human Dermal Equivalent Model for Preliminary In-Vitro Testing- Elena Lagreca
- The SCISSOR technology: Investigating Biopharmaceutics of Subcutaneously Delivered Oligonucleotides- Karin Somby
- The Aβ42:Aβ40 Ratio in Amyloid Plaques and Its Role in Blood-brain Barrier Dysfunction- Stefanie Gier
Technical Session IV - Oral Delivery II -2:00 PM - 4:00 PM
- Transbuccal Delivery of Peptides with the Suction Patch- Jean-Christophe Leroux
- Hemi-Porous Janus Microparticles as a Muco-adhesive Enteral Delivery System for BCS Class III Drugs-Akihiro Matsumoto
- An innovative Inflammation-targeting Platform for Ulcerative Colitis Treatment- Waliul Islam
- Reduced Griseofulvin Permeation Across a Hollow Fiber Membrane Due to Drug Micellization-Roshni Patel
- Evaluation of Acid-Base Supersolubilization Principle on Telmisartan to Lower HME Temperature- Mohammed Syed
- An Antioxidant MOF with Functional Coatings for Oral Antibody Delivery in Inflammatory Bowel Disease- Cheng Chen
- Lipid Formulations in Customized Enteric Capsules Show Promising Results For Oral GLP-1 RA Delivery- Vincent Jannin
- Tips and Tricks for Increasing Oral Drug Absorption from Nanoemulsions- Anette Müllertz
Technical Session IV - Immuno Delivery II -2:00 PM - 4:00 PM
- Dendritic Cell-Targeted Nanoparticles to Enhance T Cell Activation and Immune Checkpoint Modulation- Ayelet David
- "Naked" Liposomal Delivery to Heal a Broken Heart- Vincent Venditto
- Nanoparticles in Microparticles: A Potential Immunomodulatory Therapeutic System for Osteoarthritis-Paul Sagoe
- Dendrimer-Antibody Conjugates: An Innovative Approach for Targeted Intracellular Antibody Delivery- Milan Paul
- CD44v6-Driven Nanoparticles Combined with Immune Therapy for Colorectal Cancer- Ana Baião
- Targeted STING Agonism Modulates saRNA Vaccine Immunogenicity- David Peeler
- Sequential Delivery of Macrophage Activators and Checkpoint Inhibitors Reduces Mice Melanoma Burden- Madhan Mohan Chandra Sekhar Jaggarapu
- Impact of Nanofiber Physical and Chemical Properties on Immune Response- Špela Zupančič
Technical Session IV - Bioengineering II -2:00 PM - 4:00 PM
- Bioinspired Peptide-Based Materials for Regenerative Therapies- Lihi Adler-Abramovich
- Therapeutic Genome editing in Cancer via Targeted Lipid Nanoparticles entrapping RNAs- Dan Peer
- Antibody Drug-loaded Unimicelle Conjugates (ADUCs): A Novel Platform Enabling Ultra-high DAR- Kenichi Suzuki
- “Affinity Cocktails” of Alpha-Particle Radionuclide Antibody-Conjugates for Solid Tumors-Aira Sarkar
- Low-dose Chemotherapy Empowers alpha-Particle Radionuclide Therapy Against Metastatic Breast Cancer- Pooja Hariharan
- Physics-Informed Predictive Modeling of Bacterial Vaginosis Pathogen Dynamics- Bassam Fotouh
- Efficient Vascular Handoff: Rapid Cargo Transfer from Carrier RBCs to Downstream Vasculature- Jing Liu
- Development of Hybrid Cell Membrane Nanovesicles for Enhanced Pancreatic Cancer Treatment- HO THI LUU
Technical Session IV - Nanomedicine and Nanoscale Delivery (Focus: Gene)-2:00 PM - 4:00 PM
- Peptide-Lipid Conjugates for Enhancing mRNA-LNP Delivery and Colon Cancer Vaccines- Kuo-Ching Mei
- Polymeric Mesoscale Nanoparticles Selectively Target Gene Therapies to the Kidneys- Ryan Williams
- Pioneering Intranasal siRNA-based Nanovaccine- Rita Acurcio
- Lipid Stereochemistry of Lipid Nanoparticles Significantly Influences mRNA Expression Levels in Vivo- Renzo Knol
- Lipid-siRNA Organization Modulates the Intracellular Dynamics of Lipid Nanoparticles- Yulin Mo
- Dual Centrifugation: A Novel Perspective on LNP Formulation Development- Valentin Bender
- Precision Attack: GD2-Directed siRNA-Lipid Nanoparticles to Target Neuroblastoma’s Weak Spots- Amy Logan
- Targeting the Lower Regions of the Lung: A Novel Platform for Pulmonary mRNA Delivery- Rachel Sun
Technical Session IV - Nanomedicine and Nanoscale Delivery (Focus: Nano)- 2:00 PM - 4:00 PM
- Pulmonary Surfactant-based Pirfenidone-loaded Nanovesicles for Inhalation in Pulmonary Fibrosis-Chang Geun Kim
- Functional Personalized Complex Combination Nano Therapy for Osteosarcoma- Orr Bar Natan
- TGX-1214 - A Nanoemulsion Formulation of a Novel Taxoid for Treating Pancreatic Adenocarcinoma- Satveer Jagwani
- A Designer Transcytotic Paclitaxel Nanovesicle for TNBC and Pancreatic Cancer Combination Therapies- Jianqin Lu
- Integrating MD Simulations in the Design and Preparation of Ibrutinib (IBR)-loaded liposomes- Xiufang Cheng
Thursday, July 17th
YSC & Industry Foresight Council - Chat with Industry - 8;00 AM- 9:00 AM
- Introduction to Halozyme Therapeutics- David Kang
- YSC & Industry Foresight Council - Chat with Industry- Gülçin Arslan Azizoğlu
- YSC Chats with Luminaries- Marwa Sallam
Tech Session V: Gene Delivery and Gene Editing III-10:00 AM - 12:00 PM
- Evaluating the Effects of PEGylated Lipid Shedding on Targeted Nanomedicines- Lisa Volpatti
- Engineer Lipid Nanoparticle Surface Hydrophobicity to Modulate Nano-Bio Interface and Enable Tissue-Selective mRNA Delivery- Fan Zhang
- PBAE-Based Pulmonary siRNA Delivery to T-Cells: A Potential Approach for Asthma Therapy- An Ny Nguyen
- Lipid Nanoparticle-mediated Metabolic Reprogramming of Dendritic Cells for mRNA Vaccines- Dongyoon Kim
- Advancing T-Cell Therapy: mRNA Nanocarrier Optimization for Ex Vivo and in Vivo T-Cell Engineering- Elisa Battistini
- Enhancing mRNA-lipid Nanoparticle Prediction via the Language Model and Multi-Task Learning-YIYANG WU
- Microrobot-Assisted Delivery of Circular RNA-Lipid Nanoparticles to Treat Lung-Associated Diseases- Bianca Santana
- Multi-stage mixing creates high-efficiency core-then-shell DNA lipid nanoparticles- Jia Nong
Tech Session V: Imaging in Drug Delivery-10:00 AM - 12:00 PM
- Imaging Drug Delivery – What Can We Learn from Clinical Experiences?- Willemien Menke
- Multimodal Immunoimaging of CCR2-Driven Inflammation in Metabolically Stressed Myocardial Infarction- Katrien Vandoorne
- Optimizing the Biodistribution and Pharmacokinetics of Polysarcosine-based Star Dendrimers by PET/CT- Tia Gibson
- Charge-Reversed Lipid Nanoparticles Containing Metal-Organic Cages for In Vivo Anti-Cancer Treatment- Dennis Aschmann
- Vascular Pre-Treatment for Augmented Focused Ultrasound Mediated Drug Delivery- Victoria Breza
- Size-Tunable Theranostics Micelles for Subcutaneous Drug Delivery and Sentinel Lymph Node Targeting- Alec Wang
- Nanomedicine for Brain Delivery of Monoclonal Antibodies: The Impact of Nanocarrier Structure- Laura Piñeiro-Alonso
Tech Session V: Nanomedicine and Nanoscale Delivery (Focus: Nano)-10:00 AM - 12:00 PM
- Engineering Polymer-Protein Interactions to Control the Polymersome Protein Corona- Jessica Larsen
- Overcoming Fungal Cell Barriers: Nanoparticle-Mediated Photoporation for Effective RNA Delivery- Adriana Avila Flores
- Sustained Heme-Albumin Release as a Potential Therapy for Dry Age-related Macular Degeneration- Katelyn Swindle-Reilly
- Localized Delivery of Antibacterial Gallium-based Nanoparticles to Treat Lung Infections- Shengtao Yu
- Membrane Dynamics Modulate the Functional Activity of Biomimetic Nanoparticles- Mariana Arraes Salomão
- Poly (β-amino ester) Particles with Programmable Shape, Stiffness, and Degradation for Drug Release- Katherine Trese
Tech Session V: Nanomedicine and Nanoscale Delivery (Focus: Oral)-10:00 AM - 12:00 PM
- Magneto-Responsive Drug Delivery Systems for Local Treatment of Colorectal Cancer- Alexandra Teleki
- NAC-based Ionic Liquids for GLP-1 Delivery: A Mechanistic Understanding of In Vivo Performance- Zhigao Niu
- Intestinal Fc receptor-targeted nanomedicines boost semaglutide effect in type 2 diabetes- Soraia Pinto
- Oral Delivery of MSC-EVs as a Novel Approach to Treat Inflammatory Bowel Disease- Mona Belaid
- Predicting Drug Delivery of Push-Pull OROS: A Biorelevant Dissolution and PK Simulation Strategy- Grzegorz Garbacz
- Transforming Healthcare: Treatment of Inflammatory Bowel Disease with Biocatalytic Nanobots- Ana Sofia Sousa
- Improving Bioavailability of Poorly Soluble Oral Drugs- Taslima Binte Kamal
Tech Session V: Skin and Mucosal Delivery III- 10:00 AM - 12:00 PM
- Development of a new modality of transdermal platform based on nanofibers for the delivery of APIs- Jose Lagaron
- Pharmacokinetics and Skin Permeation of Psychedelic Drugs Delivered by Hydrogel-Forming Microneedles- Octavio Fandiño
- Safety Evaluation of Repeated Microarray Patch Applications Using a Miniature Pig Model- Qonita Anjani
- Integrated Fiber Microneeedles in the Oral Mucosa Prime Antigen-Specific Immunity-Carmen Ioana Tobos
- Nonspecific Binding of Biotherapeutics and the Extracellular Matrix: Implications for Drug Delivery- Evelyn Nonamaker
- Non-covalent Lipidation and Self-Nanoemulsions: Ex-vivo porcine buccal mucosal permeation of GLP-1RA- David Brayden
- Boosting Buccal Absorption: Bilosomes for Effective Therapeutic Delivery- Eleftheria Pantazoglou
Tech Session V: Women's Health II- 10:00 AM - 12:00 PM
- Nanomedicine approaches for Women's Health- Laura Ensign
- Breaking Barriers in Endometriosis: from 3D Microphysiological Models to Combination Therapies- Paola Luciani
- Next Generation 3D Printed Intravaginal Rings for Prevention of HIV and Unintended Pregnancy- S. Rahima Benhabbour
- Ultra-long-acting Biodegradable Polymeric Solid Implants for HIV Treatment Maintenance- Annu Anna Thomas
- Spatiotemporal Targeting of mRNA LNPs to the Endometrium for the Treatment of Infertility- Kimberly Bockley
- Engineering Protein-conjugated Lipid Nanoparticles for Targeted mRNA Delivery to the Placenta- Hannah Geisler
- Development of a gel-forming Vaginal Estradiol Formulation for Treatment of Postmenopausal Atrophy- Marina Better
- Long-acting Multipurpose Prevention Technology (MPT) Implants to Prevent HIV & Unintended Pregnancy-Archana Krovi
Translational Research Panel: Advancing Discoveries from the Research Bench to the Clinic- 3:00 PM - 4:00 PM
- Translational Research Panel: Advancing Discoveries from the Research Bench to the Clinic- Paolo Decuzzi
Tech Session VI: Bioengineering III-4:30 PM - 6:30 PM
- Advanced Technologies for Heart Tissue Engineering- Tal Dvir
- In-Vitro Assessment of Cell-based Drug Delivery Systems- Michael Dunne
- Engineering Narrow-band Gap Nanotherapeutics for Multimodal Treatments of Colon Cancer- Manoj Kandel
- Silicon Nanoneedles: A Breakthrough Platform for Controlled, Sustained Macular Degeneration Treatment- Phuc Nguyen
- Albubody Platform for Enhanced Anti-Tumor Efficacy of Scfv-based Drug Conjugates- Na Hyun Kwon
- Gas-entrapping Materials to Improve HIPEC for Ovarian Cancer- James Byrne
Tech Session VI: Delivery Technologies for Diversified Products -4:30 PM - 6:30 PM
- Precision Agrochemical Delivery with Nanoscale Biopolymers-Jason White
- Advancing RNAi Delivery in Plants through Guanidinylated Polymer Systems-Sven Vereecken
- Delivery Systems for Efficacy Improvement of Volatile Herbicides- Renata Raffin
- Medicine to Agriculture: Microfluidic-Produced N-Loaded Liposomes as Enhanced-Efficiency Fertilizer- Alireza Mohammadzadeh
Tech Session VI: Immuno Delivery III- 4:30 PM - 6:30 PM
- Engineering Tolerance: Acetalated Dextran Microparticles in the Generation of B-regs and T-regs-Kristy Ainslie
- The Immunological Aspects of Immune Checkpoint Blockade-Yuval Shaked
- CD47-Targeted Antibody Polymer-Drug Conjugates: Immune Checkpoint Blockade and Targeted Cytotoxicity- Jiahui Li
- Prodrug-tethered Lipid Nanoparticles for Synergistic mRNA Cancer Immunotherapy- Qiangqiang Shi
- A DC-targeted nano-vaccine to overcome immune suppression and enhance the SoC efficacy for PDAC- Ron Kleiner
- Aromatic mRNA-LNP platform Confers Vaccine Protection with Reduced off-target Delivery- Hannah Yamagata
- Anti-tumor activity of an RNA-encoded Antibody Combining T-cell Engagement and Checkpoint Inhibition- Philipp Lapuhs
- Immunomodulatory Nano-in-microgel to Prevent Extrahepatic Islet Graft Rejection in Type 1 Diabetes- Dhanashree Surve
Tech Session VI: Nanomedicine and Nanoscale Delivery (Focus: Gene)-4:30 PM - 6:30 PM
- Rational Design of mRNA Folding Architecture to Enhance Protein Production- Qianqian Ni
- Tolerogenic mRNA-lipid Nanoparticle Vaccines for Autoimmune Disease- Jilian Melamed
- Hybrid polymer-lipid Nanoparticles as Innovative Transfection Vectors for MicroRNA Delivery- Martina Coletto
- Xkr8 Knockdown Enhances Chemotherapy Efficacy Through Modulating Tumor Immune Microenvironment- Chien-Yu Chen
- Dual-Shielding Approach for TNFα Silencing in Inflammatory Bowel Disease via Bioadhesive Microbeads- Valentina Marotti
- Dual Zn2+/Cu2+ Chelation-Engineered Nanotherapeutics for DNA-Mitochondrial Disruption in TNBC- Kai Xiao
- High-throughput screening of Lipid Nanoparticles for Lung Delivery of mRNA- Marco Túllio Alves
- The Modular Platform to Deliver Bio-orthogonal Macromolecular Conjugates (BMCs) for Therapeutic Gene Editing- Ning Wang
Tech Session VI: Nanomedicine and Nanoscale Delivery (Focus: Skin / Mucosal)-4:30 PM - 6:30 PM
- Polymersome Assay for Point-of-care Blood Urea Diagnostics in Dialysis Patients- Simon Matoori
- Impact of DNA Origami Shape, Ligand, and Ligand Density on Diffusion through Intestinal Mucus- Matteo Tollemeto
- Enhancing transmucosal uptake of GLP-1RA: Ionic lipidation and Self-Nanoemulsifying Delivery System- David Brayden
- Gel-based High-permeation Vesicles for Localized Fulvestrant Delivery to Treat Breast Cancer- Junia Akhtar
- Nano Meets Micro: Enhanced Dermal Delivery of Lipophilic Tocotrienol Nanoemulsion Using Microneedles- Jing Yi Lee
- Is Transdermal Delivery Achievable for Levodopa? Microarray Patch for Parkinson’s Disease Treatment- Yaocun Li
- Novel Solid Lipid Nanoparticles-Enriched Hydrogels for Topical Delivery of Anti-Ageing Glutathione- Mengyang Liu
Tech Session VI: Oral Delivery III- 4:30 PM - 6:30 PM
- Engineering Nanotherapeutics for Local Intestinal Delivery Responding to Oxidative Cues in the Gut Microenvironment- Bruno Sarmento
- 3D Printed Ileum Targeted Tablet for the Treatment of IgA Nephropathy- Xiaoling Li
- Orally Administered Macrophage Targeted Dendrimer-Tesaglitazar for Obesity and Atherosclerosis- Jose Diego Almodiel
- Elucidation of Tablet Dissolution and Functional Excipient Behavior with In Situ Exposure- Andrew Clark
- A successful application of high-loading amorphous solid dispersions in HME & Additive Manufacturing-Leslie Benet
Friday, July 18th
Tech Session VII: Alternative Methods to Animal Testing II- 8:00 AM - 10:00 AM
- Reconstructed Human Patient Dynamic Models for Engineering Targeted Therapeutics for Aneurysms- Netanel Korin
- Elucidation of Lipid Nanoparticle Fusion Mechanisms Using Artificial Membranes- Shu Okumura
- Development of Innovative 3D Colorectal Cancer Models as Preclinical Tools for Drug Screening- Sofia Dias
- Exploring the Impact of Ion-Releasing Fabrics on Inflammatory Pathways by 3D In-RED In Vitro Model- Giovanna Della Porta
- Transport of Red Blood Cell Carriers Through Microfluidic Model Mimicking Human Pulmonary Capillary- Danielle Nemcovsky
- Blood-brain barrier/glioblastoma Interplay 3D in Vitro Model for (Nano-)therapeutic Screening- Claudia Martins
Tech Session VII: Delivery to the Nervous System II - 8:00 AM - 10:00 AM
- Empowering the Blood-Brain Barrier: VCAM Targeted Nanocarriers in Neuroinflammatory Diseases- Oscar Marcos-Contreras
- Intracerebral Delivery of Cytokine Immunotherapy with Hydrogel Accelerates Recovery Post-ICH in Rats- John Clegg
- The Nose Knows: Optimizing Nanoparticle Properties is the Shortest Route from the Bench to the Brain- Eliana Lima
- Targeted Glucose Dendrimer Ketamine Therapy Protects Against Refractory Status Epilepticus in Mice- Preeti Vyas
- Novel Triple-drug Cocktail for Glioblastoma Exhibits Potent Synergistic Antitumoral Effects- Paulo Faria
- Nose-to-Brain Delivery of Novel Fingolimod-Ibuprofen Salt for Pain Relief in Multiple Sclerosis-Minqi Fu
- Engineering of Mitochondria-enriched Brain Endothelial Cell-derived Extracellular Vesicles- Vivek Basudkar
Tech Session VII: Gene Delivery and Gene Editing IV - 8:00 AM - 10:00 AM
- NanoGhost: A Stem Cell-Based Off-the-Shelf Nano-Delivery Platform for Targeted Drug and Gene Therapy- Marcelle Machluf
- Designing Next-Gen LNPs: Tools, Challenges, and Opportunities- Yvonne Perrie
- Polymer Lipids Reduce Anti-PEG Antibody Binding for Repeated Administration of mRNA Therapeutics- Yufen Xiao
- Degradable Cyclic Amino Alcohol Ionizable Lipids as Vectors for Potent Influenza mRNA Vaccines- Akash Gupta
- Antibody-Conjugated Lipid Nanoparticles to Enhance Extrahepatic Nucleic Acid Delivery- Sanjib Saha
- Boosting CAR T cells with Advanced Adjuvant Cancer Nanovaccines- Flavia Sousa
- An Optimized Polymeric Delivery Platform for Pulmonary mRNA Vaccines- Min Jiang
- In Vivo Nucleic Acid Targeted Delivery in Bone-Marrow via Antibody Conjugated Lipid Nanoparticles- Sabrina Khan
Tech Session VII: Immuno Delivery IV- 8:00 AM - 10:00 AM
- Targeted Nanomedicine Strategies to Reprogram the Tumor Immune Microenvironment-Jai Prakash
- Poly(Beta Aminoester) – Extracellular Vesicles Hybrids for Antitumor Nucleic Acid Vaccination- Cristina Fornaguera
- Nanoparticles-mediated Inhibition of DPP4 for Improved Cancer Immuno-chemotherapy-Shangyu Chen
- Inhalable Icariin-Loaded Micelle-in-Microparticles Targeted IL-4 Signal Pathway for COPD Treatment-Chengwei Jiang
- Platelet-Drug Conjugates Engineered via One-step Fusion Approach for Cancer Treatment- Zhengjie Zhao
- Nanoparticle Metalloimmunotherapy for Cancer Eradication: Comprehensive Evaluation From Mice to NHPs- Kevin Sun
- Timely Administration of Drug Combination Improves Chemoimmunotherapy of an Immune-cold Tumor- Yanying He
Tech Session VII: Nanomedicine and Nanoscale Delivery (Focus: Bioengineering) - 8:00 AM - 10:00 AM
- Membrane-wrapped Nanoparticles for Photoacoustic Imaging and Photothermal Therapy of Triple-negative Breast Cancer- Emily Day
- Extracellular Vesicle Lipid Rafts Profiling as a Blueprint for Targeted EV-Mimetic Therapies- Oliwia Majchrzak
- Lipid Nanoparticles Comprising Polyphosphocholine Conjugates for Nucleic Acid Delivery- Evgenia Mitsou
- Novel Glucose Dendrimer Approach to Target Hyperactive Neurons in vivo: Mechanistic Insights- Narendra Kale
- Tendon-derived ECM Enables Percutaneous Delivery of iMSC-SCX+ for Tendon Defect Healing- Ahmet Pazarceviren
- Short-Chain Brushed PEGylation Evades Anti-PEG Immunity to Enhance Nanomedicine Safety and Efficacy- Si-Han Wu
- Advancing PROTAC Delivery: Liposomal, NAB, and Cyclodextrin-Based Formulations of ACBI2- Miriam Jaki
